p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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The 2007 WHO Classification of Tumours of the Central Nervous System

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

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An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

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Malignant astrocytic glioma: genetics, biology, and paths to treatment

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

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A Set of Cell Lines Derived from a Genetic Murine Glioblastoma Model Recapitulates Molecular and Morphological Characteristics of Human Tumors

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Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells

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Cancer cell-selective aggregation-induced emission probe for long-term plasma membrane imaging

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Metabolic Rewiring and Stemness: A Critical Attribute of Pancreatic Cancer Progression

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HOXDeRNA activates a cancerous transcription program and super enhancers via genome-wide binding

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Qualitative Network Modeling of the Myc-p53 Control System of Cell Proliferation and Differentiation

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Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells

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Plasmid-based target protectors allow specific blockade of miRNA silencing activity in mammalian developmental systems

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Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

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The Strange Case of Jekyll and Hyde: Parallels Between Neural Stem Cells and Glioblastoma-Initiating Cells

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p53-mediated regulation of neuronal differentiation via regulation of dual oxidase maturation factor 1

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Signals that regulate the oncogenic fate of neural stem cells and progenitors

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The role of glioma stem cells in glioma tumorigenesis

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Cancer Stem Cells in Pediatric Brain Tumors

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Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals

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Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas

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What underlies the diversity of brain tumors?

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Extended disease-free interval of 6 years in a recurrent glioblastoma multiforme patient treated with G207 oncolytic viral therapy

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Progenitor-like Traits Contribute to Patient Survival and Prognosis in Oligodendroglial Tumors

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Differentiation of Pancreatic Acinar Cells to Hepatocytes Requires an Intermediate Cell Type

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WIP-YAP/TAZ as A New Pro-Oncogenic Pathway in Glioma

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Activation of metabotropic glutamate receptor 4 regulates proliferation and neural differentiation in neural stem/progenitor cells of the rat subventricular zone and increases phosphatase and tensin homolog protein expression

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The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease

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Brain Tumor Stem Cells

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TRIAD1 inhibits MDM2‐mediated p53 ubiquitination and degradation

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Stem cells and lung cancer: future therapeutic targets?

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Branched-chain amino acid transaminase 1 regulates glioblastoma cell plasticity and contributes to immunosuppression

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Mouse Models of Experimental Glioblastoma

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Stem Cells in Brain Tumor Development

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RUNX 3 is down‐regulated in glioma by Myc‐regulated miR‐4295

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RGFP966, a histone deacetylase 3 inhibitor, promotes glioma stem cell differentiation by blocking TGF-β signaling via SMAD7

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Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy

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Pleiotrophin enhances PDGFB-induced gliomagenesis through increased proliferation of neural progenitor cells

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Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signalingPreprint

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CDYL knockdown reduces glioma development through an antitumor immune response in the tumor microenvironment

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Unravelling the mosaic: Epigenetic diversity in glioblastoma

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The impact of arsenic trioxide and all-trans retinoic acid on p53 R273H-codon mutant glioblastoma

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Revisit the Candidacy of Brain Cell Types as the Cell(s) of Origin for Human High-Grade Glioma

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Human tripartite motif protein 52 is required for cell context-dependent proliferation

Benke, S., Agerer, B., Haas, L., Stöger, M., Lercher, A., Gabler, L., Kiss, I., Scinicariello, S., Berger, W., Bergthaler, A., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24422 · Cited by 17

p53 Mutant p53N236S Induces Neural Tube Defects in Female Embryos

Zhao, J., Tian, Y., Zhang, H., Qu, L., Chen, Y., Liu, Q., Luo, Y., & Wu, X. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.31451 · Cited by 17

miR‐760 exerts an antioncogenic effect in esophageal squamous cell carcinoma by negatively driving fat metabolism via targeting c‐Myc

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Feasibility of Targeting Glioblastoma Stem Cells: From Concept to Clinical Trials

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Novel ablation methods for treatment of gliomas

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β1,4-Galactosyltransferase V regulates self-renewal of glioma-initiating cell

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The top cited articles on glioma stem cells in Web of Science.

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Cut the fat: targeting cholesterol and lipid metabolism in glioblastoma

Zekanovic, S., Sing, P. A., Leenstra, S., & Lamfers, M. L. M. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07993-3 · Cited by 16

Functional network analysis of gene-phenotype connectivity associated with temozolomide

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Asymmetric cell division: Implications for glioma development and treatment

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Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1

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Association of tumor growth rates with molecular biomarker status: a longitudinal study of high-grade glioma

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Transitioning pre-clinical glioblastoma models to clinical settings with biomarkers identified in 3D cell-based models: A systematic scoping review

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Ligand-independent androgen receptors promote ovarian teratocarcinoma cell growth by stimulating self-renewal of cancer stem/progenitor cells

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Cancer Stem Cells

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miR‑29 promotes the proliferation of cultured rat neural stem/progenitor cells via the PTEN/AKT signaling pathway

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Author Correction: Genetically engineered cerebral organoids model brain tumor formation

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Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases

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MiR-4310 induced by SP1 targets PTEN to promote glioma progression

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RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence

Regan, J. L., Schumacher, D., Staudte, S., Steffen, A., Lesche, R., Toedling, J., Jourdan, T., Haybaeck, J., Mumberg, D., Henderson, D. A., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102618 · Cited by 17

The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities

Zhuang, Q., Yang, H., & Mao, Y. Q. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00953-3 · Cited by 16

FOXG1 expression shows correlation with neuronal differentiation in cerebellar development, aggressive phenotype in medulloblastomas, and survival in a xenograft model of medulloblastoma

Adesina, A. M., Veo, B. L., Courteau, G. R., Mehta, V. P., Wu, X., Pang, K., Liu, Z., Li, X., & Peters, L. (2015) · Human Pathology · doi:10.1016/j.humpath.2015.08.003 · Cited by 15

P53 Promotes Retinoid Acid-induced Smooth Muscle Cell Differentiation by Targeting Myocardin

Tan, Z., Li, J., Zhang, X., Yang, X., Zhang, Z., Yin, K., & Huang, H. (2018) · Stem Cells and Development · doi:10.1089/scd.2017.0244 · Cited by 15

Genetic variants for head size share genes and pathways with cancer

Knol, M. J., Poot, R. A., Evans, T. E., Satizábal, C. L., Mishra, A., Sargurupremraj, M., der Auwera, S. V., Duperron, M., Jian, X., Hostettler, I. C., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101529 · Cited by 14

A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice

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Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells

Chen, X., Wang, W., Zhang, J., Li, S., Zhao, Y., Tan, L., & Luo, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.047 · Cited by 14

Xenopatients 2.0: Reprogramming the epigenetic landscapes of patient-derived cancer genomes

Menéndez, J. A., Alarcón, T., Corominas-Faja, B., Cuyàs, E., López‐Bonet, E., Martín, Á. G., & Vellón, L. (2014) · Cell Cycle · doi:10.4161/cc.27770 · Cited by 14

Cross Talk between Cellular Redox Status, Metabolism, and p53 in Neural Stem Cell Biology

Forsberg, K., & Giovanni, S. D. (2014) · The Neuroscientist · doi:10.1177/1073858413514634 · Cited by 14

Wip1 over‐expression correlated with TP53/p14ARF pathway disruption in human astrocytomas

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Basic Gene Expression Characteristics of Glioma Stem Cells and Human Glioblastoma

Sakamoto, D., Takagi, T., Fujita, M., Omura, S., Yoshida, Y., Iida, T., & Yoshimura, S. (2019) · Anticancer Research · doi:10.21873/anticanres.13153 · Cited by 14

Current understanding of gliomagenesis: from model to mechanism

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Bone marrow osteoblast vulnerability to chemotherapy

Gencheva, M., Hare, I., Kurian, S., Fortney, J. E., Piktel, D., Wysolmerski, R. B., & Gibson, L. F. (2013) · European Journal Of Haematology · doi:10.1111/ejh.12109 · Cited by 14

p53 Pathway Alterations in Brain Tumors

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The role of octamer binding transcription factors in glioblastoma multiforme

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Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner

Brumm, A. J., Nuñez, S., Doroudchi, M. M., Kawaguchi, R., Duan, J., Pellegrini, M. A., Lam, L., Carmichael, S. T., Deb, A., & Hinman, J. D. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9974-3 · Cited by 14

c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism

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Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells

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Connexin 43 drives glioblastoma cancer stem cell phenotypes through a WNK lysine-deficient protein kinase 1-c-MYC signaling axis

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Overexpression of HGF/MET axis along with p53 inhibition induces de novo glioma formation in mice

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Genome‐wide screening of aberrant DNA methylation which associated with gene expression in mouse skin cancers

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Generation of brain tumours by Cre-mediated recombination of neural progenitorsin situwith the tamoxifen metabolite endoxifen

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A simple and highly efficient method for multi‐allelic CRISPR‐Cas9 editing in primary cell cultures

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The SVZ and Its Relationship to Stem Cell Based Neuro-oncogenesis

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Helpers of the cellular gatekeeper—miRNAs dance in P53 network

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The Effect of Sodium Valproate on the Glioblastoma U87 Cell Line Tumor Development on the Chicken Embryo Chorioallantoic Membrane and on EZH2 and p53 Expression

Kavaliauskaitė, D., Stakišaitis, D., Martinkutė, J., Šlekienė, L., Kazlauskas, A., Balnytė, I., Lesauskaitė, V., & Valančiūtė, A. (2017) · BioMed Research International · doi:10.1155/2017/6326053 · Cited by 13

“Super p53” Mice Display Retinal Astroglial Changes

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Self-renewal mechanisms in neural cancer stem cells

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Novel approaches to combat chemoresistance against glioblastomas

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Anticancer effects of veratramine via the phosphatidylinositol-3-kinase/serine-threonine kinase/mechanistic target of rapamycin and its downstream signaling pathways in human glioblastoma cell lines

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The Ultrastructural Difference between CD133-positive U251 Glioma Stem Cells and Normal U251 Glioma Cells

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Phosphatase and tensin homolog deleted on chromosome 10 regulates sensory cell proliferation and differentiation of hair bundles in the mammalian cochlea

Dong, Y., Sui, L., Yamaguchi, F., Kamitori, K., Hirata, Y., Hossain, M. A., Suzuki, A., Holley, M. C., & Tokuda, M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.024 · Cited by 12

Overexpression of Transforming Acidic Coiled Coil‑Containing Protein 3 Reflects Malignant Characteristics and Poor Prognosis of Glioma

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TAp63γ Demethylation Regulates Protein Stability and Cellular Distribution during Neural Stem Cell Differentiation

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High Expression of Pirh2 is Associated with Poor Prognosis in Glioma

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Proteomic Profiling of β-hCG-Induced Spheres in BRCA1 Defective Triple Negative Breast Cancer Cells

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Molecular Action of Herbal Antioxidants in Regulation of Cancer Growth: Scope for Novel Anticancer Drugs

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Advances in Glioblastoma Diagnosis: Integrating Genetics, Noninvasive Sampling, and Advanced Imaging

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Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis

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Immune Profiling of Syngeneic Murine and Patient GBMs for Effective Translation of Immunotherapies

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Growth factor independence underpins a paroxysmal, aggressive Wnt5aHigh/EphA2Low phenotype in glioblastoma stem cells, conducive to experimental combinatorial therapy

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Pten and p53 Converge on c-Myc to Control Differentiation, Self-renewal, and Transformation of Normal and Neoplastic Stem Cells in GlioblastomaPreprint

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Stop acting so immature

Seton-Rogers, S. E. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2546

Inactivation of Pten cooperating with p53 loss induces malignant gliomas

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Pancreas and Biliary Tree

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Abstract 353: Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.

Kim, H. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-353