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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
Open accessAbstract
Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.
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“The ability of TERT to enhance Wnt signaling explains how TERT activates bulge stem cells since overexpression of b-catenin in mouse skin causes a very similar stem cell-activation phenotype (150-152).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [151]
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Metadata
- Authors
- Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K.
- Affiliations
- National Cancer Center Research Institute (JP)
- RIKEN (JP)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Hahn, William C.
- Masutomi, Kenkichi
- ORCID
- Venue
- Nature
- Published
- 2009-08-23
- Volume
- 461
- Issue
- 7261
- Pages
- 230-235
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2755635
- OpenAlex
- W2058499120
- Cited by
- 384
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 16 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 19 · 2019: 25 · 2018: 15 · 2017: 18 · 2016: 27 · 2015: 26 · 2014: 30 · 2013: 40 · 2012: 32
- FWCI
- 23.71
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-01-28)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health
- Japan Society for the Promotion of Science (19791141, 19689010)
- National Institute on Aging (R01AG023145, R01 AG23145)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- telomerase reverse transcriptase, RMRP, RNA-dependent RNA polymerase, telomerase, cartilage-hair hypoplasia, ribonucleoprotein complexes, siRNA, Dicer, double-stranded RNA, telomere homeostasis
- MeSH terms
- Cell Line, Endoribonucleases, Gene Expression Regulation, HeLa Cells, Humans, Protein Binding, Ribonucleoproteins, RNA-Dependent RNA Polymerase, RNA, Double-Stranded, Telomerase, RNA, Untranslated, RNA, Small Interfering, Ribonuclease III, RNA, Long Noncoding
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