Cited by 1,635Mitochondrial Function and PathologyCell death mechanisms and regulationSignaling Pathways in Disease

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Nakagawa, Takashi, Shimizu, Shigeomi, Watanabe, Tetsuya, Yamaguchi, Osamu, Otsu, Kinya, Yamagata, Hirotaka, Inohara, Hidenori, Kubo, Takeshi, Tsujimoto, Yoshihide·2005·Nature

DOI 10.1038/nature03317

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Abstract

Mitochondria play an important role in energy production, Ca2+ homeostasis and cell death. In recent years, the role of the mitochondria in apoptotic and necrotic cell death has attracted much attention. In apoptosis and necrosis, the mitochondrial permeability transition (mPT), which leads to disruption of the mitochondrial membranes and mitochondrial dysfunction, is considered to be one of the key events, although its exact role in cell death remains elusive. We therefore created mice lacking cyclophilin D (CypD), a protein considered to be involved in the mPT, to analyse its role in cell death. CypD-deficient mice were developmentally normal and showed no apparent anomalies, but CypD-deficient mitochondria did not undergo the cyclosporin A-sensitive mPT. CypD-deficient cells died normally in response to various apoptotic stimuli, but showed resistance to necrotic cell death induced by reactive oxygen species and Ca2+ overload. In addition, CypD-deficient mice showed a high level of resistance to ischaemia/reperfusion-induced cardiac injury. Our results indicate that the CypD-dependent mPT regulates some forms of necrotic death, but not apoptotic death.

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Authors: Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y.
Affiliations: Laboratory of Molecular Genetics (PL)
Japan Science and Technology Agency (JP)
The University of Osaka (JP)
Corresponding author: Tsujimoto, Yoshihide
ORCID: Nakagawa, Takashi
Shimizu, Shigeomi
Watanabe, Tetsuya
Yamaguchi, Osamu
Otsu, Kinya
Yamagata, Hirotaka
Inohara, Hidenori
Kubo, Takeshi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-03
Volume: 434
Issue: 7033
Pages: 652-658
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03317
OpenAlex: W2063099262
Cited by: 1,635
References: 32
Citations by year: 2026: 27 · 2025: 40 · 2024: 32 · 2023: 42 · 2022: 47 · 2021: 54 · 2020: 55 · 2019: 58 · 2018: 73 · 2017: 70 · 2016: 77 · 2015: 74 · 2014: 119 · 2013: 81 · 2012: 115
FWCI: 41.13
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: cyclophilin D, mitochondrial permeability transition, necrosis, apoptosis, cyclosporine, reactive oxygen species, calcium overload, ischemia-reperfusion injury, cardiac injury, mitochondrial dysfunction
MeSH terms: Peptidyl-Prolyl Isomerase F, Animals, Calcium, Cells, Cultured, Enzyme Activation, Fibroblasts, Hydrogen Peroxide, Mitochondria, Liver, Mitochondrial Swelling, Necrosis, Thymus Gland, Myocardial Reperfusion Injury, Myocardial Ischemia, Apoptosis, Reactive Oxygen Species, Mice, Knockout, Caspases, Cyclophilins, Hepatocytes, Mice

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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