Cited by 3,228Vagus Nerve Stimulation ResearchNicotinic Acetylcholine Receptors StudyNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Wang, Hong, Yu, Man, Ochani, Mahendar, Amella, Carol Ann, Tanovic, Mahira, Susarla, Seenu, Li, Jian Hua, Wang, Haichao, Yang, Huan, Ulloa, Luis, Al-Abed, Yousef, Czura, Christopher J., Tracey, Kevin J.·2003·Nature

DOI 10.1038/nature01339

Open this paper in CoChat — free account

Abstract

Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel disease. Highly conserved, endogenous mechanisms normally regulate the magnitude of innate immune responses and prevent excessive inflammation. The nervous system, through the vagus nerve, can inhibit significantly and rapidly the release of macrophage TNF, and attenuate systemic inflammatory responses. This physiological mechanism, termed the 'cholinergic anti-inflammatory pathway' has major implications in immunology and in therapeutics; however, the identity of the essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signals was previously unknown. Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release. Electrical stimulation of the vagus nerve inhibits TNF synthesis in wild-type mice, but fails to inhibit TNF synthesis in alpha7-deficient mice. Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway.

Integrity signals

Registry

Crossref · 10.1038/nature01339

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citation
The inflammatory reflex
Tracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Self-citation
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Self-citation
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citation
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“gif" NDATA ITEM> ]> Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel diseas”
BackgroundSelf-citation
Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
Self-citation
Tumor necrosis factor: a pleiotropic cytokine and therapuetic target
Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
Lin, W.-C., Burgess, R., Dominguez, B., Pfaff, S., Sanes, J., & Lee, K.-F. (2001) · Nature · doi:10.1038/35074025 · Cited by 560
Pharmacological stimulation of the cholinergic antiinflammatory pathway
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C. J., Ivanova, S. M., & Tracey, K. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011714 · Cited by 529
Self-citation

Flagged first, then by citations

Show all 26 references

Research works printed but not linked: 1

Lindstrom, J. M. in Hand Book of Receptors and Channels: Ligand- and Voltage-Gated Ion Channels (ed. North, A.) 153–175 (CRC Press, Boca Raton, Florida, 1995)

Sorted by citations

Items 501–600 of 1,004

Sense and Immunity: Context-Dependent Neuro-Immune Interplay
Foster, S. L., Seehus, C. R., Woolf, C. J., & Talbot, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01463 · Cited by 94
Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma
Mehta, A. K., Singh, B., Arora, N., & Gaur, S. N. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.09.004 · Cited by 92
Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research
Damar, U., Gersner, R., Johnstone, J. T., Schachter, S. C., & Rotenberg, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1175303 · Cited by 93
Macrophages under pressure: the role of macrophage polarization in hypertension
Harwani, S. C. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.011 · Cited by 95
The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism
Ren, C., Tong, Y., Li, J., Lu, Z., & Yao, Y.-M. (2016) · International Journal of Biological Sciences · doi:10.7150/ijbs.16404 · Cited by 93
Self-citation
Neuroprotective potential of berberine in modulating Alzheimer’s disease via multiple signaling pathways
Akbar, M., Shabbir, A., Rehman, K., Akash, M. S. H., & Shah, M. A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13936 · Cited by 97
Vagus nerve stimulation promotes resolution of inflammation by a mechanism that involves Alox15 and requires the α7nAChR subunit
Caravaca, A. S., Gallina, A. L., Tarnawski, L., Shavva, V. S., Colas, R. A., Dalli, J., Malin, S., Hult, H., Arnardottir, H. H., & Olofsson, P. S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023285119 · Cited by 94
Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: Effects of selective activation
Mannelli, L. D. C., Pacini, A., Matera, C., Zanardelli, M., Mello, T., Amici, M. D., Dallanoce, C., & Ghelardini, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.034 · Cited by 92
Stimulating the Central Nervous System to Prevent Intestinal Dysfunction After Traumatic Brain Injury
Bansal, V., Costantini, T. W., Ryu, S. Y., Peterson, C. Y., Loomis, W. H., Putnam, J., Elicieri, B. P., Baird, A., & Coimbra, R. S. M. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181d87373 · Cited by 93
Positive modulators of the α7 nicotinic receptor against neuroinflammation and cognitive impairment in Alzheimer's disease
Echeverría, V., Iarkov, A., & Aliev, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.002 · Cited by 95
Ghrelin and cancer progression
Lin, T., & Hsiao, M. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.02.002 · Cited by 90
Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation
Rump, K., & Adamzik, M. (2022) · Cells · doi:10.3390/cells11192954 · Cited by 96
It takes nerve to dampen inflammation
Metz, C. N., & Tracey, K. J. (2005) · Nature Immunology · doi:10.1038/ni0805-756 · Cited by 90
Self-citation
Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro
Koval, L., Lykhmus, O., Zhmak, M. N., Khruschov, A. Y., Tsetlin, V. I., Magrini, E. I., Viola, A., Chernyavsky, A. I., Qian, J., Grando, S. A., et al. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.12.003 · Cited by 90
Gut Inflammation in Association With Pathogenesis of Parkinson’s Disease
Chen, Q.-Q., Haikal, C., Li, W., & Li, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00218 · Cited by 88
Self-citation
Neuroimmune Pathophysiology in Asthma
Pavón-Romero, G. F., Serrano-Pérez, N. H., García-Sánchez, L., Jiménez, F. R., & Teran, L. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663535 · Cited by 91
Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines: Catestatin activates human mast cells
Aung, G., Niyonsaba, F., Ushio, H., Kajiwara, N., Saito, H., Ikeda, S., Ogawa, H., & Okumura, K. (2011) · Immunology · doi:10.1111/j.1365-2567.2010.03395.x · Cited by 89
Acetylcholine as an age-dependent non-neuronal source in the heart
Rana, O. R., SCHAUERTE, P. N., Kluttig, R., Schröder, J. W., Koenen, R. R., Weber, C., Nolte, K. W., Weis, J., Hoffmann, R., Marx, N., et al. (2010) · Autonomic Neuroscience · doi:10.1016/j.autneu.2010.04.011 · Cited by 89
Central activation of the cholinergic anti‐inflammatory pathway reduces surgical inflammation in experimental post‐operative ileus
The, F., Cailotto, C., van der Vliet, J., de Jonge, W. J., Bennink, R. J., Buijs, R. M., & Boeckxstaens, G. E. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01296.x · Cited by 89
Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear
Addorisio, M. E., Imperato, G. H., de Vos, A. F., Forti, S., Goldstein, R. S., Pavlov, V. A., van der Poll, T., Yang, H., Diamond, B., Tracey, K. J., et al. (2019) · Bioelectronic Medicine · doi:10.1186/s42234-019-0020-4 · Cited by 93
Self-citation
The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings
Yang, J., Liang, J., Hu, N., He, N., Liu, B., Liu, G., & Qin, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70091 · Cited by 109
α7 Nicotinic Acetylcholine Receptor Regulates Airway Epithelium Differentiation by Controlling Basal Cell Proliferation
Maouche, K., Polette, M., Jolly, T., Medjber, K., Cloëz-Tayarani, I., Changeux, J., Burlet, H., Terryn, C., Coraux, C., Zahm, J. M., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090212 · Cited by 88
Colonic treatments and targets: issues and opportunities
McConnell, E. L., Liu, F., & Basit, A. W. (2009) · Journal of drug targeting · doi:10.1080/10611860902839502 · Cited by 89
Acetylcholine-producing NK cells attenuate CNS inflammation via modulation of infiltrating monocytes/macrophages
Jiang, W., Li, D., Han, R., Zhang, C., Jin, W.-N., Wood, K., Liu, Q., Shi, F., & Hao, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705491114 · Cited by 88
Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor
Kimura, K., Tanida, M., Nagata, N., Inaba, Y., Watanabe, H., Nagashimada, M., Ota, T., Asahara, S.-I., Kido, Y., Matsumoto, M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.032 · Cited by 84
Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease
Yakel, J. L. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-012-1200-1 · Cited by 95
Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors
Hao, J., Simard, A. R., Turner, G. H., Wu, J., Whiteaker, P., Lukas, R. J., & Shi, F. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.09.020 · Cited by 87
Non‐invasive transcutaneous auricular vagus nerve stimulation prevents postoperative ileus and endotoxemia in mice
Hong, G., Zillekens, A., Schneiker, B., Pantelis, D., de Jonge, W. J., Schaefer, N., Kalff, J. C., & Wehner, S. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13501 · Cited by 88
Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung
Wang, W., Cohen, J. A., Wallrapp, A., Trieu, K. G., Barrios, J., Shao, F., Krishnamoorthy, N., Kuchroo, V. K., Jones, M. R., Fine, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.002 · Cited by 86
Therapeutic Targeting of α7 Nicotinic Acetylcholine Receptors
Papke, R. L., & Horenstein, N. A. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000097 · Cited by 92
Neuroimmune Interactions in the Intestine
Wallrapp, A., & Chiu, I. M. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-042929 · Cited by 93
Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils
Tiszlavicz, Z., Németh, B., Fülöp, F., Vécsei, L., Tápai, K., Ocsovszky, I., & Mándi, Y. (2011) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-011-0605-2 · Cited by 89
Proteomic Analysis of an α7 Nicotinic Acetylcholine Receptor Interactome
Paulo, J. A., Brucker, W. J., & Hawrot, E. (2009) · Journal of Proteome Research · doi:10.1021/pr800731z · Cited by 87
Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways
Zdanowski, R., Krzyżowska, M., Ujazdowska, D., Lewicka, A., & Lewicki, S. (2015) · Central European Journal of Immunology · doi:10.5114/ceji.2015.54602 · Cited by 94
Association between cigarette smoking and release of tumour necrosis factor and its soluble receptors by peripheral blood mononuclear cells in patients with rheumatoid arthritis
Glossop, J. R., Dawes, P. T., & Mattey, D. L. (2006) · Rheumatology · doi:10.1093/rheumatology/kel094 · Cited by 86
Signaling the brain in inflammation: the role of endothelial cells
Matsumura, K. (2004) · Frontiers in bioscience · doi:10.2741/1439 · Cited by 87
Candidate genes for nicotine dependence via linkage, epistasis, and bioinformatics
Sullivan, P. F., Neale, B. M., van den Oord, E. J. C. G., Miles, M. F., Neale, M. C., Bulik, C. M., Joyce, P. R., Straub, R. E., & Kendler, K. S. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20138 · Cited by 86
Role of neuroendocrine and neuroimmune mechanisms in chronic inflammatory rheumatic diseases--the 10-year update.
Straub, R., Bijlsma, J., Masi, A., & Cutolo, M. (2013) · Seminars in Arthritis & Rheumatism · doi:10.1016/j.semarthrit.2013.04.008 · Cited by 83
Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptor
Faghih, R., Gopalakrishnan, M., & Briggs, C. A. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm070256g · Cited by 89
Electrical vagus nerve stimulation for the treatment of chronic heart failure
Sabbah, H. N. (2011) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.78.s1.04 · Cited by 85
The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review
Couck, M., Caers, R., Spiegel, D., & Gidron, Y. (2018) · Journal of Oncology · doi:10.1155/2018/1236787 · Cited by 87
Socioeconomic Deprivation, Adverse Childhood Experiences and Medical Disorders in Adulthood: Mechanisms and Associations
Morris, G., Berk, M., Maes, M. H. J., Carvalho, A. F., & Puri, B. K. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1498-1 · Cited by 91
Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure
Maouche, K., Medjber, K., Zahm, J., Delavoie, F., Terryn, C., Coraux, C., Pons, S., Cloëz-Tayarani, I., Maskos, U., Birembaut, P. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216939110 · Cited by 85
The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring
Wu, W., Adams, C. E., Stevens, K. E., Chow, K.-H. K., Freedman, R., & Patterson, P. H. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.005 · Cited by 89
The Vagus Nerve and the Inflammatory Reflex: Wandering on a New Treatment Paradigm for Systemic Inflammation and Sepsis
Huston, J. M. (2012) · Surgical Infections · doi:10.1089/sur.2012.126 · Cited by 87
Association of heart rate variability and inflammatory response in patients with cardiovascular diseases: current strengths and limitations
Papaioannou, V. E., Pneumatikos, I. A., & Maglaveras, N. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00174 · Cited by 87
GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation
Kox, M., van Velzen, J. F., Pompe, J. C., Hoedemaekers, C., van der Hoeven, J. G., & Pickkers, P. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.096 · Cited by 85
Nicotine exposure altersin vivohuman responses to endotoxin
Wittebole, X., Hahm, S. J., Coyle, S. M., Kumar, A., Calvano, S. E., & Lowry, S. F. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03248.x · Cited by 86
Bioelectronic Medicine: From Preclinical Studies on the Inflammatory Reflex to New Approaches in Disease Diagnosis and TreatmentPreprint
Pavlov, V. A., Chavan, S. S., & Tracey, K. J. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a034140 · Cited by 85
Self-citation
Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis
Nishio, T., Taura, K., Iwaisako, K., Koyama, Y., Tanabe, K., Yamamoto, G., Okuda, Y., Ikeno, Y., Yoshino, K., Kasai, Y., et al. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-016-1304-z · Cited by 82
Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats
VAN WESTERLOO, D. J., GIEBELEN, I. A. J., MEIJERS, J. C. M., DAALHUISEN, J., DE VOS, A. F., LEVI, M., & VAN DER POLL, T. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02112.x · Cited by 84
Cholinergic signaling in myelination
Fields, R. D., Dutta, D. J., Belgrad, J., & Robnett, M. (2017) · Glia · doi:10.1002/glia.23101 · Cited by 87
Neuroimmune Interactions in the Gut and Their Significance for Intestinal Immunity
Brinkman, D. J., ten Hove, A. S., Vervoordeldonk, M. J., Luyer, M. D. P., & de Jonge, W. J. (2019) · Cells · doi:10.3390/cells8070670 · Cited by 85
miR-132 inhibits lipopolysaccharide-induced inflammation in alveolar macrophages by the cholinergic anti-inflammatory pathway
Liu, F., Li, Y., Jiang, R., Nie, C., Zeng, Z., Zhao, N., Huang, C., Shao, Q., Ding, C., Qing, C., et al. (2015) · Experimental Lung Research · doi:10.3109/01902148.2015.1004206 · Cited by 73
Sympathetic Hyperactivity After Traumatic Brain Injury and the Role of Beta-Blocker Therapy
Heffernan, D. S., Inaba, K., Arbabi, S., & Cotton, B. A. (2010) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e3181f2d3e8 · Cited by 82
Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy
Herdt, V. D., Bogaert, S., Bracke, K. R., Raedt, R., Vos, M. D., Vonck, K. E. J., & Boon, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.06.008 · Cited by 91
The α7 nicotinic acetylcholine receptor on fibroblast‐like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation
van Maanen, M. A., Stoof, S. P., van der Zanden, E. P., de Jonge, W. J., Janssen, R. A. J., Fischer, D. F., Vandeghinste, N., Brys, R., Vervoordeldonk, M. J., & Tak, P. P. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24470 · Cited by 84
Mechanisms underlying the autonomic modulation of ventricular fibrillation initiation—tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure
Brack, K. E., Winter, J., & Ng, G. A. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9314-2 · Cited by 86
Neuroendocrine factors in the regulation of inflammation: Excessive adiposity and calorie restriction
Fontana, L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.005 · Cited by 81
Single-pulse and unidirectional electrical activation of the cervical vagus nerve reduces tumor necrosis factor in endotoxemia
Olofsson, P. S., Levine, Y. A., Caravaca, A., Chavan, S. S., Pavlov, V. A., Faltys, M., & Tracey, K. J. (2015) · Bioelectronic Medicine · doi:10.15424/bioelectronmed.2015.00006 · Cited by 81
Self-citation
Advances in understanding sepsis
Shimaoka, M., & Park, E. J. (2008) · European Journal of Anaesthesiology · doi:10.1017/s0265021507003389 · Cited by 86
IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors
Kageyama‐Yahara, N., Suehiro, Y., Yamamoto, T., & Kadowaki, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.004 · Cited by 85
Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells
Rehani, K., Scott, D. A., Renaud, D. E., Hamza, H., Williams, L., Wang, H., & Martin, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.12.003 · Cited by 83
Self-citation
Targeting neural reflex circuits in immunity to treat kidney disease
Okusa, M. D., Rosin, D. L., & Tracey, K. J. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.132 · Cited by 85
Self-citation
Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors
Keever, K. R., Yakubenko, V. P., & Hoover, D. B. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106758 · Cited by 82
Is nicotine a key player or spectator in the induction and progression of cardiovascular disorders?
Balakumar, P., & Kaur, J. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.06.005 · Cited by 82
Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway
Camacho-Pérez, M. R., Covantes‐Rosales, C. E., Toledo‐Ibarra, G. A., Mercado‐Salgado, U., Ponce-Regalado, M. D., Díaz‐Reséndiz, K. J. G., & Girón‐Pérez, M. I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094523 · Cited by 88
MicroRNA‐132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti‐inflammation: A new Ahr‐based exploration
Hanieh, H., & Alzahrani, A. M. (2013) · European Journal of Immunology · doi:10.1002/eji.201343486 · Cited by 84
Hypothalamic integration of immune function and metabolism
Guijarro, A. I., Laviano, A., & Meguid, M. M. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)53022-5 · Cited by 84
Chronic nicotine inhibits inflammation and promotes influenza infection
Razani‐Boroujerdi, S., Singh, S. P., Knall, C., Hahn, F. F., Peña-Philippides, J. C., Kalra, R., Langley, R. J., & Sopori, M. L. (2004) · Cellular Immunology · doi:10.1016/j.cellimm.2004.07.007 · Cited by 82
Does stress exacerbate liver diseases?
Chida, Y., Sudo, N., & Kubo, C. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04110.x · Cited by 84
α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles
Medeiros, R., Castello, N. A., Cheng, D., Kitazawa, M., Baglietto‐Vargas, D., Green, K. N., Esbenshade, T. A., Bitner, R. S., Decker, M. W., & LaFerla, F. M. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.10.010 · Cited by 83
Heart rate and microinflammation in men: a relevant atherothrombotic link
Rogowski, O., Shapira, I., Shirom, A., Melamed, S., Toker, S., & Berliner, S. (2007) · Heart · doi:10.1136/hrt.2006.101949 · Cited by 83
Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis
Snoek, S. A., Verstege, M. I., van der Zanden, E. P., Deeks, N. J., Bulmer, D. C., Skynner, M. J., Lee, K. C., Velde, A. A. T., Boeckxstaens, G. E., & de Jonge, W. J. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00699.x · Cited by 83
Heme-Oxygenase I and PCG-1α Regulate Mitochondrial Biogenesis via Microglial Activation of Alpha7 Nicotinic Acetylcholine Receptors Using PNU282987
Navarro, E., González‐Lafuente, L., Pérez-Liébana, I., Buendía, I., López-Bernardo, E., Sánchez‐Ramos, C., Priéto, I., Cuadrado, A., Satrústegui, J., Cadenas, S., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6698 · Cited by 84
Perioperative Inflammation and Its Modulation by Anesthetics
Rossaint, J., & Zarbock, A. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002484 · Cited by 80
Cotinine: A Potential New Therapeutic Agent against Alzheimer's disease
Echeverría, V., & Zeitlin, R. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00317.x · Cited by 83
Neuroendocrine Nicotinic Receptor Activation Increases Susceptibility to Bacterial Infections by Suppressing Antimicrobial Peptide Production
Radek, K. A., Elias, P. M., Taupenot, L., Mahata, S. K., O’Connor, D. T., & Gallo, R. L. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.03.009 · Cited by 84
Intranasal Nicotine for Postoperative Pain Treatment
Flood, P. D., & Daniel, D. (2004) · Anesthesiology · doi:10.1097/00000542-200412000-00023 · Cited by 81
Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1
Fanelli, V., Morita, Y., Cappello, P., Ghazarian, M., Sugumar, B., Delsedime, L., Batt, J. A. E., Ranieri, V. M., Zhang, H., & Slutsky, A. S. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000907 · Cited by 80
Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats
Jiang, T., Wu, M., Zhang, Z., Yan, C., Ma, Z., He, S., Yuan, W., Pu, K., & Wang, Q. (2019) · Molecular Medicine · doi:10.1186/s10020-019-0091-4 · Cited by 82
Vagal-Immune Interactions Involved in Cholinergic Anti-Inflammatory Pathway
Žila, I., Mokrá, D., Kopincová, J., Kolomaznik, M., Javorka, M., & Čalkovská, A. (2017) · Physiological Research · doi:10.33549/physiolres.933671 · Cited by 78
Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor
Tang, H., Li, J., Zhou, Q., Li, S., Xie, C., Niu, L., Ma, J., & Li, C. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00852-6 · Cited by 80
Self-citation
Nicotinic acetylcholine receptors: an overview on drug discovery
D’hoedt, D., & Bertrand, D. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902841045 · Cited by 79
Vagus nerve stimulation reduces infarct size in rat focal cerebral ischemia: An unlikely role for cerebral blood flow
Ay, İ., Sorensen, A. G., & Ay, H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.03.060 · Cited by 80
Dexmedetomidine attenuates inflammatory reaction in the lung tissues of septic mice by activating cholinergic anti-inflammatory pathway
Liu, Z., Wang, Y., Wang, Y., Ning, Q., Zhang, Y., Gong, C., Zhao, W., Jing, G., & Wang, Q. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.04.003 · Cited by 80
The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study
Liu, S., Wile, D. J., Fu, J. F., Valerio, J., Shahinfard, E., McCormick, S., Mabrouk, R., Vafai, N. M., McKenzie, J., Neilson, N., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30032-2 · Cited by 80
Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects against Neuroinflammation after Tibia Fracture and Endotoxemia in Mice
Terrando, N., Yang, T., Ryu, J. K., Newton, P. T., Monaco, C. G., Feldmann, M., Ma, D., Akassoglou, K., & Maze, M. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00143 · Cited by 80
“Social Ties, Health and Wellbeing: A Literature Review and Model”,
Kemp, A. H., Arias, J. A., & Fisher, Z. (2017) · Neuroscience and Social Science · doi:10.1007/978-3-319-68421-5_17 · Cited by 79
Targeted drug delivery for tumor therapy inside the bone marrow
Mu, C., Shen, J., Liang, J., Zheng, H., Xiong, Y., Wei, Y., & Li, F. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.029 · Cited by 82
Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways
Wazea, S. A., Wadie, W., Bahgat, A. K., & El-Abhar, H. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-23359-6 · Cited by 79
Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine
Cotero, V. E., Graf, J. F., Miwa, H., Hirschstein, Z., Qanud, K., Huerta, T. S., Tai, N., Ding, Y., Jimenez-Cowell, K., Tomaio, J. N., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00870-w · Cited by 82
Self-citation
Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection
Granton, E., Brown, L., Defaye, M., Moazen, P., Almblad, H., Randall, T. E., Rich, J. D., Geppert, A., Abdullah, N. S., Hassanabad, M. F., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.001 · Cited by 79
The Vagus Nerve and Nicotinic Receptors Involve Inhibition of HMGB1 Release and Early Pro-inflammatory Cytokines Function in Collagen-Induced Arthritis
Li, T., Zuo, X., Zhou, Y., Wang, Y., Zhuang, H., Zhang, L., Zhang, H., & Xiao, X. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9346-0 · Cited by 79
The vagus nerve modulates CD4+ T cell activity
Karimi, K., Bienenstock, J., Wang, L., & Forsythe, P. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.016 · Cited by 81
Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats*
Wu, R., Dong, W., Qiang, X., Wang, H., Blau, S. A., Ravikumar, T. S., & Wang, P. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a557a2 · Cited by 81
Self-citation
Anti-arthritic Effects of Ephedra sinica STAPF Herb-Acupuncture: Inhibition of Lipopolysaccharide-Induced Inflammation and Adjuvant-Induced Polyarthritis
Yeom, M., Lee, H.-C., Kim, G.-H., Lee, H., Shim, I., Oh, S.-K., Kang, S.-K., & Hahm, D. (2006) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0050637 · Cited by 79
Lipid-Rich Enteral Nutrition Reduces Postoperative Ileus in Rats via Activation of Cholecystokinin-Receptors
Lubbers, T., Luyer, M. D. P., de Haan, J. J., Hadfoune, M., Buurman, W. A., & Greve, J. W. M. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e318194d187 · Cited by 78
Acetylcholineestarase-Inhibiting Alkaloids from Lycoris radiata Delay Paralysis of Amyloid Beta-Expressing Transgenic C. elegans CL4176
Xin, L., Yamujala, R., Wang, Y., Wang, H., Wu, W.-H., Lawton, M. A., Long, C., & Di, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063874 · Cited by 79
Self-citation
Activation of the cholinergic anti-inflammatory pathway by nicotine attenuates hepatic ischemia/reperfusion injury via heme oxygenase-1 induction
Park, J., Kang, J., & Lee, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.03.026 · Cited by 79

Authors: Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C. J., & Tracey, K. J.
Corresponding author: Tracey, Kevin J.
ORCID: Wang, Hong
Yu, Man
Amella, Carol Ann
Wang, Haichao
Yang, Huan
Ulloa, Luis
Czura, Christopher J.
Tracey, Kevin J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-12-22
Volume: 421
Issue: 6921
Pages: 384-388
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01339
OpenAlex: W2073295417
Cited by: 3,228
References: 26
Citations by year: 2026: 142 · 2025: 128 · 2024: 181 · 2023: 141 · 2022: 180 · 2021: 203 · 2020: 181 · 2019: 169 · 2018: 154 · 2017: 164 · 2016: 146 · 2015: 142 · 2014: 160 · 2013: 133 · 2012: 127
FWCI: 36.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: cholinergic anti-inflammatory pathway, vagus nerve, acetylcholine, inflammation regulation, innate immune response, cytokine production
MeSH terms: Acetylcholine, Aging, Animals, Bungarotoxins, Cells, Cultured, Electric Stimulation, Female, Humans, Inflammation, Male, Mice, Inbred C57BL, Nicotine, Receptors, Nicotinic, RNA, Messenger, Tumor Necrosis Factor-alpha, Vagus Nerve, Macrophages, Peritoneal, Mice, Knockout, Endotoxemia, Protein Subunits, Mice, alpha7 Nicotinic Acetylcholine Receptor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks