The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Abstract
Stem-cell ageing is thought to contribute to altered tissue maintenance and repair. Older humans experience increased bone marrow failure and poorer haematologic tolerance of cytotoxic injury. Haematopoietic stem cells (HSCs) in older mice have decreased per-cell repopulating activity, self-renewal and homing abilities, myeloid skewing of differentiation, and increased apoptosis with stress. Here we report that the cyclin-dependent kinase inhibitor p16INK4a, the level of which was previously noted to increase in other cell types with age, accumulates and modulates specific age-associated HSC functions. Notably, in the absence of p16INK4a, HSC repopulating defects and apoptosis were mitigated, improving the stress tolerance of cells and the survival of animals in successive transplants, a stem-cell-autonomous tissue regeneration model. Inhibition of p16INK4a may ameliorate the physiological impact of ageing on stem cells and thereby improve injury repair in aged tissue.
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In the citing paper
“This correlates with the accumulation of DNA damage (Rossi et al., 2007), and with the overexpression of cell cycle-inhibitory proteins such as p16INK4a”
From The Hallmarks of Aging (2013) · cites this paper as Janzen et al., 2006
In the citing paper
“old INK4a−/− HSCs exhibit better engraftment capacity and increased cell cycle activity compared with old wild-type HSCs”
From The Hallmarks of Aging (2013) · cites this paper as Janzen et al., 2006
In the citing paper
“Old p16INK4a−/− HSCs also exhibit increased cell cycle activity and enhanced engraftment128, although these enhancements come with a price, as p16INK4a−/− animals show an increased incidence of malignancy.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [128]
In the citing paper
“Old p16INK4a−/− HSCs also exhibit increased cell cycle activity and enhanced engraftment128, although these enhancements come with a price, as p16INK4a−/− animals show an increased incidence of malignancy.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [128]
In the citing paper
“but knockout of p16 increases the life-span of HSCs by promoting HSC self-renewal.16-19”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [19]
In the citing paper
“ROS plays an important role in mediating induction of HSC senescence under various pathological conditions, such as mutation of ATM and various Fanconi anemia genes; deletion of Bmi1, FoxOs, Mdm2, and Tsc1; and aging.15,19,20,35-38”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [19]
In the citing paper
“age-induced expression of p16INK4a in adult stem cells seems to be associated with widespread impairment in tissue regeneration 23, 24, 25”
From The common biology of cancer and ageing (2007) · cites this paper as [23]
Citations
Cites
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Self-citationLittle Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Self-citationIdentification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential
Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,323
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003
Self-citationIncreasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972
Self-citationThe aging of hematopoietic stem cells
Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996) · Nature Medicine · doi:10.1038/nm0996-1011 · Cited by 853
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Regulation of Hematopoietic Stem Cell Fate and Malignancy
Cho, H. J., Lee, J., Yoon, S. R., Lee, H. G., & Jung, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134780 · Cited by 18
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Haig, D. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0006 · Cited by 17
Jayaraman, S., Eswaran, A., Rajagopal, P., Palanisamy, C. P., Veerakumar, P., Veeraraghavan, V. P., & Sirasanagandla, S. R. (2026) · Biogerontology · doi:10.1007/s10522-026-10402-7 · Cited by 17
Sturiale, C. L., Gatto, I., Puca, A., D’Arrigo, S., Giarretta, I., Albanese, A., Rocco, C. D., Maira, G., & Pola, R. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-304045 · Cited by 17
p16 loss rescues functional decline of Brca1-deficient mammary stem cells
Scott, A., Bai, F., Chan, H. L., Liu, S., Slingerland, J. M., Robbins, D. J., Capobianco, A. J., & Pei, X. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1295185 · Cited by 18
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Reed, R., & Miwa, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-21410-3_7 · Cited by 16
Sun, S., Meng, Y., Li, M., Tang, X., Hu, W., Wu, W., Li, G., Pang, Q., Wang, W., & Liu, B. (2023) · Nature Aging · doi:10.1038/s43587-023-00512-z · Cited by 16
Fujita, Y. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02011.x · Cited by 16
Jiang, C. (2017) · Neurology India · doi:10.4103/neuroindia.ni_1074_15 · Cited by 16
Zhang, J., Brown, R., Hogan, M. V., Onishi, K., & Wang, J. H. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25470 · Cited by 18
Is NHEJ a tumor suppressor or an aging suppressor?
Hasty, P. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5807 · Cited by 16
Linking Growth, Survival, and Heterogeneity through Vitality
Anderson, J. J., Gildea, M. C., Williams, D. W., & Li, T. (2007) · The American Naturalist · doi:10.1086/524199 · Cited by 16
Hematopoietic stem cell development, aging and functional failure
Chen, J. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0856-1 · Cited by 16
Smurf2 regulates hematopoietic stem cell self‐renewal and aging
Ramkumar, C., Kong, Y., Trabucco, S. E., Gerstein, R. M., & Zhang, H. (2014) · Aging Cell · doi:10.1111/acel.12195 · Cited by 17
Wang, C., Nakamura, S., Oshima, M., Mochizuki‐Kashio, M., Nakajima‐Takagi, Y., Osawa, M., Kusunoki, Y., Kyoizumi, S., Imai, K., Nakachi, K., et al. (2012) · International Journal of Radiation Biology · doi:10.3109/09553002.2013.734947 · Cited by 16
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Melzer, D. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0684 · Cited by 15
Wang, J., Ying, Y., Chen, Z., Shao, K., Zhang, W., & Lin, S. (2020) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-020-3098-3 · Cited by 15
Fuster, J. J., Molina-Sánchez, P., Jovani-Sales, D., Vinué, Á., Serrano, M., & Andrés, V. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.12.013 · Cited by 16
Mao, C.-C., & Cai, X. (2020) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x15666200422103916 · Cited by 16
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Salih, M. M., HIGGO, A. A., & Eed, E. M. (2021) · In Vivo · doi:10.21873/invivo.12707 · Cited by 16
Sen, M., Akeno, N., Reece, A. L., Miller, A. L., Simpson, D. S., & Wikenheiser‐Brokamp, K. A. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.5 · Cited by 15
Murine hematopoietic stem cell reconstitution potential is maintained by osteopontin during aging
Li, J., García, C. C., Riedt, T., Brandes, M., Szczepanski, S., Brossart, P., Wagner, W., & Janzen, V. (2018) · Scientific Reports · doi:10.1038/s41598-018-21324-x · Cited by 16
Self-citationPriami, C., Montariello, D., de Michele, G., Ruscitto, F., Polazzi, A., Ronzoni, S., Bertalot, G., Binelli, G., Gambino, V., Luzi, L., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01029-5 · Cited by 14
Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging
Ju, Z., Zhang, J., Gao, Y., & Cheng, T. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0882-z · Cited by 14
Self-citationSturiale, C. L., Fontanella, M. M., Gatto, I., Puca, A., Giarretta, I., D’Arrigo, S., Lofrese, G., Rainero, I., Gallone, S., Pinessi, L., et al. (2014) · Cerebrovascular Diseases · doi:10.1159/000360752 · Cited by 15
Martin, N., Raguz, S., Dharmalingam, G., & Gil, J. (2013) · Cell Cycle · doi:10.4161/cc.25331 · Cited by 14
Paradoxical down-regulation of p16 mRNA with advancing age in Acute Myeloid Leukemia
de Jonge, H. J. M., Woolthuis, C. M., de Bont, E. S. J. M., & Huls, G. A. (2009) · Aging · doi:10.18632/aging.100096 · Cited by 15
Ball, H. C., Moussa, F. M., Mbimba, T., Orman, R., Safadi, F. F., & Cooper, L. N. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.05.009 · Cited by 14
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Lin, Y., Liu, B., Deng, T., Zhong, J., Feng, Z., Zeng, Q., Huang, G., & Chen, Z. (2019) · Stem Cell Research · doi:10.1016/j.scr.2019.101464 · Cited by 14
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Singh, A. K., Peng, B., Chien, S.-T., Chan, C.-H., Deng, Y.-H., Pai, H., Wei, H.-J., Wang, M.-F., Wang, S., Wu, C.-Y., et al. (2023) · Biomaterials Science · doi:10.1039/d2bm01997c · Cited by 13
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Wu, J., Liu, X., Liu, Y., Su, W., & Zhuo, Y. (2025) · Bioengineering · doi:10.3390/bioengineering12060563 · Cited by 14
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Dong, Y., Lian, X., Xu, Y., Hu, H., Chang, C., Zhang, H., & Zhang, L. (2018) · Bioscience Reports · doi:10.1042/bsr20171589 · Cited by 13
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Kimata, Y., Leturcq, M., & Aradhya, R. (2020) · FEBS Letters · doi:10.1002/1873-3468.13805 · Cited by 12
Zhang, Y., Shao, C., Li, H., Wu, K., Gong, L., Zheng, Q., Dan, J., Jia, S., Tang, X., Wu, X., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.597566 · Cited by 13
Ageing within the hematopoietic stem cell compartment
Pearce, D., & Bonnet, D. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.005 · Cited by 13
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Kook, S.-H., Yun, C.-Y., Sim, H.-J., Bhattarai, G., Lee, B.-C., Lee, K., Cho, E.-S., & Lee, J. (2016) · Leukemia · doi:10.1038/leu.2016.133 · Cited by 13
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Shapiro, M. J., Anderson, J., Lehrke, M. J., Chen, M., Holte, M. N., & Shapiro, V. S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00214 · Cited by 12
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Adorno, M., di Robilant, B. N., Sikandar, S. S., Acosta, V. H., Antony, J., Heller, C. H., & Clarke, M. F. (2018) · Scientific Reports · doi:10.1038/s41598-018-34562-w · Cited by 12
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Li, H., Malhotra, D. K., Yeh, C., Tu, R., Zhu, B., Birger, N., Wisneski, A. D., Cha, J., Karliner, J. S., & Mann, M. J. (2009) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2008.12.016 · Cited by 12
Li, M., Guo, K., Adachi, Y., & Ikehara, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020183 · Cited by 12
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Jayapal, S. R., Ang, H. Y.-K., Wang, C. Q., Bisteau, X., Caldez, M. J., Xuan, G. X., Yu, W., Tergaonkar, V., Osato, M., Lim, B., et al. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1234546 · Cited by 12
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Zhang, X., Xiao, Y., Ran, Q., Liu, Y. Z., Duan, Q., Duan, H., Ye, X., & Li, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036912 · Cited by 12
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Burgstaller-Muehlbacher, S., Marko, M., Müller, C., Wendt, J., Pehamberger, H., & Okamoto, I. (2015) · Melanoma Research · doi:10.1097/cmr.0000000000000179 · Cited by 13
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Shang, X., Shu, B., Wang, Y., Luo, Z., Wang, G., Barton, R. S., Morandi, M., Kevil, C. G., & Dong, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-08804-2 · Cited by 12
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Kídd, K. K., & Kidd, J. R. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0005 · Cited by 11
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Donehower, L. A. (2008) · Aging · doi:10.18632/aging.100010 · Cited by 12
Cheng, H., Gao, X., Huard, M., Lu, A., Ruzbarsky, J. J., Amra, S., Wang, B., & Huard, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03047-z · Cited by 12
Wang, Z., Sim, H., Liu, W., Kim, J.-C., Lee, J., Kook, S., & Kim, S. H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0713 · Cited by 11
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Zhou, Y., Yang, B., Yao, X., & Wang, Y. (2010) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-010-9372-5 · Cited by 11
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Gil-Kulik, P., Chomik, P., Krzyżanowski, A., Radzikowska-Büchner, E., Maciejewski, R., Kwaśniewska, A., Rahnama, M., & Kocki, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1027106 · Cited by 11
Liu, J., Yang, L., Wang, X., Wang, S., Huang, Z., Li, C., Liu, Y., Cheng, Y., Liu, C., & Wang, Z. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01923-0 · Cited by 11
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Oxidized low‐density lipoprotein induces hematopoietic stem cell senescence
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Yu, S., Wang, Y., Tang, B., Liu, X., Song, L., Xu, G., Zhu, H., & Sun, H. (2022) · World Journal of Surgical Oncology · doi:10.1186/s12957-022-02601-6 · Cited by 10
Graça, A. L., Gómez‐Florit, M., Gomes, M. E., & Docheva, D. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_7 · Cited by 11
Демура, Т. А., Revazova, Z. V., Коган, Е. А., & Adamyan, L. V. (2017) · Russian Journal of Archive of Pathology · doi:10.17116/patol201779319-26 · Cited by 10
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Larijani, B. A., Heravani, N. F., Alaei, S., Rezaei–Tavirani, M., Alavi-Moghadam, S., Payab, M., Goodarzi, P., Tayanloo-Beik, A., Aghayan, H. R., & Arjmand, B. (2021) · Advances in experimental medicine and biology · doi:10.1007/5584_2021_624 · Cited by 10
Age-Related Changes in Niche Cells Influence Hematopoietic Stem Cell Function
Oakley, E. J., & Zant, G. E. V. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.01.008 · Cited by 10
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Chuaire, L., Sánchez, M. C., & Ramírez-Clavijo, S. R. (2010) · International Journal of Morphology · doi:10.4067/s0717-95022010000100006 · Cited by 10
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Tallen, G. R. N., Soliman, M. A., & Riabowol, K. T. (2007) · Rejuvenation Research · doi:10.1089/rej.2007.0598 · Cited by 10
Sim, H., Kim, Y.-C., Bhattarai, G., Won, S., Lee, J., Jeong, B., & Kook, S. (2023) · Leukemia · doi:10.1038/s41375-023-01828-w · Cited by 9
Hasan, T., Pasala, A. R., Hassan, D., Hanotaux, J., Allan, D., & Maganti, H. B. (2024) · Current Oncology · doi:10.3390/curroncol31020044 · Cited by 9
Prindull, G. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.07.009 · Cited by 9
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Lichterfeld, M., Cung, T., Seiss, K., Rosenberg, E. S., Pereyra, F., & Yu, X. G. (2012) · Journal of Virology · doi:10.1128/jvi.00196-12 · Cited by 9
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Liu, Y., Zant, G. E. V., & Liang, Y. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1785-3_3 · Cited by 9
Growing old in the age of heterogeneity: the perils of shifting clonality
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Self-citationHe, L., Beghi, F., Baral, V., Dépond, M., Zhang, Y., Joulin, V., Rueda, B. R., Gonin, P., Foudi, A., Wittner, M., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.06.002 · Cited by 9
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Zhu, H., Miosge, N., Schulz, J., & Schliephake, H. (2010) · Cells Tissues Organs · doi:10.1159/000313417 · Cited by 8
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Metadata
- Authors
- Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T.
- Affiliations
- Harvard University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Scadden, David T.
- ORCID
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7110
- Pages
- 421-426
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2084289371
- Cited by
- 1,106
- References
- 33
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 17 · 2023: 21 · 2022: 48 · 2021: 34 · 2020: 37 · 2019: 44 · 2018: 39 · 2017: 57 · 2016: 57 · 2015: 62 · 2014: 66 · 2013: 70 · 2012: 59
- FWCI
- 63.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- p16INK4a, stem cell aging, hematopoietic stem cells, cyclin-dependent kinase inhibitors, tumour suppressor, stem cell self-renewal, apoptosis, stress tolerance, tissue regeneration, pancreatic islet regeneration, brain regeneration, type 2 diabetes, bone marrow failure
- MeSH terms
- Transcription Factor HES-1, Aging, Animals, Cell Count, Hematopoietic Stem Cells, Bone Marrow Transplantation, Cellular Senescence, Apoptosis, Homeodomain Proteins, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Mice, Basic Helix-Loop-Helix Proteins
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