The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
Open accessAbstract
Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The ability of TERT to enhance Wnt signaling explains how TERT activates bulge stem cells since overexpression of b-catenin in mouse skin causes a very similar stem cell-activation phenotype (150-152).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [151]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Self-citationTelomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A. A., Li, C., Seitz, H., Gvozdev, V. A., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,385
On the Role of RNA Amplification in dsRNA-Triggered Gene Silencing
Sijen, T., Fleenor, J., Simmer, F., Thijssen, K. L., Parrish, S., Timmons, L., Plasterk, R. H. A., & Fire, A. Z. (2001) · Cell · doi:10.1016/s0092-8674(01)00576-1 · Cited by 1,287
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
Watanabe, T., Totoki, Y., Toyoda, A., Kaneda, M., Kuramochi‐Miyagawa, S., Obata, Y., Chiba, H., Kohara, Y., Kono, T., Nakano, T., et al. (2008) · Nature · doi:10.1038/nature06908 · Cited by 1,147
Mourrain, P., Béclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J., Jouette, D., Lacombe, A.-M., Nikic, S., Picault, N., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)80863-6 · Cited by 1,098
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
Tam, O. H., Aravin, A. A., Stein, P., Girard, A., Murchison, E. P., Cheloufi, S., Hodges, E. C., Anger, M., Sachidanandam, R., Schultz, R. M., et al. (2008) · Nature · doi:10.1038/nature06904 · Cited by 1,042
Inhibition of telomerase limits the growth of human cancer cells
Hahn, W. C., Stewart, S. A., Brooks, M. W., York, S. G., Eaton, E. N., Kurachi, A. L., Beijersbergen, R. L., Knoll, J. H. M., Meyerson, M. M., & Weinberg, R. A. (1999) · Nature Medicine · doi:10.1038/13495 · Cited by 1,038
Self-citationWeinrich, S. L., Pruzan, R., Ma, L., Ouellette, M. M., Tesmer, V. M., Holt, S. E., Bodnar, A. G., Lichtsteiner, S., Kim, N. W., Trager, J. B., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-498 · Cited by 975
Babiarz, J., Ruby, J. G., Wang, Y., Bartel, D. P., & Blelloch, R. H. (2008) · Genes & Development · doi:10.1101/gad.1705308 · Cited by 964
Telomerase maintains telomere structure in normal human cells
Kenichi, M., Yu, E. Y., Shilagardi, K., Ben‐Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Seishi, M., DeCaprio, J. A., et al. (2006) · Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) · Cited by 738
Self-citationIdentification and properties of the RNA‐dependent RNA polymerase of hepatitis C virus.
Behrens, S., Tomei, L., & Francesco, R. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00329.x · Cited by 699
Protein Composition of Catalytically Active Human Telomerase from Immortal Cells
Cohen, S. B., Graham, M. E., Lovrecz, G. O., Bache, N., Robinson, P. J., & Reddel, R. R. (2007) · Science · doi:10.1126/science.1138596 · Cited by 669
Smardon, A. M., Spoerke, J. M., Stacey, S. C., Klein, M. E., Mackin, N. A., & Maine, E. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00323-7 · Cited by 545
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522
Ridanpää, M., van Eenennaam, H., Pelin, K., Chadwick, R. B., Johnson, C. K. H., Yuan, B., vanVenrooij, W. J., Pruijn, G. J. M., Salmela, R., Rockas, S., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00205-7 · Cited by 511
Evidence that siRNAs Function as Guides, Not Primers, in the Drosophila and Human RNAi Pathways
Schwarz, D. S., Hutvágner, G., Haley, B., & Zamore, P. D. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00651-2 · Cited by 478
Function and synthesis of small nucleolar RNAs
Tollervey, D. W., & Kiss, T. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80005-1 · Cited by 467
Molecular Biology Of Picornaviruses
Semler, B. L., & Wimmer, E. (2002) · Cited by 452
Conditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425
Yang, N., & Kazazian, H. H. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1141 · Cited by 420
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
Masutomi, K., Possemato, R., Wong, J. M. Y., Currier, J. L., Tóthová, Z., Manola, J. B., Ganesan, S., Lansdorp, P. M., Collins, K., & Hahn, W. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503095102 · Cited by 383
Self-citationRNAi as Random Degradative PCR
Lipardi, C., Qin, W., & Paterson, B. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00537-2 · Cited by 373
González‐Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martín‐Caballero, J., Jorcano, J. L., & Blasco, M. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2619 · Cited by 372
Choi, J., Southworth, L. K., Sarin, K. Y., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M. K., Shah, N., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040010 · Cited by 336
Venteicher, A. S., Meng, Z., Mason, P. J., Veenstra, T. D., & Artandi, S. E. (2008) · Cell · doi:10.1016/j.cell.2008.01.019 · Cited by 329
Constitutive telomerase expression promotes mammary carcinomas in aging mice
Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112515399 · Cited by 317
New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin
Chan, S. W.-L., & Blackburn, E. H. (2002) · Oncogene · doi:10.1038/sj.onc.1205082 · Cited by 307
Sugiyama, T., Cam, H. P., Verdel, A., Moazed, D., & Grewal, S. I. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407641102 · Cited by 298
Structure of the Tribolium castaneum telomerase catalytic subunit TERT
Gillis, A., Schuller, A. P., & Skordalakes, E. (2008) · Nature · doi:10.1038/nature07283 · Cited by 288
RNA silencing and genome regulation
Almeida, R., & Allshire, R. C. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.03.006 · Cited by 271
The RNA-Induced Silencing Complex Is a Mg2+-Dependent Endonuclease
Schwarz, D. S., Tomari, Y., & Zamore, P. D. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.008 · Cited by 268
Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing
Azuma-Mukai, A., Oguri, H., Mitsuyama, T., Qian, Z. R., Asai, K., Siomi, H., & Siomi, M. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800334105 · Cited by 259
Yamashita, T., Kaneko, S., Shirota, Y., Qin, W., Nomura, T., KOBAYASHI, K. P., & Murakami, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15479 · Cited by 241
In vitro analyses of the production and activity of secondary small interfering RNAs in C. elegans
Aoki, K., Moriguchi, H., Yoshioka, T., Okawa, K., & Tabara, H. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601910 · Cited by 236
Fu, D., & Collins, K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.023 · Cited by 236
Telomere maintenance and human bone marrow failure
Calado, R. T., & Young, N. S. (2008) · Blood · doi:10.1182/blood-2007-08-019729 · Cited by 227
Smardon, A. M., Spoerke, J. M., Stacey, S. C., Klein, M. E., Mackin, N. A., & Maine, E. M. (2000) · Current Biology · Cited by 220
Makeyev, E. V., & Bamford, D. H. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00780-3 · Cited by 191
Characterization of endogenous human argonautes and their miRNA partners in RNA silencing
向井, あ., & 東, あ. (2008) · Medical Entomology and Zoology · Cited by 179
Nishikura, K. (2001) · Cell · doi:10.1016/s0092-8674(01)00581-5 · Cited by 174
Ribosomes and marrow failure: coincidental association or molecular paradigm?
Liu, J. M., & Ellis, S. R. (2006) · Blood · doi:10.1182/blood-2005-12-4831 · Cited by 159
TERT promotes cellular and organismal survival independently of telomerase activity
Lee, J., Sung, Y. H., Cheong, C., Choi, Y. S., Jeon, H. K., Sun, W., Hahn, W. C., Ishikawa, F., & Lee, H.-W. (2008) · Oncogene · doi:10.1038/sj.onc.1211037 · Cited by 145
Self-citationMoriarty, T. J., Huard, S., Dupuis, S., & Autexier, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1253-1265.2002 · Cited by 112
Telomerase Can Inhibit the Recombination-based Pathway of Telomere Maintenance in Human Cells
Ford, L. P., Zou, Y. S., Pongracz, K., Gryaznov, S. M., Shay, J. W., & Wright, W. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104469200 · Cited by 92
The Structure of an RNAi Polymerase Links RNA Silencing and Transcription
Salgado, P. S., Koivunen, M. R. L., Makeyev, E. V., Bamford, D. H., Stuart, D. I., & Grimes, J. M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040434 · Cited by 92
Telomerase Maintains Telomere Structure in Normal Human Cells
Masutomi, K., Yu, E. Y., Khurts, S., Ben-Porath, I., Currier, J. L., Metz, G. B., Brooks, M. W., Kaneko, S., Murakami, S., DeCaprio, J. A., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00550-6 · Cited by 70
Self-citationMolecular Biology of Picornavirus
(2002) · doi:10.1128/9781555817916 · Cited by 70
Telomerase can act as a template- and RNA-independent terminal transferase
Lue, N. F., Bosoy, D., Moriarty, T. J., Autexier, C., Altman, B. J., & Leng, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502252102 · Cited by 48
Won, J., Chang, S., Oh, S., & Kim, T. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401801101 · Cited by 44
Bone marrow transplantation for cartilage-hair-hypoplasia
Guggenheim, R., Somech, R., Grunebaum, E., Atkinson, A. R., & Roifman, C. M. (2006) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705520 · Cited by 39
Tumor Cells Fail to trans -Induce Telomerase in Human Umbilical Vein Endothelial Cell Cultures
Pascale, E., Reale, G. C., & D’Ambrosio, E. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1711 · Cited by 1
Flagged first, then by citations
Cited by
Sorted by citations
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Pan-cancer patterns of somatic copy number alteration
Zack, T. I., Schumacher, S. E., Carter, S. L., Cherniack, A. D., Saksena, G., Tabak, B., Lawrence, M. S., Zhang, C., Wala, J. A., Mermel, C. H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2760 · Cited by 1,893
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Long non-coding RNAs: A new frontier in the study of human diseases
Shi, X., Sun, M., Liu, H., Yao, Y., & Song, Y. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.06.013 · Cited by 1,156
Long non-coding RNAs and cancer: a new frontier of translational research?
Spizzo, R., Almeida, M. I., Colombatti, A., & Călin, G. A. (2012) · Oncogene · doi:10.1038/onc.2011.621 · Cited by 1,004
Metadata
- Authors
- Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K.
- Affiliations
- National Cancer Center Research Institute (JP)
- RIKEN (JP)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Hahn, William C.
- Masutomi, Kenkichi
- ORCID
- Venue
- Nature
- Published
- 2009-08-23
- Volume
- 461
- Issue
- 7261
- Pages
- 230-235
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2755635
- OpenAlex
- W2058499120
- Cited by
- 384
- References
- 53
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 16 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 19 · 2019: 25 · 2018: 15 · 2017: 18 · 2016: 27 · 2015: 26 · 2014: 30 · 2013: 40 · 2012: 32
- FWCI
- 23.71
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-01-28)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Uehara Memorial Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- National Institutes of Health
- Japan Society for the Promotion of Science (19791141, 19689010)
- National Institute on Aging (R01AG023145, R01 AG23145)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- telomerase reverse transcriptase, RMRP, RNA-dependent RNA polymerase, telomerase, cartilage-hair hypoplasia, ribonucleoprotein complexes, siRNA, Dicer, double-stranded RNA, telomere homeostasis
- MeSH terms
- Cell Line, Endoribonucleases, Gene Expression Regulation, HeLa Cells, Humans, Protein Binding, Ribonucleoproteins, RNA-Dependent RNA Polymerase, RNA, Double-Stranded, Telomerase, RNA, Untranslated, RNA, Small Interfering, Ribonuclease III, RNA, Long Noncoding
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
