Cited by 68Probiotics and Fermented FoodsInflammatory Bowel DiseaseGut microbiota and health

Beneficial role of the probiotic mixture Ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis

Toumi, Ryma, Abdelouhab, Katia, Rafa, Hayet, Soufli, Imene, Raissi-Kerboua, Djamila, Djeraba, Zineb, Touil-Boukoffa, Chafia·2013·Immunopharmacology and Immunotoxicology

Abstract

The etiology of inflammatory bowel diseases which include ulcerative colitis (UC) and Crohn disease has not yet been clarified. Several hypotheses suggest a change in composition of gut microflora along with an impaired mucosal barrier that lead to excessive mucosal immunologic responses. Increased production of nitric oxide (NO) contributes greatly to the tissue injury caused by chronic inflammation. Evidence indicates that the mucus layer covering the epithelium is altered during UC and experimental colitis. Our aim in this study was to investigate the potential therapeutic effect of probiotic during DSS-induced colitis by modulating the immune system and colonic mucus production. For that purpose, the probiotic formulation Ultrabiotique(®) (Lactobacillus acidophilus, Bifidobacterium lactis, Lactobacillus plantarum and Bifidobacterium breve) was administered daily for 7 d to mice with colitis. Probiotic supplementation improved clinical symptoms and histological alterations observed during DSS induced colitis. Ultrabiotique(®) treatment down regulated the NO production by peritoneal macrophages of DSS-treated mice and enhanced mucus production in both DSS-treated and healthy mice. In conclusion, the modification of microflora by the Ultrabiotique(®) played a beneficial role in maintaining the integrity of the intestinal mucosal barrier and promoted tissue repair.

Integrity signals

Registry

Crossref · 10.3109/08923973.2013.790413

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  • Once in the intestine, probiotics interact with intestinal cells to restore intestinal permeability, stimulate mucus production, promote mucosal regeneration, maintain the intestinal mechanical barrier's normal function, and maintain the mucosal barrier's integrity.

    “Once arrived in the intestine, they interact with intestinal cells, with the aim of restoring intestinal permeability, stimulating mucus production, promoting mucosal regeneration, maintaining the intestinal mechanical barrier’s normal function, and maintaining the mucosal barrier’s integrity [85].”

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Authors
Toumi, R., Abdelouhab, K., Rafa, H., Soufli, I., Raissi-Kerboua, D., Djeraba, Z., & Touil-Boukoffa, C.
Affiliations
University of Sciences and Technology Houari Boumediene (DZ)
Venue
Immunopharmacology and Immunotoxicology
Published
2013-05-02
Volume
35
Issue
3
Pages
403-409
ISSN
  • 0892-3973 (ISSN-L)
  • 1532-2513
OpenAlex
W1970276705
Cited by
68
References
40
Citations by year
2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 4 · 2014: 5
FWCI
5.97
Type
journal article
Language
en
Open access
closed
Locations
  • Immunopharmacology and Immunotoxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
probiotics, DSS-induced colitis, intestinal barrier, inflammatory bowel disease, ulcerative colitis, nitric oxide, mucus production, peritoneal macrophages, gut microbiota, Lactobacillus acidophilus, Bifidobacterium animalis subsp. lactis, Lactobacillus plantarum, Bifidobacterium breve, tissue repair
MeSH terms
Animals, Bifidobacterium, Colitis, Ulcerative, Disease Models, Animal, Intestinal Mucosa, Lactobacillus, Macrophages, Male, Mucus, Nitric Oxide, Dextran Sulfate, Dietary Supplements, Probiotics, Goblet Cells, Mice

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