Cited by 384Telomeres, Telomerase, and SenescenceRNA Interference and Gene DeliveryRNA Research and Splicing

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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

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Maida, Yoshiko, Yasukawa, Mami, Furuuchi, Miho, Lassmann, Timo, Possemato, Richard, Okamoto, Naoko, Kasim, Vivi, Hayashizaki, Yoshihide, Hahn, William C., Masutomi, Kenkichi·2009·Nature

DOI 10.1038/nature08283PMC PMC2755635

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Abstract

Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.

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Authors: Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K.
Affiliations: National Cancer Center Research Institute (JP)
RIKEN (JP)
Brigham and Women's Hospital (US)
Broad Institute (US)
Japan Science and Technology Agency (JP)
Corresponding author: Hahn, William C.
Masutomi, Kenkichi
ORCID: Yasukawa, Mami
Lassmann, Timo
Possemato, Richard
Kasim, Vivi
Hayashizaki, Yoshihide
Hahn, William C.
Masutomi, Kenkichi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-08-23
Volume: 461
Issue: 7261
Pages: 230-235
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08283
PMC: PMC2755635
OpenAlex: W2058499120
Cited by: 384
References: 53
Citations by year: 2026: 8 · 2025: 8 · 2024: 16 · 2023: 10 · 2022: 14 · 2021: 21 · 2020: 19 · 2019: 25 · 2018: 15 · 2017: 18 · 2016: 27 · 2015: 26 · 2014: 30 · 2013: 40 · 2012: 32
FWCI: 23.71
Type: journal article
Language: en
Update notices: correction (2025-01-28)
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Uehara Memorial Foundation
Ministry of Education, Culture, Sports, Science and Technology
National Institutes of Health
Japan Society for the Promotion of Science (19791141, 19689010)
National Institute on Aging (R01AG023145, R01 AG23145)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: telomerase reverse transcriptase, RMRP, RNA-dependent RNA polymerase, telomerase, cartilage-hair hypoplasia, ribonucleoprotein complexes, siRNA, Dicer, double-stranded RNA, telomere homeostasis
MeSH terms: Cell Line, Endoribonucleases, Gene Expression Regulation, HeLa Cells, Humans, Protein Binding, Ribonucleoproteins, RNA-Dependent RNA Polymerase, RNA, Double-Stranded, Telomerase, RNA, Untranslated, RNA, Small Interfering, Ribonuclease III, RNA, Long Noncoding

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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

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