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Cited by 135Mitochondrial Function and PathologyCell death mechanisms and regulationAutophagy in Disease and Therapy

Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology

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Bonora, Massimo, Patergnani, Simone, Ramaccini, Daniela, Morciano, Giampaolo, Pedriali, Gaia, Kahsay, Asrat, Bouhamida, Esmaa, Giorgi, Carlotta +2 more·2020·Biomolecules
DOI 10.3390/biom10070998PMC PMC7408088
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Abstract

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic forces, MPT is paralleled by a massive influx of water into the mitochondrial matrix, eventually leading to the structural collapse of the organelle. Thus, MPT can initiate outer-mitochondrial-membrane permeabilization (MOMP), promoting the activation of the apoptotic caspase cascade and caspase-independent cell-death mechanisms. The induction of MPT is mostly dependent on mitochondrial reactive oxygen species (ROS) and Ca2+, but is also dependent on the metabolic stage of the affected cell and signaling events. Therefore, since its discovery in the late 1970s, the role of MPT in human pathology has been heavily investigated. Here, we summarize the most significant findings corroborating a role for MPT in the etiology of a spectrum of human diseases, including diseases characterized by acute or chronic loss of adult cells and those characterized by neoplastic initiation.

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  • Glutamate-induced cell death is associated with mitochondrial dysfunction, Ca2+ accumulation, mitochondrial permeability transition pore opening, and functional collapse of mitochondria.

    “Glutamate-induced cell death is associated with mitochondrial dysfunction, associated with accumulation of Ca2+, activating mitochondrial permeability transition pore opening and causing functional collapse of mitochondria (for review, see Szabó and Zoratti, 1992; Bonora et al., 2020).”

    From Toxic Concentrations of Glutamate Induce Ferroptosis without Affecting Mitochondrial Respiration in Rodent Brain Slice Cultures (2026) · cites this paper as Bonora et al., 2020

    Section 1.1, “Mitochondrial Routes of Cell Death” (page not available), says pathological mitochondrial Ca2+ overload triggers permeability transition and pore opening, followed by collapse of mitochondrial potential and related activities that can lead to cell death. It does not connect this sequence specifically to glutamate-induced cell death. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Bonora, M., Patergnani, S., Ramaccini, D., Morciano, G., Pedriali, G., Kahsay, A., Bouhamida, E., Giorgi, C., Wieckowski, M., & Pinton, P.
Affiliations
  • University of Ferrara (IT)
  • Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
Corresponding author
  • Bonora, Massimo
  • Pinton, Paolo
ORCID
Venue
Biomolecules
Publisher
MDPI AG
Published
2020-07-04
Volume
10
Issue
7
Pages
998
ISSN
2218-273X (ISSN-L)
DOI
10.3390/biom10070998
PMC
PMC7408088
OpenAlex
W3038384160
Cited by
135
References
22
Citations by year
2026: 13 · 2025: 23 · 2024: 18 · 2023: 20 · 2022: 27 · 2021: 25 · 2020: 9
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomolecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion, cc-by)
Funders
  • European Commission (HORIZON2020, 722619, 734719)
  • Ministero della Salute (GR2013-02356747)
  • Narodowym Centrum Nauki (UMO-2018/29/B/ NZ1 /00589)
  • Fondazione Umberto Veronesi
  • Associazione Italiana per la Ricerca sul Cancro (IG23670, AIRC, IG-23670, PRIN2017E5 L5P3, IG‐19803, 23670, 19803, PRIN20177E9EPY)
  • Università degli Studi di Ferrara (IG-23670, IG-19803, GGP11139B)
  • H2020 European Research Council (853057)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondrial permeability transition, mitochondrial permeability transition pore, inner mitochondrial membrane permeability, mitochondrial swelling, mitochondrial outer membrane permeabilization, apoptosis, caspase activation, reactive oxygen species, calcium, mitochondrial calcium uptake, cell death, human disease
MeSH terms
Mitochondrial Permeability Transition Pore, Calcium, Humans, Mitochondria, Signal Transduction, Cell Death, Reactive Oxygen Species, Membrane Potential, Mitochondrial

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