Cited by 74Ion Channels and ReceptorsSkin Protection and AgingDermatology and Skin Diseases

The role of TRPV1 channel in aged human skin

Lee, Young Mee, Kang, So Min, Chung, Jin Ho·2012·Journal of Dermatological Science

Abstract

Transient receptor potential vanilloid 1 (TRPV1) is a member of the nonselective cationic channel family. Activation of TRPV1 induces an influx of divalent and monovalent cations (i.e., Ca(2+), Na(+), and Mg(2+)) which are activated by capsaicin, heat, and acid. TRPV1 is known to be expressed in the epidermis, but little is known about the physiological significance and functional role of TRPV1 in skin. Recent studies suggested that heat- and ultraviolet (UV)-induced matrix metalloproteinases-1 (MMP-1) expression may be partly mediated by TRPV1 activation in human keratinocytes. Also, heat and UV increased expression of TRPV1 proteins in human skin in vivo. TRPV1 protein was expressed more in the sun-protected (upper-inner arm) skin of the elderly than in young subjects. In addition, the photoaged (forearm) skin of the elderly showed increased TRPV1 expression compared to sun-protected skin of the same individuals. The increased TRPV1 expression in the old skin implies that TRPV1 may be related to senile skin symptoms, such as senile pruritus and neurogenic inflammation. This review provides a summary of current researches on the role of TRPV1 channel in human skin, especially in aged skin.

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Crossref · 10.1016/j.jdermsci.2011.11.003

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Authors
Lee, Y. M., Kang, S. M., & Chung, J. H.
Affiliations
Seoul National University (KR)
Corresponding author
Chung, Jin Ho
Venue
Journal of Dermatological Science
Publisher
Elsevier BV
Published
2012-02
Volume
65
Issue
2
Pages
81-85
ISSN
0923-1811 (ISSN-L)
OpenAlex
W2007628396
Cited by
73
References
62
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 12 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 11 · 2012: 2
FWCI
0.84
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Dermatological Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
TRPV1, transient receptor potential vanilloid 1, aged skin, photoaging, sun-protected skin, human keratinocytes, MMP-1, senile pruritus, neurogenic inflammation, cation channels
MeSH terms
Calcium, Hot Temperature, Humans, Skin, Ultraviolet Rays, Skin Aging, Up-Regulation, Matrix Metalloproteinase 1, TRPV Cation Channels

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