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Weighing of biomolecules, single cells and single nanoparticles in fluid
Open accessAbstract
Nanomechanical resonators enable the measurement of mass with extraordinary sensitivity. Previously, samples as light as 7 zeptograms (1 zg = 10(-21) g) have been weighed in vacuum, and proton-level resolution seems to be within reach. Resolving small mass changes requires the resonator to be light and to ring at a very pure tone-that is, with a high quality factor. In solution, viscosity severely degrades both of these characteristics, thus preventing many applications in nanotechnology and the life sciences where fluid is required. Although the resonant structure can be designed to minimize viscous loss, resolution is still substantially degraded when compared to measurements made in air or vacuum. An entirely different approach eliminates viscous damping by placing the solution inside a hollow resonator that is surrounded by vacuum. Here we demonstrate that suspended microchannel resonators can weigh single nanoparticles, single bacterial cells and sub-monolayers of adsorbed proteins in water with sub-femtogram resolution (1 Hz bandwidth). Central to these results is our observation that viscous loss due to the fluid is negligible compared to the intrinsic damping of our silicon crystal resonator. The combination of the low resonator mass (100 ng) and high quality factor (15,000) enables an improvement in mass resolution of six orders of magnitude over a high-end commercial quartz crystal microbalance. This gives access to intriguing applications, such as mass-based flow cytometry, the direct detection of pathogens, or the non-optical sizing and mass density measurement of colloidal particles.
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“The SMR is a cantilever-based microfluidic mass sensor that measures the buoyant mass (referred to hereafter simply as mass) of live single cells with a resolution near 50 fg, which is highly precise given that the average buoyant mass of a hematopoietic cell is ~75 pg11.”
From Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate (2016) · cites this paper as [11]
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Cites
The origins and the future of microfluidics
Whitesides, G. M. (2006) · Nature · doi:10.1038/nature05058 · Cited by 9,687
Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,414
Microfluidic Large-Scale Integration
Thorsen, T., Maerkl, S. J., & Quake, S. R. (2002) · Science · doi:10.1126/science.1076996 · Cited by 2,265
Nanoparticle-Based Bio-Barcodes for the Ultrasensitive Detection of Proteins*
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2020) · Spherical Nucleic Acids · doi:10.1201/9781003056713-94 · Cited by 2,038
Microfluidic diagnostic technologies for global public health
Yager, P., Edwards, T. L., Fu, E. S., Helton, K. L., Nelson, K. E., Tam, M. R., & Weigl, B. H. (2006) · Nature · doi:10.1038/nature05064 · Cited by 1,982
Zeptogram-Scale Nanomechanical Mass Sensing
Yang, Y., Callegari, C., Feng, P. X. ‐., Ekinci, K. L., & Roukes, M. L. (2006) · Nano Letters · doi:10.1021/nl052134m · Cited by 1,045
Bioassay of prostate-specific antigen (PSA) using microcantilevers
Wu, G., Datar, R. H., Hansen, K. M., Thundat, T. G., Côté, R. J., & Majumdar, A. (2001) · Nature Biotechnology · doi:10.1038/nbt0901-856 · Cited by 1,015
Amelinckx, S., Dyck, D. V., van Landuyt, P. J., & TENDELOO, G. V. (1996) · doi:10.1002/9783527620524.ch13 · Cited by 726
Ultimate limits to inertial mass sensing based upon nanoelectromechanical systems
Ekinci, K. L., Yang, Y. T., & Roukes, M. L. (2004) · Journal of Applied Physics · doi:10.1063/1.1642738 · Cited by 696
Attogram detection using nanoelectromechanical oscillators
Ilic, B., Craighead, H. G., Krylov, S., Senaratne, W., Ober, C. K., & Neužil, P. (2004) · Journal of Applied Physics · doi:10.1063/1.1650542 · Cited by 586
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Chaste, J., Eichler, A., Moser, J., Ceballos, G., Rurali, R., & Bachtold, A. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.42 · Cited by 1,036
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Squires, T. M., Messinger, R. J., & Manalis, S. R. (2008) · Nature Biotechnology · doi:10.1038/nbt1388 · Cited by 1,015
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Mining the plasma proteome for cancer biomarkers
Hanash, S., Pitteri, S. J., & Faça, V. M. (2008) · Nature · doi:10.1038/nature06916 · Cited by 893
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Detecting single viruses and nanoparticles using whispering gallery microlasers
He, L., Özdemir, Ş. K., Zhu, J., Kim, W., & Yang, L. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.99 · Cited by 697
Towards single-molecule nanomechanical mass spectrometry
Naik, A. K., Hanay, M. S., Hiebert, W. K., Feng, P. X. ‐., & Roukes, M. L. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.152 · Cited by 699
Micro- and nanomechanical sensors for environmental, chemical, and biological detection
Waggoner, P. S., & Craighead, H. G. (2007) · Lab on a Chip · doi:10.1039/b707401h · Cited by 681
SPR Biosensors: Historical Perspectives and Current Challenges
Singh, P. (2016) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2016.01.118 · Cited by 611
Alheshibri, M., Qian, J., Jéhannin, M., & Craig, V. S. J. (2016) · Langmuir · doi:10.1021/acs.langmuir.6b02489 · Cited by 595
Cantilever-like micromechanical sensors
Boisen, A., Dohn, S., Keller, S. S., Schmid, S., & Tenje, M. (2011) · Reports on Progress in Physics · doi:10.1088/0034-4885/74/3/036101 · Cited by 594
Label-free biomarker detection from whole blood
STERN, E. W., Vacic, A., Rajan, N. K., Criscione, J. M., Park, J. Y., Ilic, B. R., Mooney, D. J., Reed, M. A., & Fahmy, T. M. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.353 · Cited by 558
Vollmer, F., & Yang, L. (2012) · Nanophotonics · doi:10.1515/nanoph-2012-0021 · Cited by 544
Intelligent Image-Activated Cell Sorting
Nitta, N., Sugimura, T., Isozaki, A., Mikami, H., Hiraki, K., Sakuma, S., Iino, T., Arai, F., Endo, T., Fujiwaki, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.028 · Cited by 545
Sapsford, K. E., Tyner, K. M., Dair, B. J., Deschamps, J. R., & Medintz, I. L. (2011) · Analytical Chemistry · doi:10.1021/ac200853a · Cited by 549
Nanoparticle Characterization: What to Measure?
Modena, M. M., Rühle, B., Burg, T. P., & Wuttke, S. (2019) · Advanced Materials · doi:10.1002/adma.201901556 · Cited by 537
Self-citationQuantum metrology and its application in biology
Taylor, M. A., & Bowen, W. P. (2015) · Physics Reports · doi:10.1016/j.physrep.2015.12.002 · Cited by 487
Eom, K., Park, H. S., Yoon, D. S., & Kwon, T. (2011) · Physics Reports · doi:10.1016/j.physrep.2011.03.002 · Cited by 473
On being the right (cell) size
Ginzberg, M. B., Kafri, R., & Kirschner, M. W. (2015) · Science · doi:10.1126/science.1245075 · Cited by 445
Using buoyant mass to measure the growth of single cells
Godin, M., Delgado, F. F., Son, S., Grover, W. H., Bryan, A. K., Tzur, A., Jorgensen, P., Payer, K., Grossman, A. D., Kirschner, M. W., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1452 · Cited by 394
Self-citationAdvances in Plasmonic Technologies for Point of Care Applications
Tokel, O., İnci, F., & Demirci, U. (2014) · Chemical Reviews · doi:10.1021/cr4000623 · Cited by 416
Biosensors based on nanomechanical systems
Tamayo, J., Kosaka, P. M., Ruz, J. J., Paulo, Á. S., & Calleja, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35293a · Cited by 407
Resonances arising from hydrodynamic memory in Brownian motion
Franosch, T., Grimm, M., Belushkin, M., Mor, F. M., Foffi, G., Laszlo Forro, C., & Jeney, S. (2011) · Nature · doi:10.1038/nature10498 · Cited by 393
Maguire, C. M., Rösslein, M., Wick, P., & Prina‐Mello, A. (2018) · Science and Technology of Advanced Materials · doi:10.1080/14686996.2018.1517587 · Cited by 424
Sorgenfrei, S., Chiu, C., Gonzalez, R. L., Yu, Y., Kim, P., Nuckolls, C. P., & Shepard, K. L. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.275 · Cited by 393
Label-free biological and chemical sensors
Hunt, H. K., & Armani, A. M. (2010) · Nanoscale · doi:10.1039/c0nr00201a · Cited by 382
Characterizing deformability and surface friction of cancer cells
Byun, S., Son, S., Amodei, D., Cermak, N., Bagnall, J., Kang, J. H., Hecht, V. C., Winslow, M. M., Jacks, T., Mallick, P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218806110 · Cited by 370
Self-citationHigh-sensitivity nanosensors for biomarker detection
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Lee, W. G., Kim, Y., Chung, B. G., Demirci, U., & Khademhosseini, A. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.11.016 · Cited by 360
Grover, W. H., Bryan, A. K., Diez-Silva, M., Suresh, S., Higgins, J. M., & Manalis, S. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104651108 · Cited by 348
Self-citationMicrofluidics for medical diagnostics and biosensors
Rivet, C. A., Lee, H., Hirsch, A., Hamilton, S. K., & Lu, H. (2010) · Chemical Engineering Science · doi:10.1016/j.ces.2010.08.015 · Cited by 372
Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides
Mannoor, M. S., Zhang, S., Link, A. J., & McAlpine, M. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008768107 · Cited by 357
Modern Tools for Rapid Diagnostics of Antimicrobial Resistance
Vasala, A., Hytönen, V. P., & Laitinen, O. H. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00308 · Cited by 354
Microcantilevers: Sensing Chemical Interactions via Mechanical Motion
Goeders, K. M., Colton, J. S., & Bottomley, L. A. (2008) · Chemical Reviews · doi:10.1021/cr0681041 · Cited by 353
The Chemistry of Reticular Framework Nanoparticles: MOF, ZIF, and COF Materials
Ploetz, E., Engelke, H., Lächelt, U., & Wuttke, S. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909062 · Cited by 355
Immunoassays in microfluidic systems
Ng, A. H. C., Uddayasankar, U., & Wheeler, A. R. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3678-8 · Cited by 344
Kang, L., Chung, B. G., Langer, R., & Khademhosseini, A. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.10.003 · Cited by 331
Scaling by shrinking: empowering single-cell 'omics' with microfluidic devices
Prakadan, S. M., Shalek, A. K., & Weitz, D. A. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.15 · Cited by 335
Bian, K., Gerber, C., Heinrich, A. J., Müller, D. J., Scheuring, S., & Jiang, Y. X. (2021) · Nature Reviews Methods Primers · doi:10.1038/s43586-021-00033-2 · Cited by 336
Biosensing using dynamic-mode cantilever sensors: A review
Johnson, B. N., & Mutharasan, R. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.10.054 · Cited by 315
A self-sustaining ultrahigh-frequency nanoelectromechanical oscillator
Feng, P. X. ‐., White, C. J., Hajimiri, A., & Roukes, M. L. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.125 · Cited by 303
Ionic Field Effect Transistors with Sub-10 nm Multiple Nanopores
Nam, S., Rooks, M. J., Kim, K. B., & Rossnagel, S. M. (2009) · Nano Letters · doi:10.1021/nl900309s · Cited by 300
Highly Sensitive and Multiplexed Protein Measurements
Cohen, L., & Walt, D. R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00257 · Cited by 298
Measurement of mass, density, and volume during the cell cycle of yeast
Bryan, A. K., Goranov, A., Amon, A., & Manalis, S. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901851107 · Cited by 278
Self-citationGil-Santos, E., Ramos, D., Martı́nez, J., Fernández-Regúlez, M., Garcia, R. A., Paulo, Á. S., Calleja, M., & Tamayo, J. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.151 · Cited by 288
A comparison of microfluidic methods for high-throughput cell deformability measurements
Urbanska, M., Munoz, H. E., Bagnall, J., Otto, O., Manalis, S. R., Carlo, D. D., & Guck, J. R. (2020) · Nature Methods · doi:10.1038/s41592-020-0818-8 · Cited by 280
Self-citationApplications of cavity optomechanics
Metcalfe, M. (2014) · Applied Physics Reviews · doi:10.1063/1.4896029 · Cited by 281
Review article: Fabrication of nanofluidic devices
Duan, C., Wang, W., & Xie, Q. (2013) · Biomicrofluidics · doi:10.1063/1.4794973 · Cited by 274
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Erb, R. M., Martin, J. J., Soheilian, R., Pan, C., & Barber, J. R. (2016) · Advanced Functional Materials · doi:10.1002/adfm.201504699 · Cited by 270
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Zheng, Y., Nguyen, J., Wei, Y., & Sun, Y. (2013) · Lab on a Chip · doi:10.1039/c3lc50355k · Cited by 268
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Zangle, T. A., & Teitell, M. A. (2014) · Nature Methods · doi:10.1038/nmeth.3175 · Cited by 260
Towards nanomicrobiology using atomic force microscopy
Dufrêne, Y. F. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1948 · Cited by 260
Frequency fluctuations in silicon nanoresonators
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Lunt, S. Y., Muralidhar, V., Hosios, A. M., Israelsen, W. J., Gui, D. Y., Newhouse, L., Ogrodzinski, M. P., Hecht, V. C., Xu, K., Acevedo, P. N. M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.10.027 · Cited by 263
Self-citationFritz, J. (2008) · The Analyst · doi:10.1039/b718174d · Cited by 256
Microfluidics for food, agriculture and biosystems industries.
Neethirajan, S., Kobayashi, I., Nakajima, M., Wu, D., Nandagopal, S., & Lin, F. (2011) · Lab on a Chip · doi:10.1039/c0lc00230e · Cited by 236
High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays
Cermak, N., Olcum, S., Delgado, F. F., Wasserman, S. C., Payer, K. R., A Murakami, M., Knudsen, S. M., Kimmerling, R. J., Stevens, M. M., Kikuchi, Y., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3666 · Cited by 227
Self-citationPlasma physics of liquids—A focused review
Vanraes, P., & Bogaerts, A. (2018) · Applied Physics Reviews · doi:10.1063/1.5020511 · Cited by 249
Magnetic levitation of single cells
Durmus, N. G., Tekin, H. C., Güven, S., Sridhar, K., Yıldız, A. A., Calibasi‐Kocal, G., Ghiran, I. C., Davis, R. W., Steinmetz, L. M., & Demirci, U. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1509250112 · Cited by 238
Micromachined Resonators: A Review
Abdolvand, R., Bahreyni, B., Lee, J. E.-Y., & Nabki, F. (2016) · Micromachines · doi:10.3390/mi7090160 · Cited by 233
Özdemir, Ş. K., Zhu, J., Xu, Y., Peng, B., Yılmaz, H., He, L., Monifi, F., Huang, S. H., Long, G. L., & Yang, L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408283111 · Cited by 231
Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods
Zölls, S., Tantipolphan, R., Wiggenhorn, M., Winter, G., Jiskoot, W., Frieß, W., & Hawe, A. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23001 · Cited by 232
Damping of acoustic vibrations in gold nanoparticles
Pelton, M. A., Sader, J. E., Burgin, J., Liu, M., Guyot‐Sionnest, P., & Gosztola, D. J. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.192 · Cited by 225
Braun, T., Ghatkesar, M. K., Backmann, N., Grange, W., Boulanger, P., Letellìer, L., Lang, H. P., Bietsch, A., Gerber, C., & Hegner, M. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.398 · Cited by 224
Direct observation of mammalian cell growth and size regulation
Son, S., Tzur, A., Weng, Y., Jorgensen, P., Kim, J., Kirschner, M. W., & Manalis, S. R. (2012) · Nature Methods · doi:10.1038/nmeth.2133 · Cited by 220
Self-citationFunctional nanoprobes for ultrasensitive detection of biomolecules: an update
Xu, J., Zhao, W., Song, S., Fan, C., & Chen, H. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60277j · Cited by 217
Current and emerging techniques for antibiotic susceptibility tests
Syal, K., Mo, M., Yu, H., Iriya, R., Jing, W., Guodong, S., Wang, S., Grys, T. E., Haydel, S. E., & Tao, N. J. (2017) · Theranostics · doi:10.7150/thno.19217 · Cited by 230
Nanosensors for diagnosis with optical, electric and mechanical transducers
Munawar, A., Ong, Y., Schirhagl, R., Tahir, M. A., Khan, W. S., & Bajwa, S. Z. (2019) · RSC Advances · doi:10.1039/c8ra10144b · Cited by 219
Microfluidic Synthesis of Barcode Particles for Multiplex Assays
Zhao, Y., Cheng, Y., Shang, L., Wang, J., Xie, Z., & Gu, Z. (2014) · Small · doi:10.1002/smll.201401600 · Cited by 213
Self-Transducing Silicon Nanowire Electromechanical Systems at Room Temperature
He, R., Feng, P. X. ‐., Roukes, M. L., & Yang, P. (2008) · Nano Letters · doi:10.1021/nl801071w · Cited by 209
Piezoelectric microelectromechanical resonant sensors for chemical and biological detection
Pang, W., Zhao, H., Kim, E. S., Zhang, H., Yu, H., & Hu, C. (2011) · Lab on a Chip · doi:10.1039/c1lc20492k · Cited by 207
Godin, M., Bryan, A. K., Burg, T. P., Babcock, K., & Manalis, S. R. (2007) · Applied Physics Letters · doi:10.1063/1.2789694 · Cited by 204
Self-citationLabel-free detection of DNA hybridization based on hydration-induced tension in nucleic acid films
Mertens, J., Rogero, C., Calleja, M., Ramos, D., Martín-Gago, J. Á., Briones, C., & Tamayo, J. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.91 · Cited by 203
Generation and stability of bulk nanobubbles: A review and perspective
Zhou, L., Wang, S., Zhang, L., & Hu, J. (2021) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2021.101439 · Cited by 202
Measurement of adherent cell mass and growth
Park, K., Millet, L. J., Kim, N., Li, H., Jin, X., Popescu, G., Aluru, N. R., Hsia, K. J., & Bashir, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011365107 · Cited by 194
Chemical and biological single cell analysis
Schmid, A., Kortmann, H., Dittrich, P. S., & Blank, L. M. (2010) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2010.01.007 · Cited by 191
Quantitative x-ray phase nanotomography
Díaz, A., Trtik, P., Guizar‐Sicairos, M., Menzel, A., Thibault, P., & Bunk, O. (2012) · Physical Review B · doi:10.1103/physrevb.85.020104 · Cited by 187
Plasmon-Enhanced Colorimetric ELISA with Single Molecule Sensitivity
Chen, S., Svedendahl, M., Duyne, R. P. V., & Käll, M. (2011) · Nano Letters · doi:10.1021/nl2006092 · Cited by 186
Measuring single cell mass, volume, and density with dual suspended microchannel resonators
Bryan, A. K., Hecht, V. C., Shen, W., Payer, K. R., Grover, W. H., & Manalis, S. R. (2013) · Lab on a Chip · doi:10.1039/c3lc51022k · Cited by 195
Self-citationMicrocantilever-based platforms as biosensing tools
Álvarez, M., & Lechuga, L. M. (2010) · The Analyst · doi:10.1039/b908503n · Cited by 185
Bimaterial Microcantilevers as a Hybrid Sensing Platform
Singamaneni, S., LeMieux, M. C., Lang, H. P., Gerber, C., Lam, Y., Zauscher, S., Datskos, P. G., Lavrik, N. V., Jiang, H., Naik, R. R., et al. (2008) · Advanced Materials · doi:10.1002/adma.200701667 · Cited by 185
Brillouin cavity optomechanics with microfluidic devices
Bahl, G., Kim, K. H., Lee, W. S., Liu, J., Fan, X., & Carmon, T. (2013) · Nature Communications · doi:10.1038/ncomms2994 · Cited by 183
Inertial imaging with nanomechanical systems
Hanay, M. S., Kelber, S. I., O’Connell, C. D., Mulvaney, P. A., Sader, J. E., & Roukes, M. L. (2015) · Nature Nanotechnology · doi:10.1038/nnano.2015.32 · Cited by 182
Toward Attogram Mass Measurements in Solution with Suspended Nanochannel Resonators
Lee, J., Shen, W., Payer, K., Burg, T. P., & Manalis, S. R. (2010) · Nano Letters · doi:10.1021/nl101107u · Cited by 181
Self-citationActin-binding proteins take the reins in growth cones
Pak, C. W., Flynn, K. C., & Bamburg, J. R. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2236 · Cited by 181
Chip in a lab: microfluidics for next generation life science research
Streets, A. M., & Huang, Y. (2013) · Biomicrofluidics · doi:10.1063/1.4789751 · Cited by 180
Piezoresistive heat engine and refrigerator
Steeneken, P. G., Phan, K. L., Goossens, M. J., Koops, G. E. J., Brom, G. J. A. M., van der Avoort, C., & van Beek, J. T. M. (2011) · Nature Physics · doi:10.1038/nphys1871 · Cited by 175
A survey of the 2006–2009 quartz crystal microbalance biosensor literature
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Metadata
- Authors
- Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Innovative Micro Technology (United States) (US)
- Corresponding author
- Manalis, Scott R.
- Venue
- Nature
- Published
- 2007-04
- Volume
- 446
- Issue
- 7139
- Pages
- 1066-1069
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2149562261
- Cited by
- 1,213
- References
- 35
- Citations by year
- 2026: 25 · 2025: 34 · 2024: 39 · 2023: 46 · 2022: 39 · 2021: 58 · 2020: 68 · 2019: 70 · 2018: 75 · 2017: 65 · 2016: 78 · 2015: 78 · 2014: 85 · 2013: 81 · 2012: 84
- FWCI
- 42.64
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- TUbilio (Technical University of Darmstadt) (submittedVersion)
- Funders
- National Institutes of Health (5p50gm068762-10)
- National Institute of General Medical Sciences (P50-GM068762)
- Topics
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Mechanical and Optical Resonators
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Acoustic Wave Resonator Technologies
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced MEMS and NEMS Technologies
- Keywords
- nanomechanical resonators, suspended microchannel resonators, viscous damping, microfluidic channels, protein adsorption, quality factor, silicon resonators, medical diagnostics, environmental monitoring
- MeSH terms
- Bacteria, Biological Products, Cells, Colloids, Molecular Weight, Proteins, Quartz, Solutions, Vacuum, Microfluidics, Nanoparticles
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