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Direct conversion of fibroblasts to functional neurons by defined factors
Open accessAbstract
Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. Recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l, that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.
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“Viral screens using focused overexpression libraries can identify putative reprogramming factors, for example, by identifying a defined set of transcription factors that are selectively required to induce pluripotent stem cells (2–4,7) or trans-differentiate from mature somatic cell into another mature somatic cell (1,8–11).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [10]
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“Despite the power of viral technologies, pooled screens for cell reprogramming have generally adopted a one-by-one elimination approach or testing for exhaustive combinations and interrogating phenotypes in cell culture from transgenic mice (1,3,10) and/or aberrantly cloned cell lines (12).”
From Establishment of single-cell screening system for the rapid identification of transcriptional modulators involved in direct cell reprogramming (2012) · cites this paper as [10]
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“Furthermore, iPSC-derived cell types from different lineages can be combined into defined three-dimensional cultures, termed assembloids9,94–98.”
From CRISPR-based functional genomics for neurological disease (2020) · cites this paper as [98]
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“MYT1L is a myelin transcription factor required to convert mouse embryonic and postnatal fibroblasts into functional neurons [68].”
From Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders (2012) · cites this paper as [68]
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“Functional induced neurons (iN) can be generated directly from fibroblasts by forced expression of neural specific transcription factors, a process also called transdifferentiation (Vierbuchen et al., 2010).”
From Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation (2016) · cites this paper as Vierbuchen et al., 2010
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Expression of a single transfected cDNA converts fibroblasts to myoblasts
Davis, R. L., Weintraub, H. M., & Lassar, A. B. (1987) · Cell · doi:10.1016/0092-8674(87)90585-x · Cited by 3,388
Bernstein, B. E., Meissner, A., & Lander, E. S. (2007) · Cell · doi:10.1016/j.cell.2007.01.033 · Cited by 2,086
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Sheep cloned by nuclear transfer from a cultured cell line
Campbell, K., McWhir, J., Ritchie, W. A., & Wilmut, I. (1996) · Nature · doi:10.1038/380064a0 · Cited by 1,868
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
Jaenisch, R., & Young, R. A. (2008) · Cell · doi:10.1016/j.cell.2008.01.015 · Cited by 1,465
Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs
Briggs, R., & King, T. J. (1952) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.38.5.455 · Cited by 1,127
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 1,005
CRISPR-based functional genomics for neurological disease
Kampmann, M. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0373-z · Cited by 163
Tang, Y., Liu, M.-L., Zang, T., & Zhang, C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00359 · Cited by 170
Molecular Co-occupancy Identifies Transcription Factor Binding Cooperativity In Vivo
Sönmezer, C., Kleinendorst, R., Imanci, D., Barzaghi, G., Villacorta, L., Schübeler, D., Benes, V., Molina, N., & Krebs, A. R. (2021) · Molecular Cell · doi:10.1016/j.molcel.2020.11.015 · Cited by 162
Neural Stem Cells: Historical Perspective and Future Prospects
Breunig, J. J., Haydar, T. F., & RAKIC, P. T. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.005 · Cited by 167
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons
Yoshimizu, T., Pan, J. Q., Mungenast, A. E., Madison, J. M., Su, S. C., Ketterman, J., Öngür, D., McPhie, D. L., Cohen, B. M., Perlis, R. H., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.143 · Cited by 161
Present state and future perspectives of using pluripotent stem cells in toxicology research
Wobus, A. M., & Löser, P. (2011) · Archives of Toxicology · doi:10.1007/s00204-010-0641-6 · Cited by 161
Zhang, Y., Li, W., Laurent, T., & Ding, S. (2012) · Journal of Cell Science · doi:10.1242/jcs.096032 · Cited by 165
Direct reprogramming of human astrocytes into neural stem cells and neurons
Corti, S. P., Nizzardo, M., Simone, C., Falcone, M., Donadoni, C., Salani, S., Rizzo, F., Nardini, M., Riboldi, G. M., Magri, F., et al. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.02.040 · Cited by 165
Bardy, C., van den Hurk, M., Kakaradov, B., Erwin, J. A., Jaeger, B. N., Hernandez, R. V., Eames, T., Paucar, A. A., Gorris, M. A. J., Marchand, C., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.158 · Cited by 166
TGF-β family signaling in stem cells
Sakaki‐Yumoto, M., Katsuno, Y., & Derynck, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.008 · Cited by 163
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions
Wang, J., Yu, H., Ma, Q., Zeng, P., Wu, D., Hou, Y., Liu, X., Jia, L., Sun, J., Chen, Y., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.04.023 · Cited by 164
Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani, H., Martin, E., Hassani, H., Clavairoly, A., Maire, C. L., Viadieu, A., Kerninon, C., Delmasure, A., Frah, M., Weber, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-13.2013 · Cited by 158
Maintaining differentiated cellular identity
Holmberg, J., & Perlmann, T. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3209 · Cited by 166
Liu, M.-L., Zang, T., & Zhang, C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.12.018 · Cited by 164
Rejuvenating Strategies for Stem Cell-Based Therapies in Aging
Neves, J., Sousa‐Victor, P., & Jasper, H. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.01.008 · Cited by 160
Gene-pair expression signatures reveal lineage control
Heinäniemi, M., Nykter, M., Kramer, R., Wienecke-Baldacchino, A. K., Sinkkonen, L., Zhou, J., Kreisberg, R., Kauffman, S. A., Huang, S., & Shmulevich, I. (2013) · Nature Methods · doi:10.1038/nmeth.2445 · Cited by 157
Induced Pluripotent Stem Cells from Individuals with Recessive Dystrophic Epidermolysis Bullosa
Tolar, J., Xia, L., Riddle, M. J., Lees, C. J., Eide, C. R., McElmurry, R. T., Titeux, M., Osborn, M. J., Lund, T. C., Hovnanian, A., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.346 · Cited by 155
In vivo reprogramming of Sox9 + cells in the liver to insulin-secreting ducts
Banga, A., Akıncı, E., Greder, L. V., Dutton, J. R., & Slack, J. M. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201701109 · Cited by 159
Sensory hair cell development and regeneration: similarities and differences
Atkinson, P. J., Najarro, E. H., Sayyid, Z. N., & Cheng, A. G.-L. (2015) · Development · doi:10.1242/dev.114926 · Cited by 156
Immunogenicity of Pluripotent Stem Cells and Their Derivatives
de Almeida, P. E., Ransohoff, J. D., Nahid, A., & Wu, J. C. (2013) · Circulation Research · doi:10.1161/circresaha.111.249243 · Cited by 159
Yoo, J., Lee, E., Kim, H. Y., Youn, D., Jung, J., Kim, H., Chang, Y., Lee, W., Shin, J., Baek, S., et al. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.133 · Cited by 154
Molecular features of cellular reprogramming and development
Smith, Z. D., Sindhu, C., & Meissner, A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.6 · Cited by 155
Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases
Marchetto, M. C. N., Winner, B., & Gage, F. H. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq159 · Cited by 152
Phorbol-Ester Mediated Suppression of hASH1 Synthesis: Multiple Ways to Keep the Level Down
Benko, E., Winkelmann, A., Meier, J. C., Persson, P. B., Scholz, H., & Fähling, M. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00001 · Cited by 150
Cell-based transplantation strategies to promote plasticity following spinal cord injury
Ruff, C. A., Wilcox, J. T., & Fehlings, M. G. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.010 · Cited by 149
Induced Pluripotent Stem Cells for Regenerative Medicine
Hirschi, K. K., Li, S., & Roy, K. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105108 · Cited by 157
Li, X., Thome, S., Ma, X., Amrute‐Nayak, M., Finigan, A. J., Kitt, L., Masters, L. M., James, J. R., Shi, Y., Meng, G., et al. (2017) · Nature Communications · doi:10.1038/ncomms15986 · Cited by 160
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors
Sheng, C., Zheng, Q., Wu, J., Xu, Z., Wang, L., Li, W., Zhang, H., Zhao, X., Liu, L., Wang, Z., et al. (2011) · Cell Research · doi:10.1038/cr.2011.175 · Cited by 148
Mu, L., Berti, L., Masserdotti, G., Covic, M., Michaelidis, T. M., Doberauer, K., Merz, K., Rehfeld, F., Haslinger, A., Wegner, M., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4679-11.2012 · Cited by 147
Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2
Lee, S., Park, C., Han, J. W., Kim, J. Y., Cho, K.-W., Kim, S., Kim, S., Lee, S.-J., Oh, S. Y., Tanaka, Y., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309833 · Cited by 147
Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling
Brumbaugh, J., Stefano, B. D., Wang, X., Borkent, M., Forouzmand, E., Clowers, K. J., Ji, F., Schwarz, B. A., Kalocsay, M., Elledge, S. J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.023 · Cited by 148
Conversion of human fibroblasts to angioblast-like progenitor cells
Kurian, L., Sancho-Martinez, I., Nivet, E., Aguirre, A., Moon, K., Pendaries, C., Volle-Challier, C., Bono, F., Herbert, J.-M., Pulecio, J., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2255 · Cited by 145
A deterministic map of Waddington's epigenetic landscape for cell fate specification
Bhattacharya, S., Zhang, Q., & Andersen, M. E. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-85 · Cited by 151
Application of Magnetic Nanoparticles to Gene Delivery
Kami, D., Takeda, S., Itakura, Y., Gojo, S., Watanabe, M., & Toyoda, M. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12063705 · Cited by 145
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex
Heinrich, C., Gascón, S., Masserdotti, G., Lepier, A., Sánchez, R., Simon‐Ebert, T., Schroeder, T., Götz, M., & Berninger, B. (2011) · Nature Protocols · doi:10.1038/nprot.2010.188 · Cited by 151
Making Sense of Transcription Networks
Sorrells, T. R., & Johnson, A. D. (2015) · Cell · doi:10.1016/j.cell.2015.04.014 · Cited by 148
Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke
Wei, L., Wei, Z. Z., Jiang, M. Q., Mohamad, O., & Yu, S. P. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.003 · Cited by 146
Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discoveryPreprint
Murre, C. (2019) · Genes & Development · doi:10.1101/gad.320663.118 · Cited by 145
Kim, Y. J., Lim, H., Li, Z., Oh, Y., Kovlyagina, I., Choi, I.-Y., Dong, X.-Z., & Lee, G. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.013 · Cited by 142
In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes
Li, W.-D., Nakanishi, M., Zumsteg, A., Shear, M. A., Wright, C., Melton, D., & Zhou, Q. (2014) · eLife · doi:10.7554/elife.01846 · Cited by 140
Pluripotent stem cell-based therapy for Parkinson’s disease: Current status and future prospects
Sonntag, K., Song, B., Lee, N., Jung, J. H., Cha, Y., Leblanc, P. R., Neff, C., Kong, S. W., Carter, B. S., Schweitzer, J., et al. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.04.005 · Cited by 144
Neural grafting in Parkinson’s disease
Brundin, P., Barker, R. A., & Parmar, M. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)84014-2 · Cited by 145
Reciprocal Modulation Between Microglia and Astrocyte in Reactive Gliosis Following the CNS Injury
Gao, Z., Zhu, Q., Zhang, Y., Zhao, Y., Cai, L., Shields, C. B., & Cai, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8460-4 · Cited by 148
Epigenetic control of embryonic stem cell fate
Christophersen, N. S., & Helin, K. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101438 · Cited by 143
Modeling Dravet syndrome using induced pluripotent stem cells (iPSCs) and directly converted neurons
Jiao, J., Yang, Y., Shi, Y., Chen, J., Gao, R., Fan, Y., Yao, H., Liao, W., Sun, X., & Gao, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt275 · Cited by 141
Balakrishnan, A., Belfiore, L., Chu, T., Fleming, T., Midha, R., Biernaskie, J. A., & Schuurmans, C. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.608442 · Cited by 149
Kaminski, M. M., Tasić, J., Kresbach, C., Engel, H., Klockenbusch, J., Müller, A.-L., Pichler, R., Grahammer, F., Kretz, O., Huber, T. B., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3437 · Cited by 142
How to make spinal motor neurons
Davis‐Dusenbery, B. N., Williams, L. A., Klim, J. R., & Eggan, K. C. (2014) · Development · doi:10.1242/dev.097410 · Cited by 146
Stem cell therapy for neonatal brain injury: Perspectives and Challenges
Titomanlio, L., Kavelaars, A., Dalous, J., Mani, S., Ghouzzi, V. E., Heijnen, C. J., Baud, O., & Gressèns, P. (2011) · Annals of Neurology · doi:10.1002/ana.22518 · Cited by 138
Rapid Chromatin Switch in the Direct Reprogramming of Fibroblasts to Neurons
Wapinski, O. L., Lee, Q. Y., Chen, A. C., Li, R., Corces, M. R., Ang, C. E., Treutlein, B., Xiang, C., Baubet, V., Suchy, F. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.011 · Cited by 147
Self-citationSUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States
Cossec, J., Theurillat, I., Chica, C., Búa, S., Gaume, X., Andrieux, A., Iturbide, A., Jouvion, G., Li, H., Bossis, G., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.10.001 · Cited by 144
Moving Stem Cells to the Clinic: Potential and Limitations for Brain Repair
Steinbeck, J. A., & Studer, L. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.002 · Cited by 138
The functions of microRNAs in pluripotency and reprogramming
Leonardo, T. R., Schultheisz, H. L., Loring, J. F., & Laurent, L. C. (2012) · Nature Cell Biology · doi:10.1038/ncb2613 · Cited by 138
Beck, D., Thoms, J. A. I., Perera, D., Schütte, J., Unnikrishnan, A., Knezevic, K., Kinston, S. J., Wilson, N. K., O’Brien, T. A., Göttgens, B., et al. (2013) · Blood · doi:10.1182/blood-2013-03-490425 · Cited by 133
Maza, I., Caspi, I., Zviran, A., Chomsky, E., Rais, Y., Viukov, S. V., Geula, S., Buenrostro, J. D., Weinberger, L., Krupalnik, V., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3270 · Cited by 136
Generation of functional human serotonergic neurons from fibroblasts
Vadodaria, K. C., Mertens, J., Paquola, A. C. M., Bardy, C., Li, X., Jappelli, R., Fung, L., Marchetto, M. C., Hamm, M., Gorris, M. A. J., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.161 · Cited by 132
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons
Jiang, H., Xu, Z., Zhong, P., Ren, Y., Liang, G., Schilling, H. A., Hu, Z., Zhang, Y., Wang, X., Chen, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms10100 · Cited by 133
Currie, K. W., & Pearson, B. J. (2013) · Development · doi:10.1242/dev.098590 · Cited by 131
Direct neuronal reprogramming: learning from and for development
Masserdotti, G., Gascón, S., & Götz, M. (2016) · Development · doi:10.1242/dev.092163 · Cited by 130
VLDLR and ApoER2 are receptors for multiple alphaviruses
Clark, L. E., Clark, S. A., Lin, C., Liu, J., Coscia, A., Smith, K. N., Yang, P., Neel, D. V., Lee, H., Brusic, V., et al. (2021) · Nature · doi:10.1038/s41586-021-04326-0 · Cited by 135
Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells
Pedrosa, E., Sandler, V. M., Shah, A., Carroll, R. C., Chang, C.-J., Rockowitz, S., Guo, X., Zheng, D., & Lachman, H. M. (2011) · Journal of Neurogenetics · doi:10.3109/01677063.2011.597908 · Cited by 129
A blueprint for engineering cell fate: current technologies to reprogram cell identity
Morris, S. A., & Daley, G. Q. (2013) · Cell Research · doi:10.1038/cr.2013.1 · Cited by 131
Sadahiro, T., Yamanaka, S., & Ieda, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.305374 · Cited by 132
Smith, D. K., Yang, J., Liu, M.-L., & Zhang, C. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.09.013 · Cited by 131
Pluripotent stem cells in neuropsychiatric disorders
Soliman, M. A., Aboharb, F., Zeltner, N., & Studer, L. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.40 · Cited by 132
Neural stem cell therapy—Brief review
Grochowski, C., Radzikowska, E., & Maciejewski, R. (2018) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2018.07.013 · Cited by 134
Carlson, A. L., Bennett, N. K., Francis, N. L., Halikere, A., Clarke, S. G., Moore, J. C., Hart, R. P., Paradiso, K. G., Wernig, M., Kohn, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10862 · Cited by 127
Self-citationA Single-Cell Roadmap of Lineage Bifurcation in Human ESC Models of Embryonic Brain Development
Yao, Z., Mich, J. K., Ku, S., Menon, V., Krostag, A.-R., Martinez, R. A., Furchtgott, L., Mulholland, H., Bort, S. J., Fuqua, M. A., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.09.011 · Cited by 130
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches
Bocchi, R., Masserdotti, G., & Götz, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.023 · Cited by 135
In vitro analysis of mesenchymal stem cells derived from human teeth and bone marrow
Tamaki, Y., Nakahara, T., Ishikawa, H., & Sato, S. (2012) · Odontology · doi:10.1007/s10266-012-0075-0 · Cited by 126
The Role of Astrocytes in the Neurorepair Process
Chiareli, R. A., Carvalho, G. A., Marques, B. L., Mota, L. S., Oliveira‐Lima, O. C., Gomes, R. M., Birbrair, A., Gomez, R. S., Simão, F., Klempin, F., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665795 · Cited by 130
Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency
Chambers, S. M., & Studer, L. (2011) · Cell · doi:10.1016/j.cell.2011.05.036 · Cited by 125
Mattioli, C. C., Rom, A., Franke, V., Imami, K., Arrey, G., Terne, M., Woehler, A., Akalin, A., Ulitsky, I., & Chekulaeva, M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1270 · Cited by 125
Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program
Karow, M., Camp, J. G., Falk, S., Gerber, T., Pataskar, A., Santel, M., Kageyama, J., Brazovskaja, A., Garding, A., Fan, W., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0168-3 · Cited by 130
MicroRNAs and Cellular Phenotypy
Kosik, K. S. (2010) · Cell · doi:10.1016/j.cell.2010.09.008 · Cited by 124
Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors
Li, J., Huang, N. F., Zou, J., Laurent, T., Lee, J. C., Okogbaa, J., Cooke, J. P., & Ding, S. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301167 · Cited by 123
Transient nuclear deformation primes epigenetic state and promotes cell reprogramming
Song, Y., Soto, J., Chen, B., Hoffman, T., Zhao, W., Zhu, N., Qin, P., Liu, L., Ly, C., Wong, P. K., et al. (2022) · Nature Materials · doi:10.1038/s41563-022-01312-3 · Cited by 124
Proneural genes in neocortical development
Wilkinson, G., Dennis, D. J., & Schuurmans, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.029 · Cited by 122
Arenas, E. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju001 · Cited by 128
Diverse reprogramming codes for neuronal identity
Tsunemoto, R. K., Lee, S., Szűcs, A. L., Chubukov, P., Sokolova, I., Blanchard, J., Eade, K., Bruggemann, J., Wu, C., Torkamani, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0103-5 · Cited by 126
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Metadata
- Authors
- Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M.
- Affiliations
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Wernig, Marius
- Venue
- Nature
- Published
- 2010-01-27
- Volume
- 463
- Issue
- 7284
- Pages
- 1035-1041
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2829121
- OpenAlex
- W2136541538
- Cited by
- 3,017
- References
- 38
- Citations by year
- 2026: 84 · 2025: 97 · 2024: 87 · 2023: 135 · 2022: 140 · 2021: 148 · 2020: 148 · 2019: 165 · 2018: 192 · 2017: 211 · 2016: 224 · 2015: 232 · 2014: 231 · 2013: 272 · 2012: 253
- FWCI
- 119.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5t32ns007280-35)
- U.S. Public Health Service (1018438-142-PABCA)
- National Heart, Lung, and Blood Institute (U01HL100397)
- National Cancer Institute (T32CA009302)
- National Institute of Neurological Disorders and Stroke (T32NS-007280, 5T32NS007280)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- ASCL1, Brn2, MYT1L, action potential, induced pluripotent stem cells, regenerative medicine
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Action Potentials, Animals, Cell Line, Cells, Cultured, Embryo, Mammalian, Fibroblasts, Nerve Tissue Proteins, Neurons, Synapses, Tail, Time Factors, Transcription Factors, Biomarkers, Cell Lineage, Regenerative Medicine, POU Domain Factors, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Cell Transdifferentiation
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