Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?

Bosserman, Rachel E.; Champion, Patricia A.

doi:10.1128/jb.00131-17

Cited by 42Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyMycobacterium research and diagnosis

Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?

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Bosserman, Rachel E., Champion, Patricia A.·2017·Journal of Bacteriology

DOI 10.1128/jb.00131-17PMC PMC5553030

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Abstract

Mycobacterial 6-kDa early secreted antigenic target (ESAT-6) system (ESX) exporters transport proteins across the cytoplasmic membrane. Many proteins transported by ESX systems are then translocated across the mycobacterial cell envelope and secreted from the cell. Although the mechanism underlying protein transport across the mycolate outer membrane remains elusive, the ESX systems are closely connected with and localize to the cell envelope. Links between ESX-associated proteins, cell wall synthesis, and the maintenance of cell envelope integrity have been reported. Genes encoding the ESX systems and those required for biosynthesis of the mycobacterial envelope are coregulated. Here, we review the interplay between ESX systems and the mycobacterial cell envelope.

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Another conserved ESX component is the serine protease MycP, although this protein is not directly integrated in the EccBCDE complex.
“Another conserved ESX component in mycobacterial ESX systems is the serine protease MycP, although this protein is not directly integrated in the EccBCDE complex (10,(41)(42)(43).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [42]

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Authors: Bosserman, R. E., & Champion, P. A.
Affiliations: University of Notre Dame (US)
ORCID: Bosserman, Rachel E.
Champion, Patricia A.
Venue: Journal of Bacteriology
Publisher: American Society for Microbiology
Published: 2017-09
Volume: 199
Issue: 17
ISSN: 0021-9193 (ISSN-L)
1098-5530
DOI: 10.1128/jb.00131-17
PMC: PMC5553030
OpenAlex: W2611319530
Cited by: 42
References: 188
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 6 · 2017: 1 · 2016: 1
FWCI: 1.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Bacteriology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: HHS | National Institutes of Health (AI106872)
National Science Foundation (DGE-1313583)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: ESX secretion system, ESAT-6, mycobacteria, cell envelope, protein secretion, cell wall biosynthesis, cell envelope integrity, gene co-regulation
MeSH terms: Type VII Secretion Systems, Cell Wall, Models, Biological, Mycobacterium, Gene Expression Regulation, Bacterial, Protein Transport

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Esx Systems and the Mycobacterial Cell Envelope: What's the Connection?

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