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Ancient human genome sequence of an extinct Palaeo-Eskimo
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We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. For the first time, the sequence of a near-complete nuclear genome has been obtained from the tissue of an ancient human. It comes from permafrost-preserved hair, about 4,000 years old, of a male palaeo-Eskimo of the Saqqaq culture, the earliest known settlers in Greenland. Functional single-nucleotide polymorphism (SNP) assessment was used to assign possible phenotypic characteristics. The analysis provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of the migration that gave rise to the modern Native Americans and Inuit. Elsewhere in the issue we profile the paper's last author Eske Willerslev, who headed the project and found the lock of hair in a Copenhagen museum basement — after a fruitless search among the archaeological sites of Peary Land. The first genome sequence of an ancient human is reported. It comes from an approximately 4,000-year-old permafrost-preserved hair from a male from the first known culture to settle in Greenland. Functional single-nucleotide polymorphism (SNP) assessment is used to assign possible phenotypic characteristics and high-confidence SNPs are compared to those of contemporary populations to find those most closely related to the individual.
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“As the Anzick-1 individual was found to be male, we were also able to quantify contamination levels based on the heterozygosity levels seen on the X chromosome19, which resulted in similarly low contamination estimates (<1.2%, SI11).”
From The genome of a Late Pleistocene human from a Clovis burial site in western Montana (2014) · cites this paper as [19]
Experimental — accuracy not yet measuredIn the citing paper
“Subsequent migration of the ancestors of the Inuit is evident from the genome sequence of ~4000-year-old Saqqaqman [39].”
From Ancient DNA and the rewriting of human history: be sparing with Occam’s razor (2016) · cites this paper as [39]
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Cites
Fast model-based estimation of ancestry in unrelated individuals
Alexander, D. H., Novembre, J., & Lange, K. (2009) · Genome Research · doi:10.1101/gr.094052.109 · Cited by 9,898
Accurate whole human genome sequencing using reversible terminator chemistry
Bentley, D. R., Balasubramanian, S., Swerdlow, H. P., Smith, G. P., Milton, J., Brown, C. G., Hall, K. P., Evers, D. J., Barnes, C. L., Bignell, H. R., et al. (2008) · Nature · doi:10.1038/nature07517 · Cited by 3,684
Intcal04 Terrestrial Radiocarbon Age Calibration, 0–26 Cal Kyr BP
(2004) · Radiocarbon · doi:10.1017/s0033822200032999 · Cited by 3,673
Self-citationThe History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
Skaletsky, H., Kuroda-Kawaguchi, T., Minx, P. J., Cordum, H. S., Hillier, L., Brown, L. G., Repping, S., Pyntikova, T., Ali, J., Bieri, T. A., et al. (2003) · Nature · doi:10.1038/nature01722 · Cited by 2,148
Genome-wide detection and characterization of positive selection in human populations
The International HapMap Consortium, Sabeti, P. C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E. H., McCarroll, S. A., et al. (2007) · Nature · doi:10.1038/nature06250 · Cited by 2,131
Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
Li, J. Z., Absher, D. M., Tang, H., Southwick, A. M., Casto, A. M., Ramachandran, S., Cann, H. M., Barsh, G. S., Feldman, M. W., Cavalli-Sforza, L. L., et al. (2008) · Science · doi:10.1126/science.1153717 · Cited by 1,915
The complete genome of an individual by massively parallel DNA sequencing
Wheeler, D. A., Srinivasan, M., Egholm, M., Shen, Y., Chen, L., McGuire, A., He, W., Chen, Y.-J., Makhijani, V., Roth, G. T., et al. (2008) · Nature · doi:10.1038/nature06884 · Cited by 1,838
The Diploid Genome Sequence of an Individual Human
Levy, S., Sutton, G., Ng, P. C., Feuk, L., Halpern, A. L., Walenz, B. P., Axelrod, N., Huang, J., Kirkness, E. F., Denisov, G., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050254 · Cited by 1,778
The history and geography of human genes
Cann, R. L. (1995) · Choice Reviews Online · doi:10.5860/choice.33-0316 · Cited by 1,328
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- Harritt, R. Paleo-eskimo beginnings in North America: a new discovery at Kuzitrin lake, Alaska. Etud. Inuit 22, 61–81 (1998)
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Items 201–300 of 845
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Zhao, X., Valen, E., Parker, B. J., & Sandelin, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023409 · Cited by 67
Pros and cons of methylation-based enrichment methods for ancient DNA
Seguin-Orlando, A., Gamba, C., Sarkissian, C. D., Ermini, L., Louvel, G., Boulygina, E., Sokolov, A., Nedoluzhko, A., Lorenzen, E. D., Lopez, P., et al. (2015) · Scientific Reports · doi:10.1038/srep11826 · Cited by 58
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Zhou, S., Ambalavanan, A., Rochefort, D. L., Xie, P., Bourassa, C. V., Hince, P., Dionne‐Laporte, A., Spiegelman, D., Gan‐Or, Z., Mirarchi, C., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.09.001 · Cited by 72
Chaitanya, L., Ralf, A., van Oven, M., Kupiec, T., Chang, J., Lagace, R. E., & Kayser, M. (2015) · Human Mutation · doi:10.1002/humu.22905 · Cited by 66
Migliano, A. B., Romero, I. G., Metspalu, M., Leavesley, M., Pagani, L., Antão, T., Huang, D., Sherman, B. T., Siddle, K., Scholes, C., et al. (2013) · Human Biology · doi:10.3378/027.085.0313 · Cited by 66
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Arango-Isaza, E., Capodiferro, M. R., Aninao, M. J., Babiker, H. M. A., Aeschbacher, S., Achilli, A., Posth, C., Campbell, R., Martínez, F. I., Heggarty, P., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.05.013 · Cited by 64
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Fortes, G. G., & Paijmans, J. L. A. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2990-0_13 · Cited by 62
Brown, S. K., Pedersen, N. C., Shoorijeh, S. J., Bannasch, D. L., Ahrens, K. D., Wu, J.-T., Okon, M., & Sacks, B. N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028496 · Cited by 63
Greenland climate change: from the past to the future
Masson‐Delmotte, V., Swingedouw, D., Landais, A., Seidenkrantz, M., Gauthier, É., Bichet, V., Massa, C., Perren, B., Jomelli, V., Ađalgeirsdóttir, G., et al. (2012) · Wiley Interdisciplinary Reviews Climate Change · doi:10.1002/wcc.186 · Cited by 63
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Bolnick, D. A., Bonine, H. M., Mata‐Míguez, J., Kemp, B. M., Snow, M. H., & LeBlanc, S. A. (2011) · American Journal of Physical Anthropology · doi:10.1002/ajpa.21647 · Cited by 65
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Malyarchuk, B. А., Derenko, M. V., Denisova, G. A., Maksimov, A., Woźniak, M., Grzybowski, T., Dambueva, I. K., & Захаров, И. А. (2011) · Journal of Human Genetics · doi:10.1038/jhg.2011.64 · Cited by 62
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Sarkissian, C. S. I. D., Ermini, L., Jónsson, H., Alekseev, A. N., Crubézy, É., Shapiro, B., & Orlando, L. (2014) · Molecular Ecology · doi:10.1111/mec.12690 · Cited by 63
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Fenger-Nielsen, R., Hollesen, J., Matthiesen, H., Andersen, E. A. S., Westergaard‐Nielsen, A., Harmsen, H., Michelsen, A., & Elberling, B. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.018 · Cited by 61
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Insights into hominin phenotypic and dietary evolution from ancient DNA sequence data
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Self-citationHerrera, B., Hanihara, T., & Godde, K. (2014) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22513 · Cited by 51
Lari, M., Rizzi, E., Mona, S., Corti, G., Catalano, G., Chen, K., Vernesi, C., Larson, G., Boscato, P., Bellis, G. D., et al. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-32 · Cited by 53
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Purdy, K. J., Hurd, P. J., Moya‐Laraño, J., Trimmer, M., Oakley, B. B., & Woodward, G. (2010) · Advances in ecological research/Advances in Ecological Research · doi:10.1016/b978-0-12-385005-8.00003-4 · Cited by 42
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Louvel, G., Der Sarkissian, C., Hanghøj, K., & Orlando, L. (2016) · Molecular Ecology Resources · doi:10.1111/1755-0998.12546 · Cited by 42
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Mizuno, F., Gojobori, J., Wang, L., Onishi, K., Sugiyama, S., Granados, J., Gomez-Trejo, C., Acuña-Alonzo, V., & Ueda, S. (2014) · Journal of Human Genetics · doi:10.1038/jhg.2014.35 · Cited by 38
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Edson, J., Brooks, E. M., McLaren, C., Robertson, J. A., McNevin, D. B., Cooper, A., & Austin, J. J. (2012) · Forensic Science International Genetics · doi:10.1016/j.fsigen.2012.10.001 · Cited by 37
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Regueiro, M., Álvarez, J., Rowold, D. J., & Herrera, R. J. (2013) · American Journal of Physical Anthropology · doi:10.1002/ajpa.22207 · Cited by 36
Kirsanow, K., & Bürger, J. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2011.11.002 · Cited by 40
Metadata
- Authors
- Rasmussen, M., Li, Y., Lindgreen, S., Pedersen, J. S., Albrechtsen, A., Moltke, I., Metspalu, M., Metspalu, E., Kivisild, T., Gupta, R., Bertalan, M., Nielsen, K., Gilbert, M. T. P., Wang, Y., Raghavan, M., Campos, P. F., Kamp, H. M., Wilson, A. S., Gledhill, A., Tridico, S., Bunce, M., Lorenzen, E. D., Binladen, J., Guo, X., Zhao, J., Zhang, X., Zhang, H., Li, Z., Chen, M., Orlando, L., Kristiansen, K., Bak, M., Tommerup, N., Bendixen, C., Pierre, T. L., Grønnow, B., Meldgaard, M., Andreasen, C., Fedorova, S. A., Osipova, L. P., Higham, T. F. G., Ramsey, C. B., Hansen, T. V. O., Nielsen, F. C., Crawford, M. H., Brunak, S., Sicheritz-Pontén, T., Villems, R., Nielsen, R., Krogh, A., Wang, J., & Willerslev, E.
- Affiliations
- University of Copenhagen (DK)
- BGI Group (China) (CN)
- Estonian Biocentre (EE)
- University of Cambridge (GB)
- Technical University of Denmark (DK)
- University of California, Berkeley (US)
- University of Bradford (GB)
- Australian Federal Police (AU)
- Murdoch University (AU)
- Lyon 1 Université (FR)
- Aarhus University (DK)
- National Museum of Denmark (DK)
- Greenland National Museum & Archives (GL)
- Institute of Cytology and Genetics (RU)
- University of Oxford (GB)
- University of Kansas (US)
- Corresponding author
- Wang, Jun
- Willerslev, Eske
- ORCID
- Rasmussen, Morten
- Li, Yingrui
- Lindgreen, Stinus
- Pedersen, Jakob Skou
- Albrechtsen, Anders
- Moltke, Ida
- Metspalu, Mait
- Metspalu, Ene
- Kivisild, Toomas
- Gupta, Ramneek
- Nielsen, Kasper
- Gilbert, M. Thomas P.
- Wang, Yong
- Raghavan, Maanasa
- Campos, Paula F.
- Kamp, Hanne Munkholm
- Wilson, Andrew S.
- Bunce, Michael
- Lorenzen, Eline D.
- Zhao, Jing
- Zhang, Xiuqing
- Zhang, Hao
- Li, Zhuo
- Chen, Minfeng
- Orlando, Ludovic
- Kristiansen, Karsten
- Bak, Mads
- Tommerup, Niels
- Bendixen, Christian
- Grønnow, Bjarne
- Meldgaard, Morten
- Andreasen, Claus
- Osipova, Ludmila P.
- Higham, Thomas F. G.
- Ramsey, Christopher Bronk
- Hansen, Thomas v. O.
- Nielsen, Finn C.
- Brunak, Søren
- Villems, Richard
- Nielsen, Rasmus
- Krogh, Anders
- Wang, Jun
- Willerslev, Eske
- Venue
- Nature
- Published
- 2010-02
- Volume
- 463
- Issue
- 7282
- Pages
- 757-762
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3951495
- OpenAlex
- W2135016593
- Cited by
- 849
- References
- 42
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 36 · 2023: 47 · 2022: 38 · 2021: 61 · 2020: 32 · 2019: 67 · 2018: 60 · 2017: 58 · 2016: 52 · 2015: 63 · 2014: 62 · 2013: 60 · 2012: 52
- FWCI
- 41.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Murdoch University Research Portal (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Bradford Scholars (University of Bradford) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- KU ScholarWorks (The University of Kansas) (submittedVersion, cc-by-nc-sa)
- Ministry of Culture Research Portal (submittedVersion, other-oa)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Funders
- National Science Foundation (0327676)
- European Commission (205419)
- National Research Foundation
- Danmarks Grundforskningsfond
- National Natural Science Foundation of China (30725008)
- Eesti Teadusfondi
- Lundbeckfonden (R70-2010-6286, R24-2008-2527, R13-2007-1172)
- Novo Nordisk
- Danmarks Frie Forskningsfond
- Danmarks Tekniske Universitet
- Novo Nordisk Fonden
- H. Lundbeck A/S
- Forsknings- og Innovationsstyrelsen
- Natural Environment Research Council (NRCF010002)
- Australian Research Council
- Danish Agency for Science and Higher Education
- Strategic Research Council
- National Human Genome Research Institute (R01HG003229)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Social Sciences › Arts and Humanities › Archeology (arts and humanities) › Paleopathology and ancient diseases
- Keywords
- ancient human genomes, single nucleotide polymorphisms, Inuit, Native Americans
- MeSH terms
- Emigration and Immigration, Inuit, Genetics, Population, Genotype, Greenland, Hair, Humans, Male, Phenotype, Phylogeny, Siberia, Genome, Human, Cryopreservation, Sequence Analysis, DNA, Polymorphism, Single Nucleotide, Genomics, History, Ancient, Extinction, Biological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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