Cited by 269Acute Lymphoblastic Leukemia researchWnt/β-catenin signaling in development and cancerAcute Myeloid Leukemia Research

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Open access

Wang, Zhong, Smith, Kevin S., Murphy, Mark, Piloto, Obdulio, Somervaille, Tim C. P., Cleary, Michael L.·2008·Nature

DOI 10.1038/nature07284PMC PMC4084721

Open this paper in CoChat — free account

Abstract

Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine kinase that participates in numerous signalling pathways involved in diverse physiological processes. Several of these pathways are implicated in disease pathogenesis, which has prompted efforts to develop GSK3-specific inhibitors for therapeutic applications. However, before now, there has been no strong rationale for targeting GSK3 in malignancies. Here we report pharmacological, physiological and genetic studies that demonstrate an oncogenic requirement for GSK3 in the maintenance of a specific subtype of poor prognosis human leukaemia, genetically defined by mutations of the MLL proto-oncogene. In contrast to its previously characterized roles in suppression of neoplasia-associated signalling pathways, GSK3 paradoxically supports MLL leukaemia cell proliferation and transformation by a mechanism that ultimately involves destabilization of the cyclin-dependent kinase inhibitor p27(Kip1). Inhibition of GSK3 in a preclinical murine model of MLL leukaemia provides promising evidence of efficacy and earmarks GSK3 as a candidate cancer drug target.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature07284

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Sato, N., Meijer, L., Skaltsounis, A., Greengard, P., & Brivanlou, A. H. (2003) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,139
GSK-3: tricks of the trade for a multi-tasking kinase
Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084
The renaissance of GSK3
Cohen, P., & Frame, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096075 · Cited by 1,493
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint
Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,411
Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
Hoeflich, K. P., Luo, J., Rubie, E. A., Tsao, M., Jin, O., & Woodgett, J. R. (2000) · Nature · doi:10.1038/35017574 · Cited by 1,401
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint
Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,113
Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3
Martin, M., Rehani, K., Jope, R. S., & Michalek, S. M. (2005) · Nature Immunology · doi:10.1038/ni1221 · Cited by 1,099
The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis
Yokoyama, A., Somervaille, T. C. P., Smith, K. S., Rozenblatt–Rosen, O., Meyerson, M. M., & Cleary, M. L. (2005) · Cell · doi:10.1016/j.cell.2005.09.025 · Cited by 698
Self-citation

Show all 43 references

Research works printed but not linked: 1

Miller, J. R. The Wnts. Genome Biol 3, 3001 (2002)

Sorted by citations

Items 101–200 of 269

Glycogen synthase kinase−3β inhibitors suppress leukemia cell growth
Song, E. Y., Palladinetti, P., Klamer, G., Ko, K., Lindeman, R., O'Brien, T. A., & Dolnikov, A. (2010) · Experimental Hematology · doi:10.1016/j.exphem.2010.06.001 · Cited by 40
Targeting phosphatidylinositol 3 kinase (PI3K)-Akt beyond rapalogs
Ogita, S., & LoRusso, P. M. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0176-7 · Cited by 40
Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia
Ricciardi, M. R., Mirabilii, S., Licchetta, R., Piedimonte, M., & Tafuri, A. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.05.002 · Cited by 41
GSK-3 as a novel prognostic indicator in leukemia
Ruvolo, P. P. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.05.001 · Cited by 39
Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia
Brown, G., & Hughes, P. (2012) · Leukemia Research and Treatment · doi:10.1155/2012/939021 · Cited by 39
Pharmacokinetics, Metabolism, and Excretion of the Glycogen Synthase Kinase-3 Inhibitor LY2090314 in Rats, Dogs, and Humans: A Case Study in Rapid Clearance by Extensive Metabolism with Low Circulating Metabolite Exposure
Zamek‐Gliszczynski, M. J., Abraham, T. L., Alberts, J. J., Kulanthaivel, P., Jackson, K. A., Chow, K. H., McCann, D., Hu, H., Anderson, S., Furr, N. A., et al. (2013) · Drug Metabolism and Disposition · doi:10.1124/dmd.112.048488 · Cited by 39
From Tyrian Purple to Kinase Modulators: Naturally Halogenated Indirubins and Synthetic Analogues
Vougogiannopoulou, K., & Skaltsounis, A. (2012) · Planta Medica · doi:10.1055/s-0032-1315261 · Cited by 38
A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity
Hu, S., Ueda, M., Stetson, L. C., Ignatz-Hoover, J. J., Moreton, S. A., Chakrabarti, A., Xia, Z., Karan, G., Lima, M. J. G. D., Agrawal, M., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0566 · Cited by 37
Glycogen synthase kinase-3 (GSK-3) inhibition induces apoptosis in leukemic cells through mitochondria-dependent pathway
Mirlashari, M. R., Randen, I., & Kjeldsen‐Kragh, J. (2011) · Leukemia Research · doi:10.1016/j.leukres.2011.11.013 · Cited by 38
Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli
Cheng, Y., Huang, W., Chen, C., Tsai, C., Wang, C., Chiu, W. C., Chen, Y., Lin, Y.-S., Chang, C., & Lin, C. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.099 · Cited by 35
GSK-3: a multifaceted player in acute leukemias
Martelli, A. M., Evangelisti, C., Paganelli, F., Chiarini, F., & McCubrey, J. A. (2021) · Leukemia · doi:10.1038/s41375-021-01243-z · Cited by 36
Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?
Somervaille, T. C. P., & Cleary, M. L. (2010) · International Journal of Hematology · doi:10.1007/s12185-010-0579-8 · Cited by 34
Self-citation
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia
Liu, X., Sato, N., Yabushita, T., Li, J., Jia, Y., Tamura, M., Asada, S., Fujino, T., Fukushima, T., Yonezawa, T., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202115631 · Cited by 34
The selective PI3Kα inhibitor BYL719 as a novel therapeutic option for neuroendocrine tumors: Results from multiple cell line models
Nölting, S., Rentsch, J., Freitag, H., Detjen, K. M., Briest, F., Möbs, M., Weissmann, V., Siegmund, B., Auernhammer, C. J., Prada, E. T. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182852 · Cited by 34
t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL
Kumar, A. R., Yao, Q., Li, Q., Sam, T. N., & Kersey, J. H. (2010) · Leukemia Research · doi:10.1016/j.leukres.2010.08.011 · Cited by 33
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells
Ching, J., Amiridis, S., Stylli, S. S., Bjorksten, A. R., Kountouri, N., Zheng, T. W., Paradiso, L., Luwor, R. B., Morokoff, A. P., O'Brien, T. J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4019 · Cited by 33
Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin Pathway
Khan, K. A., Dô, F., Marineau, A., Doyon, P., Clément, J.-F., Woodgett, J. R., Doble, B. W., & Servant, M. J. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00344-15 · Cited by 32
The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities
Mudgapalli, N., Nallasamy, P., Chava, H., Chava, S. P., Pathania, A. S., Gunda, V., Gorantla, S., Pandey, M. K., Gupta, S. C., & Challagundla, K. B. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.10.001 · Cited by 31
miR-130b and miR-128a are essential lineage-specific codrivers of t(4;11) MLL-AF4 acute leukemia
Malouf, C., Antunes, E., O’Dwyer, M. R., Jakobczyk, H., Sahm, F., Landua, S.-L., Anderson, R. A., Soufi, A., Halsey, C., & Ottersbach, K. (2021) · Blood · doi:10.1182/blood.2020006610 · Cited by 32
Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
Mayes, P. A., Dolloff, N. G., Daniel, C. J., Liu, J. J., Hart, L. S., Kuribayashi, K., Allen, J. E., Jee, D. I. H., Dorsey, J. F., Liu, Y. Y., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1383 · Cited by 32
Disruption of a Nuclear NFATc2 Protein Stabilization Loop Confers Breast and Pancreatic Cancer Growth Suppression by Zoledronic Acid
Singh, S. K., Baumgart, S., Singh, G., König, A. O., Reutlinger, K., Hofbauer, L. C., Barth, P. J., Gress, T. M., Lomberk, G. A., Urrutia, R. A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.197533 · Cited by 32
FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1
Mishra, M., Thacker, G., Sharma, A., Singh, A. K., Upadhyay, V., Sanyal, S., Verma, S. P., Tripathi, A. K., Bhatt, M. L. B., & Trivedi, A. K. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0268 · Cited by 30
GSK3 inhibitors enhance retinoic acid receptor activity and induce the differentiation of retinoic acid-sensitive myeloid leukemia cells
Si, J., Mueller, L., & Collins, S. J. (2011) · Leukemia · doi:10.1038/leu.2011.171 · Cited by 30
Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors
Bertrand‐Michel, J., Despeaux, M., Joly, S., Bourogâa, E., Gallay, N., Demur, C., Bonnevialle, P., Louache, F., Maguer‐Satta, V., Vergnolle, N., et al. (2011) · Oncogene · doi:10.1038/onc.2011.258 · Cited by 30
Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma
Madhunapantula, S. V., Sharma, A. K., Gowda, R., & Robertson, G. P. (2013) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12156 · Cited by 31
Antitumor effect of baicalin from the Scutellaria baicalensis radix extract in B-acute lymphoblastic leukemia with different chromosomal rearrangements
Orzechowska, B., Wróbel, G., Turlej, E., Jatczak, B., Sochocka, M., & Chaber, R. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106114 · Cited by 30
The Multitargeted Receptor Tyrosine Kinase Inhibitor Linifanib (ABT-869) Induces Apoptosis through an Akt and Glycogen Synthase Kinase 3β–Dependent Pathway
Hernandez‐Davies, J. E., Zape, J. P., Landaw, E. M., Tan, X., Presnell, A., Griffith, D., Heinrich, M. C., Glaser, K. B., & Sakamoto, K. M. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0904 · Cited by 29
CG0009, a Novel Glycogen Synthase Kinase 3 Inhibitor, Induces Cell Death through Cyclin D1 Depletion in Breast Cancer Cells
Kim, T. H., Kim, C., Lee, J., Jang, S. J., Hwang, J. J., Ro, S., & Choi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060383 · Cited by 29
GSK3A Is Redundant with GSK3B in Modulating Drug Resistance and Chemotherapy-Induced Necroptosis
Grassilli, E., Ianzano, L., Bonomo, S., Missaglia, C., Cerrito, M. G., Giovannoni, R., Masiero, L., & Lavitrano, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100947 · Cited by 30
Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation
Vincent, E. E., Elder, D. J. E., O′Flaherty, L., Pardo, O. E., Dzien, P., Phillips, L., Morgan, C., Pawade, J., May, M., Sohail, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114725 · Cited by 28
Lithium Chloride and Inhibition of Glycogen Synthase Kinase 3β as a Potential Therapy for Serous Ovarian Cancer
Novetsky, A. P., Thompson, D. M., Zighelboim, I., Thaker, P. H., Powell, M. A., Mutch, D. G., & Goodfellow, P. J. (2013) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e31827cfecb · Cited by 28
Glycogen Synthase Kinase 3 as an Anticancer Drug Target: Novel Experimental Findings and Trends in the Design of Inhibitors
Osolodkin, D. I., Palyulin, V. A., & Zefirov, N. S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161213804581972 · Cited by 27
Cyclin-dependent kinase inhibitors for the treatment of chronic lymphocytic leukemia
Blachly, J. S., Byrd, J. C., & Grever, M. R. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2016.02.003 · Cited by 28
Aberrant GSK3β nuclear localization promotes AML growth and drug resistance
Ignatz-Hoover, J. J., Wang, V., Mackowski, N. M., Roe, A. J., Ghansah, I. K., Ueda, M., Lazarus, H. M., de Lima, M., Paietta, E., Fernandez, H., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018016006 · Cited by 27
Concerted Suppression of STAT3 and GSK3β Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin
Li, T., Fan, F., Liu, Y., Li, W., Zhang, L., Ruan, J., Shen, C., Sheng, X., Zhu, Z., Wang, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081945 · Cited by 27
Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-κB-dependent GLUT3 expression
Watanabe, M., Abe, N., Oshikiri, Y., Stanbridge, E. J., & Kitagawa, T. (2012) · Oncogenesis · doi:10.1038/oncsis.2012.21 · Cited by 27
Targeting self-renewal pathways in myeloid malignancies
Sands, W. A., Copland, M., & Wheadon, H. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-33 · Cited by 28
Correction: c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity
Quintavalle, C., Incoronato, M., Puca, L., Acunzo, M., Zanca, C., Romano, G., Garofalo, M., Iaboni, M., Croce, C. M., & Condorelli, G. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.7 · Cited by 27
Retracted
Anticancer activity of VDR-coregulator inhibitor PS121912
Sidhu, P. S., Teske, K. A., Feleke, B., Yuan, N. Y., Guthrie, M. L., Fernstrum, G. B., Vyas, N. D., Han, L., Preston, J., Bogart, J. W., et al. (2014) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-014-2549-y · Cited by 26
Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia
Kuenzi, B. M., Rix, L. L. R., Kinose, F., Kroeger, J. L., Lancet, J. E., Padron, E., & Rix, U. (2019) · Scientific Reports · doi:10.1038/s41598-018-37174-6 · Cited by 26
Roles of GSK-3 and β-Catenin in Antiviral Innate Immune Sensing of Nucleic Acids
Marineau, A., Khan, K. A., & Servant, M. J. (2020) · Cells · doi:10.3390/cells9040897 · Cited by 29
Aberrant TRPM4 expression in MLL-rearranged acute myeloid leukemia and its blockade induces cell cycle arrest via AKT/GLI1/Cyclin D1 pathway
Wang, F., Wu, P., Gong, S., Chen, Y., Gao, J., Wang, S., Shen, Q., Tao, H., Hua, F., Zhou, Z., et al. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109643 · Cited by 26
Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma
Harrington, C. T., Sotillo, E., Robert, A., Hayer, K. E., Bogusz, A. M., Psathas, J. N., Yu, D., Taylor, D. M., Dang, C. V., Klein, P. S., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0454-4 · Cited by 28
Pro-Oncogenic and Anti-Oncogenic Pathways: Opportunities and Challenges of Cancer Therapy
Zhang, J., Chen, Y., & Lu, Q. (2010) · Future Oncology · doi:10.2217/fon.10.15 · Cited by 29
Selective treatment of mixed-lineage leukemia leukemic stem cells through targeting glycogen synthase kinase 3 and the canonical Wnt/β-catenin pathway
Fung, T. K., Gandillet, A., & So, C. W. E. (2012) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283545615 · Cited by 26
Glycogen synthase kinase-3: A potential immunotherapeutic target in tumor microenvironment
Liang, J., Yu, M., Li, Y., Zhao, L., & Wei, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116377 · Cited by 25
Lithium chloride antileukemic activity in acute promyelocytic leukemia is GSK-3 and MEK/ERK dependent
Zassadowski, F., Pokorná, K., Ferré, N., Guidez, F., Llopis, L., Chourbagi, O., Chopin, M., Poupon, J., Fenaux, P., Padua, R. A., et al. (2015) · Leukemia · doi:10.1038/leu.2015.159 · Cited by 24
HMGA2 as a potential molecular target in KMT2A-AFF1 -positive infant acute lymphoblastic leukaemia
Wu, Z., Eguchi‐Ishimae, M., Yagi, C., Iwabuki, H., Gao, W., Tauchi, H., Inukai, T., Sugita, K., Ishii, E., & Eguchi, M. (2015) · British Journal of Haematology · doi:10.1111/bjh.13763 · Cited by 25
Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia–reperfusion injury
Zhao, G., Ma, H., Shen, X., Xu, G., Zhu, Y., Chen, B., Tie, R., Qü, P., Lv, Y., Zhang, H., et al. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.05.004 · Cited by 25
Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer
O′Flaherty, L., Shnyder, S. D., Cooper, P. A., Cross, S., Wakefield, J. G., Pardo, O. E., Seckl, M. J., & Tavaré, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214610 · Cited by 25
Signaling pathways governing the behaviors of leukemia stem cells
Azizidoost, S., Nasrolahi, A., Sheykhi-Sabzehpoush, M., Anbiyaiee, A., Khoshnam, S. E., Farzaneh, M., & Shahab Uddin, M. S. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.01.008 · Cited by 29
c-FLIPL enhances anti-apoptotic Akt functions by modulation of Gsk3β activity
Quintavalle, C., Incoronato, M., Puca, L., Acunzo, M., Zanca, C., Romano, G., Garofalo, M., Iaboni, M., Croce, C. M., & Condorelli, G. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.65 · Cited by 25
Retracted
Perturbing LSD1 and WNT rewires transcription to synergistically induce AML differentiation
Hosseini, A., Dhall, A., Ikonen, N., Sikora, N., Nguyen, S., Shen, Y., Amaral, M. L. J., Jiao, A. L., Wallner, F., Sergeev, P., et al. (2025) · Nature · doi:10.1038/s41586-025-08915-1 · Cited by 25
Mutations in PIK3CA sensitize breast cancer cells to physiologic levels of aspirin
Turturro, S. B., Najor, M. S., Ruby, C. E., Cobleigh, M., & Abukhdeir, A. M. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3729-8 · Cited by 23
PAX3–FKHR sensitizes human alveolar rhabdomyosarcoma cells to camptothecin-mediated growth inhibition and apoptosis
Zeng, F.-Y., Cui, J., Liu, L., & Chen, T. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.04.016 · Cited by 23
How Ginsenosides Trigger Apoptosis in Human Lung Adenocarcinoma Cells
Han, X., Xue, Q., Zhang, Q., Li, C., Liu, X., Liu, J., Li, H., & Yang, J. (2019) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x19500885 · Cited by 24
Fuling Granule, a Traditional Chinese Medicine Compound, Suppresses Cell Proliferation and TGFβ-Induced EMT in Ovarian Cancer
Tao, F., Ruan, S., Liu, W., Wang, L., Xiong, Y., & Shen, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168892 · Cited by 23
Glycogen Synthase Kinase 3β Inhibition as a Therapeutic Approach in the Treatment of Endometrial Cancer
Yin, Y., Kizer, N. T., Thaker, P. H., Chiappinelli, K. B., Trinkaus, K. M., Goodfellow, P. J., & Ma, L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816617 · Cited by 22
Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation
Piplani, H., Rana, C., Vaish, V., Vaiphei, K., & Sanyal, S. N. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.07.011 · Cited by 21
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia
Zhang, P., Min, Z., Gao, Y., Bian, J., Lin, X., He, J., Ye, D., Li, Y., Peng, C., Cheng, Y., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c02254 · Cited by 21
Frat2 mediates the oncogenic activation of Rac by MLL fusions
Walf-Vorderwülbecke, V., de Boer, J., Horton, S. J., van Amerongen, R., Proost, N., Berns, A. J. M., & Williams, O. (2012) · Blood · doi:10.1182/blood-2012-05-432534 · Cited by 20
Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia.
Zhang, Y., Owens, K. S., Hatem, L., Glass, C., Karuppaiah, K., Camargo, F., & Perkins, A. (2013) · Blood · doi:10.1182/blood-2012-08-453662 · Cited by 21
Inhibition of glycogen synthase kinase-3β attenuates acute kidney injury in sodium taurocholate-induced severe acute pancreatitis in rats
Zhao, K., Chen, C., Shi, Q., Deng, W., Zuo, T., He, X., Liu, T., Zhao, L., & Wang, W. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2650 · Cited by 20
Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors
Crisan, L., Avram, S. I., & Pacureanu, L. M. (2017) · Molecular Diversity · doi:10.1007/s11030-016-9724-5 · Cited by 20
Aspartate β-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1α/GSK3β crosstalk
Barboro, P., Benelli, R., Tosetti, F., Costa, D., Capaia, M., Astigiano, S., Venè, R., Poggi, A. D., & Ferrari, N. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa053 · Cited by 20
Design and synthesis of (aza)indolyl maleimide-based covalent inhibitors of glycogen synthase kinase 3β
Yang, Z., Liu, H., Pan, B., He, F., & Pan, Z. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob00642c · Cited by 20
Metformin sensitizes AML cells to venetoclax through endoplasmic reticulum stress— CHOP pathway
Hua, L., Yang, N., Li, Y., Huang, K., Jiang, X., Liu, F., Yu, Z. H., Chen, J., Lai, J., Du, J., et al. (2023) · British Journal of Haematology · doi:10.1111/bjh.18968 · Cited by 20
Tetramethylpyrazine inhibits the proliferation of acute lymphocytic leukemia cell lines via decrease in GSK-3β
Wang, X., Xu, Y., Yang, G., Chen, H., & ZHANG, P. (2015) · Oncology Reports · doi:10.3892/or.2015.3860 · Cited by 19
Glycogen synthase kinase-3β inhibition induces nuclear factor-κB-mediated apoptosis in pediatric acute lymphocyte leukemia cells
Hu, Y., Gu, X., Li, R., Luo, Q., & Xu, Y. (2010) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-29-154 · Cited by 19
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability
Grey, W. E., Ivey, A., Milne, T. A., Haferlach, T., Grimwade, D. J., Uhlmann, F., Voisset, E., & Yu, V. P. C. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.09.009 · Cited by 17
Upregulation of Glycogen Synthase Kinase 3β in Human Colorectal Adenocarcinomas Correlates With Accumulation of CTNNB1
Wang, H. L., Hart, J. A. L., Fan, L., Mustafi, R., & Bissonnette, M. (2011) · Clinical Colorectal Cancer · doi:10.3816/ccc.2011.n.004 · Cited by 19
Correction: Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma
Harrington, C. T., Sotillo, E., Robert, A., Hayer, K. E., Bogusz, A. M., Psathas, J. N., Yu, D., Taylor, D. M., Dang, C. V., Klein, P. S., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0650-2 · Cited by 19
Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma
Kim, H., Kim, K. H., & Kim, A. (2016) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/62540 · Cited by 18
GSK-3β inhibitor 6-bromo-indirubin-3′-oxime promotes both adhesive activity and drug resistance in colorectal cancer cells
Liu, K., Li, J., Wu, X., Chen, M., Luo, F., & Li, J. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4163 · Cited by 18
Time-Lapse Imaging of Neuroblastoma Cells to Determine Cell Fate upon Gene Knockdown
Batra, R., Harder, N., Gogolin, S., Diessl, N., Soons, Z. I. T. A., Jaeger-Schmidt, C., Lawerenz, C., Eils, R., Rohr, K., Westermann, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050988 · Cited by 19
Small-Molecule Inhibitor of Glycogen Synthase Kinase 3β 6-Bromoindirubin-3-oxime Inhibits Hematopoietic Regeneration in Stem Cell Recipient Mice
Shen, S., Xu, N., Klamer, G., Ko, K., Khoo, M., Ma, D. D. F., Moore, J. J., O'Brien, T. A., & Dolnikov, A. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0230 · Cited by 17
GSK-3β Inhibition Attenuates LPS-Induced Death but Aggravates Radiation-Induced Death via Down-Regulation of IL-6
Li, B., Zhang, C., He, F., Liu, W., Yang, Y., Hu, L., Liu, X., Wang, J., Zhang, L., Deng, B., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356606 · Cited by 17
Calcineurin and GSK-3 inhibition sensitizes T-cell acute lymphoblastic leukemia cells to apoptosis through X-linked inhibitor of apoptosis protein degradation
Tosello, V., Bordin, F., Yu, J., Agnusdei, V., Indraccolo, S., Basso, G., Amadori, A., & Piovan, E. (2015) · Leukemia · doi:10.1038/leu.2015.335 · Cited by 17
Association between TLR2 and TLR4 Expression and Response to Induction Therapy in Acute Myeloid Leukemia Patients
Ramzi, M., Khalafi‐Nezhad, A., Saadi, M. I., & Jowkar, Z. (2018) · International Journal of Hematology-Oncology and Stem Cell Research · doi:10.18502/ijhoscr.v12i4.109 · Cited by 17
The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer
Borden, B. A., Baca, Y., Xiu, J., Tavora, F., Winer, I., Weinberg, B. A., Vanderwalde, A. M., Darabi, S., Korn, W. M., Mazar, A. P., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0497 · Cited by 15
Sidestream Smoke Exposure Increases the Susceptibility of Airway Epithelia to Adenoviral Infection
Sharma, P., Kolawole, A. O., Core, S. B., Kajon, A. E., & Excoffon, K. J. D. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049930 · Cited by 15
Gambogic acid inhibits proliferation and induces apoptosis of human acute T‑cell leukemia cells by inducing autophagy and downregulating β‑catenin signaling pathway: Mechanisms underlying the effect of Gambogic acid on T‑ALL cells
Wang, T., Du, J., Kong, D., Yang, G., Zhou, Q., You, F., Lin, Y., & Wang, Y. (2020) · Oncology Reports · doi:10.3892/or.2020.7726 · Cited by 15
Drug Repurposing for Targeting Acute Leukemia With KMT2A (MLL)—Gene Rearrangements
Tsakaneli, A., & Williams, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.741413 · Cited by 16
The Pivotal Roles of GSK3β in Glioma Biology
Nakada, M., Minamoto, T., Ilya, V. V., Hayashi, Y., & Ham, J.-I. (2011) · InTech eBooks · doi:10.5772/21458 · Cited by 14
Structure–activity relationship of the 7-hydroxy benzimidazole analogs as glycogen synthase kinase 3β inhibitor
Lee, S., Shin, D., Cho, J. M., Ro, S., & Suh, Y. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.01.065 · Cited by 14
Mechanisms of mixed-lineage leukemia
Muntean, A. G. (2013) · International Journal of Hematologic Oncology · doi:10.2217/ijh.13.20 · Cited by 14
Cardiac Hypertrophy is Positively Regulated by MicroRNA-24 in Rats
Gao, J., Zhu, M., Liu, R.-F., Zhang, J.-S., & Xu, M. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.232793 · Cited by 14
Molecular Pathology of Mixed-Lineage Leukemia
Bach, C., & Slany, R. K. (2009) · Future Oncology · doi:10.2217/fon.09.96 · Cited by 14
Creatine kinase pathway inhibition alters GSK3 and WNT signaling in EVI1-positive AML
Benajiba, L., Alexe, G., Su, A. H., Raffoux, E., Soulier, J., Hemann, M. T., Hermine, O., Itzykson, R., Stegmaier, K., & Puissant, A. (2018) · Leukemia · doi:10.1038/s41375-018-0291-x · Cited by 14
Synthesis of aryl anilinomaleimide based derivatives as glycogen synthase kinase-3β inhibitors with potential role as antidepressant agents
Tantray, M. A., Khan, I., Hamid, H., Alam, M. S., Dhulap, A., & Kalam, A. (2016) · New Journal of Chemistry · doi:10.1039/c5nj02896e · Cited by 13
Emerging drug discovery approaches for selective targeting of "precursor" metastatic breast cancer cells: highlights and perspectives.
Aalaoui-Jamali, M., Bijian, K., & Batist, G. (2011) · Europe PMC (PubMed Central) · Cited by 13
Pim Kinase Inhibitors Increase Gilteritinib Cytotoxicity in FLT3-ITD Acute Myeloid Leukemia Through GSK-3β Activation and c-Myc and Mcl-1 Proteasomal Degradation
Lee, J. K., Chatterjee, A., Scarpa, M., Bailey, C. M., Niyongere, S., Singh, P., Ali, M. K. M., Kapoor, S., Wang, Y., Silvestri, G., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0379 · Cited by 12
Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia
Ueda, M., Stefan, T., Stetson, L. C., Ignatz-Hoover, J. J., Tomlinson, B. K., Creger, R. J., Cooper, B., Lazarus, H. M., Lima, M. J. G. D., Wald, D. N., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00327 · Cited by 12
Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells
Eisenlöffel, C., Schmöle, A., Pews‐Davtyan, A., Brennführer, A., Kuznetsov, S. A., Hübner, R., Frech, S., Schult, C., Junghanß, C., Beller, M., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.12.013 · Cited by 12
Aberrant glycogen synthase kinase 3β in the development of pancreatic cancer
Shimasaki, T., Motoo, Y., Minamoto, T., & Kitano, A. (2012) · Journal of Carcinogenesis · doi:10.4103/1477-3163.100866 · Cited by 12
A novel treatment strategy for glioblastoma multiforme and glioma associated seizures: Increasing glutamate uptake with PPARγ agonists
Ching, J., Amiridis, S., Stylli, S. S., Morokoff, A. P., O'Brien, T. J., & Kaye, A. H. (2014) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2014.09.001 · Cited by 12
GSK3β suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells
Lee, Y., Shi, Y., Wang, L., Chiou, J., Huang, C., & Chang, L. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29884 · Cited by 12
Proteasome Inhibitors Interrupt the Activation of Non-Canonical NF-κB Signaling Pathway and Induce Cell Apoptosis in Cytarabine-Resistant HL60 Cells
Wang, S.-Y., Shih, Y.-H., Shieh, T., & Tseng, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010361 · Cited by 12
Glycogen Synthase Kinase-3 and Leukemia: Restoring the Balance
Birch, N. W., & Zeleznik‐Le, N. J. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.017 · Cited by 12
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer
Gao, Y., Ye, D., Zhou, W., & Chu, Y. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.04.039 · Cited by 12

Authors: Wang, Z., Smith, K. S., Murphy, M., Piloto, O., Somervaille, T. C. P., & Cleary, M. L.
Affiliations: Stanford Medicine (US)
Corresponding author: Cleary, Michael L.
ORCID: Wang, Zhong
Smith, Kevin S.
Murphy, Mark
Somervaille, Tim C. P.
Cleary, Michael L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-09-17
Volume: 455
Issue: 7217
Pages: 1205-1209
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07284
PMC: PMC4084721
OpenAlex: W1964632863
Cited by: 265
References: 43
Citations by year: 2026: 3 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 9 · 2021: 10 · 2020: 17 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 14 · 2015: 14 · 2014: 23 · 2013: 29 · 2012: 26
FWCI: 19.78
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: David and Lucile Packard Foundation
Lawrence Foundation
National Cancer Institute (CA 116606, R01CA116606, CA-55029, R01CA055029)
Topics: Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords: glycogen synthase kinase-3, p27, cyclin-dependent kinase inhibitors, GSK-3 inhibitors, oncogenic signaling, therapeutic target
MeSH terms: Proto-Oncogene Mas, Animals, Cell Division, Cell Line, Transformed, Cell Transformation, Neoplastic, Disease Models, Animal, Humans, Isoenzymes, Leukemia, Lymphoid, Mice, Inbred C57BL, Histone-Lysine N-Methyltransferase, G1 Phase, Mice, SCID, Myeloid Progenitor Cells, Glycogen Synthase Kinase 3, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Cell Proliferation, Cyclin-Dependent Kinase Inhibitor p27, Mice, Myeloid-Lymphoid Leukemia Protein, Precursor Cells, B-Lymphoid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks