Cited by 2,086Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Qin, Graham, Timothy E., Mody, Nimesh, Preitner, Frederic, Peroni, Odile D., Zabolotny, Janice M., Kotani, Ko, Quadro, Loredana, Kahn, Barbara B.·2005·Nature

DOI 10.1038/nature03711

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Abstract

In obesity and type 2 diabetes, expression of the GLUT4 glucose transporter is decreased selectively in adipocytes. Adipose-specific Glut4 (also known as Slc2a4) knockout (adipose-Glut4(-/-)) mice show insulin resistance secondarily in muscle and liver. Here we show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4(-/-) mice. We show that serum RBP4 levels are elevated in insulin-resistant mice and humans with obesity and type 2 diabetes. RBP4 levels are normalized by rosiglitazone, an insulin-sensitizing drug. Transgenic overexpression of human RBP4 or injection of recombinant RBP4 in normal mice causes insulin resistance. Conversely, genetic deletion of Rbp4 enhances insulin sensitivity. Fenretinide, a synthetic retinoid that increases urinary excretion of RBP4, normalizes serum RBP4 levels and improves insulin resistance and glucose intolerance in mice with obesity induced by a high-fat diet. Increasing serum RBP4 induces hepatic expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) and impairs insulin signalling in muscle. Thus, RBP4 is an adipocyte-derived 'signal' that may contribute to the pathogenesis of type 2 diabetes. Lowering RBP4 could be a new strategy for treating type 2 diabetes.

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Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
A decade of molecular biology of retinoic acid receptors
Chambon, P. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.9.8801176 · Cited by 2,889
A transgenic model of visceral obesity and the metabolic syndrome
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766
Hyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637
Self-citation
Glucose Transporters and Insulin Action — Implications for Insulin Resistance and Diabetes Mellitus
Shepherd, P. R., & Kahn, B. B. (1999) · New England Journal of Medicine · doi:10.1056/nejm199907223410406 · Cited by 1,295
Self-citation
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,276
Self-citation
Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors
Lee, C., Olson, P., & Evans, R. M. (2003) · Endocrinology · doi:10.1210/en.2003-0288 · Cited by 891
The Framingham Offspring Study
Allhoff, P., Laaser, U., & Heinrich, J. (1991) · Springer eBooks · doi:10.1007/978-3-642-95642-3_25 · Cited by 832
Nutrient Requirements of Laboratory Animals,
National Research Council (1995) · National Academies Press eBooks · doi:10.17226/4758 · Cited by 735

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Kotani, K., Kim, Y. B., Peroni, O., Mundt, A. & Kahn, B. B. Rosiglitazone treatment normalizes glucose tolerance in adipose-specific GLUT4 knockout mice but renders muscle-specific GLUT4 knockout more diabetic [abstract]. Diabetes 50, A274 (2001)

Sorted by citations

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Graham, T., & Kahn, B. B. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-985879 · Cited by 127
Self-citation
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García-Martín, R., Brandão, B. B., Thomou, T., Altındiş, E., & Kahn, C. R. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110277 · Cited by 127
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Vitamin A Metabolism and Adipose Tissue Biology
Frey, S. K., & Vogel, S. (2011) · Nutrients · doi:10.3390/nu3010027 · Cited by 123
Clinical and laboratory diagnosis of the metabolic syndrome
Olufadi, R., & Byrne, C. D. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048363 · Cited by 123
Obesity alters circadian expressions of molecular clock genes in the brainstem
Kaneko, K., Yamada, T., Tsukita, S., Takahashi, K., Ishigaki, Y., Oka, Y., & Katagiri, H. (2009) · Brain Research · doi:10.1016/j.brainres.2008.12.071 · Cited by 127
Transcriptional regulation of the GLUT4 gene: from PPAR-γ and FOXO1 to FFA and inflammation
Armoni, M., Harel, C., & Karnieli, E. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.02.001 · Cited by 125
Insulin-Sensitizing Effects of Exercise on Adiponectin and Retinol-Binding Protein-4 Concentrations in Young and Middle-Aged Women
Lim, S. K., Choi, S. H., Jeong, I.-K., Kim, J. H., Moon, M. K., Park, K. S., Lee, H. K., Kim, Y., & Jang, H. C. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2028 · Cited by 122
The Clockwork of Metabolism
Ramsey, K. M., Marcheva, B., Kohsaka, A., & Bass, J. T. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093546 · Cited by 120
The efficiency of cellular energy transduction and its implications for obesity
Harper, M.-E., Green, K., & Brand, M. D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155357 · Cited by 121
Obesidad y psoriasis: naturaleza inflamatoria de la obesidad, relación entre psoriasis y obesidad e implicaciones terapéuticas
Carrascosa, J. M., Rocamora, V., Fernandez-Torres, R. M., Jiménez-Puya, R. J., Moreno, J. C., Coll-Puigserver, N., & Fonseca, E. (2012) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2012.08.003 · Cited by 122
Deletion of the Androgen Receptor in Adipose Tissue in Male Mice Elevates Retinol Binding Protein 4 and Reveals Independent Effects on Visceral Fat Mass and on Glucose Homeostasis
McInnes, K. J., Smith, L. B., Hunger, N. I., Saunders, P. T. K., Andrew, R., & Walker, B. R. (2012) · Diabetes · doi:10.2337/db11-1136 · Cited by 124
Beneficial effects of cinnamon and its extracts in the management of cardiovascular diseases and diabetes
Shang, C., Lin, H., Fang, X., Wang, Y., Jiang, Z., Qu, Y., Xiang, M., Shen, Z., Xin, L., Lu, Y., et al. (2021) · Food & Function · doi:10.1039/d1fo01935j · Cited by 129
Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling
Kienesberger, P. C., Lee, D., Pulinilkunnil, T., Brenner, D. S., Cai, L., Magnes, C., Koefeler, H. C., Streith, I. E., Rechberger, G. N., Haemmerle, G., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.047787 · Cited by 120
Acylated anthocyanins: A review on their bioavailability and effects on postprandial carbohydrate metabolism and inflammation
Jokioja, J., Yang, B., & Linderborg, K. M. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12836 · Cited by 122
Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells
Hammarstedt, A., Graham, T. E., & Kahn, B. B. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-42 · Cited by 122
Self-citation
Role of Adipokines and Other Inflammatory Mediators in Gestational Diabetes Mellitus and Previous Gestational Diabetes Mellitus
Vrachnis, N., Belitsos, P., Sifakis, S., Dafopoulos, K. C., Siristatidis, C. S., Pappa, K. I., & Iliodromiti, Z. (2012) · International Journal of Endocrinology · doi:10.1155/2012/549748 · Cited by 122
Retinol‐binding protein 4 as a plasma biomarker of renal dysfunction and cardiovascular disease in type 2 diabetes
Cabré, A., Lázaro, I., Girona, J., Manzanares, J. M., Marimón, F., Plana, N., Heras, M., & Masana, L. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01849.x · Cited by 119
Plasma Retinol-Binding Protein 4 (RBP4) Levels and Risk of Coronary Heart Disease
Sun, Q., Kiernan, U. A., Shi, L., Phillips, D. A., Kahn, B. B., Hu, F. B., Manson, J. E., Albert, C. M., & Rexrode, K. M. (2013) · Circulation · doi:10.1161/circulationaha.113.002073 · Cited by 118
Self-citation
Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts
Nowak, C., Sundström, J., Gustafsson, S., Giedraitis, V., Lind, L., Ingelsson, E., & Fall, T. (2015) · Diabetes · doi:10.2337/db15-0881 · Cited by 122
The Metabolic Syndrome as a Concept of Adipose Tissue Disease
Oda, E. (2008) · Hypertension Research · doi:10.1291/hypres.31.1283 · Cited by 120
Hypoadiponectinemia—Cause or Consequence of Human “Insulin Resistance”?
Cook, J. R., & Semple, R. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2286 · Cited by 119
Engineered skeletal muscles for disease modeling and drug discovery
Wang, J., Khodabukus, A., Rao, L., VanDusen, K. W., Abutaleb, N. O., & Bursac, N. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119416 · Cited by 125
Chronic Ethanol‐Induced Insulin Resistance Is Associated With Macrophage Infiltration Into Adipose Tissue and Altered Expression of Adipocytokines
Kang, L., Sebastian, B. M., Pritchard, M. T., Pratt, B. T., Previs, S. F., & Nagy, L. E. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00452.x · Cited by 119
Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces Remission of Diabetes in db/db Mice
Han, M. S., Chung, K. W., Cheon, H. G., Rhee, S. D., Yoon, C., Lee, M., Kim, K., & Lee, M. (2009) · Diabetes · doi:10.2337/db08-0080 · Cited by 117
Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6
Berry, D. C., O'Byrne, S. M., Vreeland, A. C., Blaner, W. S., & Noy, N. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00505-12 · Cited by 116
RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis
Karunanithi, S., Levi, L., DeVecchio, J., Karagkounis, G., Reizes, O., Lathia, J. D., Kalady, M. F., & Noy, N. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.002 · Cited by 117
Effects of myostatin deletion in aging mice
Morissette, M. R., Stricker, J., Rosenberg, M. A., Buranasombati, C., Levitan, E. B., Mittleman, M. A., & Rosenzweig, A. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00508.x · Cited by 123
Drosophila gains traction as a repurposed tool to investigate metabolism
Padmanabha, D., & Baker, K. D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.03.011 · Cited by 115
Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study
Derosa, G., Fogari, E., D’Angelo, A., Bianchi, L., Bonaventura, A., Romano, D., & Maffioli, P. (2013) · Inflammation · doi:10.1007/s10753-013-9620-4 · Cited by 119
The Metabolic Syndrome—from Insulin Resistance to Obesity and Diabetes
Gallagher, E. J., LeRoith, D., & Karnieli, E. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.05.002 · Cited by 118
Sleep duration and circulating adipokine levels
Hayes, A. L., Xu, F., Babineau, D., & Patel, S. R. (2011) · Sleep · doi:10.1093/sleep/34.2.147 · Cited by 114
Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly
Ingelsson, E., Sundström, J., Melhus, H., Michaëlsson, K., Berne, C., Vasan, R. S., Risérus, U., Blomhoff, R., Lind, L., & Ärnlöv, J. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.02.029 · Cited by 114
Hepatokines and adipokines in NASH-related hepatocellular carcinoma
Kücükoglu, Ö., Sowa, J., Mazzolini, G. D., Syn, W., & Canbay, A. E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.10.030 · Cited by 114
Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice
Kim, J. H., Meyers, M. S., Khuder, S. S., Abdallah, S. L., Muturi, H. T., Russo, L., Tate, C. R., Hevener, A. L., Najjar, S. M., Leloup, C., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.12.009 · Cited by 115
Fatty liver and the metabolic syndrome
Neuschwander‐Tetri, B. A. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32801421a9 · Cited by 114
Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk
Gustafson, B., & Smith, U. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.04.812 · Cited by 114
The role of estrogen in adipose tissue metabolism: insights into glucose homeostasis regulation [Review]
Kim, J. H., Cho, H. T., & Kim, Y. J. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0262 · Cited by 111
Urinary MCP-1 and RBP: Independent predictors of renal outcome in macroalbuminuric diabetic nephropathy
Titan, S., Vieira, J. M., Dominguez, W. V., Moreira, S. R. S., Pereira, A. B., Barros, R. T., & Zatz, R. (2012) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2012.06.006 · Cited by 111
Adipose tissue changes in obesity and the impact on metabolic function
Sam, S., & Mazzone, T. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.008 · Cited by 113
Triglyceride Levels and Not Adipokine Concentrations Are Closely Related to Severity of Nonalcoholic Fatty Liver Disease in an Obesity Surgery Cohort
Kashyap, S. R., Diab, D. L., Baker, A. R., Yerian, L. M., BAJAJ, H. S., Gray‐McGuire, C., Schauer, P. R., Gupta, M. K., Feldstein, A. E., Hazen, S. L., et al. (2009) · Obesity · doi:10.1038/oby.2009.89 · Cited by 111
Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas
Tritschler, S., Theis, F. J., Lickert, H., & Böttcher, A. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.021 · Cited by 112
Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo
Kulaj, K., Harger, A., Bauer, M., Çalışkan, Ö. Ş., Gupta, T. K., Chiang, D. M., Milbank, E., Reber, J., Karlas, A., Kotzbeck, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36148-1 · Cited by 117
Adipose tissue and reproductive health
Mathew, H., Castracane, V. D., & Mantzoros, C. S. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.006 · Cited by 109
Identification of a regulatory SNP in the retinol binding protein 4 gene associated with type 2 diabetes in Mongolia
Munkhtulga, L., Nakayama, K., Utsumi, N., Yanagisawa, Y., Gotoh, T., Omi, T., Kumada, M., Erdenebulgan, B., Zolzaya, K., Lkhagvasuren, T., et al. (2006) · Human Genetics · doi:10.1007/s00439-006-0264-4 · Cited by 109
Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin‐resistant rats
Qin, B., Polansky, M. M., Dawson, H. D., & Anderson, R. A. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900306 · Cited by 109
Evidence That Kidney Function but Not Type 2 Diabetes Determines Retinol-Binding Protein 4 Serum Levels
Henze, A., Frey, S. K., Raila, J., Tepel, M., Scholze, A., Pfeiffer, A. F. H., Weickert, M. O., Spranger, J., & Schweigert�, F. J. (2008) · Diabetes · doi:10.2337/db08-0866 · Cited by 109
Adipokines in reproductive function: a link between obesity and polycystic ovary syndrome
Chen, X., Jia, X., Qiao, J., Guan, Y., & Kang, J. (2013) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0247 · Cited by 112
The usefulness of circulating adipokine levels for the assessment of obesity-related health problems
Inadera, H. (2008) · International Journal of Medical Sciences · doi:10.7150/ijms.5.248 · Cited by 109
The stellate cell system (vitamin A-storing cell system)
Senoo, H., Mezaki, Y., & Fujiwara, M. (2017) · Anatomical Science International · doi:10.1007/s12565-017-0395-9 · Cited by 112
Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus
Zhang, W., Yan-cheng, X. U., Fang-jian, G. U. O., Ye, M., & Li, M. (2008) · Chinese Medical Journal · doi:10.1097/00029330-200811010-00003 · Cited by 107
Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis
Preitner, F., Mody, N., Graham, T. E., Peroni, O. D., & Kahn, B. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00362.2009 · Cited by 106
Self-citation
[Inflammatory biomarkers: the link between obesity and associated pathologies].
Zulet, M. Á., Puchau, B., Navarro, C., Martí, A., & Martínez, J. A. (2007) · PubMed · Cited by 106
Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging
Perdomo, G., & Dong, H. H. (2008) · Aging · doi:10.18632/aging.100004 · Cited by 110
Effect of exercise training on A‐FABP, lipocalin‐2 and RBP4 levels in obese women
Choi, K. M., Kim, T. N., Yoo, H. J., Lee, K. W., Cho, G. J., Hwang, T. G., Baik, S. H., Choi, D. S., & Kim, S. M. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03374.x · Cited by 104
Obesity and Psoriasis: Inflammatory Nature of Obesity, Relationship Between Psoriasis and Obesity, and Therapeutic Implications
Carrascosa, J. M., Rocamora, V., Fernandez-Torres, R. M., Jiménez-Puya, R. J., Moreno, J. C., Coll-Puigserver, N., & Fonseca, E. (2014) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2012.08.024 · Cited by 105
Role of vitamins and minerals in prevention and management of type 2 diabetes mellitus
Martini, L. A., Catania, A. S., & Ferreira, S. R. G. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00296.x · Cited by 105
STRA6, a Cell-Surface Receptor for Retinol-Binding Protein: The Plot Thickens
Blaner, W. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.006 · Cited by 103
Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
Shih, M., Kane, M. A., Zhou, P., Yen, C.-L., Streeper, R. S., Napoli, J. L., & Farese, R. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807503200 · Cited by 105
Effect of Weight Loss on LDL and HDL Kinetics in the Metabolic Syndrome
Ng, T. W., Watts, G. F., Barrett, P. H. R., Rye, K., & Chan, D. C. (2007) · Diabetes Care · doi:10.2337/dc07-0768 · Cited by 103
Maternal–fetal transfer and metabolism of vitamin A and its precursor β-carotene in the developing tissues
Spiegler, E., Kim, Y., Wassef, L., Shete, V., & Quadro, L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.05.003 · Cited by 109
Self-citation
Adiposopathy: how do diet, exercise and weight loss drug therapies improve metabolic disease in overweight patients?
Bays, H. E., Blonde, L., & Rosenson, R. S. (2006) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.4.6.871 · Cited by 103
The Alternative Stimulatory G Protein α-Subunit XLαs Is a Critical Regulator of Energy and Glucose Metabolism and Sympathetic Nerve Activity in Adult Mice
Xie, T., Plagge, A., Gavrilova, O., Pack, S., Jou, W., Lai, E. W., Frontera, M., Kelsey, G., & Weinstein, L. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511752200 · Cited by 102
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Tamori, Y., Sakaue, H., & Kasuga, M. (2006) · Nature Medicine · doi:10.1038/nm0106-30 · Cited by 102
Resistance Exercise Did Not Alter Intramuscular Adipose Tissue but Reduced Retinol-binding Protein-4 Concentration in Individuals with Type 2 Diabetes Mellitus
Ku, Y., Han, K. D., Ahn, H., Kwon, H.-R., Koo, B., Kim, H. C., & Min, K. (2010) · Journal of International Medical Research · doi:10.1177/147323001003800305 · Cited by 102
Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis
Berry, D. C., & Noy, N. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.002 · Cited by 100
Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children
Sanchis-Chordà, J., del Pulgar, E. M. G., Carrasco‐Luna, J., Benítez‐Páez, A., Sanz, Y., & Codoñer‐Franch, P. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1828-5 · Cited by 101
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Lee, S., Yuen, J. J., Jiang, H., Kahn, B. B., & Blaner, W. S. (2016) · Hepatology · doi:10.1002/hep.28659 · Cited by 101
Self-citation
Serum retinol‐binding protein 4 levels are elevated in non‐alcoholic fatty liver disease
Seo, J. A., Kim, N. H., Park, S. Y., Kim, H. Y., Ryu, O., Lee, K. W., Lee, J., Kim, D. L., Choi, K. M., Baik, S. H., et al. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03072.x · Cited by 99
RBP‐to‐retinol ratio, but not total RBP, is elevated in patients with type 2 diabetes
Erikstrup, C., Mortensen, O. H., Nielsen, A. R., Fischer, C. P., Plomgaard, P., Petersen, A. M., Krogh‐Madsen, R., Lindegaard, B., Erhardt, J. G., Ullum, H., et al. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00901.x · Cited by 100
Leptin, adiponectin, visfatin and retinol‐binding protein‐4 – mediators of comorbidities in patients with psoriasis?
Gerdes, S., Osadtschy, S., Rostami‐Yazdi, M., Buhles, N., Weichenthal, M., & Mrowietz, U. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01402.x · Cited by 98
Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness
Bobbert, T., Raila, J., Schwarz, F., Mai, K., Henze, A., Pfeiffer, A. F. H., Schweigert�, F. J., & Spranger, J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.07.063 · Cited by 98
Type 2 diabetes – An autoinflammatory disease driven by metabolic stress
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 101
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Authors: Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B.
Affiliations: Beth Israel Deaconess Medical Center (US)
Columbia University (US)
Corresponding author: Kahn, Barbara B.
ORCID: Yang, Qin
Mody, Nimesh
Quadro, Loredana
Kahn, Barbara B.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-07
Volume: 436
Issue: 7049
Pages: 356-362
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature03711
OpenAlex: W2092136583
Cited by: 2,086
References: 50
Citations by year: 2026: 43 · 2025: 50 · 2024: 80 · 2023: 53 · 2022: 85 · 2021: 86 · 2020: 95 · 2019: 69 · 2018: 76 · 2017: 91 · 2016: 88 · 2015: 120 · 2014: 115 · 2013: 124 · 2012: 135
FWCI: 89.83
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK043051)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: retinol-binding protein 4, insulin resistance, type 2 diabetes, obesity, GLUT4, adipose tissue, rosiglitazone, fenretinide, phosphoenolpyruvate carboxykinase, hepatic gluconeogenesis, impaired glucose tolerance
MeSH terms: Rosiglitazone, Adipose Tissue, Animals, Diabetes Mellitus, Type 2, Disease Models, Animal, Gene Expression Regulation, Insulin, Insulin Resistance, Liver, Monosaccharide Transport Proteins, Muscle Proteins, Muscles, Obesity, Phosphoenolpyruvate Carboxykinase (GTP), Retinol-Binding Proteins, Signal Transduction, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Hepatocytes, Thiazolidinediones, Glucose Transporter Type 4, Mice, Retinol-Binding Proteins, Plasma

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

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