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Integrating molecular and network biology to decode endocytosis
Abstract
The strength of network biology lies in its ability to derive cell biological information without a priori mechanistic or molecular knowledge. It is shown here how a careful understanding of a given biological pathway can refine an interactome approach. This permits the elucidation of additional design principles and of spatio-temporal dynamics behind pathways, and aids in experimental design and interpretation.
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The dynamic instability within the Retromer accessory protein network is likely a feature in pathway progression and pathway fidelity that ensures directionality towards the successful biogenesis of a cargo-loaded transport carrier decorated with the appropriate RAB identity code, with post-translational modifications modifying and fine-tuning pathway progression by strengthening and weakening the
“The dynamic instability within the Retromer accessory protein network is likely a feature in pathway progression and pathway fidelity that ensures directionality towards the successful biogenesis of a cargo-loaded transport carrier decorated with the appropriate RAB identity code”
From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [123]
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Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation
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Metadata
- Authors
- Schmid, E. M., & McMahon, H. T.
- Venue
- Nature
- Published
- 2007-08
- Volume
- 448
- Issue
- 7156
- Pages
- 883-888
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 315
- References
- 5
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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