Misfolded proteins partition between two distinct quality control compartments

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Adapting Proteostasis for Disease Intervention

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

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Molecular mechanisms of spatial protein quality control

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Phosphorylation and nuclear transit modulate the balance between normal function and terminal aggregation of the yeast RNA-binding protein Ssd1

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Nuclear pore dysfunction and disease: a complex opportunity

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The Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality Control

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Assessment of human nter and cterBRCA1mutations using growth and localization assays in yeast

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Subcellular Fractionation Analysis of the Extraction of Ubiquitinated Polytopic Membrane Substrate during ER-Associated Degradation

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The mechanisms of Mallory–Denk body formation are similar to the formation of aggresomes in Alzheimer's disease and other neurodegenerative disorders

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Translation, modification and cellular distribution of two AC4 variants of African cassava mosaic virus in yeast and their pathogenic potential in plants

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Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD

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Quality control of mislocalized and orphan proteins

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Small Heat Shock Proteins: Protein Aggregation Amelioration and Neuro- and Age-Protective Roles

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Stress-induced NEDDylation promotes cytosolic protein aggregation through HDAC6 in a p62-dependent manner

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Nuclear protein quality control in yeast: The latest INQuiries

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Protein Condensates and Protein Aggregates: In Vitro, in the Cell, and In Silico

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J-domain proteins: From molecular mechanisms to diseases

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Social Evolution: This Microbe Will Self-Destruct

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A network of genes connects polyglutamine toxicity to ploidy control in yeast

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Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells

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Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation

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It's not just a phase; ubiquitination in cytosolic protein quality control

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Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance

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Protein aggregation propensity is a crucial determinant of intracellular inclusion formation and quality control degradation

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Identification of Mammalian Protein Quality Control Factors by High-Throughput Cellular Imaging

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Screening for Toxic Amyloid in Yeast Exemplifies the Role of Alternative Pathway Responsible for Cytotoxicity

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Hsp104 as a key modulator of prion-mediated oxidative stress in Saccharomyces cerevisiae

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Putting Huntingtin “Aggregation” in View with Windows into the Cellular Milieu

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CHIP as a membrane-shuttling proteostasis sensor

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Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells

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An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging

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Proteostasis impairment and ALS

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Roles of Hsp104 and trehalose in solubilisation of mutant huntingtin in heat shocked Saccharomyces cerevisiae cells

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Proteasome dynamics between proliferation and quiescence stages ofSaccharomyces cerevisiae

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A reversible liquid drop aggregation controls glucose response in yeast

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HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease

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To Kill or to Be Killed: How Does the Battle between the UPS and Autophagy Maintain the Intracellular Homeostasis in Eukaryotes?

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Three-Dimensional Remodeling of SARS-CoV2-Infected Cells Revealed by Cryogenic Soft X-ray Tomography

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Asymmetric damage segregation at cell division via protein aggregate fusion and attachment to organelles

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Gene Therapy for Misfolding Protein Diseases of the Central Nervous System

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A role for the proteasome in the turnover of S up35p and in [ PSI +] prion propagation

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Prion‐promoted phosphorylation of heterologous amyloid is coupled with ubiquitin‐proteasome system inhibition and toxicity

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Polyglutamine shows a urea-like affinity for unfolded cytosolic protein

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Role of Protein Quality Control Failure in Alcoholic Hepatitis Pathogenesis

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How and why do toxic conformers of aberrant proteins accumulate during ageing?

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Amyloids of multiple species: are they helpful in survival?

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Nucleolus: A Liquid Droplet Compartment for Misbehaving Proteins

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A New Autophagy-related Checkpoint in the Degradation of an ERAD-M Target

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Increased [ PSI + ] Appearance by Fusion of Rnq1 with the Prion Domain of Sup35 in Saccharomyces cerevisiae

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Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis

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Disrupted nuclear import-export in neurodegeneration

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Wine Yeast Cells Acquire Resistance to Severe Ethanol Stress and Suppress Insoluble Protein Accumulation during Alcoholic Fermentation

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The Metabolostasis Network and the Cellular Depository of Aggregation‐Prone Metabolites

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Protein aggregation: A detrimental symptom or an adaptation mechanism?

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PaCS Is a Novel Cytoplasmic Structure Containing Functional Proteasome and Inducible by Cytokines/Trophic Factors

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Kinetics of Formation and Asymmetrical Distribution of Hsp104-Bound Protein Aggregates in Yeast

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Studying Coxiella burnetii Type IV Substrates in the Yeast Saccharomyces cerevisiae: Focus on Subcellular Localization and Protein Aggregation

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Spatial Organization of Proteasome Aggregates in the Regulation of Proteasome Homeostasis

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Mapping the degradation pathway of a disease-linked aspartoacylase variant

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Nuclear Import of Yeast Proteasomes

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Functional differences between two major ubiquitin receptors in the proteasome; S5a and hRpn13

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Proteotoxicity: A Fatal Consequence of Environmental Pollutants-Induced Impairments in Protein Clearance Machinery

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Cks1 proteasomal degradation is induced by inhibiting Hsp90-mediated chaperoning in cancer cells

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Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders

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The fitness cost and benefit of phase‐separated protein deposits

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Small Molecule Screen Reveals Joint Regulation of Stress Granule Formation and Lipid Droplet Biogenesis

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Maturing Autophagosomes are Transported Towards the Cell Periphery

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Artificial Loading of ASC Specks with Cytosolic Antigens

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Dicer and Hsp104 Function in a Negative Feedback Loop to Confer Robustness to Environmental Stress

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Spatial sequestration of misfolded proteins as an active chaperone-mediated process during heat stress

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Polyglutamine Aggregation in Huntington and Related Diseases

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Newly imported proteins in mitochondria are particularly sensitive to aggregation

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Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model

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Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress

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Mutations, protein homeostasis, and epigenetic control of genome integrity

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Comparison of endogenously expressed fluorescent protein fusions behaviour for protein quality control and cellular ageing research

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Formation of Non-Nucleoplasmic Proteasome Foci during the Late Stage of Hyperosmotic Stress

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Endosomal sorting drives the formation of axonal prion protein endoggresomes

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Quality control of cytoplasmic proteins inside the nucleus

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Yca1 metacaspase: diverse functions determine how yeast live and let die

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The evolving world of ubiquitin: transformed polyubiquitin chains

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The yeast ubiquitin ligase Rsp5 downregulates the alpha subunit of nascent polypeptide‐associated complex Egd2 under stress conditions

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Fundamental Structures and Behaviors of Proteins

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An engineered mutant of a host phospholipid synthesis gene inhibits viral replication without compromising host fitness

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Adaptability of wine yeast to ethanol-induced protein denaturation

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Aptamer Reduces Aggregation of Mutant Huntingtin and Rescues Proteostasis Network in Non-Neuronal and Neuronal Cells

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Proteasome dynamics in response to metabolic changes

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Flow Cytometric Quantification and Characterization of Intracellular Protein Aggregates in Yeast

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Aggregation dynamics and identification of aggregation-prone mutants of the von Hippel–Lindau tumor suppressor protein

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Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies

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Spatial sequestration of misfolded proteins in neurodegenerative diseases

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Balanced activities of Hsp70 and the ubiquitin proteasome system underlie cellular protein homeostasis

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