The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Direct conversion of fibroblasts to functional neurons by defined factors
Open accessAbstract
Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Viral screens using focused overexpression libraries can identify putative reprogramming factors, for example, by identifying a defined set of transcription factors that are selectively required to induce pluripotent stem cells (2–4,7) or trans-differentiate from mature somatic cell into another mature somatic cell (1,8–11).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [10]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Despite the power of viral technologies, pooled screens for cell reprogramming have generally adopted a one-by-one elimination approach or testing for exhaustive combinations and interrogating phenotypes in cell culture from transgenic mice (1,3,10) and/or aberrantly cloned cell lines (12).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [10]
In the citing paper
“Furthermore, iPSC-derived cell types from different lineages can be combined into defined three-dimensional cultures, termed assembloids9,94–98.”
From CRISPR-based functional genomics for neurological disease (2020) · cites this paper as [98]
In the citing paper
“MYT1L is a myelin transcription factor required to convert mouse embryonic and postnatal fibroblasts into functional neurons [68].”
From Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders (2012) · cites this paper as [68]
In the citing paper
“Functional induced neurons (iN) can be generated directly from fibroblasts by forced expression of neural specific transcription factors, a process also called transdifferentiation (Vierbuchen et al., 2010).”
From Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation (2016) · cites this paper as Vierbuchen et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388
Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Sheep cloned by nuclear transfer from a cultured cell line
Campbell, K., McWhir, J., Ritchie, W. A., & Wilmut, I. (1996) · Nature · doi:10.1038/380064a0 · Cited by 1,868
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
Jaenisch, R., & Young, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.01.015 · Cited by 1,465
Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs
Briggs, R., & King, T. J. (1952) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.38.5.455 · Cited by 1,127
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 1,005
Blanchet, P., Bebin, M., Bruet, S., Cooper, G. M., Thompson, M. L., Duban‐Bedu, B., Gérard, B., Piton, A., Sukno, S., Deshpande, C., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006957 · Cited by 87
Rapid, modular and reliable construction of complex mammalian gene circuits
Guye, P., Li, Y., Wróblewska, L., Duportet, X., & Weiss, R. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt605 · Cited by 86
FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells
Kolundžić, E., Ofenbauer, A., Bulut, S., Uyar, B., Baytek, G., Sommermeier, A., Seelk, S., He, M., Hirsekorn, A., Vučićević, D., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.07.006 · Cited by 83
Single-cell genomics to guide human stem cell and tissue engineering
Camp, J. G., Wollny, D., & Treutlein, B. (2018) · Nature Methods · doi:10.1038/s41592-018-0113-0 · Cited by 83
Tan, H. Y., Cho, H., & Lee, L. P. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-020-00643-3 · Cited by 87
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
Giehrl‐Schwab, J., Giesert, F., Rauser, B., Lao, C. L., Hembach, S., Lefort, S., Ibarra, I. L., Koupourtidou, C., Luecken, M. D., Truong, D. J., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114797 · Cited by 84
Mouse embryonic stem cells can differentiate via multiple paths to the same state
Briggs, J. A., Li, V. C., Lee, S., Woolf, C. J., Klein, A., & Kirschner, M. W. (2017) · eLife · doi:10.7554/elife.26945 · Cited by 82
Human pluripotent stem cell–derived models and drug screening in CNS precision medicine
Silva, M. C., & Haggarty, S. J. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14012 · Cited by 88
Bioprinting Neural Systems to Model Central Nervous System Diseases
Qiu, B., Bessler, N., Figler, K. P., Buchholz, M., Rios, A. C., Malda, J., Levato, R., & Caiazzo, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910250 · Cited by 83
Stem cell therapy in neurodegenerative diseases: From principles to practice.
Sakthiswary, R., & Raymond, A. A. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.23.009 · Cited by 81
Haston, K. M., & Finkbeiner, S. M. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103548 · Cited by 84
Mesenchymal Stem Cell-Like Properties in Fibroblasts
Chang, Y., He, L. N., & Guo, Z. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000363035 · Cited by 83
Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming
Lim, K. T., Lee, S. C., Gao, Y., Kim, K.-P., Song, G., An, S. Y., Adachi, K., Jang, Y. J., Kim, J., Oh, K., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.071 · Cited by 82
Wang, Y., Qin, J., Wang, S., Zhang, W., Duan, J., Zhang, J., Wang, X., Yan, F., Chang, M., Liu, X., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.006 · Cited by 81
Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses
Patzke, C., Brockmann, M. M., Dai, J., Gan, K. J., Grauel, M. K., Fenske, P., Liu, Y., Acuna, C., Rosenmund, C., & Südhof, T. C. (2019) · Cell · doi:10.1016/j.cell.2019.09.011 · Cited by 85
Self-citationProneural bHLH Genes in Development and Disease
Huang, C., Chan, J. A.-W., & Schuurmans, C. J. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-405943-6.00002-6 · Cited by 80
Recent Advances in the Genetics of Schizophrenia
Avramopoulos, D. (2018) · Complex Psychiatry · doi:10.1159/000488679 · Cited by 84
Pak, C., Dankó, T., Mirabella, V. R., Wang, J., Liu, Y., Vangipuram, M., Grieder, S. D., Zhang, X., Ward, T., Huang, Y. A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025598118 · Cited by 84
Self-citationDevelopmental and Regenerative Biology of Multipotent Cardiovascular Progenitor Cells
Sturzu, A. C., & Wu, S. M. (2011) · Circulation Research · doi:10.1161/circresaha.110.227066 · Cited by 82
Morris, S. A. (2016) · Development · doi:10.1242/dev.138263 · Cited by 85
Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., Elinger, D., Viukov, S., Geula, S., Krupalnik, V., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.07.004 · Cited by 79
Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1
Vasconcelos, F. F., & Castro, D. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00412 · Cited by 81
Hirai, H., Tani, T., Katoku-Kikyo, N., Kellner, S., Karian, P., Firpo, M. T., & Kikyo, N. (2011) · Stem Cells · doi:10.1002/stem.684 · Cited by 80
Steinle, H., Behring, A., Schlensak, C., Wendel, H. P., & Avci‐Adali, M. (2016) · Stem Cells · doi:10.1002/stem.2402 · Cited by 78
New neurons in adult brain: distribution, molecular mechanisms and therapies
Pino, A., Fumagalli, G. F., Bifari, F., & Decimo, I. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.003 · Cited by 83
Józefczuk, J., Prigione, A., Chávez, L., & Adjaye, J. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0361 · Cited by 77
Behbahan, I. S., Duan, Y., Lam, A., Khoobyari, S., Ma, X., Ahuja, T. P., & Zern, M. Α. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9216-4 · Cited by 77
Miskinyte, G., Devaraju, K., Hansen, M. G., Monni, E., Tornero, D., Woods, N. B., Bengzon, J., Ahlenius, H., Lindvall, O., & Kokaia, Z. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0658-3 · Cited by 80
Vivi, E., & Benedetto, B. D. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02534-4 · Cited by 83
Identification of Transcription Factors for Lineage-Specific ESC Differentiation
Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D., & Ko, M. S. H. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.10.006 · Cited by 82
Global DNA methylation remodeling during direct reprogramming of fibroblasts to neurons
Luo, C., Lee, Q. Y., Wapinski, O., Castanon, R., Nery, J. R., Mall, M., Kareta, M. S., Cullen, S. M., Goodell, M. A., Chang, H. Y., et al. (2019) · eLife · doi:10.7554/elife.40197 · Cited by 76
Self-citationNeutralization of terminal differentiation in gliomagenesis
Hu, J., Ho, A. L., Yuan, L., Hu, B., Hua, S., Hwang, S. S., Zhang, J., Hu, T., Zheng, H., Gan, B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308610110 · Cited by 76
“Seq-ing” Insights into the Epigenetics of Neuronal Gene Regulation
Telese, F., Gamliel, A., Skowronska‐Krawczyk, D., García-Bassets, I., & Rosenfeld, M. G. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.034 · Cited by 81
Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation
Masip, M., Veiga, A., Belmonte, J. C. I., & Simón, C. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq059 · Cited by 76
ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
Roper, S. J., Chrysanthou, S., Senner, C. E., Sienerth, A. R., Gnan, S., Murray, A., Masutani, M., Latos, P. A., & Hemberger, M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku591 · Cited by 76
Tissue-specific demethylation in CpG-poor promoters during cellular differentiation
Nagae, G., Isagawa, T., Shiraki, N., Fujita, T., Yamamoto, S., Tsutsumi, S., Nonaka, A., Yoshiba, S., Matsusaka, K., Midorikawa, Y., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr170 · Cited by 76
Fibroblasts as maestros orchestrating tissue regeneration
Costa‐Almeida, R., Soares, R. A., & Granja, P. L. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2405 · Cited by 76
Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules
Yang, Y., Chen, R., Wu, X., Zhao, Y., Fan, Y., Xiao, Z., Han, J., Sun, L., Wang, X., & Dai, J. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.09.007 · Cited by 76
Towards stem cell based therapies for Parkinson's disease
Parmar, M. (2018) · Development · doi:10.1242/dev.156117 · Cited by 75
Parambi, D. G. T., Alharbi, K. S., Kumar, R., Harilal, S., Batiha, G. E., Martins, N. A., Hendawy, O. M., Musa, A., Panda, D. S., & Mathew, B. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02555-y · Cited by 76
Liu, H., Gao, J., Sun, J., Li, S., Zhang, B., Wang, Z., Zhou, C., Sulis, D. B., Wang, J. P., Chiang, V. L., et al. (2022) · New Phytologist · doi:10.1111/nph.18028 · Cited by 75
Dedifferentiation of Neurons Precedes Tumor Formation in lola Mutants
Southall, T. D., Davidson, C. M., Miller, C., Carr, A. R., & Brand, A. H. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.01.030 · Cited by 77
Review: The future of cell therapies and brain repair: P arkinson's disease leads the way
Petit, G. H., Olsson, T. T., & Brundin, P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12110 · Cited by 74
Induced pluripotent stem cells: A new era for hepatology
Asgari, S., Pournasr, B., Salekdeh, G. H., Ghodsizadeh, A., Ott, M., & Baharvand, H. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.05.009 · Cited by 75
Stem Cell and Biomaterials Research in Dental Tissue Engineering and Regeneration
Horst, O. V., Chavez, M. G., Jheon, A. H., Desai, T. A., & Klein, O. D. (2012) · Dental Clinics of North America · doi:10.1016/j.cden.2012.05.009 · Cited by 74
Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors
Cheng, Z., He, Z., Cai, Y., Zhang, C., Fu, G., Li, H., Sun, W. C., Liu, C., Cui, X., Ning, B., et al. (2018) · Cell Research · doi:10.1038/s41422-018-0111-x · Cited by 76
Direct conversion of mouse fibroblasts into induced neural stem cells
Kim, S. M., Flaßkamp, H., Hermann, A., Araúzo-Bravo, M. J., Lee, S. C., Lee, S. H., Seo, E. H., Lee, S., Storch, A., Lee, H. T., et al. (2014) · Nature Protocols · doi:10.1038/nprot.2014.056 · Cited by 74
Transdifferentiation: a new promise for neurodegenerative diseases
Mollinari, C., Zhao, J., Lupacchini, L., Garaci, E., Merlo, D., & Pei, G. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0891-4 · Cited by 73
The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders
Ang, C. E., Ma, Q., Wapinski, O. L., Fan, S., Flynn, R. A., Lee, Q. Y., Coe, B. P., Onoguchi, M., Olmos, V. H., Do, B. T., et al. (2019) · eLife · doi:10.7554/elife.41770 · Cited by 76
Self-citationDocampo, E., Escaramís, G., Gratacòs, M., Villatoro, S., Puig, A., Kogevinas, M., Collado, A., Abelló, J. C., Rivera, J., Vidal, J., et al. (2014) · Pain · doi:10.1016/j.pain.2014.02.016 · Cited by 79
Nicaise, A. M., Willis, C. M., Crocker, S. J., & Pluchino, S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00247 · Cited by 76
Induced pluripotent stem cell (iPSCs) and their application in immunotherapy
Jiang, Z., Han, Y., & Cao, X. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.62 · Cited by 73
Mönnich, M., Kuriger, Z., Print, C. G., & Horsfield, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020051 · Cited by 72
Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration
van den Berg, D. L. C., Azzarelli, R., Oishi, K., Martynoga, B., Urbán, N., Dekkers, D. H. W., Demmers, J., & Guillemot, F. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.047 · Cited by 75
Ex vivo gene therapy for the treatment of neurological disorders
Gowing, G., Svendsen, S. P., & Svendsen, C. N. (2017) · Progress in brain research · doi:10.1016/bs.pbr.2016.11.003 · Cited by 74
Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors
Zhang, K., Liu, G., Yi, F., Montserrat, N., Hishida, T., Esteban, C. R., & Belmonte, J. C. I. (2013) · Protein & Cell · doi:10.1007/s13238-013-0011-2 · Cited by 72
Using human induced pluripotent stem cells to treat retinal disease
Borooah, S., Phillips, M. J., Bilican, B., Wright, A. F., Wilmut, I., Chandran, S., Gamm, D. M., & Dhillon, B. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.09.002 · Cited by 76
Malik, V., Glaser, L. V., Zimmer, D., Velychko, S., Weng, M., Holzner, M., Arend, M., Chen, Y., Srivastava, Y., Veerapandian, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11054-7 · Cited by 72
Cell therapy for central nervous system disorders: Current obstacles to progress
Yasuhara, T., Kawauchi, S., Kin, K., Morimoto, J., Kameda, M., Sasaki, T., Bonsack, B., Kingsbury, C., Tajiri, N., Borlongan, C. V., et al. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13247 · Cited by 73
Black, J. B., McCutcheon, S. R., Dube, S., Barrera, A., Klann, T. S., Rice, G., Adkar, S. S., Soderling, S. H., Reddy, T. E., & Gersbach, C. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108460 · Cited by 71
Olesen, M. A., Villavicencio-Tejo, F., & Quintanilla, R. A. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00308-y · Cited by 80
Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD
Kim, D.-S., Ross, P. J., Zaslavsky, K., & Ellis, J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00109 · Cited by 70
Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening.
Greenhough, S., Medine, C. N., & Hay, D. C. (2010) · Toxicology · doi:10.1016/j.tox.2010.07.012 · Cited by 71
Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors
Yang, R., Zheng, Y., Li, L., Liu, S., Burrows, M., Wei, Z., Nace, A., Herlyn, M., Cui, R., Guo, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6807 · Cited by 76
Unmet needs in paediatric psychopharmacology: Present scenario and future perspectives
Persico, A. M., Arango, C., Buitelaar, J. K., Correll, C. U., Glennon, J. C., Hoekstra, P. J., Moreno, C., Vitiello, B., Vorstman, J. A. S., & Zuddas, A. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.06.009 · Cited by 73
Down-regulation of Beclin1 promotes direct cardiac reprogramming
Wang, L., Ma, H., Huang, P., Xie, Y., Near, D., Wang, H., Xu, J., Yang, Y., Xu, Y., Garbutt, T. A., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay7856 · Cited by 70
Matsubara, S., Matsuda, T., & Nakashima, K. (2021) · Cells · doi:10.3390/cells10051145 · Cited by 72
Toward stem cell-based phenotypic screens for neurodegenerative diseases
Khurana, V., Tardiff, D. F., Chung, C. Y., & Lindquist, S. L. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.79 · Cited by 72
Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc
Giorgetti, A., Marchetto, M. C., Li, M., Yu, D. X., Fazzina, R., Mu, Y., Adamo, A., Paramonov, I., Castaño, J., Barragán, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209523109 · Cited by 70
Shahbazi, E., Moradi, S., Nemati, S., Satarian, L., Basiri, M., Gourabi, H., Mehrjardi, N. Z., Günther, P. S., Lampert, A., Händler, K., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.02.013 · Cited by 70
Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer
Huilgol, D., Venkataramani, P., Nandi, S., & Bhattacharjee, S. (2019) · Genes · doi:10.3390/genes10100794 · Cited by 75
Ten years of genetics and genomics: what have we achieved and where are we heading?
Heard, É., Tishkoff, S. A., Todd, J. A., Vidal, M., Wagner, G. P., Wang, J., Weigel, D., & Young, R. A. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2878 · Cited by 71
Reprogramming the fate of human glioma cells to impede brain tumor development
Su, Z., Zang, T., Liu, M.-L., Wang, L.-L., Niu, W., & Zhang, C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.425 · Cited by 69
Reprogramming of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4
Wu, T., Wang, H., He, J., Kang, L., Jiang, Y.-H., Liu, J., Zhang, Y., Kou, Z.-H., Liu, L., Zhang, X.-H., et al. (2011) · Stem Cells · doi:10.1002/stem.617 · Cited by 70
Stem Cell Therapy: A New Treatment for Burns?
Arno, A. I., Smith, A. H., Blit, P. H., Shehab, M. A., Gauglitz, G. G., & Jeschke, M. G. (2011) · Pharmaceuticals · doi:10.3390/ph4101355 · Cited by 69
MicroRNAs: Not “Fine-Tuners” but Key Regulators of Neuronal Development and Function
Davis, G. M., Haas, M., & Pocock, R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00245 · Cited by 69
DC3 is a method for deconvolution and coupled clustering from bulk and single-cell genomics data
Zeng, W., Chen, X. X., Duren, Z., Wang, Y., Jiang, R., & Wong, W. H. (2019) · Nature Communications · doi:10.1038/s41467-019-12547-1 · Cited by 70
Critical Factors for Cardiac Reprogramming
Srivastava, D., & Ieda, M. (2012) · Circulation Research · doi:10.1161/circresaha.112.271452 · Cited by 70
Stem Cell Challenges in the Treatment of Neurodegenerative Disease
Feng, Z., & Gao, F. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2011.00239.x · Cited by 68
Mitchell, R. R., Szabo, E., Benoit, Y. D., Case, D. T., Mechael, R., Alamilla, J., Lee, J., Fiebig‐Comyn, A., Gillespie, D. C., & Bhatia, M. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0023 · Cited by 68
Zheng, Z. S., Jia, J., Zhang, X., Zara, J. N., Yin, W., Chiang, M., Liu, Y., Wang, J., Pang, S., Ting, K., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.049 · Cited by 68
The Rise of Cell Therapy Trials for Stroke: Review of Published and Registered Studies
Rosado-de-Castro, P. H., Pimentel‐Coelho, P. M., da Fonseca, L. M. B., de Freitas, G. R., & Méndez‐Otero, R. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0089 · Cited by 68
Cancian, L., Hansen, A., & Boshoff, C. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.04.001 · Cited by 68
From fibroblast cells to cardiomyocytes: direct lineage reprogramming
Yang, L. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt42 · Cited by 68
The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors
Horisawa, K., Udono, M., Ueno, K., Ohkawa, Y., Nagasaki, M., Sekiya, S., & Suzuki, A. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.012 · Cited by 68
Transcriptional regulation of the peripheral nervous system in Ciona intestinalis
Tang, W. J., Chen, J. S., & Zeller, R. W. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.03.016 · Cited by 67
Stem cells and stroke: opportunities, challenges and strategies
Burns, T. C., & Steinberg, G. K. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.552883 · Cited by 70
Neural stem cell therapy for cancer
Bagó, J. R., Sheets, K., & Hingtgen, S. (2015) · Methods · doi:10.1016/j.ymeth.2015.08.013 · Cited by 67
mi R ‐124‐9‐9* potentiates A scl1‐induced reprogramming of cultured M üller glia
Wohl, S. G., & Reh, T. A. (2016) · Glia · doi:10.1002/glia.22958 · Cited by 70
The conserved sex regulator DMRT1 recruits SOX9 in sexual cell fate reprogramming
Lindeman, R. E., Murphy, M. W., Agrimson, K. S., Gewiss, R. L., Bardwell, V. J., Gearhart, M. D., & Zarkower, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab448 · Cited by 66
Modeling psychiatric disorders through reprogramming
Brennand, K., & Gage, F. H. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008268 · Cited by 68
Michalek, J. L., Besold, A. N., & Michel, S. L. J. (2011) · Dalton Transactions · doi:10.1039/c1dt11071c · Cited by 66
Systematic Search for Recipes to Generate Induced Pluripotent Stem Cells
Chang, R. R., Shoemaker, R., & Wang, W. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002300 · Cited by 66
Luoni, M., Giannelli, S., Indrigo, M. T., Niro, A., Massimino, L., Iannielli, A., Passeri, L., Russo, F., Morabito, G., Calamita, P., et al. (2020) · eLife · doi:10.7554/elife.52629 · Cited by 65
The mesenchymal-to-epithelial transition in somatic cell reprogramming
Esteban, M. A., Bao, X., Zhuang, Q., Zhou, T., Qin, B., & Pei, D. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.09.004 · Cited by 68
Chemical Strategies for Stem Cell Biology and Regenerative Medicine
Zhu, S., Wei, W., & Ding, S. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124715 · Cited by 66
Choi, W.-Y., & Poss, K. D. (2012) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-387786-4.00010-5 · Cited by 67
RNA-Based Tools for Nuclear Reprogramming and Lineage-Conversion: Towards Clinical Applications
Bernal, J. A. (2013) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-013-9494-8 · Cited by 65
Pluripotent stem cell-based disease modeling: current hurdles and future promise
Zeltner, N., & Studer, L. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.10.008 · Cited by 68
A Dynamical Model of Genetic Networks for Cell DifferentiationPreprint
Serra, R., Marco, V., & Barbieri, A. (2010) · Nature Precedings · doi:10.1371/journal.pone.0017703 · Cited by 65
Metadata
- Authors
- Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M.
- Affiliations
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Wernig, Marius
- Venue
- Nature
- Published
- 2010-01-27
- Volume
- 463
- Issue
- 7284
- Pages
- 1035-1041
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2829121
- OpenAlex
- W2136541538
- Cited by
- 3,017
- References
- 38
- Citations by year
- 2026: 84 · 2025: 97 · 2024: 87 · 2023: 135 · 2022: 140 · 2021: 148 · 2020: 148 · 2019: 165 · 2018: 192 · 2017: 211 · 2016: 224 · 2015: 232 · 2014: 231 · 2013: 272 · 2012: 253
- FWCI
- 119.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5t32ns007280-35)
- U.S. Public Health Service (1018438-142-PABCA)
- National Heart, Lung, and Blood Institute (U01HL100397)
- National Cancer Institute (T32CA009302)
- National Institute of Neurological Disorders and Stroke (T32NS-007280, 5T32NS007280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- ASCL1, Brn2, MYT1L, action potential, induced pluripotent stem cells, regenerative medicine
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Action Potentials, Animals, Cell Line, Cells, Cultured, Embryo, Mammalian, Fibroblasts, Nerve Tissue Proteins, Neurons, Synapses, Tail, Time Factors, Transcription Factors, Biomarkers, Cell Lineage, Regenerative Medicine, POU Domain Factors, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Cell Transdifferentiation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
