The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Abstract
Stem-cell ageing is thought to contribute to altered tissue maintenance and repair. Older humans experience increased bone marrow failure and poorer haematologic tolerance of cytotoxic injury. Haematopoietic stem cells (HSCs) in older mice have decreased per-cell repopulating activity, self-renewal and homing abilities, myeloid skewing of differentiation, and increased apoptosis with stress. Here we report that the cyclin-dependent kinase inhibitor p16INK4a, the level of which was previously noted to increase in other cell types with age, accumulates and modulates specific age-associated HSC functions. Notably, in the absence of p16INK4a, HSC repopulating defects and apoptosis were mitigated, improving the stress tolerance of cells and the survival of animals in successive transplants, a stem-cell-autonomous tissue regeneration model. Inhibition of p16INK4a may ameliorate the physiological impact of ageing on stem cells and thereby improve injury repair in aged tissue.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This correlates with the accumulation of DNA damage (Rossi et al., 2007), and with the overexpression of cell cycle-inhibitory proteins such as p16INK4a”
From The Hallmarks of Aging (2013) · cites this paper as Janzen et al., 2006
In the citing paper
“old INK4a−/− HSCs exhibit better engraftment capacity and increased cell cycle activity compared with old wild-type HSCs”
From The Hallmarks of Aging (2013) · cites this paper as Janzen et al., 2006
In the citing paper
“Old p16INK4a−/− HSCs also exhibit increased cell cycle activity and enhanced engraftment128, although these enhancements come with a price, as p16INK4a−/− animals show an increased incidence of malignancy.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [128]
In the citing paper
“Old p16INK4a−/− HSCs also exhibit increased cell cycle activity and enhanced engraftment128, although these enhancements come with a price, as p16INK4a−/− animals show an increased incidence of malignancy.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [128]
In the citing paper
“but knockout of p16 increases the life-span of HSCs by promoting HSC self-renewal.16-19”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [19]
In the citing paper
“ROS plays an important role in mediating induction of HSC senescence under various pathological conditions, such as mutation of ATM and various Fanconi anemia genes; deletion of Bmi1, FoxOs, Mdm2, and Tsc1; and aging.15,19,20,35-38”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [19]
In the citing paper
“age-induced expression of p16INK4a in adult stem cells seems to be associated with widespread impairment in tissue regeneration 23, 24, 25”
From The common biology of cancer and ageing (2007) · cites this paper as [23]
Citations
Cites
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Self-citationLittle Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Self-citationIdentification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential
Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,323
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003
Self-citationIncreasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972
Self-citationThe aging of hematopoietic stem cells
Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996) · Nature Medicine · doi:10.1038/nm0996-1011 · Cited by 853
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 998
Specific Age-Associated DNA Methylation Changes in Human Dermal Fibroblasts
Koch, C., Suschek, C. V., Lin, Q., Bork, S., Goergens, M., Joussen, S., Pallua, N., Ho, A. D., Zenke, M., & Wagner, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016679 · Cited by 135
Balancing regeneration and cancer
Beausejour, C. M., & Campisi, J. (2006) · Nature · doi:10.1038/nature05221 · Cited by 134
WIP1 phosphatase at the crossroads of cancer and aging
Guezennec, X. L., & Bulavin, D. V. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.005 · Cited by 135
Epigenetic regulation of aging stem cells
Pollina, E. A., & Brunet, A. (2011) · Oncogene · doi:10.1038/onc.2011.45 · Cited by 111
Genome instability, cancer and aging
Maslov, A. Y., & Vijg, J. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.03.020 · Cited by 134
Adiponectin as a potential biomarker of vascular disease
Mohammadi, S., Arefhosseini, S. R., Ebrahimi‐Mameghani, M., Fallah, P., & Bazi, Z. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s48753 · Cited by 129
The Adventitia: A Progenitor Cell Niche for the Vessel Wall
Majesky, M. W., Dong, X. R., Hoglund, V. J., Daum, G., & Mahoney, W. M. (2011) · Cells Tissues Organs · doi:10.1159/000331413 · Cited by 130
Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging
Zhang, H. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20919 · Cited by 136
Hadjiargyrou, M., & O’Keefe, R. J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2373 · Cited by 127
Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging
Phadwal, K., Watson, A., & Simon, A. K. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1032-3 · Cited by 129
Badders, N. M., Goel, S., Clark, R. J., Klos, K. S., Kim, S. Y., Bafico, A., Lindvall, C. J., Williams, B. O., & Alexander, C. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006594 · Cited by 133
Bmi-1: At the crossroads of physiological and pathological biology
Bhattacharya, R., Mustafi, S. B., Street, M., Dey, A., & Dwivedi, S. K. D. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2015.04.001 · Cited by 132
Jung, J., Lee, S., Seo, M., Park, S., Kurtz, A., Kang, S., & Kang, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0242-9 · Cited by 127
Skeletal Muscle Stem Cells: Effects of Aging and Metabolism on Muscle Regenerative FunctionPreprint
Jang, Y. C., Sinha, M., Cerletti, M., Dall’Osso, C., & Wagers, A. J. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010652 · Cited by 127
The BAF53a subunit of SWI/SNF-like BAF complexes is essential for hemopoietic stem cell function
Krasteva, V., Buscarlet, M., Diaz‐Tellez, A., Bernard, M.-A., Crabtree, G. R., & Lessard, J. A. (2012) · Blood · doi:10.1182/blood-2012-04-427047 · Cited by 126
Cudejko, C., Wouters, K., Fuentes, L., Hannou, S. A., Paquet, C., Bantubungi, K., Bouchaert, E., Vanhoutte, J., Fleury, S., Rémy, P., et al. (2011) · Blood · doi:10.1182/blood-2010-10-313106 · Cited by 133
Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3
Janzen, V., Fleming, H. E., Riedt, T., Karlsson, G., Riese, M. J., Celso, C. L., Reynolds, G., Milne, C. D., Paige, C. J., Karlsson, S., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.012 · Cited by 125
Self-citationSelective Targeting of Cancer Stem Cells
Körkaya, H., & Wicha, M. S. (2007) · BioDrugs · doi:10.2165/00063030-200721050-00002 · Cited by 126
Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantation
Koppelstaetter, C., Schratzberger, G., Perco, P., Hofer, J., Mark, W., Öllinger, R., Oberbauer, R., Schwarz, C., Mitterbauer, C., Kainz, A., et al. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00398.x · Cited by 124
mTOR Signaling from Cellular Senescence to Organismal Aging
Xu, S. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500263 · Cited by 125
Wong, E. S. M., Guezennec, X. L., Demidov, O. N., Marshall, N. T., Wang, S. T., Krishnamurthy, J., Sharpless, N. E., Dunn, N. R., & Bulavin, D. V. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.05.009 · Cited by 131
Self-citationA network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties
Nishino, J., Kim, S., Zhu, Y., Zhu, H., & Morrison, S. J. (2013) · eLife · doi:10.7554/elife.00924 · Cited by 118
Kang, C. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.0298 · Cited by 129
Zhang, Y., Herbert, B., Gangaraju, R., Ingram, D. A., Yöder, M. C., Clauss, M. A., & Rehman, J. (2009) · The FASEB Journal · doi:10.1096/fj.08-110296 · Cited by 120
Mechanisms and rejuvenation strategies for aged hematopoietic stem cells
Li, X., Zeng, X., Xu, Y., Wang, B., Zhao, Y., Lai, X., Qian, P., & Huang, H. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00864-8 · Cited by 119
Stressing the cell cycle in senescence and aging
Chandler, H., & Peters, G. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.07.005 · Cited by 119
Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment
Wang, S., Prizment, A. E., Thyagarajan, B., & Blaes, A. H. (2021) · Cancers · doi:10.3390/cancers13030427 · Cited by 118
Sun, X., Cao, B., Naval-Sánchez, M., Pham, T. A., Sun, Y., Williams, B., Heazlewood, S. Y., Deshpande, N., Li, J., Kraus, F., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22863-0 · Cited by 120
A Limited Role for p21Cip1/Waf1 in Maintaining Normal Hematopoietic Stem Cell Functioning
van Os, R. P., Kamminga, L. M., Ausema, A., Bystrykh, L. V., Draijer, D. P., van Pelt, K., Dontje, B., & de Haan, G. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0631 · Cited by 118
The great unravelling: chromatin as a modulator of the aging process
O’Sullivan, R. J., & Karlseder, J. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.08.001 · Cited by 120
Cell Senescence: A Challenge in Cartilage Engineering and Regeneration
Li, J., & Pei, M. (2012) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0583 · Cited by 114
Cellular Senescence - its role in cancer and the response to ionizing radiation
Sabin, R. J., & Anderson, R. M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-7 · Cited by 123
Liu, Y., Weng, W., Gao, R., & Liu, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/4598167 · Cited by 118
Expression of p16INK4a prevents cancer and promotes aging in lymphocytes
Liu, Y., Johnson, S. M., Fedoriw, Y., Rogers, A. B., Yuan, H., Krishnamurthy, J., & Sharpless, N. E. (2011) · Blood · doi:10.1182/blood-2010-09-304402 · Cited by 114
Self-citationMuñoz-Nájar, U., & Sedivy, J. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3250 · Cited by 114
Lunyak, V. V., Amaro-Ortiz, A., & Gaur, M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00220 · Cited by 119
Cellular senescence: Its role in tumor suppression and aging
Ohtani, N., Mann, D. J., & Hara, E. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01123.x · Cited by 119
Cancer as a Manifestation of Aberrant Chromatin Structure
Brock, M. V., Herman, J. G., & Baylin, S. B. (2007) · The Cancer Journal · doi:10.1097/ppo.0b013e31803c5415 · Cited by 114
Mouse Models to Disentangle the Hallmarks of Human Aging
Folgueras, A. R., Freitas-Rodríguez, S., Velasco, G., & López-Otín, C. (2018) · Circulation Research · doi:10.1161/circresaha.118.312204 · Cited by 113
Chang, J., Li, Y., Huang, Y., Lam, K. S. L., Hoo, R. L. C., Wong, W. T., Cheng, K. K. Y., Wang, Y., Vanhoutte, P. M., & Xu, A. (2010) · Diabetes · doi:10.2337/db10-0582 · Cited by 113
Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112
Paramos-de-Carvalho, D., Jacinto, A., & Saúde, L. (2021) · eLife · doi:10.7554/elife.72449 · Cited by 111
Jin, Y., Kato, T., Furu, M., Nasu, A., Kajita, Y., Mitsui, H., Ueda, M., Aoyama, T., Nakayama, T., Nakamura, T., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.12.096 · Cited by 111
Bigot, A., Klein, A. F., Gasnier, E., Jacquemin, V., Ravassard, P., Butler-Browne, G. S., Mouly, V., & Furling, D. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080560 · Cited by 124
Pei, X., Bai, F., Smith, M. D., Usary, J., Fan, C., Pai, S., Ho, I., Perou, C. M., & Xiong, Y. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.004 · Cited by 113
Effects of Donor Age and Cell Senescence on Kidney Allograft Survival
Melk, A., Schmidt, B. M. W., Braunc, H., Vongwiwatana, A., Urmson, J. R., Zhu, L. F., Rayner, D. C., & Halloran, P. F. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02500.x · Cited by 109
Redaelli, S., Bentivegna, A., Foudah, D., Miloso, M., Redondo, J., Riva, G., Baronchelli, S., Dalprà, L., & Tredici, G. (2012) · Stem Cell Research & Therapy · doi:10.1186/scrt138 · Cited by 109
Effects of exercise on cellular and tissue aging
Carapeto, P. V., & Aguayo-Mazzucato, C. (2021) · Aging · doi:10.18632/aging.203051 · Cited by 107
PR-domain–containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function
Zhang, Y., Stehling-Sun, S., Lezon-Geyda, K., Juneja, S. C., Coillard, L., Chatterjee, G., Wuertzer, C. A., Camargo, F. D., & Perkins, A. S. (2011) · Blood · doi:10.1182/blood-2011-02-334680 · Cited by 108
Quiescence: Good and Bad of Stem Cell Aging
Tümpel, S., & Rudolph, K. L. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.05.002 · Cited by 108
Stem Cells, Redox Signaling, and Stem Cell Aging
Liang, R., & Ghaffari, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5300 · Cited by 106
Stem Cells: A Renaissance in Human Biology Research
Wu, J., & Belmonte, J. C. I. (2016) · Cell · doi:10.1016/j.cell.2016.05.043 · Cited by 111
Anti‐aging activity of the Ink4/Arf locus
Matheu, A., Maraver, A., Collado, M., Garcia‐Cao, I., Cañamero, M., Borras, C., Flores, J. M., Klatt, P., Viña, J., & Serrano, M. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00458.x · Cited by 94
The PKB/FOXO switch in aging and cancer
Kloet, D. E. A., & Burgering, B. M. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.04.003 · Cited by 106
Aging-Related Genes in Mesenchymal Stem Cells: A Mini-Review
Yu, K.-R., & Kang, K.-S. (2013) · Gerontology · doi:10.1159/000353857 · Cited by 103
Cell cycle control of pituitary development and disease
Quereda, V., & Malumbres, M. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0146 · Cited by 103
An evolutionary perspective on chronic myelomonocytic leukemia
Itzykson, R., & Solary, É. (2013) · Leukemia · doi:10.1038/leu.2013.100 · Cited by 108
Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks
Kawahara, T. L. A., Rapicavoli, N. A., Wu, A. R., Qu, K., Quake, S. R., & Chang, H. Y. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002153 · Cited by 104
Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch
López‐Arribillaga, E., Rodilla, V., Pellegrinet, L., Guiu, J., Iglesias, M., Román, Á., Gutarra, S., González, S., Muñoz‐Cánoves, P., Fernández‐Salguero, P. M., et al. (2014) · Development · doi:10.1242/dev.107714 · Cited by 105
Young, K. A., Borikar, S., Bell, R. K., Kuffler, L., Philip, V. M., & Trowbridge, J. J. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160168 · Cited by 96
Zhao, R., Xuan, Y., Li, X., & Xi, R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00379.x · Cited by 101
Signer, R. A. J., Montecino-Rodriguez, E., Witte, O. N., & Dorshkind, K. (2008) · Genes & Development · doi:10.1101/gad.1715808 · Cited by 102
The role of immunity in elderly cancer
Malaguarnera, L., Cristaldi, E., & Malaguarnera, M. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.06.002 · Cited by 103
Kruta, M., Sunshine, M. J., Chua, B. A., Fu, Y., Chawla, A., Dillingham, C. H., Hidalgo San Jose, L., De Jong, B., Zhou, F. J., & Signer, R. A. J. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.07.009 · Cited by 100
Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance
Perry, S. S., Zhao, Y., Nie, L., Cochrane, S. W., Huang, Z., & Sun, X.-H. (2007) · Blood · doi:10.1182/blood-2007-01-069914 · Cited by 100
Ink4‐Arf locus in cancer and aging
Sherr, C. J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.40 · Cited by 104
Production of Mesenchymal Stem Cells through Stem Cell Reprogramming
Dayem, A. A., Lee, S. B., Kim, K., Lim, K. M., Jeon, T.-I., Seok, J., & Cho, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081922 · Cited by 98
Aging in the lympho-hematopoietic stem cell compartment
Geiger, H., & Rudolph, K. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.010 · Cited by 103
Tamama, K., Kawasaki, H., Kerpedjieva, S. S., Guan, J., Ganju, R. K., & Sen, C. K. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22961 · Cited by 98
Interleukin-7 and Immunosenescence
Nguyen, V., Mendelsohn, A., & Larrick, J. W. (2017) · Journal of Immunology Research · doi:10.1155/2017/4807853 · Cited by 96
Aging and Regeneration in Vertebrates
Sousounis, K., Baddour, J., & Tsonis, P. A. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-391498-9.00008-5 · Cited by 96
Cellular senescence and chromatin organisation
Narita, M. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603636 · Cited by 96
AGING OF THE SUBVENTRICULAR ZONE NEURAL STEM CELL NICHE.
Conover, J. C., & Shook, B. A. (2011) · Europe PMC (PubMed Central) · Cited by 92
Repair of senescent myocardium by mesenchymal stem cells is dependent on the age of donor mice
Khan, M., Mohsin, S., Khan, S. N., & Riazuddin, S. A. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00998.x · Cited by 93
Programmed cell senescence in skeleton during late puberty
Li, C., Chai, Y., Wang, L., Gao, B., Chen, H., Gao, P., Zhou, F.-Q., Luo, X., Crane, J. L., Yu, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01509-0 · Cited by 92
The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle
Milanovic, M., Yu, Y., & Schmitt, C. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.09.001 · Cited by 92
The p53 tumor suppressor protein regulates hematopoietic stem cell fate
Asai, T., Liu, Y., Bae, N., & Nimer, S. D. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22561 · Cited by 102
Liu, S., Liu, S., Wang, X., Zhou, J., Cao, Y., Wang, F., & Duan, E. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00704.x · Cited by 93
Cluett, C., McDermott, M. M., Guralnik, J. M., Ferrucci, L., Bandinelli, S., Miljkovic, I., Zmuda, J. M., Li, R., Tranah, G. J., Harris, T. B., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.108.825935 · Cited by 93
Cardiovascular development: towards biomedical applicability
Torella, D., Ellison, G. M., Karakikes, I., & Nadal‐Ginard, B. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6519-y · Cited by 90
Feng, X., Feng, G., Xing, J., Shen, B., Tan, W., Huang, D. Y., Lu, X., Tao, T., Zhang, J., Li, L., et al. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1799-7 · Cited by 88
Cellular Senescence in the Development and Treatment of Cancer
Saretzki, G. C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161210789941874 · Cited by 92
Connecting autophagy to senescence in pathophysiology
Young, A. R. J., & Narita, M. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.005 · Cited by 98
Aging of hematopoietic stem cells: DNA damage and mutations?
Moehrle, B., & Geiger, H. (2016) · Experimental Hematology · doi:10.1016/j.exphem.2016.06.253 · Cited by 87
DeGregori, J. V. (2012) · Oncogene · doi:10.1038/onc.2012.281 · Cited by 88
Kent, D. G., Li, J., Tanna, H., Fink, J., Kirschner, K., Pask, D. C., Silber, Y., Hamilton, T. L., Sneade, R., Simons, B. D., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001576 · Cited by 87
p16INK4a reporter mice reveal age-promoting effects of environmental toxicants
Sorrentino, J. A., Krishnamurthy, J., Tilley, S. L., Alb, J. G., Burd, C. E., & Sharpless, N. E. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70960 · Cited by 85
Self-citationSon, M. J., Kwon, Y., Son, T., & Cho, Y. S. (2016) · Stem Cells · doi:10.1002/stem.2460 · Cited by 85
A common variant of the p16INK4a genetic region is associated with physical function in older people
Melzer, D., Frayling, T. M., Murray, A., Hurst, A. J., Harries, L. W., Song, H., Khaw, K., Luben, R., Surtees, P. G., Bandinelli, S. S., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.03.005 · Cited by 84
Escape of hair follicle stem cells causes stem cell exhaustion during aging
Zhang, C., Wang, D., Wang, J., Wang, L., Qiu, W., Kume, T., Dowell, R. D., & Yi, R. (2021) · Nature Aging · doi:10.1038/s43587-021-00103-w · Cited by 87
Autophagy at the intersection of aging, senescence, and cancer
Cassidy, L. D., & Narita, M. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13269 · Cited by 93
Influence of the Mediterranean Diet on Healthy Aging
Andreo-López, M. C., Contreras-Bolívar, V., Muñoz‐Torres, M., García-Fontana, B., & García‐Fontana, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054491 · Cited by 94
Sox2 Suppression by miR-21 Governs Human Mesenchymal Stem Cell Properties
Trohatou, O., Zagoura, D., Bitsika, V., Pappa, K. I., Antsaklis, A., Anagnou, N. P., & Roubelakis, M. G. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0081 · Cited by 84
Mitterberger, M. C., Lechner, S., Mattesich, M., & Zwerschke, W. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt043 · Cited by 85
Chromatin Architectural Changes during Cellular Senescence and Aging
Sun, L., Yu, R., & Dang, W. (2018) · Genes · doi:10.3390/genes9040211 · Cited by 90
Liu, T. M., Ng, W. M., Tan, H. S., Denslin, V., Yang, Z., Fan, J., Zou, Y. S., Hui, J. H. P., Lee, E. H., & Lim, B. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0222 · Cited by 83
Tower, J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.56 · Cited by 85
Spallarossa, P., Altieri, P., Barisione, C., Passalacqua, M., Aloi, C., Fugazza, G., Frassoni, F., Podestà, M., Canepa, M., Ghigliotti, G., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015583 · Cited by 83
Aging of signal transduction pathways, and pathology
Carlson, M. E., Silva, H. S., & Conboy, I. M. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.03.017 · Cited by 84
PTEN expression is a strong predictor of survival in mesothelioma patients☆
Opitz, I., Soltermann, A., Abaecherli, M., Hinterberger, M., Probst-Hensch, N. M., Stahel, R. A., Moch, H., & Weder, W. (2008) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2007.09.045 · Cited by 80
Metadata
- Authors
- Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T.
- Affiliations
- Harvard University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Scadden, David T.
- ORCID
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7110
- Pages
- 421-426
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2084289371
- Cited by
- 1,106
- References
- 33
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 17 · 2023: 21 · 2022: 48 · 2021: 34 · 2020: 37 · 2019: 44 · 2018: 39 · 2017: 57 · 2016: 57 · 2015: 62 · 2014: 66 · 2013: 70 · 2012: 59
- FWCI
- 63.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- p16INK4a, stem cell aging, hematopoietic stem cells, cyclin-dependent kinase inhibitors, tumour suppressor, stem cell self-renewal, apoptosis, stress tolerance, tissue regeneration, pancreatic islet regeneration, brain regeneration, type 2 diabetes, bone marrow failure
- MeSH terms
- Transcription Factor HES-1, Aging, Animals, Cell Count, Hematopoietic Stem Cells, Bone Marrow Transplantation, Cellular Senescence, Apoptosis, Homeodomain Proteins, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Mice, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
