Is the use of resveratrol in the treatment and prevention of obesity premature?
Open accessAbstract
Obesity is a multi-faceted disease, predisposing sufferers to numerous co-morbidities such as epithelial dysfunction and insulin resistance which ultimately result in CVD. Visceral adipose tissue in particular is associated with inflammation due to the release of pro-inflammatory cytokines by adipocytes. Inflammation seems to be rather central in causing damage to endothelial cells as well as exerting negative effects on glucose metabolism, ultimately leading to insulin resistance. Resveratrol is a naturally occurring phenolic substance which has been found to display anti-inflammatory, vasoprotective and insulin-sensitising effects, among others. The popularity of resveratrol use is escalating in the treatment of various ailments including obesity in adults. The use of the substance in childhood obesity is, however, a worrying factor, as no studies have as yet been performed on adolescent animals and there is evidence of kidney toxicity of resveratrol and its metabolites at intake levels below those currently approved as safe. Another cause for concern is the uncertainty surrounding long-term, low-dose administration of the substance in humans. The supplement should thus not be recommended for use in the prevention and treatment of obesity until conclusive research is established on the safety of long-term usage of resveratrol in both children and adults.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resveratrol administration appears to improve the metabolic profile in obese and/or insulin-resistant patients.
“Administration of resveratrol appears to improve the metabolic profile in obese and/or insulin-resistant patients.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [3]
In animal models, resveratrol improves mitochondrial function and cellular sensitivity to insulin in mice fed a high-energy diet.
“It also improves mitochondrial function, which is compromised in numerous metabolic diseases, and cellular sensitivity to insulin in mice fed a high-energy diet [3].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Pharmacological preconditioning with resveratrol: role of nitric oxide
Hattori, R., Otani, H., Maulik, N., & Das, D. K. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01012.2001 · Cited by 202 · see citing works
RetractedResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works
Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893 · see citing works
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · cited 1× · see citing works
“Obesity has been shown to increase endothelium-dependent vasoconstriction in the absence of endothelial NO((5,33)).”
Inoguchi, T., Li, P., Umeda, F., Yu, H. Y., Kakimoto, M., Imamura, M., Aoki, T., Etoh, T., Hashimoto, T., Naruse, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1939 · Cited by 1,577 · see citing works
Gene expression profile of aging and its retardation by caloric restriction
Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works
Tominaga, M., Eguchi, H., Manaka, H., Igarashi, K., Kato, T., & Sekikawa, A. (1999) · Diabetes Care · doi:10.2337/diacare.22.6.920 · Cited by 1,165 · see citing works
Inhibition of human LDL oxidation by resveratrol
Frankel, E. N., Waterhouse, A. L., & Kinsella, J. E. (1993) · The Lancet · doi:10.1016/0140-6736(93)92472-6 · Cited by 889 · see citing works
Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. J., & Goldberg, D. M. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06045-1 · Cited by 871 · see citing works
Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis
Stern, M. P. (1995) · Diabetes · doi:10.2337/diab.44.4.369 · Cited by 739 · see citing works
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., & Sinclair, D. A. (2003) · Nature · doi:10.1038/nature01578 · Cited by 736 · see citing works
Resveratrol stimulates AMP kinase activity in neurons
Dasgupta, B., & Milbrandt, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610068104 · Cited by 723 · see citing works
Inflammatory pathways and insulin action
Hotamisligil, G. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802502 · Cited by 717 · see citing works
Barger, J. L., Kayo, T., Vann, J. M., Arias, E. B., Wang, J., Hacker, T. A., Wang, Y., Raederstorff, D., Morrow, J. D., Leeuwenburgh, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002264 · Cited by 580 · see citing works
Biological Effects of Resveratrol
Bhat, K., Kosmeder, J. W., & Pezzuto, J. M. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203567 · Cited by 510 · see citing works
Joe, A. K., Liu, H., Suzui, M., Vural, M. E., Xiao, D., & Weinstein, I. B. (2002) · PubMed · Cited by 455 · see citing works
Endothelial Dysfunction in Obesity and Insulin Resistance: A Road to Diabetes and Heart Disease
Caballero, A. E. (2003) · Obesity Research · doi:10.1038/oby.2003.174 · Cited by 416 · see citing works
de Jongh, R. T., Serné, E. H., IJzerman, R. G., de Vries, G., & Stehouwer, C. D. A. (2004) · Circulation · doi:10.1161/01.cir.0000129772.26647.6f · Cited by 407 · see citing works
Resveratrol, a remarkable inhibitor of ribonucleotide reductase
Fontecave, M., Lepoivre, M., Elleingand, E. F., Gerez, C., & Guittet, O. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01572-x · Cited by 383 · see citing works
Resveratrol-Associated Renal Toxicity
Crowell, J. A. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh263 · Cited by 321 · see citing works
Adipose tissue, insulin action and vascular disease: inflammatory signals
Yudkin, J. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802496 · Cited by 311 · cited 1× · see citing works
“Adipose tissue is being implicated, more and more, as a key regulator of inflammation through secretion of pro-inflammatory cytokines (i.e. TNF-a ) which seem to play a chief role in affecting both endothelial function and glucose metabolism (1,20) .”
The Daily Oral Administration of High Doses of trans-Resveratrol to Rats for 28 Days Is Not Harmful
Juan, M. E., Vinardell, M. P., & Planas, J. M. (2002) · Journal of Nutrition · doi:10.1093/jn/132.2.257 · Cited by 293 · see citing works
Grove, J., Daly, A. K., Bassendine, M. F., & Day, C. P. (1997) · Hepatology · doi:10.1002/hep.510260119 · Cited by 287 · see citing works
Meng, X., Maliakal, P. P., Lu, H., Lee, M., & Yang, C. S. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030582e · Cited by 281 · see citing works
Virkamäki, A., Korsheninnikova, E., Seppälä‐Lindroos, A., Vehkavaara, S., Goto, T., Halavaara, J. T., Häkkinen, A., & Yki‐Järvinen, H. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2337 · Cited by 261 · see citing works
Resveratrol in Cardioprotection: A Therapeutic Promise of Alternative Medicine
Das, D. K. (2006) · Molecular Interventions · doi:10.1124/mi.6.1.7 · Cited by 258 · see citing works
Cardioprotection of red wine: role of polyphenolic antioxidants.
Das, D. K., Sato, M. H., Ray, P. S., Maulik, G., Engelman, R. M., Bertelli, A., & Bertelli, A. A. A. (1999) · PubMed · Cited by 249 · see citing works
Resveratrol Is a Selective Human Cytochrome P450 1A1 Inhibitor
Chun, Y. J., Kim, M. Y., & Guengerich, F. P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1152 · Cited by 243 · see citing works
Bioactivity and metabolism oftrans-resveratrol orally administered to Wistar rats
Wenzel, E., Soldo, T., Erbersdobler, H. F., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500003 · Cited by 236 · see citing works
Virgili, M., & Contestabile, A. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00820-x · Cited by 234 · see citing works
Periyasamy, P., & Subramanian, S. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.06.037 · Cited by 229 · see citing works
Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK
Breen, D. M., Sanli, T., Giacca, A., & Tsiani, E. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.104 · Cited by 214 · see citing works
Hwa, J. J., Ghibaudi, L., Williams, P. B., et al. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.3.h952 · Cited by 191 · see citing works
Mechanisms of endothelial dysfunction in obesity.
Avogaro, A., & de Kreutzenberg, S. V. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.04.020 · Cited by 188 · see citing works
Causes and consequences of adult obesity: health, social and economic impacts in the United States
Wellman, N. S., & Friedberg, B. A. (2002) · Asia Pacific Journal of Clinical Nutrition · doi:10.1046/j.1440-6047.11.s8.6.x · Cited by 181 · see citing works
Resveratrol, a Polyphenolic Phytoalexin, Attenuates Diabetic Nephropathy in Rats
Sharma, S., Anjaneyulu, M., Kulkarni, S., & Chopra, K. (2005) · Pharmacology · doi:10.1159/000089720 · Cited by 177 · see citing works
Plasma and tissue resveratrol concentrations and pharmacological activity.
Bertelli, A., Bertelli, A. A. E., Gozzini, A., & Giovannini, L. (1998) · PubMed · Cited by 169 · see citing works
Nitric Oxide, Atherosclerosis and the Clinical Relevance of Endothelial Dysfunction
Anderson, T. J. (2003) · Heart Failure Reviews · doi:10.1023/a:1022199021949 · Cited by 157 · see citing works
Gao, X., Xu, Y. X., Divine, G., Janakiraman, N., Chapman, R., & Gautam, S. C. (2002) · Journal of Nutrition · doi:10.1093/jn/132.7.2076 · Cited by 126 · see citing works
Lekli, I., Szabó, G. V., Juhász, B., Das, S., Das, M., Varga, E., Szendrei, L., Gesztelyi, R., Váradi, J., Bak, I., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01048.2007 · Cited by 113 · see citing works
THE PHARMACOLOGY AND TOXICOLOGY OF POLYPHENOLIC-GLUTATHIONE CONJUGATES
Monks, T. J., & Lau, S. S. (1998) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.38.1.229 · Cited by 99 · see citing works
Myocardial protection by Protykin, a novel extract oftrans-resveratrol and emodin
Sato, M., Maulik, G., Bagchi, D., & Das, D. K. (2000) · Free Radical Research · doi:10.1080/10715760000300141 · Cited by 85 · see citing works
Estrogenic Activity in White and Red Wine Extracts
Klinge, C. M., Risinger, K. E., Watts, M. B., Beck, V., Eder, R., & Jungbauer, A. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0259821 · Cited by 83 · see citing works
Schuster, D. P., & Duvuuri, V. (2002) · Clinics in Podiatric Medicine and Surgery · doi:10.1016/s0891-8422(03)00082-x · Cited by 83 · see citing works
Penumathsa, S. V., Koneru, S., Samuel, S. M., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.07.012 · Cited by 69 · see citing works
Effects of resveratrol on glycerol-induced renal injury
Soares, T. D. J., Volpini, R. A., Francescato, H. D. C., et al. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.06.032 · Cited by 63 · see citing works
Wong, Y. T., Gruber, J., Jenner, A. M., Ng, M. P.-E., Ruan, R., & Tay, F. E. H. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.016 · Cited by 63 · see citing works
Molecular diagnostics in monogenic and multifactorial forms of Type 2 diabetes
McCarthy, M. I., & Hattersley, A. T. (2001) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.1.4.403 · Cited by 41 · see citing works
Obesity and cardiovascular dysfunction: A role for resveratrol?
Naderali, E. K. (2008) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2008.10.005 · Cited by 25 · see citing works
Childhood obesity prevention: compelling challenge of the twenty‐first century
Levy, L. Z., & Petty, K. H. (2008) · Early Child Development and Care · doi:10.1080/03004430600852072 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Kawser Hossain, M., Abdal Dayem, A., Han, J., Yin, Y., Kim, K., Kumar Saha, S., Yang, G.-M., Choi, H., & Cho, S.-G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040569 · Cited by 495 · see citing works
Novel Role of the SIRT1 in Endocrine and Metabolic Diseases
Lu, C., Zhao, H., Liu, Y., Yang, Z., Yao, H., Liu, T., Gou, T., Wang, L., Zhang, J., Tian, Y., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.78654 · Cited by 160 · see citing works
The Role of Resveratrol Administration in Human Obesity
Mongioì, L. M., La Vignera, S., Cannarella, R., Cimino, L., Compagnone, M., Condorelli, R. A., & Calogero, A. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094362 · Cited by 71 · see citing works
Christenson, J., Whitby, S. J., Mellor, D., Thomas, J., McKune, A., Roach, P. D., & Naumovski, N. (2016) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0035 · Cited by 47 · see citing works
- Authors
- van der Spuy, W. J., & Pretorius, E.
- Affiliations
- University of Pretoria (ZA)
- Corresponding author
- Pretorius, Etheresia
- ORCID
- Pretorius, Etheresia
- Venue
- Nutrition Research Reviews
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-09-22
- Volume
- 22
- Issue
- 2
- Pages
- 111-117
- ISSN
- 0954-4224 (ISSN-L)
- 1475-2700
- OpenAlex
- W2099267774
- Cited by
- 26
- References
- 56
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nutrition Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- UpSpace Institutional Repository (University of Pretoria) (submittedVersion)
- Funders
- National Research Foundation
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- resveratrol, obesity, obesity prevention, childhood obesity, insulin resistance, visceral adipose tissue, inflammation, inflammatory cytokines, endothelial dysfunction, cardiovascular disease, nephrotoxicity, dietary supplements, long-term safety, vascular protection
- MeSH terms
- Resveratrol, Adult, Animals, Antioxidants, Child, Drug Administration Schedule, Humans, Inflammation, Kidney, Obesity, Phenols, Plant Extracts, Stilbenes, Intra-Abdominal Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
