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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
Abstract
Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel disease. Highly conserved, endogenous mechanisms normally regulate the magnitude of innate immune responses and prevent excessive inflammation. The nervous system, through the vagus nerve, can inhibit significantly and rapidly the release of macrophage TNF, and attenuate systemic inflammatory responses. This physiological mechanism, termed the 'cholinergic anti-inflammatory pathway' has major implications in immunology and in therapeutics; however, the identity of the essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signals was previously unknown. Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release. Electrical stimulation of the vagus nerve inhibits TNF synthesis in wild-type mice, but fails to inhibit TNF synthesis in alpha7-deficient mice. Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway.
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In the citing paper
“vagus nerve stimulation in α7 nAChR-knockout animals fails to suppress cytokine synthesis whereas it significantly inhibits cytokine release in wild-type littermates (26).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [26]
In the citing paper
“This indicates that vagus nerve-derived cholinergic signals provide tonic or continuous neurological modulation of cytokine synthesis, functioning as a governor on an engine that limits the magnitude of the immune response.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [26]
In the citing paper
“Macrophages and other cytokine-producing cells express acetylcholine receptors (AChRs), which transduce an intracellular signal that inhibits cytokine synthesis (26,27).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [26]
In the citing paper
“The best characterized of these cholinergic receptors that suppress cytokines is the α7 subunit of the nicotinic AChR (α7 nAChR).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [26]
In the citing paper
“Mice exposed to endotoxin realize an unbalanced, excessive cytokine response characterized by exaggerated TNF levels if they are deficient in either the α7 nAChR subunit (as a result of genetic knockout) or vagus nerve activity (as a result of vagotomy) (18,26).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [26]
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Cites
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Self-citationTracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Self-citationHMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Self-citationShock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Self-citationAnti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“gif" NDATA ITEM> ]> Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel diseas”
BackgroundSelf-citationSéguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401
Self-citationTumor necrosis factor: a pleiotropic cytokine and therapuetic target
Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
Lin, W.-C., Burgess, R., Dominguez, B., Pfaff, S., Sanes, J., & Lee, K.-F. (2001) · Nature · doi:10.1038/35074025 · Cited by 560
Pharmacological stimulation of the cholinergic antiinflammatory pathway
Bernik, T. R., Friedman, S. G., Ochani, M., DiRaimo, R., Ulloa, L., Yang, H., Sudan, S., Czura, C. J., Ivanova, S. M., & Tracey, K. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011714 · Cited by 529
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Research works printed but not linked: 1
- Lindstrom, J. M. in Hand Book of Receptors and Channels: Ligand- and Voltage-Gated Ion Channels (ed. North, A.) 153–175 (CRC Press, Boca Raton, Florida, 1995)
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Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
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Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724
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Rosas-Ballina, M., Olofsson, P. S., Ochani, M., Valdés-Ferrer, S. I., Levine, Y. A., Reardon, C., Tusche, M. W., Pavlov, V. A., Andersson, U., Chavan, S., et al. (2011) · Science · doi:10.1126/science.1209985 · Cited by 1,551
Self-citationPhysiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563
Self-citationThe vagus nerve at the interface of the microbiota-gut-brain axis
Bonaz, B., Bazin, T., & Pellissier, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00049 · Cited by 1,397
Harmful molecular mechanisms in sepsis
Rittirsch, D., Flierl, M. A., & Ward, P. A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2402 · Cited by 1,230
Annane, D., Bellissant, É., & Cavaillon, J. (2005) · The Lancet · doi:10.1016/s0140-6736(04)17667-8 · Cited by 1,262
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170
Self-citationTracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154
Self-citationKorte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
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de Jonge, W. J., van der Zanden, E. P., The, F. O., Bijlsma, M. F., van Westerloo, D. J., Bennink, R. J., Berthoud, H.-R., Uematsu, S., Akira, S., van den Wijngaard, R. M., et al. (2005) · Nature Immunology · doi:10.1038/ni1229 · Cited by 1,074
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Self-citationNeural regulation of innate immunity: a coordinated nonspecific host response to pathogens
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Central nervous system injury-induced immune deficiency syndrome
Meisel, C., Schwab, J. M., Prass, K., Meisel, A., & Dirnagl, U. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1765 · Cited by 981
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Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969
Autonomic innervation and regulation of the immune system (1987–2007)
Nance, D. M., & Sanders, V. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.008 · Cited by 855
Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans
Wessler, I. K., & Kirkpatrick, C. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.185 · Cited by 872
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Agirman, G., Yu, K. B., & Hsiao, E. Y. (2021) · Science · doi:10.1126/science.abi6087 · Cited by 867
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Gotti, C., & Clementi, F. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.09.006 · Cited by 970
The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
Pavlov, V. A., Wang, H., Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Molecular Medicine · doi:10.1007/bf03402177 · Cited by 772
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Rosas‐Ballina, M., Ochani, M., Parrish, W. R., Ochani, K., Harris, Y., Huston, J. M., Chavan, S. S., & Tracey, K. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803237105 · Cited by 762
Self-citationTobacco Smoke, Indoor Air Pollution and Tuberculosis: A Systematic Review and Meta-Analysis
Lin, H.-H., Ezzati, M., & Murray, M. B. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040020 · Cited by 761
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Tuppo, E. E., & Arias, H. R. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.07.009 · Cited by 734
Tian, T., Wang, Z., & Zhang, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4535194 · Cited by 740
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Chiu, I. M., von Hehn, C. A., & Woolf, C. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3144 · Cited by 686
Huston, J. M., Ochani, M., Rosas-Ballina, M., Liao, H., Ochani, K., Pavlov, V. A., Gallowitsch-Puerta, M., Ashok, M., Czura, C. J., Foxwell, B., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052362 · Cited by 683
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Self-citationDopamine mediates vagal modulation of the immune system by electroacupuncture
Rosas, R. T., Yehia, G., Peña, G., Mishra, P., Thompson-Bonilla, M. D. R., Moreno‐Eutímio, M. A., Arriaga‐Pizano, L., Isibasi, A., & Ulloa, L. (2014) · Nature Medicine · doi:10.1038/nm.3479 · Cited by 633
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Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626
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de Jonge, W. J., & Ulloa, L. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707264 · Cited by 634
Self-citationHomeostasis of the gut barrier and potential biomarkers
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New insights into the development of lymphoid tissues
van de Pavert, S. A., & Mebius, R. E. (2010) · Nature reviews. Immunology · doi:10.1038/nri2832 · Cited by 616
Perry, V. H., & Teeling, J. L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0382-8 · Cited by 638
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Terrando, N., Eriksson, L. I., Ryu, J. K., Yang, T., Monaco, C. G., Feldmann, M., Fagerlund, M. J., Charo, I. F., Akassoglou, K., & Maze, M. (2011) · Annals of Neurology · doi:10.1002/ana.22664 · Cited by 582
Cholinergic control of inflammation
Rosas‐Ballina, M., & Tracey, K. J. (2009) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2009.02098.x · Cited by 592
Self-citationBonaz, B., Sinniger, V., & Pellissier, S. (2016) · The Journal of Physiology · doi:10.1113/jp271539 · Cited by 561
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Heneka, M. T., & O'Banion, M. K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.017 · Cited by 782
Thomson, N. C., Chaudhuri, R., & Livingston, E. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00039004 · Cited by 560
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Self-citationCholinergic modulation of microglial activation by α7 nicotinic receptors
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Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004037 · Cited by 499
Saeed, R. W., Varma, S., Peng-Nemeroff, T., Sherry, B., Balakhaneh, D., Huston, J., Tracey, K. J., Al-Abed, Y., & Metz, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040463 · Cited by 489
Self-citationMicrobiome–microglia connections via the gut–brain axis
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Hosomi, K., Saito, M., Park, J., Murakami, H., Shibata, N., Ando, M., Nagatake, T., Konishi, K., Ohno, H., Tanisawa, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32015-7 · Cited by 481
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Bessis, A., Béchade, C., Bernard, D., & Roumier, A. (2006) · Glia · doi:10.1002/glia.20459 · Cited by 486
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Matteoli, G., Gomez‐Pinilla, P. J., Némethova, A., Giovangiulio, M. D., Cailotto, C., van Bree, S. H., Michel, K., Tracey, K. J., Schemann, M., Boesmans, W., et al. (2013) · Gut · doi:10.1136/gutjnl-2013-304676 · Cited by 448
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Cinel, İ., & Opal, S. M. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31819267fb · Cited by 400
Peres, T. V., Schetinger, M. R. C., Chen, P., Carvalho, F. B., Ávila, D. S., Bowman, A. B., & Aschner, M. (2016) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-016-0099-0 · Cited by 403
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Metadata
- Authors
- Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C. J., & Tracey, K. J.
- Corresponding author
- Tracey, Kevin J.
- ORCID
- Venue
- Nature
- Published
- 2002-12-22
- Volume
- 421
- Issue
- 6921
- Pages
- 384-388
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2073295417
- Cited by
- 3,228
- References
- 26
- Citations by year
- 2026: 142 · 2025: 128 · 2024: 181 · 2023: 141 · 2022: 180 · 2021: 203 · 2020: 181 · 2019: 169 · 2018: 154 · 2017: 164 · 2016: 146 · 2015: 142 · 2014: 160 · 2013: 133 · 2012: 127
- FWCI
- 36.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- cholinergic anti-inflammatory pathway, vagus nerve, acetylcholine, inflammation regulation, innate immune response, cytokine production
- MeSH terms
- Acetylcholine, Aging, Animals, Bungarotoxins, Cells, Cultured, Electric Stimulation, Female, Humans, Inflammation, Male, Mice, Inbred C57BL, Nicotine, Receptors, Nicotinic, RNA, Messenger, Tumor Necrosis Factor-alpha, Vagus Nerve, Macrophages, Peritoneal, Mice, Knockout, Endotoxemia, Protein Subunits, Mice, alpha7 Nicotinic Acetylcholine Receptor
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