Cited by 1,115Pluripotent Stem Cells ResearchDevelopmental Biology and Gene RegulationCancer-related Molecular Pathways

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Open access

Kawamura, Teruhisa, Suzuki, Jotaro, Wang, Yunyuan V., Menendez, Sergio, Morera, Laura Batlle, Raya, Angel, Wahl, Geoffrey M., Belmonte, Juan Carlos Izpisúa·2009·Nature

DOI 10.1038/nature08311PMC PMC2735889

Open this paper in CoChat — free account

Abstract

Reprogramming somatic cells to induced pluripotent stem (iPS) cells has been accomplished by expressing pluripotency factors and oncogenes, but the low frequency and tendency to induce malignant transformation compromise the clinical utility of this powerful approach. We address both issues by investigating the mechanisms limiting reprogramming efficiency in somatic cells. Here we show that reprogramming factors can activate the p53 (also known as Trp53 in mice, TP53 in humans) pathway. Reducing signalling to p53 by expressing a mutated version of one of its negative regulators, by deleting or knocking down p53 or its target gene, p21 (also known as Cdkn1a), or by antagonizing reprogramming-induced apoptosis in mouse fibroblasts increases reprogramming efficiency. Notably, decreasing p53 protein levels enabled fibroblasts to give rise to iPS cells capable of generating germline-transmitting chimaeric mice using only Oct4 (also known as Pou5f1) and Sox2. Furthermore, silencing of p53 significantly increased the reprogramming efficiency of human somatic cells. These results provide insights into reprogramming mechanisms and suggest new routes to more efficient reprogramming while minimizing the use of oncogenes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature08311

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Generation of germline-competent induced pluripotent stem cells
Okita, K., Ichisaka, T., & Yamanaka, S. (2007) · Nature · doi:10.1038/nature05934 · Cited by 4,438
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Reprogramming of human somatic cells to pluripotency with defined factors
Park, I.-H., Zhao, R., West, J. A., Yabuuchi, A., Huo, H., Ince, T. A., Lerou, P. H., Lensch, M. W., & Daley, G. Q. (2008) · Nature · doi:10.1038/nature06534 · Cited by 2,436
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N., & Yamanaka, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1374 · Cited by 2,380
Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins
Kim, D., Kim, C.-H., Moon, J.-I., Chung, Y.-G., Chang, M.-Y., Han, B.-S., Ko, S., Yang, E., Cha, K. Y., Lanza, R., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.005 · Cited by 1,814
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
Zhang, Y., Xiong, Y., & Yarbrough, W. G. (1998) · Cell · doi:10.1016/s0092-8674(00)81401-4 · Cited by 1,626

Flagged first, then by citations

Show all 40 references

Sorted by citations

Items 201–300 of 1,000

Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming
Malik, V., Zimmer, D., & Jauch, R. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2748-5 · Cited by 98
Induced pluripotent stem cells and reprogramming: seeing the science through the hype
Belmonte, J. C. I., Ellis, J., Hochedlinger, K., & Yamanaka, S. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2700 · Cited by 98
Self-citation
Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells
Vázquez‐Martín, A., Vellón, L., Quirós, P. M., Cufí, S., de Galarreta, E. R., Oliveras‐Ferraros, C., Martín, Á. G., Martı́n-Castillo, B., López-Otı́n, C., & Menéndez, J. A. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19450 · Cited by 98
The EMT spectrum and therapeutic opportunities
Voon, D. C., Huang, R. Y., Jackson, R. A., & Thiery, J. P. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12082 · Cited by 99
Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy
Song, B., Yang, P., & Zhang, S. (2024) · 癌症：英文版 · doi:10.1002/cac2.12520 · Cited by 103
Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53
Takenaka, C., Nishishita, N., Takada, N., Jakt, L. M., & Kawamata, S. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.11.003 · Cited by 96
Efficient Generation of Integration-Free iPS Cells from Human Adult Peripheral Blood Using BCL-XL Together with Yamanaka Factors
Su, R. J., Baylink, D. J., Neises, A., Kiroyan, J. B., Meng, X., Payne, K. J., Tschudy-Seney, B., Duan, Y., Appleby, N. C., Kearns‐Jonker, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064496 · Cited by 100
Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation
Katz, S., Lechel, A., Obenauf, A. C., Begus‐Nahrmann, Y., Kraus, J. M., Hoffmann, E. M., Duda, J., Eshraghi, P., Hartmann, D., Liss, B., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.009 · Cited by 96
NF-κB activation impairs somatic cell reprogramming in ageing
Soria‐Valles, C., Osorio, F. G., Gutiérrez‐Fernández, A., Angeles, A. D. L., Bueno, C., Menéndez, P. R., Martín-Subero, J. I., Daley, G. Q., Freije, J. M. P., & López-Otı́n, C. (2015) · Nature Cell Biology · doi:10.1038/ncb3207 · Cited by 97
Retracted
Systematic Identification of Barriers to Human iPSC Generation
Qin, H., Diaz, A. A., Blouin, L., Lebbink, R. J., Patena, W., Tanbun, P., LeProust, E. M., McManus, M. T., Song, J. S., & Ramalho‐Santos, M. (2014) · Cell · doi:10.1016/j.cell.2014.05.040 · Cited by 97
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogrammingPreprint
Percharde, M., Lavial, F., Ng, J.-H., Kumar, V., Tomaz, R. A., Martin, N., Yeo, J.-C., Gil, J., Prabhakar, S., Ng, H., et al. (2012) · Genes & Development · doi:10.1101/gad.195545.112 · Cited by 97
Energy metabolism plasticity enables stemness programs
Folmes, C. D. L., Nelson, T. J., Dzeja, P. P., & Terzic, A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06487.x · Cited by 94
Regulation of pluripotency and differentiation by deubiquitinating enzymes
Suresh, B., Lee, J., Kim, S., & Ramakrishna, S. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.53 · Cited by 93
Runx3 Protects Gastric Epithelial Cells Against Epithelial-Mesenchymal Transition-Induced Cellular Plasticity and Tumorigenicity
Voon, D. C., Wang, H., Koo, J. K. W., Nguyen, T. A. P., Hor, Y. T., Chu, Y., Ito, K., Fukamachi, H., Chan, S. L., Thiery, J. P., et al. (2012) · Stem Cells · doi:10.1002/stem.1183 · Cited by 93
LIF-Dependent Signaling: New Pieces in the Lego
Mathieu, M.-E., Saucourt, C., Mournetas, V., Gauthereau, X., Thézé, N., Praloran, V., Thiébaud, P., & Bœuf, H. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9261-7 · Cited by 96
The Senescence–Stemness Alliance – A Cancer-Hijacked Regeneration Principle
Milanovic, M., Yu, Y., & Schmitt, C. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.09.001 · Cited by 92
The p53 tumor suppressor protein regulates hematopoietic stem cell fate
Asai, T., Liu, Y., Bae, N., & Nimer, S. D. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22561 · Cited by 102
Metastatic cancer stem cells: from the concept to therapeutics.
Liao, W., Ye, Y., Deng, Y., Bian, X., & Ding, Y.-Q. (2014) · Europe PMC (PubMed Central) · Cited by 91
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation
Li, Z., & Rana, T. M. (2012) · Nature Communications · doi:10.1038/ncomms2059 · Cited by 89
Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression
de Vries, N. A., Hulsman, D., Akhtar, W., de Jong, J., Miles, D. C., Blom, M., van Tellingen, O., Jonkers, J., & van Lohuizen, M. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.028 · Cited by 93
Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma
Singh, D. K., Kollipara, R. K., Vemireddy, V., Yang, X.-L., Sun, Y., Regmi, N. L., Klingler, S., Hatanpaa, K. J., Raisanen, J. M., Cho, S. K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.064 · Cited by 86
Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
Wuputra, K., Ku, C., Wu, D., Lin, Y., Saito, S., & Yokoyama, K. K. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01584-0 · Cited by 103
Interspecies somatic cell nuclear transfer: a salvage tool seeking first aid
Loi, P., Modlinski, J. A., & Ptak, G. (2011) · Theriogenology · doi:10.1016/j.theriogenology.2011.01.016 · Cited by 90
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming
Qin, H., Blaschke, K., Wei, G., Ohi, Y., Blouin, L., Qi, Z., Yu, J., Yeh, R., Hebrok, M., & Ramalho‐Santos, M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds023 · Cited by 92
Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming
Tan, L., Ke, Z., Tombline, G., Macoretta, N., Hayes, K., Tian, X., Lv, R., Ablaeva, J., Gilbert, M., Bhanu, N. V., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.001 · Cited by 88
Knockdown of p21Cip1/Waf1 enhances proliferation, the expression of stemness markers, and osteogenic potential in human mesenchymal stem cells
Yew, T., Chiu, F., Tsai, C., Chen, H., Lee, W., Chen, Y., Chang, M.-C., & Hung, S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00676.x · Cited by 90
Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency
Ohmine, S., Squillace, K. A., Hartjes, K. A., Deeds, M. C., Armstrong, A. S., Thatava, T., Sakuma, T., Terzic, A., Kudva, Y. C., & Ikeda, Y. (2012) · Aging · doi:10.18632/aging.100428 · Cited by 89
Reprogramming of mouse and human somatic cells by high‐performance engineered factors
Wang, Y., Chen, J., Hu, J., Wei, X., Qin, D., Gao, J., Zhang, L., Jiang, J., Li, J., Liu, J., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.11 · Cited by 87
Self-citation
Transgene-Free Disease-Specific Induced Pluripotent Stem Cells from Patients with Type 1 and Type 2 Diabetes
Kudva, Y. C., Ohmine, S., Greder, L. V., Dutton, J. R., Armstrong, A. S., Lamo, J. G. D., Khan, Y. K., Thatava, T., Hasegawa, M., Fusaki, N., et al. (2012) · Stem Cells Translational Medicine · doi:10.5966/sctm.2011-0044 · Cited by 87
A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly
Krastev, D. B., Slabicki, M. M., Paszkowski‐Rogacz, M., Hubner, N. C., Junqueira, M., Shevchenko, A., Mann, M., Neugebauer, K. M., & Buchholz, F. (2011) · Nature Cell Biology · doi:10.1038/ncb2264 · Cited by 88
Short-term gain, long-term pain: the senescence life cycle and cancer
Chan, A. S. L., & Narita, M. (2019) · Genes & Development · doi:10.1101/gad.320937.118 · Cited by 80
Defining Human Pluripotency
Yilmaz, A., & Benvenisty, N. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.06.010 · Cited by 91
Quantifying the Landscape for Development and Cancer from a Core Cancer Stem Cell Circuit
Li, C., & Wang, J. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0079 · Cited by 85
Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency
Ebrahimi, B. (2015) · Cell Regeneration · doi:10.1186/s13619-015-0024-9 · Cited by 87
The emergence of protein complexes: quaternary structure, dynamics and allostery
Perica, T., Marsh, J. A., Sousa, F. L., Natan, E., Colwell, L. J., Ahnert, S. E., & Teichmann, S. A. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120056 · Cited by 87
Multiple Roles of p53-Related Pathways in Somatic Cell Reprogramming and Stem Cell Differentiation
Yi, L., Lu, C.-W., Hu, W., Sun, Y., & Levine, A. J. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1451 · Cited by 87
Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer
Menéndez, J. A., Cufí, S., Oliveras‐Ferraros, C., Martı́n-Castillo, B., Joven, J., Vellón, L., & Vázquez‐Martín, A. (2011) · Aging · doi:10.18632/aging.100407 · Cited by 84
p53 in stem cells
Solozobova, V. (2011) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v2.i9.202 · Cited by 87
Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1Preprint
Edel, M. J., Menchón, C., Ménendez, S., Consiglio, A., Izpisúa Belmonte, J. C., & Belmonte, J. C. I. (2010) · Genes & Development · doi:10.1101/gad.1876710 · Cited by 84
Self-citation
The Promise of Stem Cell Research in Pigs and Other Ungulate Species
Telugu, B. P. V. L., Ezashi, T., & Roberts, R. M. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9101-1 · Cited by 83
Antioxidant Supplementation Reduces Genomic Aberrations in Human Induced Pluripotent Stem Cells
Ji, J., Sharma, V., Qi, S., Guarch, M. E., Zhao, P., Luo, Z., Fan, W., Wang, Y., Mbabaali, F., Neculai, D., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.11.004 · Cited by 85
Self-citation
Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research
Yagi, T., Kosakai, A., Ito, D., Okada, Y., Akamatsu, W., Nihei, Y., Nabetani, A., Ishikawa, F., Arai, Y., Hirose, N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041572 · Cited by 84
Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State
Gonzãlez, F., Georgieva, D., Vanoli, F., Shi, Z., Stadtfeld, M., Ludwig, T., Jasin, M., & Huangfu, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.005 · Cited by 86
MYC Activates Stem-like Cell Potential in Hepatocarcinoma by a p53-Dependent Mechanism
Akita, H., Marquardt, J. U., Durkin, M. E., Kitade, M., Seo, D., Conner, E. A., Andersen, J. B., Factor, V. M., & Thorgeirsson, S. S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0527 · Cited by 84
Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
Sancho-Martinez, I., Nivet, E., Xia, Y. F., Hishida, T., Aguirre, A., Ocampo, A., Ma, L., Morey, R. E., Krause, M. N., Zembrzycki, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10743 · Cited by 81
Self-citation
Regulation of Pluripotency and Self- Renewal of ESCs through Epigenetic- Threshold Modulation and mRNA Pruning
Jia, J., Zheng, X., Hu, G., Cui, K., Zhang, J., Zhang, A., Jiang, H., Lu, B., Yates, J. R., Liu, C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.023 · Cited by 84
Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma
Xie, X., Piao, L., Bullock, B. N., Smith, A., Su, T., Zhang, M., Teknos, T. N., Arora, P. S., & Pan, Q. (2013) · Oncogene · doi:10.1038/onc.2013.25 · Cited by 80
Clinical Outcomes of TP53 Mutations in CancersPreprint
Robles, A. I., Jen, J., & Harris, C. C. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026294 · Cited by 86
Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction
Wang, S., Min, Z., Ji, Q., Geng, L., Su, Y., Liu, Z., Hu, H., Wang, L., Zhang, W., Suzuiki, K., et al. (2019) · Protein & Cell · doi:10.1007/s13238-019-0623-2 · Cited by 78
Reprogramming of Postnatal Neurons into Induced Pluripotent Stem Cells by Defined Factors
Kim, J., Lengner, C. J., Kirak, O., Hanna, J. H., Cassady, J. P., Lodato, M. A., Wu, S., Faddah, D. A., Steine, E. J., Gao, Q., et al. (2011) · Stem Cells · doi:10.1002/stem.641 · Cited by 83
microRNAs as novel regulators of stem cell pluripotency and somatic cell reprogramming
Li, M. A., & He, L. (2012) · BioEssays · doi:10.1002/bies.201200019 · Cited by 77
Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies
Selvaraj, V., Plane, J. M., Williams, A. J., & Deng, W. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.01.002 · Cited by 83
Functions of p53 in pluripotent stem cells
Fu, X., Wu, S., Li, B., Xu, Y., & Liu, J. (2019) · Protein & Cell · doi:10.1007/s13238-019-00665-x · Cited by 80
The evolving biology of small molecules: controlling cell fate and identity
Efe, J. A., & Ding, S. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0006 · Cited by 77
DNA double‐strand break response in stem cells: Mechanisms to maintain genomic integrity
Nagaria, P. K., Robert, C., & Rassool, F. V. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.001 · Cited by 78
Identification of Oct4-activating compounds that enhance reprogramming efficiency
Li, W., Tian, E., Chen, Z., Sun, G., Peng, Y., Yang, S. J., Lu, D., Xie, J., Ho, T., Tsark, W. M. K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219181110 · Cited by 79
The cell cycle and pluripotency
Hindley, C. J., & Philpott, A. (2013) · Biochemical Journal · doi:10.1042/bj20121627 · Cited by 81
Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator
Zhou, X. Y., Hao, Q., Liao, P., Luo, S., Zhang, M., Hu, G., Liu, H., Zhang, Y.-W., Cao, B., Baddoo, M., et al. (2016) · eLife · doi:10.7554/elife.15099 · Cited by 84
A Transcriptional Roadmap to the Induction of Pluripotency in Somatic Cells
Wang, Y., Mah, N., Prigione, A., Wolfrum, K., Andrade-Navarro, M. A., & Adjaye, J. (2010) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9137-2 · Cited by 76
Self-citation
Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation
Masip, M., Veiga, A., Belmonte, J. C. I., & Simón, C. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq059 · Cited by 76
Self-citation
Mechanisms of gene regulation in human embryos and pluripotent stem cells
Theunissen, T. W., & Jaenisch, R. (2017) · Development · doi:10.1242/dev.157404 · Cited by 77
Cancer Stemness: p53 at the Wheel
Ghatak, D., Ghosh, D. D., & Roychoudhury, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.604124 · Cited by 75
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Alle, Q., Le Borgne, E., Bensadoun, P., Lemey, C., Béchir, N., Gabanou, M., Estermann, F., Bertrand‐Gaday, C., Pessemesse, L., Toupet, K., et al. (2022) · Aging Cell · doi:10.1111/acel.13714 · Cited by 66
Emerging roles of hypoxia‐inducible factors and reactive oxygen species in cancer and pluripotent stem cells
Saito, S., Lin, Y., Tsai, M., Lin, C., Murayama, Y., Sato, R., & Yokoyama, K. K. (2015) · The Kaohsiung Journal of Medical Sciences · doi:10.1016/j.kjms.2015.03.002 · Cited by 76
Induced pluripotent stem cells: A new era for hepatology
Asgari, S., Pournasr, B., Salekdeh, G. H., Ghodsizadeh, A., Ott, M., & Baharvand, H. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.009 · Cited by 75
Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells
Horikawa, I., Park, K., Isogaya, K., Hiyoshi, Y., Li, H., Anami, K., Robles, A. I., Mondal, A. M., Fujita, K., Serrano, M., et al. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.48 · Cited by 76
Reprogramming with Small Molecules instead of Exogenous Transcription Factors
Lin, T., & Wu, S. (2015) · Stem Cells International · doi:10.1155/2015/794632 · Cited by 78
MiR-25 Regulates Wwp2 and Fbxw7 and Promotes Reprogramming of Mouse Fibroblast Cells to iPSCs
Lu, D., Davis, M. P. A., Abreu‐Goodger, C., Wang, W., Campos, L. S., Siede, J., Vigorito, E., Skarnes, W. C., Dunham, I., Enright, A. J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040938 · Cited by 74
Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells
Trokovic, R., Weltner, J., Noisa, P., Raivio, T., & Otonkoski, T. (2015) · Stem Cell Research · doi:10.1016/j.scr.2015.06.001 · Cited by 74
Foxd1 is a mediator and indicator of the cell reprogramming process
Koga, M., Matsuda, M., Kawamura, T., Sogo, T., Shigeno, A., Nishida, E., & Ebisuya, M. (2014) · Nature Communications · doi:10.1038/ncomms4197 · Cited by 73
Self-citation
Systematic Review of Induced Pluripotent Stem Cell Technology as a Potential Clinical Therapy for Spinal Cord Injury
Kramer, A. S., Harvey, A. R., Plant, G. W., & Hodgetts, S. I. (2012) · Cell Transplantation · doi:10.3727/096368912x655208 · Cited by 73
Notch inhibition allows oncogene-independent generation of iPS cells
Ichida, J. K., Julia, T. C. W., Williams, L. A., Carter, A. C., Shi, Y., Moura, M. T., Ziller, M. J., Singh, S., Amabile, G., Bock, C., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1552 · Cited by 75
Metabolism in pluripotency: Both driver and passenger?
Dahan, P., Lu, V., Nguyen, R., Kennedy, S. A. L., & Teitell, M. A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm117.000832 · Cited by 74
The emerging role of p53 in stem cells
Bonizzi, G., Cicalese, A., Insinga, A., & Pelicci, P. G. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.08.002 · Cited by 74
p53-Facilitated miR-199a-3p Regulates Somatic Cell Reprogramming
Wang, J., He, Q., Han, C., Gu, H., Jin, L., Li, Q., Mei, Y., & Wu, M. (2012) · Stem Cells · doi:10.1002/stem.1121 · Cited by 72
Integration-Free iPS Cells Engineered Using Human Artificial Chromosome Vectors
Hiratsuka, M., Uno, N., Ueda, K., Kurosaki, H., Imaoka, N., Kazuki, K., Ueno, E., Akakura, Y., Katoh, M., Osaki, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025961 · Cited by 70
Concise Review: Immune Recognition of Induced Pluripotent Stem Cells
Boyd, A. S., Rodrigues, N. P., Lui, K. O., Fu, X., & Xu, Y. (2012) · Stem Cells · doi:10.1002/stem.1066 · Cited by 76
p53 connects tumorigenesis and reprogramming to pluripotency
Tàpia, N., & Schöler, H. R. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101866 · Cited by 71
Premature aging/senescence in cancer cells facing therapy: good or bad?
Calvo, L., Ghadaouia, S., Martinez, A., & Rodier, F. (2015) · Biogerontology · doi:10.1007/s10522-015-9593-9 · Cited by 74
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 78
Stacking the DEK: From chromatin topology to cancer stem cells
Vinnedge, L. M. P., Kappes, F., Nassar, N. N., & Wells, S. I. (2012) · Cell Cycle · doi:10.4161/cc.23121 · Cited by 70
Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets
Fragola, G., Germain, P., Laise, P., Cuomo, A., Blasimme, A., Groß, F., Signaroldi, E., Bucci, G., Sommer, C., Pruneri, G., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003292 · Cited by 74
Two Factor Reprogramming of Human Neural Stem Cells into Pluripotency
Hester, M. E., Song, S., Miranda, C. J., Eagle, A., Schwartz, P. H., & Kaspar, B. K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007044 · Cited by 70
Direct Generation of Induced Pluripotent Stem Cells from Human Nonmobilized Blood
Kunisato, A., Wakatsuki, M., Shinba, H., Ota, T., Ishida, I., & Nagao, K. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0063 · Cited by 70
Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog
Yang, V. S., Carter, S. A., Hyland, S. J., Tachibana-Konwalski, K., Laskey, R. A., & Gonzalez, M. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.026 · Cited by 69
An Insight into Reprogramming Barriers to iPSC Generation
Haridhasapavalan, K. K., Raina, K., Dey, C., Adhikari, P., & Thummer, R. P. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09931-1 · Cited by 70
Methods of induced pluripotent stem cells for clinical application
Seki, T. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i1.116 · Cited by 69
Tumor suppressors: enhancers or suppressors of regeneration?
Pomerantz, J. H., & Blau, H. M. (2013) · Development · doi:10.1242/dev.084210 · Cited by 68
High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes
Ruiz, S., Brennand, K., Panopoulos, A. D., Herrerias, A., Gage, F. H., & Izpisúa‐Belmonte, J. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015526 · Cited by 70
MicroRNAs and cancer stem cells: Therapeutic approaches and future perspectives
Leal, J. A., & LLeonart, M. E. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.020 · Cited by 68
Reprogramming: identifying the mechanisms that safeguard cell identity
Brumbaugh, J., Stefano, B. D., & Hochedlinger, K. (2019) · Development · doi:10.1242/dev.182170 · Cited by 66
The m 6 A RNA methyltransferase METTL3/METTL14 promotes leukemogenesis through the mdm2/p53 pathway in acute myeloid leukemia
Sang, L., Wu, X., Yan, T., Naren, D., Liu, X., Zheng, X. Y., Zhang, N., Wang, H., Li, Y., & Gong, Y. (2022) · Journal of Cancer · doi:10.7150/jca.60381 · Cited by 69
From microRNAs to targets: pathway discovery in cell fate transitions
Subramanyam, D., & Blelloch, R. H. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.04.011 · Cited by 69
Hypoxia Inhibits Cellular Senescence to Restore the Therapeutic Potential of Old Human Endothelial Progenitor Cells via the Hypoxia-Inducible Factor-1α–TWIST-p21 Axis
Lee, S. H., Lee, J. H., Yoo, S. Y., Hur, J., Kim, H.-S., & Kwon, S. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301931 · Cited by 68
RNAi Reveals Phase-Specific Global Regulators of Human Somatic Cell Reprogramming
Toh, C.-X. D., Chan, J. C. W., Chong, Z., Wang, H., Guo, H., Satapathy, S., Ma, D., Goh, G. Y. L., Khattar, E., Yang, L., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.049 · Cited by 62
Stem Cells in Normal Development and Cancer
D'Angelo, R. C., & Wicha, M. S. (2010) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385071-3.00006-x · Cited by 68
Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming
Ruiz, S., Gore, A., Li, Z., Panopoulos, A. D., Montserrat, N., Fung, H.-L., Giorgetti, A., Bilić, J., Batchelder, E. M., Zaehres, H., et al. (2013) · Nature Communications · doi:10.1038/ncomms2381 · Cited by 67
Self-citation
Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency
Hernandez, C. C., Wang, Z., Ramazanov, B. R., Tang, Y., Mehta, S. S., Dambrot, C., Lee, Y.-W., Tessema, K. K., Kumar, I., Astudillo, M. G., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.08.001 · Cited by 65
NUMB phosphorylation destabilizes p53 and promotes self‐renewal of tumor‐initiating cells by a NANOG‐dependent mechanism in liver cancer
Siddique, H. R., Feldman, D. E., Chen, C., Punj, V., Tokumitsu, H., & Machida, K. (2015) · Hepatology · doi:10.1002/hep.27987 · Cited by 67
Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8
Chakravarti, D., Su, X., Cho, M. S., Bui, N. H. B., Coarfa, C., Venkatanarayan, A., Benham, A. L., González, R. E. F., Alana, J., Xiao, W., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319743111 · Cited by 67

Authors: Kawamura, T., Suzuki, J., Wang, Y. V., Menendez, S., Morera, L. B., Raya, A., Wahl, G. M., & Belmonte, J. C. I.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Wahl, Geoffrey M.
Belmonte, Juan Carlos Izpisúa
ORCID: Kawamura, Teruhisa
Wahl, Geoffrey M.
Belmonte, Juan Carlos Izpisúa
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-08
Volume: 460
Issue: 7259
Pages: 1140-1144
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08311
PMC: PMC2735889
OpenAlex: W2070672434
Cited by: 1,115
References: 40
Citations by year: 2026: 13 · 2025: 12 · 2024: 30 · 2023: 34 · 2022: 31 · 2021: 36 · 2020: 29 · 2019: 41 · 2018: 55 · 2017: 60 · 2016: 65 · 2015: 77 · 2014: 96 · 2013: 111 · 2012: 136
FWCI: 57.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R33HL088293)
National Cancer Institute (R01CA100845, R01CA061449)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: p53, somatic cell reprogramming, induced pluripotent stem cells, Oct4, SOX2, p21, Nutlin-3, reprogramming efficiency, malignant transformation, fibroblasts, oncogenes, apoptosis
MeSH terms: Animals, Cells, Cultured, Embryo, Mammalian, Female, Fibroblasts, Humans, Male, Mice, Inbred C57BL, Down-Regulation, Keratinocytes, Tumor Suppressor Protein p53, Pluripotent Stem Cells, Cyclin-Dependent Kinase Inhibitor p21, Mice, Cellular Reprogramming

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks