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A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
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Abstract
Recent advances in cell reprogramming showed that OSKM induction is able to improve cell physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is sufficient to prevent musculoskeletal functions deterioration of mice, when applied in early life. In addition, in old age, treated mice have improved tissue structures in kidney, spleen, skin, and lung, with an increased lifespan of 15% associated with organ‐specific differential age‐related DNA methylation signatures rejuvenated by the treatment. Altogether, our results indicate that a single short reprogramming early in life might initiate and propagate an epigenetically related mechanism to promote a healthy lifespan.
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A single 2.5-week period of continuous overexpression increased lifespan by 15% and partially ameliorated the premature signs of aging in mice, despite having no noticeable difference in the median age of death.
“Furthermore, a single 2.5-week period of continuous overexpression increased lifespan by 15% and partially ameliorated the premature signs of aging in mice, despite having no noticeable difference in the median age of death.”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [104]
In Results and Discussion, “A single early short transient reprogramming increases late age lifespan” (page unavailable), a single 2.5-week treatment improved late-life survival without a noticeable change in median age at death. The paper reports the third-quartile age at death rising from 44.3 to 54.8 weeks, not a 15% lifespan increase. Its Introduction and Conclusion describe improvements in age-related tissue deterioration, supporting that part of the claim. (LLM, conf=0.89)
Experimental — accuracy not yet measuredContinuous overexpression of OSKM with a lower dosage of DOX (0.2 mg ml-1) in LAKI/+;4F/+ mice produced a near-identical increase in lifespan compared with the standard Ocampo protocol.
“Specifically, they compared continuous overexpression of OSKM with a lower dosage of DOX (0.2 mg ml -1 ) in LAKI/+;4F/+ mice to the standard protocol of Ocampo and colleagues and observed a near-identical increase in the lifespan of mice treated with both protocols.”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [104]
When the same protocol was applied to nonprogeric mice, the effects were markedly less pronounced, with lifespan only being extended by 18 weeks.
“Interestingly, when the same protocol was applied to nonprogerice mice, the effects were markedly less pronounced, with lifespan only being extended by 18 weeks.”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [104]
Alle and colleagues demonstrated that rejuvenation outcomes might be more consistent by modifying OSKM methods.
“A recent paper published by Alle and colleagues demonstrated that rejuvenation outcomes might be more consistent by modifying OSKM methods (Fig. 3c) 104 .”
From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [104]
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Citations
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Metadata
- Authors
- Alle, Q., Le Borgne, E., Bensadoun, P., Lemey, C., Béchir, N., Gabanou, M., Estermann, F., Bertrand‐Gaday, C., Pessemesse, L., Toupet, K., Desprat, R., Vialaret, J., Hirtz, C., Noël, D., Jorgensen, C., Casas, F., Milhavet, O., & Lemaitre, J.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2022-10-17
- Volume
- 21
- Issue
- 11
- ISSN
- 1474-9718
- 1474-9726
- PMC
- PMC9649606
- Cited by
- 66
- References
- 31
- Language
- en
- Funders
- Centre Hospitalier Régional Universitaire de Montpellier (Facilities)
- Institut National de la Santé et de la Recherche Médicale (Recurrent annual grant)
- Ligue Contre le Cancer (Comité régional Aveyron et Hérault)
- Université de Montpellier (Annual dotation)
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