Cited by 4,364Inflammatory Bowel DiseaseGut microbiota and healthOcular Diseases and Behçet’s Syndrome

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Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., Podolsky, D. K.·2007·Nature

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Abstract

Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Inflammatory Bowel Disease
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
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Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Mayr, G., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,948
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842

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Miraldi, E. R., Pokrovskii, M. V., Watters, A., Castro, D. M., Veaux, N. D., Hall, J. A., Lee, J., Ciofani, M., Madar, A., Carriero, N., et al. (2019) · Genome Research · doi:10.1101/gr.238253.118 · Cited by 109
Regulatory B cells in human inflammatory and autoimmune diseases: from mouse models to clinical research
Miyagaki, T., Fujimoto, M., & Sato, S. (2015) · International Immunology · doi:10.1093/intimm/dxv026 · Cited by 115
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Seo, D. H., Che, X., Kwak, M. S., Kim, S., Kim, J. H., Ma, H. W., Kim, D. H., Kim, T. I., Kim, W. H., Kim, S. W., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00840-2 · Cited by 107
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IKK/NF-κB signaling in intestinal epithelial cells controls immune homeostasis in the gut
Pasparakis, M. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.53 · Cited by 99
Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8
Mishiro, T., Kusunoki, R., Otani, A., Ansary, M. M. U., Tongu, M., Harashima, N., Yamada, T., Sato, S., Amano, Y., Itoh, K., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.70 · Cited by 97
Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis
Yang, M., Lin, H.-B., Gong, S., Chen, P., Geng, L., Zeng, Y., & Li, D. (2014) · Cytokine · doi:10.1016/j.cyto.2014.07.250 · Cited by 97
Role of Intestinal HIF-2α in Health and Disease
Ramakrishnan, S. K., & Shah, Y. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105202 · Cited by 100
Protective effect of quercetin on pig intestinal integrity after transport stress is associated with regulation oxidative status and inflammation
Zou, Y., Wei, H.-K., Xiang, Q., Wang, J., Zhou, Y.-F., & Peng, J. (2016) · Journal of Veterinary Medical Science · doi:10.1292/jvms.16-0090 · Cited by 77
Evodiamine prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome
Shen, P. F., Zhang, Z., Zhu, K., Cao, H., Liu, J., Lu, X., Li, Y., Jing, Y., Yuan, X., Fu, Y., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.033 · Cited by 99
A self-assembled, ROS-responsive Janus-prodrug for targeted therapy of inflammatory bowel disease
Li, S., Xie, A., Li, H., Zou, X., & Zhang, Q. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.054 · Cited by 96
The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat
Liang, S., Deng, X., Lei, L., Zheng, Y., Ai, J., Chen, L., Xiong, H. Y., Mei, Z., Cheng, Y., & Ren, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01466 · Cited by 96
Ginsenoside Rg1 ameliorated experimental colitis by regulating the balance of M1/M2 macrophage polarization and the homeostasis of intestinal flora
Long, J., Liu, X., Kang, Z.-P., Wang, M., Zhao, H., Huang, J., Xiao, Q., Liu, D., & Zhong, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174742 · Cited by 96
Probiotic Bacteria Lactobacillus and Bifidobacterium Attenuate Inflammation in Dextran Sulfate Sodium-Induced Experimental Colitis in Mice
Toumi, R., Soufli, I., Rafa, H., Belkhelfa, M., Biad, A., & Touil–Boukoffa, C. (2014) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201402700418 · Cited by 96
Update on Janus Kinase Antagonists in Inflammatory Bowel Disease
Boland, B. S., Sandborn, W. J., & Chang, J. T. (2014) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2014.05.011 · Cited by 95
Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis
Roth, S., Spalinger, M. R., Gottier, C., Biedermann, L., Zeitz, J., Lang, S., Weber, A., Rogler, G., & Scharl, M. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154817 · Cited by 96
Dysregulation of Anti-Inflammatory Annexin A1 Expression in Progressive Crohns Disease
Sena, A. A. S., Grishina, I., Thai, A., Goulart, L., Macal, M., Fenton, A. N., Li, J., Prindiville, T. P., Oliani, S. M., Dandekar, S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076969 · Cited by 94
Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis
Li, X.-D., Chiu, Y., Ismail, A. S., Behrendt, C. L., Wight‐Carter, M., Hooper, L. V., & Chen, Z. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107114108 · Cited by 93
Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications
Pae, M., & Wu, D. (2013) · Food & Function · doi:10.1039/c3fo60076a · Cited by 95
Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
Eurich, K., Segawa, M., Toei-Shimizu, S., & Mizoguchi, E. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5249 · Cited by 89
Novel Anti-Glycan Antibodies Related to Inflammatory Bowel Disease Diagnosis and Phenotype
Seow, C. H., Stempak, J. M., Xu, W., Lan, H. Y., Griffiths, A. M., Greenberg, G. R., Steinhart, A. H., Dotan, N., & Silverberg, M. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.79 · Cited by 95
Soluble Fibers and Resistant Starch Ameliorate Disease Activity in Interleukin-10–Deficient Mice with Inflammatory Bowel Disease
Bassaganya-Riera, J., DiGuardo, M. A., Viladomiu, M., de Horna, A., Sanchez, S. P., Einerhand, A. W. C., Sanders, L., & Hontecillas, R. (2011) · Journal of Nutrition · doi:10.3945/jn.111.139022 · Cited by 94
Influence of food and lifestyle on the risk of developing inflammatory bowel disease
Niewiadomski, O., Studd, C., Wilson, J., Williams, J. S., Hair, C., KNIGHT, R. E., Prewett, E. J., Dabkowski, P., Alexander, S., Allen, B., et al. (2016) · Internal Medicine Journal · doi:10.1111/imj.13094 · Cited by 98
Protective effects of tryptophan-catabolizing Lactobacillus plantarum KLDS 1.0386 against dextran sodium sulfate-induced colitis in mice
Shi, J., Du, P., Xie, Q., Wang, N., Li, H., Smith, E. E., Li, C., Liu, F., Huo, G., & Li, B. (2020) · Food & Function · doi:10.1039/d0fo02622k · Cited by 94
Polystyrene microplastics exacerbate experimental colitis in mice tightly associated with the occurrence of hepatic inflammation
Luo, T., Wang, D., Zhao, Y., Li, X., Yang, G., & Jin, Y. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156884 · Cited by 96
The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls
Moreira, L. O., Kasmi, K. C. E., Smith, A. M., Finkelstein, D., Fillon, S., Kim, Y.-G., Núñez, G., TUOMANEN, E. I., & Murray, P. J. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01189.x · Cited by 95
Adherent-invasive Escherichia coli (AIEC) in pediatric Crohn’s disease patients: phenotypic and genetic pathogenic features
Conte, M. P., Longhi, C., Marazzato, M., Conte, A. L., Aleandri, M., Lepanto, M. S., Zagaglia, C., Nicoletti, M., Aloi, M., Totino, V., et al. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-748 · Cited by 94
Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease
Liu, Z., Yang, L., Cui, Y., Wang, X., Guo, C., Huang, Z., Kan, Q., Liu, Z., & Liu, Y. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20923 · Cited by 98
Promoting longevity by maintaining metabolic and proliferative homeostasis
Wang, L., Karpac, J., & Jasper, H. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.089920 · Cited by 91
Mechanisms of Microbe–Host Interaction in Crohn’s Disease: Dysbiosis vs. Pathobiont Selection
Buttó, L. F., Schaubeck, M., & Haller, D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00555 · Cited by 97
Patchouli alcohol ameliorates dextran sodium sulfate-induced experimental colitis and suppresses tryptophan catabolism
Qu, C. F., Yuan, Z., Yu, X., Huang, Y., Yang, G., Chen, J., Lai, X., Su, Z., Zeng, H., Xie, Y., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.017 · Cited by 93
Mango (Mangifera indica L.) polyphenols reduce IL-8, GRO, and GM-SCF plasma levels and increase Lactobacillus species in a pilot study in patients with inflammatory bowel disease
Kim, H., Venâncio, V. P., Fang, C., Dupont, A. W., Talcott, S. T., & Mertens‐Talcott, S. U. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.01.002 · Cited by 96
Extracellular Vesicles Derived from Kefir Grain Lactobacillus Ameliorate Intestinal Inflammation via Regulation of Proinflammatory Pathway and Tight Junction Integrity
Kang, E. A., Choi, H., Hong, S. W., Kang, S., Jegal, H.-Y., Choi, E. W., Park, B.-S., & Kim, J. S. (2020) · Biomedicines · doi:10.3390/biomedicines8110522 · Cited by 94

Authors: Xavier, R. J., & Podolsky, D. K.
Affiliations: Harvard University (US)
Corresponding author: Podolsky, D. K.
ORCID: Xavier, R. J.
Podolsky, D. K.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-07
Volume: 448
Issue: 7152
Pages: 427-434
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06005
OpenAlex: W2078621117
Cited by: 4,364
References: 100
Citations by year: 2026: 134 · 2025: 183 · 2024: 224 · 2023: 247 · 2022: 258 · 2021: 230 · 2020: 249 · 2019: 211 · 2018: 217 · 2017: 221 · 2016: 255 · 2015: 279 · 2014: 286 · 2013: 236 · 2012: 258
FWCI: 21.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, pathogenesis, susceptibility genes, epithelial barrier function, innate immunity, adaptive immunity, commensal bacteria, immune dysregulation, macrophages, mouse model
MeSH terms: Animals, Autophagy, Colitis, Humans, Immunity, Innate, Intestinal Mucosa, Inflammatory Bowel Diseases, Genetic Predisposition to Disease

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