Misfolded proteins partition between two distinct quality control compartments

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

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Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

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Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease

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A Caspase Cleaved Form of Tau Is Preferentially Degraded through the Autophagy Pathway

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Sorting out the trash: the spatial nature of eukaryotic protein quality control

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Autophagic Turnover of Inactive 26S Proteasomes in Yeast Is Directed by the Ubiquitin Receptor Cue5 and the Hsp42 Chaperone

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Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

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Yeast Prions: Structure, Biology, and Prion-Handling Systems

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Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

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Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

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Dynamic Reorganization of Metabolic Enzymes into Intracellular Bodies

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β-Amyloid and the Pathomechanisms of Alzheimer’s Disease: A Comprehensive View

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A Super-Assembly of Whi3 Encodes Memory of Deceptive Encounters by Single Cells during Yeast Courtship

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Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity

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Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

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Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies

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The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis

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Localization of Protein Aggregation in Escherichia coli Is Governed by Diffusion and Nucleoid Macromolecular Crowding Effect

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Protein aggregates are associated with replicative aging without compromising protein quality control

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Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

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Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae

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Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

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Evolution of cellular stress response mechanisms

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INS-gene mutations: From genetics and beta cell biology to clinical disease

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Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

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Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease

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Quality Control Against Misfolded Proteins in the Cytosol: A Network for Cell Survival

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Redox Activity Within the Lysosomal Compartment: Implications for Aging and Apoptosis

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Molecular phenotyping of aging in single yeast cells using a novel microfluidic device

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Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

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Proteotoxic stress and the ubiquitin proteasome system

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Restricted access: spatial sequestration of damaged proteins during stress and aging

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Mechanisms for Countering Oxidative Stress and Damage in Retinal Pigment Epithelium

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Advanced Methods for High-Throughput Microscopy Screening of Genetically Modified Yeast Libraries

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A role for ubiquitin in the clearance of nonfunctional rRNAsPreprint

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The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

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Organization out of disorder: liquid–liquid phase separation in plants

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Biogenesis of the Saccharomyces cerevisiae Pheromone a -Factor, from Yeast Mating to Human Disease

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Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

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Crowded Cell-like Environment Accelerates the Nucleation Step of Amyloidogenic Protein Misfolding

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A ‘garbage can’ for ribosomes: how eukaryotes degrade their ribosomes

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Protein folding alterations in amyotrophic lateral sclerosis

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Role of sHsps in organizing cytosolic protein aggregation and disaggregation

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A first order phase transition mechanism underlies protein aggregation in mammalian cells

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Yeast and Fungal Prions

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Cellular Regulation of Amyloid Formation in Aging and Disease

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Biomolecular Assemblies: Moving from Observation to Predictive Design

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Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting

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Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease

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Disaggregating Chaperones: An Unfolding Story

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Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

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Structure, Dynamics and Function of the 26S Proteasome

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The Upsides and Downsides of Organelle Interconnectivity

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Chaperone-like activity of the AAA+ proteins Rvb1 and Rvb2 in the assembly of various complexes

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Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

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tRNA genes rapidly change in evolution to meet novel translational demands

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Exposed hydrophobicity is a key determinant of nuclear quality control degradation

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Sequence grammar underlying the unfolding and phase separation of globular proteins

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The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells

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Disruption of the nuclear membrane by perinuclear inclusions of mutant huntingtin causes cell-cycle re-entry and striatal cell death in mouse and cell models of Huntington's disease

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Age-Related Oxidative Stress Compromises Endosomal Proteostasis

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The cellular economy of the Saccharomyces cerevisiae zinc proteome

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Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

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Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease

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Equivalent Mutations in the Eight Subunits of the Chaperonin CCT Produce Dramatically Different Cellular and Gene Expression Phenotypes

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Cadmium Causes Misfolding and Aggregation of Cytosolic Proteins in Yeast

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The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

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Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse model

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The yeast replicative aging model

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Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

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Regulation of Hsf1 and the Heat Shock Response

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Glycoprotein folding and quality-control mechanisms in protein-folding diseases

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Quality Control of Membraneless Organelles

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Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding

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