Cited by 4,364Inflammatory Bowel DiseaseGut microbiota and healthOcular Diseases and Behçet’s Syndrome

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Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., Podolsky, D. K.·2007·Nature

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Abstract

Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

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Authors: Xavier, R. J., & Podolsky, D. K.
Affiliations: Harvard University (US)
Corresponding author: Podolsky, D. K.
ORCID: Xavier, R. J.
Podolsky, D. K.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-07
Volume: 448
Issue: 7152
Pages: 427-434
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06005
OpenAlex: W2078621117
Cited by: 4,364
References: 100
Citations by year: 2026: 134 · 2025: 183 · 2024: 224 · 2023: 247 · 2022: 258 · 2021: 230 · 2020: 249 · 2019: 211 · 2018: 217 · 2017: 221 · 2016: 255 · 2015: 279 · 2014: 286 · 2013: 236 · 2012: 258
FWCI: 21.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, pathogenesis, susceptibility genes, epithelial barrier function, innate immunity, adaptive immunity, commensal bacteria, immune dysregulation, macrophages, mouse model
MeSH terms: Animals, Autophagy, Colitis, Humans, Immunity, Innate, Intestinal Mucosa, Inflammatory Bowel Diseases, Genetic Predisposition to Disease

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