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Unravelling the pathogenesis of inflammatory bowel disease
Abstract
Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.
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“Additionally, decreased Muc2 expression has been implicated in the etiopathogenesis of sporadic and IBD-associated colon cancers.14,15”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [15]
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Metadata
- Authors
- Xavier, R. J., & Podolsky, D. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Podolsky, D. K.
- Venue
- Nature
- Published
- 2007-07
- Volume
- 448
- Issue
- 7152
- Pages
- 427-434
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2078621117
- Cited by
- 4,364
- References
- 100
- Citations by year
- 2026: 134 · 2025: 183 · 2024: 224 · 2023: 247 · 2022: 258 · 2021: 230 · 2020: 249 · 2019: 211 · 2018: 217 · 2017: 221 · 2016: 255 · 2015: 279 · 2014: 286 · 2013: 236 · 2012: 258
- FWCI
- 21.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- inflammatory bowel disease, Crohn's disease, ulcerative colitis, pathogenesis, susceptibility genes, epithelial barrier function, innate immunity, adaptive immunity, commensal bacteria, immune dysregulation, macrophages, mouse model
- MeSH terms
- Animals, Autophagy, Colitis, Humans, Immunity, Innate, Intestinal Mucosa, Inflammatory Bowel Diseases, Genetic Predisposition to Disease
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