Cited by 3,228Vagus Nerve Stimulation ResearchNicotinic Acetylcholine Receptors StudyNeuroinflammation and Neurodegeneration Mechanisms

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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Wang, Hong, Yu, Man, Ochani, Mahendar, Amella, Carol Ann, Tanovic, Mahira, Susarla, Seenu, Li, Jian Hua, Wang, Haichao, Yang, Huan, Ulloa, Luis, Al-Abed, Yousef, Czura, Christopher J., Tracey, Kevin J.·2003·Nature

DOI 10.1038/nature01339

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Abstract

Excessive inflammation and tumour-necrosis factor (TNF) synthesis cause morbidity and mortality in diverse human diseases including endotoxaemia, sepsis, rheumatoid arthritis and inflammatory bowel disease. Highly conserved, endogenous mechanisms normally regulate the magnitude of innate immune responses and prevent excessive inflammation. The nervous system, through the vagus nerve, can inhibit significantly and rapidly the release of macrophage TNF, and attenuate systemic inflammatory responses. This physiological mechanism, termed the 'cholinergic anti-inflammatory pathway' has major implications in immunology and in therapeutics; however, the identity of the essential macrophage acetylcholine-mediated (cholinergic) receptor that responds to vagus nerve signals was previously unknown. Here we report that the nicotinic acetylcholine receptor alpha7 subunit is required for acetylcholine inhibition of macrophage TNF release. Electrical stimulation of the vagus nerve inhibits TNF synthesis in wild-type mice, but fails to inhibit TNF synthesis in alpha7-deficient mice. Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway.

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Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
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Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
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Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
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Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
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Lindstrom, J. M. in Hand Book of Receptors and Channels: Ligand- and Voltage-Gated Ion Channels (ed. North, A.) 153–175 (CRC Press, Boca Raton, Florida, 1995)

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Broussard, G. J., Mytar, J. O., Li, R., & Klapstein, G. J. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0130-z · Cited by 71
Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation
Imai, J., & Katagiri, H. (2021) · International Immunology · doi:10.1093/intimm/dxab023 · Cited by 71
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D’Haens, G., Eberhardson, M., Čabrijan, Ž., Danese, S., van den Berg, R., Löwenberg, M., Fiorino, G., Schuurman, P. R., Lind, G., Almqvist, P. M., et al. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad151 · Cited by 75
Self-citation
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Yoshiyama, S., Chen, Z., Okagaki, T., Kohama, K., Kawaharada, R., Izumi, T., Ohshima, N., Nagai, T., & Nakamura, A. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.019 · Cited by 68
The inflammatory reflex – Introduction
Andersson, J. (2005) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01440.x · Cited by 68
Cigarette smoke impairs cytokine responses and BCG containment in alveolar macrophages
van Zyl-Smit, R. N., Binder, A. B., Meldau, R., Semple, P. L., Evans, A., Smith, P., Bateman, E. D., & Dheda, K. U. J. (2013) · Thorax · doi:10.1136/thoraxjnl-2013-204229 · Cited by 68
Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation.
Rosa, M. D. D., Dionisio, L., Agriello, E., Bouzat, C., & Esandi, M. D. C. (2009) · Life Science · doi:10.1016/j.lfs.2009.07.010 · Cited by 63
Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis
JULIAN, M. W., Shao, G., Schlesinger, L. S., Huang, Q., Cosmar, D., Bhatt, N. Y., Culver, D. A., Baughman, R. P., Wood, K. L., & Crouser, E. D. (2013) · CHEST Journal · doi:10.1378/chest.12-0383 · Cited by 68
Scientific and Clinical Challenges in Sepsis
Ulloa, L., Brunner, M., Ramos, L., & Deitch, E. A. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788453248 · Cited by 66
Self-citation
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Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney
Inoue, T., Abe, C., Kohro, T., Tanaka, S., Huang, L., Yao, J., Zheng, S., Ye, H., Inagi, R., Stornetta, R. L., et al. (2019) · Kidney International · doi:10.1016/j.kint.2018.09.020 · Cited by 68
Does environmental exposure to the greenhouse gas, N 2 O, contribute to etiological factors in neurodevelopmental disorders? A mini-review of the evidence
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Biological Activities of Lactose-Derived Prebiotics and Symbiotic with Probiotics on Gastrointestinal System
Nath, A., Haktanirlar, G., Varga, Á., Molnár, M. A., Albert, K., Galambos, I., Koris, A. K., & Vatai, G. N. (2018) · Medicina · doi:10.3390/medicina54020018 · Cited by 69
Risk factors associated with pulmonary tuberculosis
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Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain
Gao, B.-X., Hierl, M., Clarkin, K., Juan, T., Nguyen, H. Q., van der Valk, M., Deng, H. X., Guo, W., Lehto, S. G., Matson, D. J., et al. (2010) · Pain · doi:10.1016/j.pain.2010.01.007 · Cited by 67
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Zhou, H. F., Liang, H., Li, Z., Xiang, H., Liu, W., & Li, J.-G. (2013) · Shock · doi:10.1097/shk.0b013e318299e9c0 · Cited by 67
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Lee, S., Chu, K., Jung, K., Kang, K.-M., Kim, J. H., Bahn, J.-J., Jeon, D., Kim, M., Lee, S. K., & Roh, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.10.076 · Cited by 68
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Oke, S. L., & Tracey, K. J. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0607363 · Cited by 67
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Li, D., Huang, F., Ni, M., Fu, H., Zhang, L., & Shen, F. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307157 · Cited by 67
Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor
Zuelli, F. M. D. G. C., Brognara, F., Quirino, G. F. S., Hiroki, C. H., Fais, R. S., Del‐Ben, C. M., Ulloa, L., Salgado, H. C., Kanashiro, A., & Loureiro, C. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00618 · Cited by 73
Self-citation
Electroacupuncture therapy in inflammation regulation: current perspectives
Park, J.-Y., & Namgung, U. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s141198 · Cited by 67
Review: Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed
Dinarello, C. A. (2004) · Journal of Endotoxin Research · doi:10.1177/09680519040100040301 · Cited by 67
Anti-inflammatory and Immune Therapy for Alzheimers Disease: Current Status and Future Directions
Walker, D., & Lue, L.-F. (2007) · Current Neuropharmacology · doi:10.2174/157015907782793667 · Cited by 66
Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo
Darreh-Shori, T., Forsberg, A., Modiri, N., Andreasen, N., Blennow, K., Kamil, C., Ahmed, H., Almkvist, O., Långström, B., & Nordberg, A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.028 · Cited by 64
Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism
Du, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i36.5988 · Cited by 66
The autonomic nervous system and inflammatory bowel disease
Taylor, C. T., & Keely, S. J. (2007) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.11.005 · Cited by 69
Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus–seropositive women
Wojna, V., Robles, L., Skolasky, R. L., Mayo, R., Selnes, O. A., de la Torre, T., Maldonado, E., Nath, A., Meléndez, L. M., & Lasalde‐Dominicci, J. A. (2007) · Journal of NeuroVirology · doi:10.1080/13550280701620747 · Cited by 66
The Hepatic Vagus Nerve Attenuates Fas-Induced Apoptosis in the Mouse Liver via α7 Nicotinic Acetylcholine Receptor
Hiramoto, T., Chida, Y., Sonoda, J., Yoshihara, K., Sudo, N., & Kubo, C. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.005 · Cited by 67
Role of the Cholinergic Antiinflammatory Pathway in Murine Autoimmune Myocarditis
Leib, C., Göser, S., Lüthje, D., Öttl, R., Tretter, T., Lasitschka, F., Zittrich, S., Pfitzer, G., Katus, H. A., & Kaya, Z. (2011) · Circulation Research · doi:10.1161/circresaha.111.245563 · Cited by 66

Authors: Wang, H., Yu, M., Ochani, M., Amella, C. A., Tanovic, M., Susarla, S., Li, J. H., Wang, H., Yang, H., Ulloa, L., Al-Abed, Y., Czura, C. J., & Tracey, K. J.
Corresponding author: Tracey, Kevin J.
ORCID: Wang, Hong
Yu, Man
Amella, Carol Ann
Wang, Haichao
Yang, Huan
Ulloa, Luis
Czura, Christopher J.
Tracey, Kevin J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-12-22
Volume: 421
Issue: 6921
Pages: 384-388
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01339
OpenAlex: W2073295417
Cited by: 3,228
References: 26
Citations by year: 2026: 142 · 2025: 128 · 2024: 181 · 2023: 141 · 2022: 180 · 2021: 203 · 2020: 181 · 2019: 169 · 2018: 154 · 2017: 164 · 2016: 146 · 2015: 142 · 2014: 160 · 2013: 133 · 2012: 127
FWCI: 36.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: cholinergic anti-inflammatory pathway, vagus nerve, acetylcholine, inflammation regulation, innate immune response, cytokine production
MeSH terms: Acetylcholine, Aging, Animals, Bungarotoxins, Cells, Cultured, Electric Stimulation, Female, Humans, Inflammation, Male, Mice, Inbred C57BL, Nicotine, Receptors, Nicotinic, RNA, Messenger, Tumor Necrosis Factor-alpha, Vagus Nerve, Macrophages, Peritoneal, Mice, Knockout, Endotoxemia, Protein Subunits, Mice, alpha7 Nicotinic Acetylcholine Receptor

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Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

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