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Cited by 56Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsGenetics, Aging, and Longevity in Model Organisms

Back and forth in time: Directing age in iPSC-derived lineages

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Cornacchia, Daniela, Studer, Lorenz·2017·Brain Research
DOI 10.1016/j.brainres.2015.11.013PMC PMC4870156
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Abstract

The advent of induced pluripotent stem cells (iPSC) has transformed the classic approach of studying human disease, providing in vitro access to disease-relevant cells from patients for the study of disease pathogenesis and for drug screening. However, in spite of the broad repertoire of iPSC-based disease models developed in recent years, increasing evidence suggests that this technology might not be fully suitable for the study of conditions of old age, such as neurodegeneration. The difficulty in recapitulating late-stage features of disease in cells of pluripotent origin is believed to be a discrepancy between the fetal-like nature of iPSC-progeny and the advanced age of onset of neurodegenerative syndromes. In parallel to the issue of functional immaturity known to affect derivatives of pluripotent cells, latest findings suggest that reprogramming also subjects cells to a process of "rejuvenation", giving rise to cells that are too "young" to manifest phenotypes of age-related diseases. Thus, following the significant progress in manipulating cellular fate, the stem cell field will now have to face the new challenge of controlling cellular age, in order to fully harness the potential of iPSC-technology to advance the research and cure of diseases of the aging brain. This article is part of a Special Issue entitled SI: Exploiting human neurons.

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  • Typical cytoskeletal and synaptic proteins and their co-localization were identified in neurons, but no major changes were found between Neu-Ctrl and Neu-AD cells for hallmarks.

    “Here, we identified typical cytoskeletal and synaptic proteins (and their co-localization) in neurons, but we did not find major changes between Neu-Ctrl and Neu-AD cells for hallmarks that may derive, at least in part, from their “age resetting” reprogramming process [114].”

    From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [114]

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Authors
Cornacchia, D., & Studer, L.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Studer, Lorenz
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2017-02
Volume
1656
Pages
14-26
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2015.11.013
PMC
PMC4870156
OpenAlex
W2174598103
Cited by
56
References
32
Citations by year
2026: 5 · 2025: 3 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 5
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Starr Foundation
  • National Institutes of Health
  • National Cancer Institute (P30CA008748)
  • National Institute of Neurological Disorders and Stroke (R01NS072381, R21NS084334)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
induced pluripotent stem cells, cellular aging, neurodegeneration, age-related diseases, iPSC-derived neurons, cellular rejuvenation, reprogramming, disease modeling, drug screening
MeSH terms
Cellular Reprogramming Techniques, Aging, Animals, Humans, Cell Lineage, Induced Pluripotent Stem Cells

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