The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Abstract
Stem-cell ageing is thought to contribute to altered tissue maintenance and repair. Older humans experience increased bone marrow failure and poorer haematologic tolerance of cytotoxic injury. Haematopoietic stem cells (HSCs) in older mice have decreased per-cell repopulating activity, self-renewal and homing abilities, myeloid skewing of differentiation, and increased apoptosis with stress. Here we report that the cyclin-dependent kinase inhibitor p16INK4a, the level of which was previously noted to increase in other cell types with age, accumulates and modulates specific age-associated HSC functions. Notably, in the absence of p16INK4a, HSC repopulating defects and apoptosis were mitigated, improving the stress tolerance of cells and the survival of animals in successive transplants, a stem-cell-autonomous tissue regeneration model. Inhibition of p16INK4a may ameliorate the physiological impact of ageing on stem cells and thereby improve injury repair in aged tissue.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This correlates with the accumulation of DNA damage (Rossi et al., 2007), and with the overexpression of cell cycle-inhibitory proteins such as p16INK4a”
From The Hallmarks of Aging (2013) · cites this paper as Janzen et al., 2006
In the citing paper
“old INK4a−/− HSCs exhibit better engraftment capacity and increased cell cycle activity compared with old wild-type HSCs”
From The Hallmarks of Aging (2013) · cites this paper as Janzen et al., 2006
In the citing paper
“Old p16INK4a−/− HSCs also exhibit increased cell cycle activity and enhanced engraftment128, although these enhancements come with a price, as p16INK4a−/− animals show an increased incidence of malignancy.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [128]
In the citing paper
“Old p16INK4a−/− HSCs also exhibit increased cell cycle activity and enhanced engraftment128, although these enhancements come with a price, as p16INK4a−/− animals show an increased incidence of malignancy.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [128]
In the citing paper
“but knockout of p16 increases the life-span of HSCs by promoting HSC self-renewal.16-19”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [19]
In the citing paper
“ROS plays an important role in mediating induction of HSC senescence under various pathological conditions, such as mutation of ATM and various Fanconi anemia genes; deletion of Bmi1, FoxOs, Mdm2, and Tsc1; and aging.15,19,20,35-38”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [19]
In the citing paper
“age-induced expression of p16INK4a in adult stem cells seems to be associated with widespread impairment in tissue regeneration 23, 24, 25”
From The common biology of cancer and ageing (2007) · cites this paper as [23]
Citations
Cites
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287
Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
Osawa, M., Hanada, K., Hamada, H., & Nakauchi, H. (1996) · Science · doi:10.1126/science.273.5272.242 · Cited by 2,141
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Ink4a/Arf expression is a biomarker of aging
Krishnamurthy, J., Torrice, C., Ramsey, M. R., Kovalev, G. I., Al-Regaiey, K., Su, L., & Sharpless, N. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22475 · Cited by 1,486
Self-citationLittle Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339
Self-citationIdentification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential
Adolfsson, J., Månsson, R., Buza-Vidas, N., Hultquist, A., Liuba, K., Jensen, C. T., Bryder, D., Yang, L., Borge, O. J., Thorén, L., et al. (2005) · Cell · doi:10.1016/j.cell.2005.02.013 · Cited by 1,323
p16INK4a induces an age-dependent decline in islet regenerative potential
Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003
Self-citationIncreasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972
Self-citationThe aging of hematopoietic stem cells
Morrison, S. J., Wandycz, A. M., Akashi, K., Globerson, A., & Weissman, I. L. (1996) · Nature Medicine · doi:10.1038/nm0996-1011 · Cited by 853
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 998
Ink4a/Arf Regulation by let-7b and Hmga2: A Genetic Pathway Governing Stem Cell Aging
Tzatsos, A., & Bardeesy, N. M. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.10.008 · Cited by 39
The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb–E2F1
Liu, Y., Costantino, M. E., Montoya-Durango, D. E., Higashi, Y., Darling, D. S., & Dean, D. C. (2007) · Biochemical Journal · doi:10.1042/bj20070344 · Cited by 39
Epigenetics of hematopoietic stem cell aging and disease
Oshima, M., & Iwama, A. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1647-2 · Cited by 39
Use of DNA Methylation for Cancer Detection and Molecular Classification
Zhu, J., & Yao, X. (2007) · BMB Reports · doi:10.5483/bmbrep.2007.40.2.135 · Cited by 39
Are aging biomarkers clinically relevant in oncogeriatrics?
Falandry, C., Gilson, É., & Rudolph, K. L. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.08.004 · Cited by 39
Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer InitiationPreprint
Zouabi, L. A., & Bardin, A. J. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036210 · Cited by 39
Wang, W. E., Chen, X., Houser, S. R., & Zeng, C. (2013) · Clinical Science · doi:10.1042/cs20130019 · Cited by 38
Liu, J., Xu, K., Chase, M., Ji, Y., Logan, J. K., & Buchsbaum, R. J. (2012) · Journal of Cell Science · doi:10.1242/jcs.089466 · Cited by 37
SOX2 expression diminishes with ageing in several tissues in mice and humans
Carrasco‐García, E., Moreno‐Cugnon, L., García, I., Borrás, C., Revuelta, M., Izeta, A., López‐Lluch, G., de Pancorbo, M. M., Vergara, I., Viña, J., et al. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.008 · Cited by 38
Remodeling chromatin for senescence.
Adams, P. D. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00313.x · Cited by 37
Chen, P., Lin, C., Li, N., Wu, Y., Lin, M., Hung, S., & Yen, M. (2015) · Oncotarget · doi:10.18632/oncotarget.6178 · Cited by 37
Neural stem and progenitor cells in the aged subependyma are activated by the young niche
Piccin, D., Tufford, A., & Morshead, C. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.026 · Cited by 37
Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans
Zimmerman, S. M., Hinkson, I. V., Elias, J. E., & Kim, S. K. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005725 · Cited by 35
Savickienė, J., Baronaitė, S., Zentelytė, A., Treigytė, G., & Navakauskienė, R. (2016) · Stem Cells International · doi:10.1155/2016/2019498 · Cited by 39
Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?
Cianflone, E., Torella, M., Chimenti, C., Angelis, A. D., Beltrami, A. P., Urbanek, K., Rota, M., & Torella, D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5813147 · Cited by 40
Yonetani, S., Moriyama, M., Nishigori, C., Osawa, M., & Nishikawa, S. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700997 · Cited by 35
A role for cellular senescence in birth timing
Cha, J. M., & Aronoff, D. M. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1371888 · Cited by 41
Pustavoitau, A., Barodka, V., Sharpless, N. E., Torrice, C., Nyhan, D., Berkowitz, D. E., Shah, A. S., Bandeen Roche, K. J., & Walston, J. D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2015.12.003 · Cited by 36
Self-citationDecottignies, A., & di Fagagna, F. D. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.003 · Cited by 37
Age-dependent decline in neurogenesis of the hippocampus and extracellular nucleotides
Takei, Y. (2019) · Human Cell · doi:10.1007/s13577-019-00241-9 · Cited by 36
Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells
Sun, Y., Lin, X., Liu, B., Zhang, Y., Li, W., Zhang, S., He, F., Tian, H., Zhu, X., Liu, X., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj6877 · Cited by 37
Müller Glia maintain their regenerative potential despite degeneration in the aged zebrafish retina
Martins, R. R., Zamzam, M. E., Tracey‐White, D., Moosajee, M., Thummel, R., Henriques, C. M., & MacDonald, R. B. (2022) · Aging Cell · doi:10.1111/acel.13597 · Cited by 35
Cellular senescence and neurodegeneration
Holloway, K., Neherin, K., Dam, K. U., & Zhang, H. (2023) · Human Genetics · doi:10.1007/s00439-023-02565-x · Cited by 40
Huai, J., Firat, E., Nil, A., Million, D., Gaedicke, S., Kanzler, B., Freudenberg, M. A., Endert, P. V., Köhler, G., Pahl, H. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801413105 · Cited by 37
Conboy, I. M., Yousef, H., & Conboy, M. J. (2011) · Aging · doi:10.18632/aging.100333 · Cited by 33
How hormones mediate trade-offs in human health and disease
Bribiescas, R. G., & Ellison, P. T. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199207466.003.0007 · Cited by 36
At the stem of youth and health
Beltrami, A. P., Cesselli, D., & Beltrami, C. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.10.005 · Cited by 36
Wang, Z. A., & Kalderon, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909272106 · Cited by 33
Senotherapy: growing old and staying young?
Schmitt, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1972-4 · Cited by 36
Anti-aging effects of Ribes meyeri anthocyanins on neural stem cells and aging mice
Gao, J., Wu, Y., He, D., Zhu, X., Li, H., Liu, H., & Liu, H. (2020) · Aging · doi:10.18632/aging.103955 · Cited by 35
Patterson, A. M., Vemula, S., Plett, P. A., Sampson, C. H., Chua, H. L., Fisher, A., Wu, T., Sellamuthu, R., Feng, H., Katz, B. P., et al. (2022) · Radiation Research · doi:10.1667/rade-22-00071.1 · Cited by 37
The Er71 Is an Important Regulator of Hematopoietic Stem Cells in Adult Mice
Lee, D., Kim, T., & Lim, D. (2011) · Stem Cells · doi:10.1002/stem.597 · Cited by 34
Telomere length maintenance in stem cell populations
Allen, N. D., & Baird, D. M. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.02.004 · Cited by 35
The Biology of Aging and Lymphoma: a Complex Interplay
Sarkozy, C., Salles, G. A., & Falandry, C. (2015) · Current Oncology Reports · doi:10.1007/s11912-015-0457-x · Cited by 36
Rhee, Y., Kim, T., Jo, A. Y., Chang, M., Park, C., Kim, S.-M., Song, J., Oh, S., Yi, S., Kim, H. H., et al. (2016) · Brain · doi:10.1093/brain/aww203 · Cited by 35
Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation
Nurković, J., Volarević, V., Lako, M., Armstrong, L., Arsenijević, N., & Stojković, M. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1676 · Cited by 34
Liu, O., Li, J., Gong, M., Xu, M., Du, J., & Zhang, H. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.159 · Cited by 34
Khatiwala, R. V., Zhang, S., Li, X., Devejian, N. S., Bennett, E. V., & Cai, C. (2018) · Stem Cell Reviews and Reports · doi:10.1007/s12015-018-9815-z · Cited by 34
Samuel, N., & Radovanovic, I. (2019) · Neurosurgical FOCUS · doi:10.3171/2019.4.focus19204 · Cited by 34
Acute lymphoblastic leukemia and developmental biology
Campos‐Sánchez, E., Toboso-Navasa, A., Romero-Camarero, I., Barajas-Diego, M., Sánchez-Garcı́a, I., & Cobaleda, C. (2011) · Cell Cycle · doi:10.4161/cc.10.20.17779 · Cited by 34
How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?
Hinkal, G. W., & Donehower, L. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.005 · Cited by 33
Brunet, A., & Rando, T. A. (2007) · Nature · doi:10.1038/449288a · Cited by 34
Navarro, H. G., Vinué, Á., Sanz, M., Delgado, M., Pozo, M. A., Serrano, M., Burks, D. J., & Andrés, V. (2012) · Aging Cell · doi:10.1111/acel.12023 · Cited by 35
Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain
Yadav, A. K., Sahasrabuddhe, A. A., Dimri, M., Bommi, P. V., Sainger, R., & Dimri, G. P. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-158 · Cited by 35
Reduced stem cell aging in exercised human skeletal muscle is enhanced by ginsenoside Rg1
Lee, T. X. Y., Wu, J., Jean, W., Condello, G., AlKhatib, A. H., Hsieh, C.-C., Hsieh, Y., Huang, C., & Kuo, C. (2021) · Aging · doi:10.18632/aging.203176 · Cited by 33
The systemic milieu as a mediator of dietary influence on stem cell function during ageing
Murphy, T., & Thuret, S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.004 · Cited by 34
Stable Form of JAB1 Enhances Proliferation and Maintenance of Hematopoietic Progenitors
Mori, M., Yoneda‐Kato, N., Yoshida, A., & Kato, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804539200 · Cited by 33
B-MYB delays cell aging by repressing p16 INK4α transcription
Huang, Y., Wu, J., Li, R., Wang, P., Han, L., Zhang, Z., & Tong, T. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0501-9 · Cited by 34
Stem Cell Ageing and Apoptosis
Fulle, S., Centurione, L., Mancinelli, R., Sancilio, S., Manzoli, F. A., & Pietro, R. D. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799859657 · Cited by 33
Sinha, S., Dwivedi, T. R., Yengkhom, R., Bheemsetty, V. A., Abe, T., Kiyonari, H., VijayRaghavan, K., & Inamdar, M. S. (2019) · Blood · doi:10.1182/blood.2019000530 · Cited by 32
Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status
Song, Z., Ju, Z., & Rudolph, K. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.009 · Cited by 34
Gadd45a regulates hematopoietic stem cell stress responses in mice
Chen, Y., Ma, X., Zhang, M., Wang, X., Wang, C.-X., Wang, H., Guo, P., Yuan, W., Rudolph, K. L., Zhan, Q., et al. (2013) · Blood · doi:10.1182/blood-2013-05-504084 · Cited by 34
Gao, P., Han, P., Jiang, D., Yang, S., Cui, Q., & Li, Z. (2017) · Cytotechnology · doi:10.1007/s10616-017-0084-5 · Cited by 32
Antonioli, E., Torres, N., Ferretti, M., Piccinato, C. D. A., & Sertie, A. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0204784 · Cited by 35
Gene regulation and tumor suppression by the bromodomain-containing protein BRD7
Mantovani, F., Drost, J., Voorhoeve, P. M., Sal, G. D., & Agami, R. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12309 · Cited by 33
Role of the high mobility group A proteins in the regulation of pituitary cell cycle
Fedele, M., & Fusco, A. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0178 · Cited by 32
Inflammageing and clonal haematopoiesis interplay and their impact on human disease
Hajishengallis, G., & Chavakis, T. (2026) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00936-y · Cited by 37
Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution
Dudakov, J. A., Khong, D., Boyd, R. L., & Chidgey, A. P. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.02.002 · Cited by 31
Hilpert, M., Legrand, C., Bluteau, D., Balayn, N., Betems, A., Bluteau, O., Villeval, J., Louache, F., Gonin, P., Debili, N., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.005 · Cited by 31
Zhang, X., Xu, G. B., Zhou, D., & Pan, Y. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0595-5 · Cited by 33
Cyclin-dependent kinase inhibitors in malignant hematopoiesis
Schirripa, A., Sexl, V., & Kollmann, K. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.916682 · Cited by 39
Autophagy regulates the cell cycle of murine HSPCs in a nutrient-dependent manner
Cao, Y., Zhang, A., Cai, J., Yuan, N., Lin, W., Liu, S., Xu, F., Song, L., Li, X., Fang, Y., et al. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.11.002 · Cited by 33
Cdc42 and aging of hematopoietic stem cells
Geiger, H., & Zheng, Y. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283615aba · Cited by 32
Decline in cellular function of aged mouse c‐kit+ cardiac progenitor cells
Castaldi, A., Dodia, R. M., Orogo, A. M., Zambrano, C. M., Najor, R. H., Gustafsson, Å. B., Brown, J. H., & Purcell, N. H. (2017) · The Journal of Physiology · doi:10.1113/jp274775 · Cited by 31
Saunderson, E. A., Encabo, H. H., Devis, J., Rouault‐Pierre, K., Piganeau, M., Bell, C. G., Gribben, J. G., Bonnet, D. A., & Ficz, G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2300224120 · Cited by 34
Conserved epigenetic hallmarks of T cell aging during immunity and malignancy
Tian, M., Soerens, A. G., Alli, S., Kang, T. G., Vasandan, A. B., Wang, Z., Vezys, V., Kimura, S., Iacobucci, I., Baylin, S. B., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00649-5 · Cited by 32
Wu, A., Dong, Q., Gao, H., Shi, Y., Chen, Y., Zhang, F., Bandyopadhyay, A. M., Wang, D., Gorena, K. M., Huang, C., et al. (2016) · Scientific Reports · doi:10.1038/srep32190 · Cited by 31
Tinaburri, L., D’Errico, M., Sileno, S., Maurelli, R., Degan, P., Magenta, A., & Dellambra, E. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9147326 · Cited by 31
Hematopoietic stem cell regulation by the proteostasis network
Chua, B. A., & Signer, R. A. J. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000591 · Cited by 30
Fichtel, P., Bonin, M. V., Kuhnert, R., Möbus, K., Bornhäuser, M., & Wobus, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.892661 · Cited by 30
The CDK inhibitors: potential targets for therapeutic stem cell manipulations?
Boyer, M. J., & Cheng, T. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303064 · Cited by 34
Self-citationTumor suppressor mechanisms in immune aging
Liu, Y., & Sharpless, N. E. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.011 · Cited by 31
Self-citationDong, Q., Gao, H., Shi, Y., Zhang, F., Gu, X., Wu, A., Wang, D., Chen, Y., Bandyopadhyay, A., Yeh, I.-T., et al. (2016) · Aging · doi:10.18632/aging.101082 · Cited by 29
Ppm1d truncating mutations promote the development of genotoxic stress-induced AML
Burócziová, M., Daněk, P., Oravetzova, A., Chalupova, Z., Alberich-Jordà, M., & Macůrek, L. (2023) · Leukemia · doi:10.1038/s41375-023-02030-8 · Cited by 28
Potential and pitfalls of stem cell therapy in old age
Piccin, D., & Morshead, C. M. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.003137 · Cited by 29
Aberrant expression of p14 ARF in human cancers: A new biomarker?
Inoue, K., & Fry, E. A. (2018) · Tumor and Microenvironment · doi:10.4103/tme.tme_24_17 · Cited by 31
CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging
Rui, Y., Chen, M., Li, Y., Xiao, L., Geng, P., Wang, P., Xu, Z.-Y., Zhang, X.-P., & Dai, G.-C. (2019) · Stem Cells International · doi:10.1155/2019/6257537 · Cited by 29
Aging and leukemic evolution of hematopoietic stem cells under various stress conditions
Kurosawa, S., & Iwama, A. (2020) · Inflammation and Regeneration · doi:10.1186/s41232-020-00138-3 · Cited by 29
Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis
Little, S. E., Rubin, J. E., Diekman, B. O., Rubin, C. T., McGrath, C., Pagnotti, G. M., Klett, E. L., & Styner, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.011 · Cited by 30
Molecular and Cellular Basis of Regeneration and Tissue Repair
Pajalunga, D., Mazzola, A., Franchitto, A., Puggioni, E. M. R., & Crescenzi, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7425-z · Cited by 29
p16INK4a Expression and Breast Cancer Risk in Women with Atypical Hyperplasia
Radisky, D. C., Santisteban, M., Berman, H. K., Gauthier, M. L., Frost, M. H., Reynolds, C. A., Vierkant, R. A., Pankratz, V. S., Visscher, D. W., Tlsty, T. D., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0282 · Cited by 27
tRNA m1A modification regulate HSC maintenance and self-renewal via mTORC1 signaling
Zuo, H., Wu, A., Wang, M., Hong, L., & Wang, H. (2024) · Nature Communications · doi:10.1038/s41467-024-50110-9 · Cited by 28
Papaconstantinou, J., Wang, C. Z., Zhang, M., Yang, S. F., DeFord, J. H., Bulavin, D. V., & Ansari, N. H. (2015) · Aging · doi:10.18632/aging.100802 · Cited by 27
Aging mechanisms—A perspective mostly from Drosophila
Tsurumi, A., & Li, W. X. (2020) · Advanced Genetics · doi:10.1002/ggn2.10026 · Cited by 33
Liang, D., Gao, Q., Meng, Z., Li, W., Song, J., & Xue, K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121781 · Cited by 28
Chen, J., Tarry‐Adkins, J. L., Heppolette, C. A. A., Palmer, D. B., & Ozanne, S. E. (2009) · Clinical Science · doi:10.1042/cs20090429 · Cited by 28
Yang, Q., Esplin, B. L., & Borghesi, L. (2011) · Blood · doi:10.1182/blood-2010-07-297689 · Cited by 27
Liu, J., Xu, C., Cai, S., Zhou, Y., Li, J., Jiang, R., & Wang, Y. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.11.6549 · Cited by 27
Zhou, P., Wu, G., Zhang, P., Xu, R., Ge, J., Fu, Y., Zhang, Y., Du, Y., Ye, J., Cheng, J., et al. (2016) · Aging · doi:10.18632/aging.101041 · Cited by 28
Signaling Pathways Regulating Hematopoietic Stem Cell and Progenitor Aging
Singh, A. K., Althoff, M. J., & Cancelas, J. A. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0128-6 · Cited by 27
Bi, S., Wang, H., & Kuang, W. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.005 · Cited by 27
Scanning the Genome for Coronary Risk
Rosenzweig, A. (2007) · New England Journal of Medicine · doi:10.1056/nejme078121 · Cited by 28
Cho, J. S., Kook, S. H., Robinson, A. R., Niedernhofer, L. J., & Lee, B.-C. (2013) · Stem Cells · doi:10.1002/stem.1261 · Cited by 27
Influences of donor and host age on human muscle-derived stem cell-mediated bone regeneration
Gao, X., Lu, A., Tang, Y. M., Schneppendahl, J., Liebowitz, A. B., Scibetta, A. C., Morris, E. R., Cheng, H., Huard, C., Amra, S., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1066-z · Cited by 27
Valenzuela, C. A., Quintanilla, R., Olate‐Briones, A., Venturini, W., Mancilla, D., Cayo, Á., Moore‐Carrasco, R., & Brown, N. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215292 · Cited by 29
p21 cιp/WAF is a key regulator of long‐term radiation damage in mesenchyme‐derived tissues
Mehrara, B. J., Avraham, T., Soares, M. A., Fernandez, J. G., Yan, A., Zampell, J. C., de Andrade, V. P., Cordeiro, A. P., & Sorrento, C. M. (2010) · The FASEB Journal · doi:10.1096/fj.10-155762 · Cited by 28
PIAS1 SUMO ligase regulates the self‐renewal and differentiation of hematopoietic stem cells
Liu, B., Yee, K. M., Tahk, S., Mackie, R., Hsu, C., & Shuai, K. (2013) · The EMBO Journal · doi:10.1002/embj.201283326 · Cited by 27
Cardenas, J. C., Owens, A. P., Krishnamurthy, J., Sharpless, N. E., Whinna, H. C., & Church, F. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221721 · Cited by 27
Self-citationSharpless, N. E., & Schatten, G. P. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln070 · Cited by 27
Self-citationOxaloacetate decarboxylase FAHD1 – a new regulator of mitochondrial function and senescence
Etemad, S., Petit, M., Weiss, A. K. H., Schrattenholz, A. S., Baraldo, G., & Jansen‐Dürr, P. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.07.007 · Cited by 27
Metadata
- Authors
- Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T.
- Affiliations
- Harvard University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Scadden, David T.
- ORCID
- Venue
- Nature
- Published
- 2006-09
- Volume
- 443
- Issue
- 7110
- Pages
- 421-426
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2084289371
- Cited by
- 1,106
- References
- 33
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 17 · 2023: 21 · 2022: 48 · 2021: 34 · 2020: 37 · 2019: 44 · 2018: 39 · 2017: 57 · 2016: 57 · 2015: 62 · 2014: 66 · 2013: 70 · 2012: 59
- FWCI
- 63.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- p16INK4a, stem cell aging, hematopoietic stem cells, cyclin-dependent kinase inhibitors, tumour suppressor, stem cell self-renewal, apoptosis, stress tolerance, tissue regeneration, pancreatic islet regeneration, brain regeneration, type 2 diabetes, bone marrow failure
- MeSH terms
- Transcription Factor HES-1, Aging, Animals, Cell Count, Hematopoietic Stem Cells, Bone Marrow Transplantation, Cellular Senescence, Apoptosis, Homeodomain Proteins, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, Mice, Basic Helix-Loop-Helix Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
