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Direct conversion of fibroblasts to functional neurons by defined factors
Open accessAbstract
Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.
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“Viral screens using focused overexpression libraries can identify putative reprogramming factors, for example, by identifying a defined set of transcription factors that are selectively required to induce pluripotent stem cells (2–4,7) or trans-differentiate from mature somatic cell into another mature somatic cell (1,8–11).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [10]
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“Despite the power of viral technologies, pooled screens for cell reprogramming have generally adopted a one-by-one elimination approach or testing for exhaustive combinations and interrogating phenotypes in cell culture from transgenic mice (1,3,10) and/or aberrantly cloned cell lines (12).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [10]
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“Furthermore, iPSC-derived cell types from different lineages can be combined into defined three-dimensional cultures, termed assembloids9,94–98.”
From CRISPR-based functional genomics for neurological disease (2020) · cites this paper as [98]
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“MYT1L is a myelin transcription factor required to convert mouse embryonic and postnatal fibroblasts into functional neurons [68].”
From Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders (2012) · cites this paper as [68]
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“Functional induced neurons (iN) can be generated directly from fibroblasts by forced expression of neural specific transcription factors, a process also called transdifferentiation (Vierbuchen et al., 2010).”
From Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation (2016) · cites this paper as Vierbuchen et al., 2010
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Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388
Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Sheep cloned by nuclear transfer from a cultured cell line
Campbell, K., McWhir, J., Ritchie, W. A., & Wilmut, I. (1996) · Nature · doi:10.1038/380064a0 · Cited by 1,868
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
Jaenisch, R., & Young, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.01.015 · Cited by 1,465
Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs
Briggs, R., & King, T. J. (1952) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.38.5.455 · Cited by 1,127
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Items 501–600 of 1,005
Herdy, J., Schafer, S., Kim, Y., Ansari, Z., Zangwill, D., Ku, M., Paquola, A., Lee, H., Mertens, J., & Gage, F. H. (2019) · eLife · doi:10.7554/elife.41356 · Cited by 64
Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling
Pacitti, D., Privolizzi, R., & Bax, B. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00129 · Cited by 66
Essayan-Perez, S., & Südhof, T. C. (2023) · Neuron · doi:10.1016/j.neuron.2023.07.005 · Cited by 66
Self-citationConcise Review: Dedifferentiation Meets Cancer Development: Proof of Concept for Epigenetic Cancer
Yamada, Y., Haga, H., & Yamada, Y. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0090 · Cited by 64
Xu, X., & Zhong, Z. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.63 · Cited by 67
Induced pluripotent stem cells: epigenetic memories and practical implications
Sullivan, G. J., Bai, Y., Fletcher, J. M., & Wilmut, I. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq091 · Cited by 64
Direct in vivo cellular reprogramming involves transition through discrete, non-pluripotent steps
Richard, J. P., Zuryn, S., Fischer, N., Pavet, V., Vaucamps, N., & Jarriault, S. (2011) · Development · doi:10.1242/dev.063115 · Cited by 67
Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation
Iyer, N. R., Wilems, T. S., & Sakiyama‐Elbert, S. E. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26074 · Cited by 65
De novo assembly of plant body plan: a step ahead of Deadpool
Kareem, A., Radhakrishnan, D., Sondhi, Y., Aiyaz, M., Roy, M. V., Sugimoto, K., & Prasad, K. (2016) · Regeneration · doi:10.1002/reg2.68 · Cited by 64
Chanda, S., Marro, S. G., Wernig, M., & Südhof, T. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316240110 · Cited by 64
Self-citationViscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity
Wu, Y., Song, Y., Soto, J., Hoffman, T., Lin, X. Y., Zhang, A., Chen, S., Massad, R. N., Han, X., Qi, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59190-7 · Cited by 65
Berneman, Z. N., Molakandov, K., Elgart, M., Mor, E., Fornoni, A., Domínguez, M. R., Kerr-Conte, J. A., Ott, M., Meivar‐Levy, I., & Ferber, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087812 · Cited by 63
Direct Reprogramming of Melanocytes to Neural Crest Stem-Like Cells by One Defined Factor
Zabierowski, S. E., Baubet, V., Himes, B. T., Li, L., Fukunaga‐Kalabis, M., Patel, S. K., McDaid, R., Guerra, M., Gimotty, P. A., Dahamne, N., et al. (2011) · Stem Cells · doi:10.1002/stem.740 · Cited by 63
Cell transplantation in Parkinson's disease: problems and perspectives
Allan, L. E., Petit, G. H., & Brundin, P. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32833b1f62 · Cited by 63
Francis, N. L., Bennett, N. K., Halikere, A., Pang, Z. P., & Moghe, P. V. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00156 · Cited by 63
Self-citationTargeting of cancer stem cells by differentiation therapy
Arima, Y., Nobusue, H., & Saya, H. (2020) · Cancer Science · doi:10.1111/cas.14504 · Cited by 67
Dynamics and control of state-dependent networks for probing genomic organization
Rajapakse, I., Groudine, M. T., & Mesbahi, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113249108 · Cited by 63
Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB
Maimon, R., Chillon-Marinas, C., Snethlage, C. E., Singhal, S. M., McAlonis-Downes, M., Ling, K., Rigo, F., Bennett, C. F., Da Cruz, S., Hnasko, T. S., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00864-y · Cited by 62
Direct Conversion of Human Fibroblasts into Neuronal Restricted Progenitors
Zou, Q., Yan, Q., Zhong, J., Wang, K., Sun, H., Yi, X., & Lai, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.516112 · Cited by 63
The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development
Oh, S.-Y., Kim, J. Y., & Park, C. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0331 · Cited by 66
Reprogramming of the chick retinal pigmented epithelium after retinal injury
Luz-Madrigal, A., Grajales‐Esquivel, E., McCorkle, A., DiLorenzo, A. M., Barbosa-Sabanero, K., Tsonis, P. A., & Rio‐Tsonis, K. D. (2014) · BMC Biology · doi:10.1186/1741-7007-12-28 · Cited by 62
Neural tissue engineering using embryonic and induced pluripotent stem cells
Willerth, S. M. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt58 · Cited by 62
MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis
Vasconcelos, F. F., Sessa, A., Laranjeira, C., Raposo, A. A. S. F., Teixeira, V., Hagey, D. W., Tomaz, D. M., Muhr, J., Broccoli, V., & Castro, D. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.024 · Cited by 62
MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts
Ghasemi‐Kasman, M., Hajikaram, M., Baharvand, H., & Javan, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127878 · Cited by 62
Transittability of complex networks and its applications to regulatory biomolecular networks
Wu, F., Wu, L., Wang, J., Liu, J., & Chen, L. (2014) · Scientific Reports · doi:10.1038/srep04819 · Cited by 62
DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells
Harterink, M., da Silva, M. E., Will, L., Turan, J., Ibrahim, A., Lang, A. E., van Battum, E. Y., Pasterkamp, R. J., Kapitein, L. C., Kudryashov, D. S., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4257 · Cited by 61
Chen, J., Lambo, M. E., Ge, X., Dearborn, J. T., Liu, Y., McCullough, K. B., Swift, R. G., Tabachnick, D. R., Tian, L., Noguchi, K., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.09.009 · Cited by 65
The Pharmacology of Regenerative Medicine
Christ, G. J., Saul, J. M., Furth, M. E., & Andersson, K. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007393 · Cited by 63
Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes
Tian, E., Sun, G., Sun, G., Chao, J., Ye, P., Warden, C., Riggs, A. D., & Shi, Y. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.042 · Cited by 61
Bertacchi, M., Parisot, J., & Studer, M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.024 · Cited by 64
ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility
van der Raadt, J., van Gestel, S. H. C., Kasri, N. N., & Albers, C. A. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz273 · Cited by 62
Directed Differentiation of Pluripotent Stem Cells by Transcription Factors.
Oh, Y., & Jang, J. (2019) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2019.2439 · Cited by 61
Using Dental Pulp Stem Cells for Stroke Therapy
Gancheva, M. R., Kremer, K. L., Gronthos, S., & Koblar, S. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00422 · Cited by 62
Cell Reprogramming: The Many Roads to Success
Aydın, B., & Mazzoni, E. O. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125127 · Cited by 63
Epigenetic reprogramming of cell identity: lessons from development for regenerative medicine
Basu, A., & Tiwari, V. K. (2021) · Clinical Epigenetics · doi:10.1186/s13148-021-01131-4 · Cited by 61
Direct Neuronal Reprogramming: Bridging the Gap Between Basic Science and Clinical Application
Vasan, L., Park, E., David, L. A., Fleming, T., & Schuurmans, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.681087 · Cited by 61
Developing nociceptor-selective treatments for acute and chronic pain
Jayakar, S. S., Shim, J., Jo, S., Bean, B. P., Singeç, I., & Woolf, C. J. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj9837 · Cited by 62
Strategies of pluripotent stem cell-based therapy for retinal degeneration: update and challenges
Maeda, T., Mandai, M., Sugita, S., Kime, C., & Takahashi, M. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.03.001 · Cited by 63
Reprogramming Cancer into Antigen-Presenting Cells as a Novel Immunotherapy
Linde, M. H., Fan, A. C., Köhnke, T., Trotman-Grant, A. C., Gurev, S. F., Phan, P., Zhao, F., Haddock, N. L., Nuno, K. A., Gars, E. J., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0502 · Cited by 61
Capturing epidermal stemness for regenerative medicine
Barrandon, Y., Grasset, N., Zaffalon, A., Gorostidi, F., Claudinot, S., Droz-Georget, S. L., Nanba, D., & Rochat, A. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.09.011 · Cited by 61
Miyamoto, K., & Gurdon, J. B. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1235-7 · Cited by 60
Glioma Gene Therapy Using Induced Pluripotent Stem Cell Derived Neural Stem Cells
Lee, E. X., Lam, D. H., Wu, C., Yang, J., Tham, C. K., Ng, W. H., & Wang, S. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200127u · Cited by 60
RetractedConversion of MyoD to a Neurogenic Factor: Binding Site Specificity Determines Lineage
Fong, A. P., Yao, Z., Zhong, J. W., Johnson, N. M., Farr, G. H., Maves, L., & Tapscott, S. J. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.055 · Cited by 60
Retinal regeneration in birds and mice
Wilken, M. S., & Reh, T. A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.028 · Cited by 60
Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes
Chouchane, M., de Farias, A. R. M., Moura, D. M. D. S., Hilscher, M. M., Schroeder, T., Leão, R. N., & Costa, M. R. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.009 · Cited by 60
BRN 2, a POU erful driver of melanoma phenotype switching and metastasis
Fane, M. E., Chhabra, Y., Smith, A. G., & Sturm, R. A. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12710 · Cited by 66
Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming
Fang, J., Hsueh, Y., Soto, J., Sun, W., Wang, J., Gu, Z., Khademhosseini, A., & Li, S. (2020) · ACS Nano · doi:10.1021/acsnano.9b04837 · Cited by 61
Qiang, L., Fujita, R., & Abeliovich, A. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.002 · Cited by 59
Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells
Cassady, J. P., D’Alessio, A. C., Sarkar, S., Dani, V. S., Fan, Z. P., Ganz, K., Roessler, R., Sur, M., Young, R. A., & Jaenisch, R. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.10.001 · Cited by 59
Zhang, S., Bell, E., Zhi, H., Brown, S., Imran, S. A. M., Azuara, V., & Cui, W. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1228-7 · Cited by 59
Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology
Pei, D., Xu, J., Zhuang, Q., Tse, H., & Esteban, M. A. (2010) · Springer eBooks · doi:10.1007/10_2010_72 · Cited by 59
Barker, R. A., & de Beaufort, I. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.04.003 · Cited by 59
Nonviral Direct Conversion of Primary Mouse Embryonic Fibroblasts to Neuronal Cells
Adler, A. F., Grigsby, C. L., Kulangara, K., Wang, H., Yasuda, R., & Leong, K. W. (2012) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2012.25 · Cited by 60
Xu, L., Zhang, K., & Wang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105216 · Cited by 59
Methods to assess stem cell lineage, fate and function
Nguyen, P. K. P., Nag, D., & Wu, J. C. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.08.008 · Cited by 59
Chemically Induced Reprogramming of Somatic Cells to Pluripotent Stem Cells and Neural Cells
Biswas, D., & Jiang, P. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020226 · Cited by 60
Application of Stem Cells in Oral Disease Therapy: Progresses and Perspectives
Yang, B., Qiu, Y., Zhou, N., Ouyang, H., Ding, J., Cheng, B., & Sun, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00197 · Cited by 60
Hemmer, K., Zhang, M., van Wüllen, T., Sakalem, M. E., Tàpia, N., Baumuratov, A., Kaltschmidt, C., Kaltschmidt, B., Schöler, H. R., Zhang, W., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.06.017 · Cited by 58
Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos
Armant, O., März, M., Viales, R. R., Ferg, M., Diotel, N., Ertzer, R., Bryne, J. C., Yang, L., Baader, I., Reischl, M., et al. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.05.006 · Cited by 61
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Foshay, K. M., Looney, T. J., Chari, S., Mao, F. F., Lee, J. H., Zhang, L., Fernandes, C. J., Baker, S. W., Clift, K. L., Gaetz, J., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.013 · Cited by 59
Castro, D. S., & Guillemot, F. (2011) · Cell Cycle · doi:10.4161/cc.10.23.18578 · Cited by 61
Rocker, N. D., Vergult, S., Koolen, D. A., Jacobs, E., Hoischen, A., Zeesman, S., Bang, B., Béna, F., Bockaert, N., Bongers, E. M. H. F., et al. (2014) · Genetics in Medicine · doi:10.1038/gim.2014.124 · Cited by 58
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Silber, B. M. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000169 · Cited by 60
Making a Hematopoietic Stem Cell
Daniel, M. G., Pereira, C., Lemischka, I. R., & Moore, K. A. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.002 · Cited by 61
Aoki, H., Hara, A., Era, T., Kunisada, T., & Yamada, Y. (2012) · Development · doi:10.1242/dev.072272 · Cited by 58
Doucet-Beaupré, H., Ang, S., & Lévesque, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.10.020 · Cited by 58
The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells
Cortés, D., Carballo-Molina, O. A., Castellanos‐Montiel, M. J., & Velasco, I. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00258 · Cited by 58
Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.086 · Cited by 66
Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L. J., Eckert, D., Hebisch, M., Fischer, J., Kesavan, J., Weykopf, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06398-5 · Cited by 59
Chemical compound-based direct reprogramming for future clinical applications.
Takeda, Y., Harada, Y., Yoshikawa, T., & Dai, P. (2018) · Bioscience Reports · doi:10.1042/bsr20171650 · Cited by 57
The complex simplicity of the brittle star nervous system
Zueva, O. R., Khoury, M., Heinzeller, T., Mashanova, D., & Mashanov, V. S. (2018) · Frontiers in Zoology · doi:10.1186/s12983-017-0247-4 · Cited by 57
Babos, K. N., Galloway, K. E., Kisler, K., Zitting, M., Li, Y., Shi, Y., Quintino, B., Chow, R. H.-P., Zloković, B. V., & Ichida, J. K. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.08.005 · Cited by 58
Oh, B., Wu, Y., Swaminathan, V., Lam, V., Ding, J., & George, P. M. (2021) · Advanced Science · doi:10.1002/advs.202002112 · Cited by 57
Phenotypic plasticity during metastatic colonization
Jehanno, C., Vulin, M., Richina, V., Richina, F., & Bentires‐Alj, M. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.03.007 · Cited by 60
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Mantegazza, M., Rusconi, R., Scalmani, P., AVANZINI, G., & Franceschetti, S. (2010) · Epilepsy Research · doi:10.1016/j.eplepsyres.2010.08.003 · Cited by 59
Illich, D. J., Demir, N., Stojković, M., Scheer, M., Rothamel, D., Neugebauer, J., Hescheler, J., & Zöller, J. E. (2011) · Stem Cells · doi:10.1002/stem.611 · Cited by 57
MYT1L is a candidate gene for intellectual disability in patients with 2p25.3 (2pter) deletions
Stevens, S. J. C., van Ravenswaaij‐Arts, C. M. A., Janssen, J. W. H., Wassink‐Ruiter, J. S. K., van Essen, A. J., Dijkhuizen, T., van Rheenen, J., Heuts‐Vijgen, R., Stegmann, A. P. A., Smeets, E., et al. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.34274 · Cited by 57
Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion
Capellera-Garcia, S., Pulecio, J., Dhulipala, K., Siva, K., Rayon-Estrada, V., Singbrant, S., Sommarin, M. N. E., Walkley, C. R., Soneji, S., Karlsson, G., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.027 · Cited by 63
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Sartorelli, V., & Puri, P. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.04.025 · Cited by 59
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Metadata
- Authors
- Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M.
- Affiliations
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Wernig, Marius
- Venue
- Nature
- Published
- 2010-01-27
- Volume
- 463
- Issue
- 7284
- Pages
- 1035-1041
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2829121
- OpenAlex
- W2136541538
- Cited by
- 3,017
- References
- 38
- Citations by year
- 2026: 84 · 2025: 97 · 2024: 87 · 2023: 135 · 2022: 140 · 2021: 148 · 2020: 148 · 2019: 165 · 2018: 192 · 2017: 211 · 2016: 224 · 2015: 232 · 2014: 231 · 2013: 272 · 2012: 253
- FWCI
- 119.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5t32ns007280-35)
- U.S. Public Health Service (1018438-142-PABCA)
- National Heart, Lung, and Blood Institute (U01HL100397)
- National Cancer Institute (T32CA009302)
- National Institute of Neurological Disorders and Stroke (T32NS-007280, 5T32NS007280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- ASCL1, Brn2, MYT1L, action potential, induced pluripotent stem cells, regenerative medicine
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Action Potentials, Animals, Cell Line, Cells, Cultured, Embryo, Mammalian, Fibroblasts, Nerve Tissue Proteins, Neurons, Synapses, Tail, Time Factors, Transcription Factors, Biomarkers, Cell Lineage, Regenerative Medicine, POU Domain Factors, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Cell Transdifferentiation
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