Weighing of biomolecules, single cells and single nanoparticles in fluid

The origins and the future of microfluidics

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Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins

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Microfluidic Large-Scale Integration

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Nanoparticle-Based Bio-Barcodes for the Ultrasensitive Detection of Proteins*

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Microfluidic diagnostic technologies for global public health

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Zeptogram-Scale Nanomechanical Mass Sensing

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Bioassay of prostate-specific antigen (PSA) using microcantilevers

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Scanning Force Microscopy

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Ultimate limits to inertial mass sensing based upon nanoelectromechanical systems

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Attogram detection using nanoelectromechanical oscillators

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Quartz crystal microbalance as a sensing active element for rupture scanning within frequency band

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Femtogram scale high frequency nano-optomechanical resonators in water

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Viscoelasticity Enhances Nanometer-Scale Slip in Gigahertz-Frequency Liquid Flows

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Energy dissipation in microfluidic beam resonators: Effect of Poisson's ratio

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Current status and future prospects of non-toxicity carbon-dot-based miniaturized lasers

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Towards nano-diagnostics for rapid diagnosis of infectious diseases – current technological state

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Microcantilever Biosensors: Probing Biomolecular Interactions at the Nanoscale

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Size-dependent longitudinal–transverse mode interaction of fluid-conveying nanotubes under base excitation

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Cell-intrinsic mechanical regulation of plasma membrane accumulation at the cytokinetic furrow

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Giant resonance tuning of micro and nanomechanical oscillators

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Case Studies Applying Biophysical Techniques to Better Characterize Protein Aggregates and Particulates of Varying Size

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μ-‘Diving suit’ for liquid-phase high-Q resonant detection

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Stimuli-responsive anisotropic actuation of melem-formaldehyde polymer

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Anatase porous titania nanosheets for resonant-gravimetric detection of ppb-level NO 2 at room-temperature

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Label-Free Measurement of Amyloid Elongation by Suspended Microchannel Resonators

Wang, Y., Modena, M. M., Platen, M., Schaap, I. A. T., & Burg, T. P. (2014) · Analytical Chemistry · doi:10.1021/ac503845f · Cited by 13

Suspended nanochannel in MEMS plate resonator for mass sensing in liquid

Agache, V., Blanco-Gomez, G., Cochet, M., & Caillat, P. (2011) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/memsys.2011.5734385 · Cited by 13

Frontiers in Microbial Nanoscopy

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Electrolyte-Insulator-Semiconductor pH Sensors with Arrayed Patterns Manufactured by Nano Imprint Technology

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Cantilever-Droplet-Based Sensing of Magnetic Particle Concentrations in Liquids

Nyang’au, W. O., Setiono, A., Bertke, M., Bosse, H., & Peiner, E. (2019) · Sensors · doi:10.3390/s19214758 · Cited by 13

High quality factor silicon cantilever driven by piezoelectric thin film actuator for resonant based mass detection

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Electrokinetic effect for molecular recognition: A label-free approach for real-time biosensing

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Quantitative Assessment of Protein Adsorption on Microparticles with Particle Mass Spectrometry

Xiong, C., Zhou, X., Zhang, N., Zhan, L., Chen, S., Wang, J., Peng, W., Chang, H., & Nie, Z. (2014) · Analytical Chemistry · doi:10.1021/ac4042312 · Cited by 13

The Interfacial Properties and Thermodynamic/Kinetic Stabilization Mechanisms of Bulk Nanobubbles: A Molecular Dynamics Simulation Study

Zhang, X., Fan, Z., Fu, Y., Cai, L., & Liu, J. (2025) · Langmuir · doi:10.1021/acs.langmuir.5c02395 · Cited by 12

Boundary Condition Induced Passive Chaotic Mixing in Straight Microchannels

Ouro-Koura, H., Ogunmolasuyi, A., Suleiman, O., Omodia, I., Easter, J., Roye, Y., & Das, K. (2021) · The Physics of Fluids · doi:10.1063/5.0088014 · Cited by 16

Level Attraction due to Dissipative Phonon–Phonon Coupling in an Opto-Mechano-Fluidic Resonator

Lu, Q., Guo, J., Zhang, Y., Fu, Z., Chen, L., Xiang, Y., & Xie, S. (2023) · ACS Photonics · doi:10.1021/acsphotonics.2c01772 · Cited by 12

Flexibly designable wettability gradient for passive control of fluid motion via physical surface modification

Funayama, K., Miura, A., & Tanaka, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-33737-4 · Cited by 12

High-throughput single-cell density measurements enable dynamic profiling of immune cell and drug response from patient samples

Wu, W., Ishamuddin, S. H., Quinn, T. W., Yerrum, S., Zhang, Y., Debaize, L., Kao, P.-L., Duquette, S. M., Murakami, M. A., Mohseni, M., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01408-6 · Cited by 19

Analysis of an optical biosensor based on elastic light scattering from diamond‐, glass‐, and sapphire microspheres

Murib, M. S., Tran, A. Q., Ceuninck, W. D., Schöning, M. J., Nesládek, M., Serpengüzel, A., & Wagner, P. (2012) · physica status solidi (a) · doi:10.1002/pssa.201100795 · Cited by 12

Soft X‐ray induced oxidation on acrylic acid grafted luminescent silicon quantum dots in ultrahigh vacuum

Chao, Y., Wang, Q., Pietzsch, A., Hennies, F., & Ni, H. (2011) · physica status solidi (a) · doi:10.1002/pssa.201127212 · Cited by 12

Nanomechanics of superbugs and superdrugs: new frontiers in nanomedicine

McKendry, R. A. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120082 · Cited by 12

Monitoring the hydration of DNA self-assembled monolayers using an extensional nanomechanical resonator

Cagliani, A., Kosaka, P. M., Tamayo, J., & Davis, Z. J. (2012) · Lab on a Chip · doi:10.1039/c2lc40047b · Cited by 12

Application of a Best Practice Approach Using Resonant Mass Measurement for Biotherapeutic Product Characterization

Krueger, A. B., Hadley, J., Cheney, P. P., Markova, N., Carpenter, J. F., & Fradkin, A. H. (2018) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2018.12.017 · Cited by 10

Direct whole blood analysis by the antigen-antibody chemically-delayed dissociation from nanosensors arrays

Zverzhinetsky, M., Krivitsky, V., & Patolsky, F. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112658 · Cited by 12

Nonlocal Timoshenko modeling effectiveness for carbon nanotube-based mass sensors

Ceballes, S. M., Saunders, B. E., & Abdelkefi, A. (2021) · European Journal of Mechanics - A/Solids · doi:10.1016/j.euromechsol.2021.104462 · Cited by 12

Nanomechanical Sensing Using Heater-Integrated Fluidic Resonators

Ko, J., Khan, F., Nam, Y., Lee, B. J., & Lee, J. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01572 · Cited by 12

Efficient mRNA Delivery with Lyophilized Human Serum Albumin-Based Nanobubbles

Kida, H., Yamasaki, Y., Feril, L. B., Endo, H., Itaka, K., & Tachibana, K. (2023) · Nanomaterials · doi:10.3390/nano13071283 · Cited by 12

Synergistic improvement of gas sensing performance by micro-gravimetrically extracted kinetic/thermodynamic parameters

Guo, S., Xu, P., Yu, H., Cheng, Z., & Li, X. (2015) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.01.019 · Cited by 13

Real-time enzyme-digesting identification of double-strand DNA in a resonance-cantilever embedded micro-chamber

Xu, T., Yu, H., Xu, P., Xu, W., Chen, W., Chen, C., & Li, X. (2013) · Lab on a Chip · doi:10.1039/c3lc51294k · Cited by 12

Fabrication and Characterization of an Integrated Microsystem for Protein Preconcentration and Sensing

Dextras, P., Payer, K. R., Burg, T. P., Shen, W., Wang, Y., Han, J., & Manalis, S. R. (2010) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2010.2093563 · Cited by 12

Stiction-free poly-SiGe resonators for monolithic integration of biosensors with CMOS

Lenci, S., Pieri, F., Haspeslagh, L., Coster, J. D., Decoutere, S., Caro, A. M., Armini, S., & Witvrouw, A. (2011) · International Conference on Solid-State Sensors, Actuators and Microsystems · doi:10.1109/transducers.2011.5969323 · Cited by 12

Research progress on energy dissipation mechanisms in micro- and nano-mechanical resonators

Zhang, W., Yan, H., Peng, Z., & Meng, G. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972016-00463 · Cited by 12

NEMS Resonators for Detection of Chemical Warfare Agents Based on Graphene Sheet

Anđelić, N., Car, Z., & Čanađija, M. (2019) · Mathematical Problems in Engineering · doi:10.1155/2019/6451861 · Cited by 12

Coherent Optical Transduction of Suspended Microcapillary Resonators for Multi-Parameter Sensing Applications

Martín-Pérez, A., Ramos, D., Tamayo, J., & Calleja, M. (2019) · Sensors · doi:10.3390/s19235069 · Cited by 12

Measuring wear by combining friction force and dynamic force microscopy

Schmutz, J.-E., Fuchs, H., & Hölscher, H. (2009) · Wear · doi:10.1016/j.wear.2009.09.010 · Cited by 12

Non-linear mixing in coupled photonic crystal nanobeam cavities due to cross-coupling opto-mechanical mechanisms

Ramos, D., Frank, I. W., Deotare, P. B., Bulu, İ., & Lončar, M. (2014) · Applied Physics Letters · doi:10.1063/1.4901441 · Cited by 12

Study on Sensing Properties of Ion-Sensitive Field-Effect-Transistors Fabricated With Stack Sensing Membranes

Lee, T. N., Chen, H. J. H., & Hsieh, K. C. (2016) · IEEE Electron Device Letters · doi:10.1109/led.2016.2619714 · Cited by 12

Recent advances in deformation-assisted microfluidic cell sorting technologies

Sun, J., Huang, X., Chen, J., Xiang, R., Ke, X., Lin, S., Xuan, W., Liu, S., Cao, Z., & Sun, L. (2023) · The Analyst · doi:10.1039/d3an01150j · Cited by 11

Thin Films - Growth, Characterization and Electrochemical Applications

Sarf, F., Yakar, E., & Er, İ. K. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.107556 · Cited by 11

Advanced microfluidic systems with temperature modulation for biological applications

Ko, J., & Lee, J. (2025) · Biomicrofluidics · doi:10.1063/5.0251893 · Cited by 11

Fabrication and Testing of Microfluidic Optomechanical Oscillators

Han, K., Kim, K. H., Kim, J., Lee, W. S., Liu, J., Fan, X., Carmon, T., & Bahl, G. (2014) · Journal of Visualized Experiments · doi:10.3791/51497 · Cited by 11

Quasi-dynamic mode of nanomembranes for time-of-flight mass spectrometry of proteins

Park, J., Kim, H., & Blick, R. H. (2012) · Nanoscale · doi:10.1039/c2nr11779g · Cited by 11

Method to Determine the Closed-Loop Precision of Resonant Sensors From Open-Loop Measurements

Manzaneque, T., Steeneken, P. G., Alijani, F., & Ghatkesar, M. K. (2020) · IEEE Sensors Journal · doi:10.1109/jsen.2020.3008557 · Cited by 11

Investigation of the effects of design parameters on sensitivity of surface plasmon resonance biosensors

Islam, M. S., Kouzani, A. Z., Dai, X. J., & Michalski, W. P. (2010) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2010.11.005 · Cited by 11

A Simple Weighing Method for Spherical Cells

Zhao, Q., Shirinzadeh, B., Cui, M., Sun, M., & Zhao, X. J. (2015) · SLAS TECHNOLOGY · doi:10.1177/2211068215583629 · Cited by 11

A measurement criterion for accurate mass detection using vibrating suspended microchannel resonators

Yan, H., Zhang, W., Jiang, H., Hu, K., Hong, F., Peng, Z., & Meng, G. (2017) · Journal of Sound and Vibration · doi:10.1016/j.jsv.2017.05.030 · Cited by 11

Detecting a Zeptogram of Pyridine with a Hybrid Plasmonic–Photonic Nanosensor

Proust, J., Martin, J., Gérard, D., Bijeon, J.-L., & Plain, J. (2019) · ACS Sensors · doi:10.1021/acssensors.8b01068 · Cited by 11

Size- and Surface-Dependent Photoresponses of Solution-Processed Aluminum Nanoparticles

Cheng, Y., Smith, K. J., Arinze, E. S., Dziatko, R. A., Gao, T., Frank, B. P., Thon, S. M., & Bragg, A. E. (2020) · ACS Photonics · doi:10.1021/acsphotonics.9b01170 · Cited by 11

Thin Film Biosensors

Koydemir, H. C., Külah, H., & Özgen, C. (2013) · Biological and medical physics series · doi:10.1007/978-94-007-2592-8_8 · Cited by 13

Nanomechanical Molecular Mass Sensing Using Suspended Microchannel Resonators

Martín-Pérez, A., Ramos, D., Tamayo, J., & Calleja, M. (2021) · Sensors · doi:10.3390/s21103337 · Cited by 12

Silicon Carbide-Gated Nanofluidic Membrane for Active Control of Electrokinetic Ionic Transport

Silvestri, A., Trani, N. D., Canavese, G., Ros, P. M., Iannucci, L., Grassini, S., Wang, Y., Liu, X., Demarchi, D., & Grattoni, A. (2021) · Membranes · doi:10.3390/membranes11070535 · Cited by 11

Nanomechanical bio-sensing for fast and reliable detection of viability and susceptibility of microorganisms

Venturelli, L., Harrold, Z., Murray, A. E., Villalba, M. I., Lundin, E. M., Dietler, G., Kasas, S., & Foschia, R. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130650 · Cited by 11

Cellular and biomolecular detection based on suspended microchannel resonators

Ko, J., Jeong, J., Son, S., & Lee, J. (2021) · Biomedical Engineering Letters · doi:10.1007/s13534-021-00207-7 · Cited by 12

Ultrasensitive Detection of Biomarkers in a Color‐Switchable Microcavity‐Reactor Laser

Li, R., Song, Z., Zhu, H., Zhang, F., Chen, L., Ning, C., & Ruan, S. (2022) · Advanced Science · doi:10.1002/advs.202202326 · Cited by 10

Stochastic dynamics of micron-scale doubly clamped beams in a viscous fluid

Villa, M. M., & Paul, M. R. (2009) · Physical Review E · doi:10.1103/physreve.79.056314 · Cited by 11

Optimization of the performances of SU-8 organic microcantilever resonators by tuning the viscoelastic properties of the polymer

Dubourg, G., Dufour, I., Pellet, C., & Ayela, C. (2012) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2012.04.088 · Cited by 11

Wavelength-division multiplexing of nano-optomechanical doubly clamped beam systems

Sauer, V. T. K., Diao, Z., Freeman, M. R., & Hiebert, W. K. (2015) · Optics Letters · doi:10.1364/ol.40.001948 · Cited by 11

Modeling a Nanocantilever-Based Biosensor Using a Stochastically Perturbed Harmonic Oscillator

Snyder, P. J., Joshi, A., & Serna, J. D. (2014) · International Journal of Nanoscience · doi:10.1142/s0219581x14500112 · Cited by 11

Out-of-plane single-mode photonic microcantilevers for integrated nanomechanical sensing platform

Fariña, D., Álvarez, M., Márquez, S., Domı́nguez, C., & Lechuga, L. M. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.03.041 · Cited by 11

Biosensing Using Nanoelectromechanical Systems

Yeri, A., & Gao, D. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-052-2_9 · Cited by 11

A gap method for increasing the sensitivity of cantilever biosensors

Leahy, S., & Lai, Y. (2017) · Journal of Applied Physics · doi:10.1063/1.4989959 · Cited by 11

ESI MS for Microsized Bioparticles

Özdemir, A., Lin, J., Gülfen, M., Lai, S., Hsiao, C.-J., Chen, N. G., & Chen, C. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02937 · Cited by 11

Detecting the mass and position of a particle by the vibration of a cantilevered micro-plate

Ma, S., Bai, H., Wang, S., Zhao, L., Yang, K., Fang, R. M., & Zhou, X. (2019) · International Journal of Mechanical Sciences · doi:10.1016/j.ijmecsci.2019.105413 · Cited by 11

Quantification of disease marker in undiluted serum using an actuating layer-embedded microcantilever

Hwang, K. S., Jeon, H. K., Lee, S.-M., Kim, S. K., & Kim, T. S. (2009) · Journal of Applied Physics · doi:10.1063/1.3116105 · Cited by 11

Recent experimental advances in probing the colloidal properties of viruses

Armanious, A., Radiom, M., & Mezzenga, R. (2023) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2023.101703 · Cited by 10

Flexural-Mode Piezoelectric Resonators: Structure, Performance, and Emerging Applications in Physical Sensing Technology, Micropower Systems, and Biomedicine

Cai, X., Wang, Y., Cao, Y., Yang, W., Xia, T., & Li, W. (2024) · Sensors · doi:10.3390/s24113625 · Cited by 10

Performance of the LifeScale automated rapid phenotypic antimicrobial susceptibility testing on Gram-negative rods directly from positive blood cultures

Snyder, J. W., Chaudhry, N., & Hoffmann, W. (2024) · Journal of Clinical Microbiology · doi:10.1128/jcm.00922-24 · Cited by 10

Nanoelectromechanical devices in a fluidic environment

Svitelskiy, O. V., Sauer, V. T. K., Vick, D., Cheng, K.-M., Liu, N., Freeman, M. R., & Hiebert, W. K. (2012) · Physical Review E · doi:10.1103/physreve.85.056313 · Cited by 10

Critical conditions for escape of a high-speed fullerene from a BNC nanobeam after collision

Cai, K., Yang, L., Shi, J., & Qin, Q. (2018) · Scientific Reports · doi:10.1038/s41598-017-18789-7 · Cited by 10

Volumetric mass density measurements of mesenchymal stem cells in suspension using a density meter

Drobek, C., Meyer, J., Mau, R., Wolff, A., Peters, K., & Seitz, H. (2022) · iScience · doi:10.1016/j.isci.2022.105796 · Cited by 10

Analytical Methods for Determining the Size (Distribution) in Parenteral Dispersions

Driscoll, D. F., & Nicoli, D. F. (2015) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-16241-6_7 · Cited by 10

An autonomous CMOS hysteretic sensor for the detection of desorption-free DNA hybridization

Lee, K., Choi, S., Lee, J.-O., Sohn, M., Yoon, J., & Cho, G. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.04.033 · Cited by 10

Columnar shaped microresonators for mass detection and gas analysis

Kehrbusch, J., Bozek, P., Radzio, B., Ilin, E. A., & Oesterschulze, E. (2009) · Microelectronic Engineering · doi:10.1016/j.mee.2009.11.075 · Cited by 10

Microwave sensor for detection of E. coli in water

Oberoi, S., Daya, K. S., & Tirumalai, P. S. (2012) · International Conference on Sensing Technology · doi:10.1109/icsenst.2012.6461753 · Cited by 10

Performances and improvement of coupled dual-microcantilevers in sensitivity

Chen, Z., Cai, G., Li, Y., Chen, Q., & Wu, W. (2019) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2019.01.023 · Cited by 10

Experimental and numerical evaluation of a genetically engineered M13 bacteriophage with high sensitivity and selectivity for 2,4,6-trinitrotoluene

Kim, W., Zueger, C., Kim, C., Wong, W. S., Devaraj, V., Yoo, H., Hwang, S., Oh, J., & Lee, S. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob03075h · Cited by 10

Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development

Hawe, A., Weinbuch, D., Zölls, S., Reichel, A., & Carpenter, J. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-444-64173-1.00010-x · Cited by 10

Photonic detection and characterization of DNA using sapphire microspheres

Murib, M. S., Yeap, W. S., Martens, D., Bienstman, P., Ceuninck, W. D., van Grinsven, B., Schöning, M. J., Michiels, L., Haenen, K., Ameloot, M. M., et al. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.9.097006 · Cited by 10

Numerical Analysis of Hydrodynamic Flow in Microfluidic Biochip for Single-Cell Trapping Application

Khalili, A. A., & Ahmad, M. R. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125987 · Cited by 10

Phonon Coupling between a Nanomechanical Resonator and a Quantum Fluid

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Microfluidics for real-time direct monitoring of self- and co-assembly biomolecular processes

Arnon, Z. A., Gilead, S., & Gazit, E. (2018) · Nanotechnology · doi:10.1088/1361-6528/aaf7b1 · Cited by 10

Nanomechanical Sensing for Mass Flow Control in Nanowire-Based Open Nanofluidic Systems

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Plasma membrane folding enables constant surface area-to-volume ratio in growing mammalian cells

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3D Suspended Polymeric Microfluidics (SPMF3) with Flow Orthogonal to Bending (FOB) for Fluid Analysis through Kinematic Viscosity

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Parametric study on fluid structure interaction of a 3D suspended polymeric microfluidics (SPMF3)

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A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements

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Simple and inexpensive immunoassay-based diagnostic tests

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Quantifying Particle Coatings Using High-Precision Mass Measurements

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High-Throughput Characterization of Microcantilever Resonator Arrays for Low-Concentration Detection of Small Molecules

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Linear and non-linear vibrations of fluid-filled hollow microcantilevers interacting with small particles

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On-chip silicon photonics based grating assisted vibration sensor

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Weight inside

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Fabrication of a Nanomechanical Mass Sensor Containing a Nanofluidic Channel

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Weighing nanoparticles in solution at the attogram scale

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Top down bottom up: Weigh to go

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Research highlights

(2007) · Nature Biotechnology · doi:10.1038/nbt0607-649