p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

The 2007 WHO Classification of Tumours of the Central Nervous System

Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0243-4 · Cited by 15,675

In silico prediction of protein-protein interactions in human macrophages

Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785

Significance analysis of microarrays applied to the ionizing radiation response

Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568

Erratum to: The 2007 WHO classification of tumours of the central nervous system

Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P. (2007) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-156115 · Cited by 4,435

Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.

Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

Clarke, M. F., Dick, J. E., Dirks, P. B., Eaves, C., Jamieson, C., Jones, D. L., Visvader, J., Weissman, I. L., & Wahl, G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3126 · Cited by 3,124

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

Ben‐Porath, I., Thomson, M., Carey, V. J., Ge, R., Bell, G. W., Regev, A., & Weinberg, R. A. (2008) · Nature Genetics · doi:10.1038/ng.127 · Cited by 2,571

Malignant astrocytic glioma: genetics, biology, and paths to treatment

Furnari, F. B., Fenton, T., Bachoo, R. M., Mukasa, A., Stommel, J. M., Stegh, A., Hahn, W. C., Ligon, K. L., Louis, D. N., Brennan, C., et al. (2007) · Genes & Development · doi:10.1101/gad.1596707 · Cited by 2,316

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,411

Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors

Hwang, I., Cao, D., Na, Y., Kim, D.-Y., Zhang, T., Yao, J., Oh, H., HU, J. L., Zheng, H., Yao, Y., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.013 · Cited by 38

Role and mechanism of neural stem cells of the subventricular zone in glioblastoma

Zhang, G., Wang, C., Qian, C., Ji, Y., & Wang, Y. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i7.877 · Cited by 39

Novel Perspectives on p53 Function in Neural Stem Cells and Brain Tumors

Hede, S., Nazarenko, I., Nistér, M., & Lindström, M. S. (2010) · Journal of Oncology · doi:10.1155/2011/852970 · Cited by 40

Sublethal dose of irradiation enhances invasion of malignant glioma cells through p53-MMP 2 pathway in U87MG mouse brain tumor model

Pei, J., Park, I.-H., Ryu, H., Li, S.-Y., Li, C., Lim, S.-H., Wen, M., Jang, W., & Jung, S. (2015) · Radiation Oncology · doi:10.1186/s13014-015-0475-8 · Cited by 37

The Impact of Hypoxia and Mesenchymal Transition on Glioblastoma Pathogenesis and Cancer Stem Cells Regulation

Karsy, M. J., Guan, J., Jensen, R. L., Huang, E. L., & Colman, H. (2015) · World Neurosurgery · doi:10.1016/j.wneu.2015.12.032 · Cited by 40

A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications

Fan, X., Xiong, Y., & Wang, Y. (2019) · Frontiers of Medicine · doi:10.1007/s11684-019-0700-1 · Cited by 37

The Subventricular Zone in Glioblastoma: Genesis, Maintenance, and Modeling

Beiriger, J., Habib, A., Jovanovich, N., Kodavali, C. V., Edwards, L., Amankulor, N., & Zinn, P. O. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.790976 · Cited by 38

The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy

Wang, G., Wang, J., Zhao, H., Wang, J., & To, S. S. T. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.07.005 · Cited by 38

Glioblastoma Multiforme Stem Cells

Dimov, I., Tasic-Dimov, D., Conić, I., & Stefanović, V. (2011) · The Scientific World JOURNAL · doi:10.1100/tsw.2011.42 · Cited by 38

p53-dependent pathways in neurite outgrowth and axonal regeneration

Giovanni, S. D., & Rathore, K. I. (2012) · Cell and Tissue Research · doi:10.1007/s00441-011-1292-5 · Cited by 37

Clustering methods applied in the detection of Ki67 hot‐spots in whole tumor slide images: An efficient way to characterize heterogeneous tissue‐based biomarkers

Lopez, X. M., Debeir, O., Maris, C., Rorive, S., Roland, I. H., Saerens, M., Salmon, I. J., & Decaestecker, C. (2012) · Cytometry Part A · doi:10.1002/cyto.a.22085 · Cited by 36

Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide

Schmid, R. S., Simon, J. M., Vitucci, M., McNeill, R. S., Bash, R., Werneke, A. M., Huey, L., White, K., Ewend, M. G., Wu, J., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/nov321 · Cited by 36

Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma

Marampon, F., Leoni, F., Mancini, A., Pietrantoni, I., Codenotti, S., Letizia, F., Megiorni, F., Porro, G., Galbiati, E., Pozzi, P., et al. (2018) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-018-2800-8 · Cited by 36

p300- and Myc-mediated regulation of glioblastoma multiforme cell differentiation

Panicker, S. P., Raychaudhuri, B., Sharma, P., Tipps, R. S., Mazumdar, T., Mal, A. K., Palomo, J. M., Vogelbaum, M. A., & Haque, S. J. (2010) · Oncotarget · doi:10.18632/oncotarget.139 · Cited by 36

Proteomic Analysis of Zika Virus Infected Primary Human Fetal Neural Progenitors Suggests a Role for Doublecortin in the Pathological Consequences of Infection in the Cortex

Jiang, X. J., Dong, X., Li, S., Zhou, Y., Rayner, S., Xia, H., Gao, G. F., Yuan, H., Tang, Y., & Luo, M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01067 · Cited by 35

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling

Xu, J., Du, Y.-L., Xu, J.-W., Hu, X., Gu, L.-F., Li, X., Hu, P.-H., Liao, T., Xia, Q.-Q., Sun, Q., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00518 · Cited by 35

Hemispherical Pediatric High-Grade Glioma: Molecular Basis and Therapeutic Opportunities

Haase, S., Núñez, F. M., Gauss, J. C., Thompson, S., Brumley, E. K., Lowenstein, P. R., & Castro, M. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249654 · Cited by 35

Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc

Kim, H. S., Woolard, K., Lai, C., Bauer, P. O., Maric, D., Song, H., Li, A., Kotliarova, S. E., Zhang, W., & Fine, H. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-2594 · Cited by 36

Modeling microRNA-Transcription Factor Networks in Cancer

Aguda, B. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1_9 · Cited by 34

Seeing is Believing: Are Cancer Stem Cells the Loch Ness Monster of Tumor Biology?

Lathia, J. D., Venere, M., Rao, M. S., & Rich, J. N. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9194-6 · Cited by 34

S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53

Yang, T., Cheng, J., Yang, Y., Qi, W., Zhao, Y., Long, H., Xie, R., & Zhu, B. (2016) · Stem Cells · doi:10.1002/stem.2472 · Cited by 34

Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons

Jauhari, A., Singh, T., & Yadav, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1009-9 · Cited by 24

Deficiency of STING Signaling in Embryonic Cerebral Cortex Leads to Neurogenic Abnormalities and Autistic‐Like Behaviors

Zhang, D., Liu, C., Li, H., & Jiao, J. (2020) · Advanced Science · doi:10.1002/advs.202002117 · Cited by 35

Cancer Association Study of Aminoacyl-tRNA Synthetase Signaling Network in Glioblastoma

Kim, Y., Kwon, C., Liu, J.-L., Kim, S. H., & Kim, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040960 · Cited by 34

Epigenetic setting and reprogramming for neural cell fate determination and differentiation

Imamura, T., Uesaka, M., & Nakashima, K. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0511 · Cited by 33

miR-19 targeting of PTEN mediates butyl benzyl phthalate-induced proliferation in both ER(+) and ER(−) breast cancer cells

Wu, J., Jiang, Y., Cao, W., Li, X., Xie, C., Geng, S., Zhu, M., Liang, Z., Zhu, J., Zhu, W., et al. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.05.040 · Cited by 33

p53 balances between tissue hierarchy and anarchy

Koifman, G., Aloni-Grinstein, R., & Rotter, V. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz022 · Cited by 33

Xanthohumol suppresses glioblastoma via modulation of Hexokinase 2 -mediated glycolysis

Yuan, J., Peng, G., Xiao, G., Yang, Z., Huang, J., Liu, Q., Yang, Z., & Liu, D. (2020) · Journal of Cancer · doi:10.7150/jca.33045 · Cited by 33

The Evolution of Tumor Microenvironment in Gliomas and Its Implication for Target Therapy

Hu, Y., Li, Z., Zhang, Y., Wu, Y. C., Liu, Z., Zeng, J., Hao, Z., Li, J., Ren, J., & Yao, M. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83531 · Cited by 37

Will Kinase Inhibitors Make it as Glioblastoma Drugs?

Mellinghoff, I. K., Schultz, N. D., Mischel, P. S., & Cloughesy, T. F. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_178 · Cited by 36

Nanog, Gli, and p53: a new network of stemness in development and cancer

Brandner, S. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.162 · Cited by 33

Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse

Nardella, C., Carracedo, A., Salmena, L., & Pandolfi, P. P. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_62 · Cited by 34

Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting

Balasubramaniyan, V., Vaillant, B. D., Wang, S., Gumin, J., Butalid, M. E., Sai, K., Mukheef, F., Kim, S. H., Boddeke, H. W. G. M., Lang, F. F., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5219 · Cited by 32

A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis

Wang, Q., Jia, S., Wang, D., Chen, X., Kalvakolanu, D. V., Zheng, H., Wei, X., Wen, N., Liang, H., Guo, B., et al. (2020) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0037 · Cited by 32

Genetic Abnormalities, Clonal Evolution, and Cancer Stem Cells of Brain Tumors

Testa, U., Castelli, G., & Pelosi, E. (2018) · Medical Sciences · doi:10.3390/medsci6040085 · Cited by 33

Pten Loss in Olig2 Expressing Neural Progenitor Cells and Oligodendrocytes Leads to Interneuron Dysplasia and Leukodystrophy

Maire, C. L., Ramkissoon, S. H., Hayashi, M., Haidar, S., Ramkissoon, L. A., DiTomaso, E., & Ligon, K. L. (2013) · Stem Cells · doi:10.1002/stem.1590 · Cited by 30

FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition

Firat, E., & Niedermann, G. (2016) · Oncotarget · doi:10.18632/oncotarget.10702 · Cited by 30

Differentiation Induces Dramatic Changes in miRNA Profile, Where Loss of Dicer Diverts Differentiating SH-SY5Y Cells Toward Senescence

Jauhari, A., Singh, T., Pandey, A., Singh, P., Singh, N., Srivastava, A. K., Pant, A. B., Parmar, D., & Yadav, S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0042-9 · Cited by 30

Bax Activation Blocks Self-Renewal and Induces Apoptosis of Human Glioblastoma Stem Cells

Daniele, S., Pietrobono, D., Costa, B., Giustiniano, M., Pietra, V. L., Giacomelli, C., Regina, G. L., Silvestri, R., Taliani, S., Trincavelli, M. L., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00023 · Cited by 31

p53 and its mutants on the slippery road from stemness to carcinogenesis

Molchadsky, A., & Rotter, V. (2017) · Carcinogenesis · doi:10.1093/carcin/bgw092 · Cited by 30

Multifunctional Hydroxyapatite Nanobelt Haystacks Integrated Neural Stem Cell Spheroid for Rapid Spinal Cord Injury Repair

Hao, M., Chen, L., He, J., Zhao, X., Xia, H., Chen, X., Yu, L., Qiu, J., Feng, S., Sang, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214869 · Cited by 29

Dual Pten/Tp53 Suppression Promotes Sarcoma Progression by Activating Notch Signaling

Guijarro, M. V., Dahiya, S. M., Danielson, L. S., Segura, M. F., Vales-Lara, F. M., Menéndez, S., Popiolek, D. A., Mittal, K., Wei, J., Zavadil, J., et al. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.02.035 · Cited by 29

HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss

Shin, C., Robinson, J. P., Sonnen, J. A., Welker, A., Yu, D., VanBrocklin, M. W., & Holmen, S. L. (2017) · Oncogene · doi:10.1038/onc.2017.83 · Cited by 29

Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades

Li, N., Zhang, Y., Šidlauskas, K., Ellis, M. J., Evans, I. M., Frankel, P., Lau, J., El-Hassan, T., Guglielmi, L., Broni, J., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0277-1 · Cited by 30

The necessity for standardization of glioma stem cell culture: a systematic review

Zhang, L., Yu, H., Yuan, Y., Yu, J. S., Lou, Z., Xue, Y., & Liu, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01589-8 · Cited by 29

The potential origin of glioblastoma initiating cells

David, A. C. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/261 · Cited by 29

Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models

Yang, Y., Lee, J. H., Shu, L., Zhang, C., Su, Z., Lu, Y.-P., Huang, M., Ramirez, C. N., Pung, D., Huang, Y. S., et al. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.07.031 · Cited by 29

NKX2.2 Suppresses Self-Renewal of Glioma-Initiating Cells

Muraguchi, T., Tanaka, S., Yamada, D., Tamase, A., Nakada, M., Nakamura, H., Hoshii, T., Ooshio, T., Tadokoro, Y., Naka, K., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2304 · Cited by 30

Glioblastoma Stem Cells: A Neuropathologist's View

McLendon, R. E., & Rich, J. N. (2010) · Journal of Oncology · doi:10.1155/2011/397195 · Cited by 29

Gatekeeper Between Quiescence and Differentiation

Quadrato, G., & Giovanni, S. D. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-398309-1.00005-6 · Cited by 28

A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity

Riddick, G., Kotliarova, S. E., Rodriguez, V., Kim, H., Linkous, A. G., Storaska, A. J., Ahn, S. J., Walling, J., Belova, G. I., & Fine, H. A. (2017) · Scientific Reports · doi:10.1038/srep43605 · Cited by 28

Matricellular protein tenascin C: Implications in glioma progression, gliomagenesis, and treatment

Fu, Z., Zhu, G., Luo, C., Chen, Z., Dou, Z., Chen, Y., Chen, Z., Su, S., & Liu, F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.971462 · Cited by 29

Immunological considerations of modern animal models of malignant primary brain tumors

Sughrue, M. E., Yang, I., Kane, A. J., Rutkowski, M. J., Fang, S., James, C. D., & Parsa, A. T. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-84 · Cited by 28

Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis

Şengelen, A., & Uçar, E. Ö. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156060 · Cited by 27

HMGA2 sustains self-renewal and invasiveness of glioma-initiating cells

Zhong, X., Liu, X., Li, Y., Cheng, M., Wang, W., Tian, K., Mu, L., Zeng, T., Liu, Y., Jiang, X., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9744 · Cited by 27

Synthesis, in vitro and structural aspects of cap substituted Suberoylanilide hydroxamic acid analogs as potential inducers of apoptosis in Glioblastoma cancer cells via HDAC /microRNA regulation

Ramaiah, M. J., Ramalingam, P. S., Mathavan, S., Yamajala, R. B. R. D., Moparthi, N. R., Kurappalli, R. K., & Manyam, R. R. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109876 · Cited by 27

Pre-clinical models for evaluating glioma targeted immunotherapies

Frederico, S. C., Zhang, X., Hu, B., & Kohanbash, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1092399 · Cited by 27

Dissecting Intra-tumor Heterogeneity in the Glioblastoma Microenvironment Using Fluorescence-Guided Multiple Sampling

García‐Montaño, L. A., Licón-Muñoz, Y., Martinez, F. J., Keddari, Y. R., Ziemke, M. K., Chohan, M. O., & Piccirillo, S. G. M. (2023) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-23-0048 · Cited by 27

The dosage of Patz1 modulates reprogramming process

Ma, H., Ow, J. R., Tan, B. C. P., Goh, Z., Feng, B., Loh, Y., Fedele, M., Li, H., & Wu, Q. (2014) · Scientific Reports · doi:10.1038/srep07519 · Cited by 27

From Birth Till Death: Neurogenesis, Cell Cycle, and Neurodegeneration

Demir, O., Singh, S. K., Klimaschewski, L. P., & Kurnaz, I. A. (2009) · The Anatomical Record · doi:10.1002/ar.20980 · Cited by 27

The A2Aadenosine receptor rescues neuritogenesis impaired by p53 blockage via KIF2A, a kinesin family member

Sun, C., Chuang, H., Wang, J., Chen, S.-S., Cheng, Y., Lee, C.-F., & Chern, Y. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20802 · Cited by 27

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration

Frattini, V., Pisati, F., Speranza, M. C., Poliani, P. L., Frigè, G., Cantini, G., Kapetis, D., Cominelli, M., Rossi, A., Finocchiaro, G., et al. (2012) · Oncotarget · doi:10.18632/oncotarget.644 · Cited by 27

Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

Xie, S.-Z., Ni, J., McFaline-Figueroa, J., Wang, Y., Bronson, R., Ligon, K., Wen, P., Roberts, T., & Zhao, J. J. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108196 · Cited by 24

The adaptive significance of adult neurogenesis: an integrative approach

Konefal, S., Elliot, M., & Crespi, B. J. (2013) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2013.00021 · Cited by 29

QKI deficiency maintains glioma stem cell stemness by activating the SHH/GLI1 signaling pathway

Han, B. R., Wang, R., Chen, Y., Meng, X., Wu, P., Li, Z., Duan, C., Li, Q., Li, Y., Zhao, S., et al. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00463-x · Cited by 26

To Become or Not to Become Tumorigenic: Subventricular Zone Versus Hippocampal Neural Stem Cells

Fontán‐Lozano, Á., Morcuende, S., de Carrizosa, M. A. D., Benítez‐Temiño, B., Mejı́as, R., & Matarredona, E. R. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.602217 · Cited by 28

Regional Development of Glioblastoma: The Anatomical Conundrum of Cancer Biology and Its Surgical Implication

Luca, C. D., Virtuoso, A., Papa, M., Certo, F., Barbagallo, G. M. V., & Altieri, R. (2022) · Cells · doi:10.3390/cells11081349 · Cited by 27

RSL3 triggers glioma stem cell differentiation via the Tgm2/AKT/ID1 signaling axis

Li, M., Song, D. E., Chen, X., Wang, X., Xu, L., Yang, M., Yang, J., Kalvakolanu, D. V., Wei, X., Liu, X., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166529 · Cited by 26

Epigenetic Regulation of Survivin by Bmi1 Is Cell Type Specific During Corticogenesis and in Gliomas

Acquati, S., Greco, A., Licastro, D., Bhagat, H., Ceric, D., Rossini, Z., Grieve, J., Shaked-Rabi, M., Henriquez, N. V., Brandner, S., et al. (2012) · Stem Cells · doi:10.1002/stem.1274 · Cited by 27

Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells

Lin, Y., Murayama, Y., Hashimoto, K., Nakamura, Y., Lin, C.-S., Yokoyama, K. K., & Saito, S. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt447 · Cited by 27

microRNA-200a silencing protects neural stem cells against cerebral ischemia/reperfusion injury

Ma, J., Shui, S., Han, X., Guo, D., Li, T., & Lei, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172178 · Cited by 26

MiR-212-3p improves rat functional recovery and inhibits neurocyte apoptosis in spinal cord injury models via PTEN downregulation-mediated activation of AKT/mTOR pathway

Guan, C., Luan, L., Li, J., & Yang, L. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147576 · Cited by 26

A comprehensive overview on the molecular biology of human glioma: what the clinician needs to know

López, P. D. D., Saiz-López, P., Gargini, R., Sola-Vendrell, E., & Tejada, S. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02340-8 · Cited by 26

MCT-1 expression and PTEN deficiency synergistically promote neoplastic multinucleation through the Src/p190B signaling activation

Wu, M., Chen, Y., Chen, H.-H., Chang, K.-W., Chang, I.-S., Wang, L., & Hsu, H. L. (2014) · Oncogene · doi:10.1038/onc.2014.125 · Cited by 25

Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma

Yamaki, T., Suenaga, Y., Iuchi, T., Alagu, J., Takatori, A., Itami, M., Araki, A., Ohira, M., Inoue, M., Kageyama, H., et al. (2013) · Scientific Reports · doi:10.1038/srep01160 · Cited by 25

Absence of IDH1-R132H mutation predicts rapid progression of nonenhancing diffuse glioma in older adults

Olar, A., Raghunathan, A., Albarracin, C. T., Aldape, K., Cahill, D. P., Powell, S. Z.-E., Goodman, J. C., & Fuller, G. N. (2011) · Annals of Diagnostic Pathology · doi:10.1016/j.anndiagpath.2011.08.010 · Cited by 25

Generation of Induced Pluripotent Stem Cells from Somatic Cells

Sohn, Y.-D., Han, J. W., & Yoon, Y. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398459-3.00001-0 · Cited by 25

Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme

Yu, Q., Takahashi, M., Sheets, K. G., Soto, H., Tsui, J. L., Pelargos, P. E., Antonios, J. P., Kasahara, N., Yang, I., Prins, R. M., et al. (2017) · Journal of Neuro-Oncology · doi:10.1007/s11060-017-2507-8 · Cited by 25

Foxr2 promotes formation of CNS-embryonal tumors in a Trp53-deficient background

Poh, B. M., Koso, H., Momota, H., Komori, T., Suzuki, Y., Yoshida, N., Ino, Y., Todo, T., & Watanabe, S. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz067 · Cited by 26

Genetic changes in the PTEN gene and their association with breast cancer in Pakistan.

Baig, R. M., Mahjabeen, I., Sabir, M., Masood, N., Hafeez, S., Malik, F. A., & Kayani, M. A. (2011) · PubMed · Cited by 25

Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

Long, P. M., Tighe, S. W., Driscoll, H. E., Moffett, J. R., Namboodiri, A. M. A., Viapiano, M. S., Lawler, S. E., & Jaworski, D. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080714 · Cited by 25

CCNA2 and NEK2 regulate glioblastoma progression by targeting the cell cycle

Zhou, H.-Y., Wang, Y., Wang, T., Wu, W., Cao, Y., Zhang, B.-C., Wang, M., & Mao, P. (2024) · Oncology Letters · doi:10.3892/ol.2024.14339 · Cited by 25

DiME: A Scalable Disease Module Identification Algorithm with Application to Glioma Progression

Liu, Y., Tennant, D. A., Zhu, Z., Heath, J. K., Yao, X., & He, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086693 · Cited by 24

Neural Stem Cells Adopt Tumorigenic Properties by Constitutively Activated NF-κB and Subsequent VEGF Up-Regulation

Kaus, A., Widera, D., Kassmer, S. H., Peter, J. O., Zaenker, K. S., Kaltschmidt, C., & Kaltschmidt, B. (2010) · Stem Cells and Development · doi:10.1089/scd.2009.0416 · Cited by 24

Essential Gene Pathways for Glioblastoma Stem Cells: Clinical Implications for Prevention of Tumor Recurrence

Yamada, K., Tso, J. L., Ye, F., Choe, J., Liu, Y., Liau, L. M., & Tso, C.-L. (2011) · Cancers · doi:10.3390/cancers3021975 · Cited by 24

Role of MEK partner-1 in cancer stemness through MEK/ERK pathway in cancerous neural stem cells, expressing EGFRviii

Kwon, S.-J., Kwon, O., Kim, K.-T., Go, Y.-H., Yu, S.-I., Lee, B., Miyoshi, H., Oh, E., Cho, S.-J., & Cha, H. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0703-y · Cited by 24

Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance

Liu, B., Zhang, G., Cui, S., & Du, G. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-01038-3 · Cited by 24

Taxifolin inhibits melanoma proliferation/migration impeding USP18/Rac1/JNK/β-catenin oncogenic signaling

Xu, L., Zhang, L., Zhang, S., Yang, J., Zhu, A., Sun, J., Kalvakolanu, D. V., Cong, X., Zhang, J., Tang, J., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155199 · Cited by 24

Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme

Mencke, P., Hanss, Z., Boussaad, I., Sugier, P., Elbaz, A., & Krüger, R. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00898 · Cited by 25

Is there a CDKN2A-centric network in pancreatic ductal adenocarcinoma?

Wu, C. L., Yang, P., Liu, B., & Tang, Y. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s232464 · Cited by 29

Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss–Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities

Verma, R., Chen, X., Xin, D. E., Luo, Z., Ogurek, S., Xin, M., Rao, R., Berry, K., & Lu, Q. R. (2023) · Cancer Research · doi:10.1158/0008-5472.can-22-1577 · Cited by 23

Insights gained from modelling high‐grade glioma in the mouse

Rankin, S. L., Zhu, G., & Baker, S. J. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2011.01231.x · Cited by 23

In Vivo Modeling of Malignant Glioma

Kegelman, T. P., Hu, B., Emdad, L., Das, S. K., Sarkar, D., & Fisher, P. B. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00007-x · Cited by 23

Molecular, histopathological, and genomic variants of glioblastoma

Karsy, M. J. (2014) · Frontiers in bioscience · doi:10.2741/4268 · Cited by 23

Cancer Stem Cells and the Biology of Brain Tumors

Flores, D. G., Ledur, P. F., Abujamra, A. L., Brunetto, A. L., Schwartsmann, G., Lenz, G., & Roesler, R. (2009) · Current Stem Cell Research & Therapy · doi:10.2174/157488809789649214 · Cited by 23

Temozolomide inhibits cellular growth and motility via targeting ERK signaling in glioma C6 cells

Wang, Y., Gao, S., Wang, W., & Liang, J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5964 · Cited by 23

Differential pro-apoptotic effects of synthetic 4-thiazolidinone derivative Les-3288, doxorubicin and temozolomide in human glioma U251 cells

Коbylinska, L. I., Klyuchivska, O., Grytsyna, I. I., Finiuk, N. S., Panchuk, R. R., Starykovych, M. O., Lehka, L., Lesyk, R., Zimenkovsky, B. S., & Stoika, R. S. (2017) · Croatian Medical Journal · doi:10.3325/cmj.2017.58.150 · Cited by 23

Insufficient Apaf-1 expression in early stages of neural differentiation of human embryonic stem cells might protect them from apoptosis

Karimzadeh, S., Hosseinkhani, S., Fathi, A., Ataei, F., & Baharvand, H. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.01.005 · Cited by 22

Design of carbon and graphene quantum dots based nanotheranostics applications for glioblastoma management: Recent advanced and future prospects

Nangare, S., Chandankar, S., & Patil, P. O. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105060 · Cited by 22

Pten and p53 Converge on c-Myc to Control Differentiation, Self-renewal, and Transformation of Normal and Neoplastic Stem Cells in GlioblastomaPreprint

Zheng, H., Ying, H., Yan, H., Kimmelman, A. C., Hiller, D. J., Chen, A.-J., Perry, S. R., Tonon, G., Chu, G. C., Ding, Z., et al. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.047 · Cited by 122

Stop acting so immature

Seton-Rogers, S. E. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2546

Inactivation of Pten cooperating with p53 loss induces malignant gliomas

Zheng, H., Ying, H., Kimmelman, A. C., Yang, H., Chen, A.-J., Perry, S. R., Chu, G. C., Ding, J., Ligon, K. L., Wiedemeyer, R., et al. (2008) · Cancer Research

Pancreas and Biliary Tree

(2016) · Modern Pathology · doi:10.1038/modpathol.2016.19 · Cited by 3

Abstract 353: Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.

Kim, H. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-353