The role of TRPV1 channel in aged human skin
Abstract
Transient receptor potential vanilloid 1 (TRPV1) is a member of the nonselective cationic channel family. Activation of TRPV1 induces an influx of divalent and monovalent cations (i.e., Ca(2+), Na(+), and Mg(2+)) which are activated by capsaicin, heat, and acid. TRPV1 is known to be expressed in the epidermis, but little is known about the physiological significance and functional role of TRPV1 in skin. Recent studies suggested that heat- and ultraviolet (UV)-induced matrix metalloproteinases-1 (MMP-1) expression may be partly mediated by TRPV1 activation in human keratinocytes. Also, heat and UV increased expression of TRPV1 proteins in human skin in vivo. TRPV1 protein was expressed more in the sun-protected (upper-inner arm) skin of the elderly than in young subjects. In addition, the photoaged (forearm) skin of the elderly showed increased TRPV1 expression compared to sun-protected skin of the same individuals. The increased TRPV1 expression in the old skin implies that TRPV1 may be related to senile skin symptoms, such as senile pruritus and neurogenic inflammation. This review provides a summary of current researches on the role of TRPV1 channel in human skin, especially in aged skin.
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Photoaging is the most crucial factor causing skin aging damage.
“Among them, photoaging is the most crucial factor causing skin aging damage.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [2]
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- Authors
- Lee, Y. M., Kang, S. M., & Chung, J. H.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Chung, Jin Ho
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 65
- Issue
- 2
- Pages
- 81-85
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2007628396
- Cited by
- 73
- References
- 62
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 12 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 11 · 2012: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- TRPV1, transient receptor potential vanilloid 1, aged skin, photoaging, sun-protected skin, human keratinocytes, MMP-1, senile pruritus, neurogenic inflammation, cation channels
- MeSH terms
- Calcium, Hot Temperature, Humans, Skin, Ultraviolet Rays, Skin Aging, Up-Regulation, Matrix Metalloproteinase 1, TRPV Cation Channels
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