Cited by 4,364Inflammatory Bowel DiseaseGut microbiota and healthOcular Diseases and Behçet’s Syndrome

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Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., Podolsky, D. K.·2007·Nature

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Abstract

Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

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Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
Inflammatory Bowel Disease
Podolsky, D. K. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020831 · Cited by 3,183
Self-citation
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
Hampe, J., Franke, A., Rosenstiel, P. C., Till, A., Teuber, M., Huse, K., Albrecht, M., Mayr, G., Vega, F. M. D. L., Briggs, J. C., et al. (2006) · Nature Genetics · doi:10.1038/ng1954 · Cited by 1,948
IL-17 family cytokines and the expanding diversity of effector T cell lineages
Weaver, C. T., Hatton, R. D., Mangan, P. R., & Harrington, L. E. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141557 · Cited by 1,842
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,834
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
Rioux, J. D., Xavier, R. J., Taylor, K. D., Silverberg, M. S., Goyette, P., Huett, A., Green, T., Kuballa, P., Barmada, M. M., Datta, L. W., et al. (2007) · Nature Genetics · doi:10.1038/ng2032 · Cited by 1,769
Self-citation
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,609
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
Yen, D., Cheung, J., Scheerens, H., Poulet, F. M., McClanahan, T. K., McKenzie, B. S., Kleinschek, M. A., Owyang, A. M., Mattson, J. D., Blumenschein, W. M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci21404 · Cited by 1,567
TH-17 cells in the circle of immunity and autoimmunity
Bettelli, E., Oukka, M., & Kuchroo, V. K. (2007) · Nature Immunology · doi:10.1038/ni0407-345 · Cited by 1,520
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence, A., Tato, C. M., Davidson, T. S., Kanno, Y., Chen, Z., Yao, Z., Blank, R. B., Meylan, F., Siegel, R., Hennighausen, L., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.02.009 · Cited by 1,507
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
Takeda, K., Clausen, B. E., Kaisho, T., Tsujimura, T., Terada, N., Förster, I., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80005-9 · Cited by 1,220
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,175
Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Helwig, U., Venturi, A., Lammers, K. M., Brigidi, P., Vitali, B., Poggioli, G., Miglioli, M., & Campieri, M. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00171-9 · Cited by 1,147
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 1,026
Reduced Paneth cell α-defensins in ileal Crohn's disease
Wehkamp, J., Salzman, N. H., Porter, E. M., Nuding, S., Weichenthal, M., Petras, R. E., Shen, B., Schaeffeler, E., Schwab, M. G., Linzmeier, R. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505256102 · Cited by 1,023
NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
Inohara, N., Chamaillard, M., McDonald, C., & Núñez, G. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133347 · Cited by 1,019
Human IRGM Induces Autophagy to Eliminate Intracellular Mycobacteria
Singh, S. B., Davis, A. S., Taylor, G. A., & Deretic, V. (2006) · Science · doi:10.1126/science.1129577 · Cited by 915
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Kobayashi, K. S., Inohara, N., Hernandez, L. D., Galán, J. E., Núñez, G., Janeway, C. A., Medzhitov, R. M., & Flavell, R. A. (2002) · Nature · doi:10.1038/416194a · Cited by 888
NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression
Wehkamp, J., Harder, J., Weichenthal, M., Schwab, M. G., Schäffeler, E., Schlee, M., Herrlinger, K. R., Stallmach, A., Noack, F., Fritz, P., et al. (2004) · Gut · doi:10.1136/gut.2003.032805 · Cited by 860
Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease
Darfeuille–Michaud, A., Neut, C., Barnich, N., Lederman, E., Martino, P. D., Desreumaux, P., Gambiez, L. P., Joly, B., Cortot, A., & Colombel, J.-F. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70019-8 · Cited by 859
Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination
Neish, A. S., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., & Madara, J. (2000) · Science · doi:10.1126/science.289.5484.1560 · Cited by 843
Functional variants of OCTN cation transporter genes are associated with Crohn disease
Peltekova, V. D., Wintle, R. F., Rubin, L. A., Amos, C. I., Huang, Q., Gu, X., Newman, W. G., Oene, M. V., Cescon, D. W., Greenberg, G. R., et al. (2004) · Nature Genetics · doi:10.1038/ng1339 · Cited by 837
Escape of Intracellular Shigella from Autophagy
Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N., & Sasakawa, C. (2004) · Science · doi:10.1126/science.1106036 · Cited by 830
Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking.
Tysk, C., Lindberg, E. H., Järnerot, G., & FLODERUS-MYRHED, B. (1988) · Gut · doi:10.1136/gut.29.7.990 · Cited by 828
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061099 · Cited by 823
Protein Turnover Via Autophagy: Implications for Metabolism
Mizushima, N., & Klionsky, D. J. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093749 · Cited by 813
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
Fuss, I. J., Heller, F., Boirivant, M., Leon, F., Yoshida, M., Fichtner‐Feigl, S., Yang, Z., Exley, M. A., Kitani, A., Blumberg, R. S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19836 · Cited by 799
Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation
Kastelein, R. A., Hunter, C. A., & Cua, D. J. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104758 · Cited by 777
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
Rioux, J. D., Daly, M. J., Silverberg, M. S., Lindblad‐Toh, K., Steinhart, H., Cohen, Z., DelMonte, T. A., Kocher, K., Miller, K. L., Guschwan-McMahon, S., et al. (2001) · Nature Genetics · doi:10.1038/ng1001-223 · Cited by 774
Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors
Cario, E., Rosenberg, I. M., Brandwein, S. L., Beck, P. L., Reinecker, H., & Podolsky, D. K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.966 · Cited by 751
Self-citation
Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing
Maeda, S., Hsu, L.-C., Liu, H., Bankston, L. A., Iimura, M., Kagnoff, M. F., Eckmann, L., & Karin, M. (2005) · Science · doi:10.1126/science.1103685 · Cited by 748
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
Chieppa, M., Rescigno, M., Huang, A. Y.-C., & Germain, R. N. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061884 · Cited by 711
Impaired Defense of Intestinal Mucosa in Mice Lacking Intestinal Trefoil Factor
Mashimo, H. L., Wu, D., Podolsky, D. K., & Fishman, M. C. (1996) · Science · doi:10.1126/science.274.5285.262 · Cited by 702
Self-citation
Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology
Uhlig, H. H., McKenzie, B. S., Hüe, S., Thompson, C., Joyce-Shaikh, B., Štëpánková, R., Robinson, N., Buonocore, S. M., Tlaskalová‐Hogenová, H., Cua, D. J., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.017 · Cited by 692
Familial Occurrence of Inflammatory Bowel Disease
Orholm, M. K., Munkholm, P. S., Langholz, E., Nielsen, O. H., Sørensen, T. I. A., & Binder, V. (1991) · New England Journal of Medicine · doi:10.1056/nejm199101103240203 · Cited by 685
Phagocytosis
Stuart, L. M., & Ezekowitz, R. A. B. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.002 · Cited by 667
CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells
Hisamatsu, T., Suzuki, M., Reinecker, H., Nadeau, W. J., McCormick, B. A., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1053/gast.2003.50153 · Cited by 632
Self-citation
Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis
Franchimont, D. P., Vermeire, S., Housni, H. E., Pierik, M. J., Steen, K. V., Gustot, T., Quertinmont, E., Abramowicz, M., Gossum, A. V., Devière, J., et al. (2004) · Gut · doi:10.1136/gut.2003.030205 · Cited by 596
IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
Kullberg, M. C., Jankovic, D. L., Feng, C. G., Hüe, S., Gorelick, P. L., McKenzie, B. S., Cua, D. J., Powrie, F. M., Cheever, A. W., Maloy, K. J., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061082 · Cited by 592
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
Barnich, N., Carvalho, F. A., Glasser, A.-L., Darcha, C., Jantscheff, P., Allez, M., Peeters, H., Bommelaer, G., Desreumaux, P., Colombel, J., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30504 · Cited by 590
A Case for Regulatory B Cells
Mizoguchi, A., & Bhan, A. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.2.705 · Cited by 580
Novel Crohn Disease Locus Identified by Genome-Wide Association Maps to a Gene Desert on 5p13.1 and Modulates Expression of PTGER4
Libioulle, C., Louis, E. J., Hansoul, S., Sandor, C., Farnir, F., Franchimont, D. P., Vermeire, S., Dewit, O., Vos, M. D., Dixon, A., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030058 · Cited by 561
Inflammatory Bowel Disease
Podolsky, D. K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199110033251406 · Cited by 537
Self-citation
Double blind, placebo controlled trial of metronidazole in Crohn's disease.
Sutherland, L. R., Singleton, J., Sessions, J. T., Hanauer, S., Krawitt, E. L., Rankin, G. B., Summers, R. J., Mekhjian, H. S., Greenberger, N. J., & Kelly, M. (1991) · Gut · doi:10.1136/gut.32.9.1071 · Cited by 527
Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
Zaph, C., Troy, A. E., Taylor, B. C., Berman-Booty, L. D., Guild, K. J., Du, Y., Yost, E. A., Gruber, A. D., May, M. J., Greten, F. R., et al. (2007) · Nature · doi:10.1038/nature05590 · Cited by 496
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
Ízcue, A., Coombes, J. L., & Powrie, F. M. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00423.x · Cited by 481
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
Yamazaki, K., McGovern, D. P. B., Ragoussis, J., Paolucci, M., Butler, H., Jewell, D. P., Cardon, L. R., Takazoe, M., Tanaka, T., Ichimori, T., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi379 · Cited by 468
Claudins regulate the intestinal barrier in response to immune mediators
Kinugasa, T., Sakaguchi, T., Gu, X., & Reinecker, H. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70351-9 · Cited by 463
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14459 · Cited by 443
A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
Mayor, A., Martinon, F., Smedt, T. D., Pétrilli, V., & Tschopp, J. (2007) · Nature Immunology · doi:10.1038/ni1459 · Cited by 438
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
Kabashima, K., Saji, T., Murata, T., Nagamachi, M., Matsuoka, T., Segi‐Nishida, E., Tsuboi, K., Sugimoto, Y., Kobayashi, T., Miyachi, Y., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214459 · Cited by 418
Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414
Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation?
Bühner, S., Büning, C., Genschel, J., Kling, K., Herrmann, D., Dignass, A., Kuechler, I., Krueger, S., Schmidt, H. H.-J., & Lochs, H. (2005) · Gut · doi:10.1136/gut.2005.065557 · Cited by 381
Inflammatory bowel disease is associated with changes of enterocytic junctions
Gaßler, N., Rohr, C. M., Schneider, A., Kartenbeck, J., Bach, A., Obermüller, N., Otto, H. F., & Autschbach, F. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g216 · Cited by 363
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
Becker, C., Wirtz, S. J., Blessing, M., Pirhonen, J., Strand, D. J., Bechthold, O., Frick, J., Galle, P. R., Autenrieth, I. B., & Neurath, M. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17464 · Cited by 360
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans
An, G., Wei, B., Xia, B., McDaniel, J. M., Ju, T., Cummings, R. D., Braun, J., & Xia, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061929 · Cited by 352
Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1
Bruey, J., Bruey-Sédano, N., Luciano, F., Zhai, D., Balpai, R., Xu, C., Kress, C. L., Bailly‐Maitre, B., Li, X., Osterman, A. L., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.045 · Cited by 319
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
Becker, C., Wirtz, S. J., Blessing, M., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317464 · Cited by 318
Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
May, G. R., Sutherland, L. R., & Meddings, J. B. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90638-s · Cited by 316
Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease
Söderholm, J. D., Olaison, G., Peterson, K. H., Franzén, L. E., Lindmark, T., Wirén, M., Tagesson, C., & Sjödahl, R. (2002) · Gut · doi:10.1136/gut.50.3.307 · Cited by 290
Increased intestinal permeability precedes the onset of Crohn's disease in a subject with familial risk
Irvine, E. J., & Marshall, J. K. (2000) · Gastroenterology · doi:10.1053/gast.2000.20231 · Cited by 286
Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases
Pierik, M. J., Joossens, S. B. A., Steen, K. V., Schuerbeek, N. V., VLIETINCK, R. F., Rutgeerts, P., & Vermeire, S. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000195389.11645.ab · Cited by 280
Regulation of IL-8 and IL-1 expression in Crohn's disease associated NOD2/CARD15 mutations
Li, J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh182 · Cited by 272
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
Yoshida, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27821 · Cited by 237
Intestinal macrophages: unique effector cells of the innate immune system
Smith, P. D., Ochsenbauer‐Jambor, C., & Smythies, L. E. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00288.x · Cited by 225
Nucleotide Binding Oligomerization Domain 2 Deficiency Leads to Dysregulated TLR2 Signaling and Induction of Antigen-Specific Colitis
Watanabe, T., Kitani, A., Murray, P. J., Wakatsuki, Y., Fuss, I. J., & Strober, W. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.018 · Cited by 218
Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway
Schnurr, M. M., Toy, T., Shin, A., Wagner, M., Cebon, J. S., & Maraskovsky, E. (2004) · Blood · doi:10.1182/blood-2004-05-1718 · Cited by 216
The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
Akbar, A. N., Vukmanovic‐Stejic, M., Taams, L. S., & Macallan, D. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2037 · Cited by 215
Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria
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Authors: Xavier, R. J., & Podolsky, D. K.
Affiliations: Harvard University (US)
Corresponding author: Podolsky, D. K.
ORCID: Xavier, R. J.
Podolsky, D. K.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-07
Volume: 448
Issue: 7152
Pages: 427-434
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06005
OpenAlex: W2078621117
Cited by: 4,364
References: 100
Citations by year: 2026: 134 · 2025: 183 · 2024: 224 · 2023: 247 · 2022: 258 · 2021: 230 · 2020: 249 · 2019: 211 · 2018: 217 · 2017: 221 · 2016: 255 · 2015: 279 · 2014: 286 · 2013: 236 · 2012: 258
FWCI: 21.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, pathogenesis, susceptibility genes, epithelial barrier function, innate immunity, adaptive immunity, commensal bacteria, immune dysregulation, macrophages, mouse model
MeSH terms: Animals, Autophagy, Colitis, Humans, Immunity, Innate, Intestinal Mucosa, Inflammatory Bowel Diseases, Genetic Predisposition to Disease

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Unravelling the pathogenesis of inflammatory bowel disease

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