The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Migrastatin analogues target fascin to block tumour metastasis
Open accessAbstract
Tumour metastasis is the primary cause of death of cancer patients. Development of new therapeutics preventing tumour metastasis is urgently needed. Migrastatin is a natural product secreted by Streptomyces, and synthesized migrastatin analogues such as macroketone are potent inhibitors of metastatic tumour cell migration, invasion and metastasis. Here we show that these migrastatin analogues target the actin-bundling protein fascin to inhibit its activity. X-ray crystal structural studies reveal that migrastatin analogues bind to one of the actin-binding sites on fascin. Our data demonstrate that actin cytoskeletal proteins such as fascin can be explored as new molecular targets for cancer treatment, in a similar manner to the microtubule protein tubulin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Coot : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922
REFMAC 5 dictionary: organization of prior chemical knowledge and guidelines for its use
Vagin, A. A., Steiner, R. A., Lebedev, A. A., Potterton, L., McNicholas, S., Long, F., & Murshudov, G. N. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904023510 · Cited by 1,350
Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis
Yang, S., Zhang, J. J., & Huang, X.-Y. (2009) · Cancer Cell · doi:10.1016/j.ccr.2008.12.019 · Cited by 742
Self-citationDistinct organ-specific metastatic potential of individual breast cancer cells and primary tumors
Minn, A. J., Kang, Y., Serganova, I. S., Gupta, G. P., Giri, D. D., Doubrovin, M., Ponomarev, V., Gerald, W. L., Blasberg, R. G., & Massagué, J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522320 · Cited by 742
Doane, A. S., Danso, M., Lal, P., Donaton, M., Zhang, L., Hudis, C., & Gerald, W. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209415 · Cited by 603
Role of fascin in filopodial protrusion
Vignjevic, D., Kojima, S.-I., Aratyn, Y., Danciu, O., Svitkina, T., & Borisy, G. G. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603013 · Cited by 484
Roles of fascin in cell adhesion and motility
Adams, J. C. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.07.009 · Cited by 373
Rodríguez-Pinilla, S. M., Sarrió, D., Honrado, E., Hardisson, D., Calero, F., Benitez, J., & Palacios, J. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2281 · Cited by 324
Cited by
Tumor Metastasis: Molecular Insights and Evolving Paradigms
Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011
STAT3 Target Genes Relevant to Human Cancers
Carpenter, R., & Lo, H.-W. (2014) · Cancers · doi:10.3390/cancers6020897 · Cited by 511
Lou, E., Fujisawa, S., Morozov, A., Barlas, A., Romin, Y., Dogan, Y., Gholami, S., Moreira, A. L., Manova-Todorova, K., & Moore, M. A. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033093 · Cited by 420
Roles of Rap1 signaling in tumor cell migration and invasion
Yi-Lei, Z., Yi-Lei, Z., Ruo-Chen, W., Ken, C., Brian Z., R., Li, S., Ruo-Chen, W., Ken, C., Brian Z., R., & Li, S. (2017) · Cancer Biology & Medicine · doi:10.20892/j.issn.2095-3941.2016.0086 · Cited by 244
Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac
Deinhardt, K., Kim, T., Spellman, D. S., Mains, R. E., Eipper, B. A., Neubert, T. A., Chao, M. V., & Hempstead, B. L. (2011) · Science Signaling · doi:10.1126/scisignal.2002060 · Cited by 183
Metadata
- Authors
- Chen, L., Yang, S., Jakoncic, J., Zhang, J. J., & Huang, X.-Y.
- Venue
- Nature
- Published
- 2010-04-15
- Volume
- 464
- Issue
- 7291
- Pages
- 1062-1066
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2023024480
- Cited by
- 268
- References
- 32
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Migrastatin analogues target fascin to block tumour metastasis. https://app.cochat.ai/papers/10.1038/nature08978
- The paper
- Chen, L., Yang, S., Jakoncic, J., Zhang, J. J., & Huang, X.-Y. (2010). Migrastatin analogues target fascin to block tumour metastasis. Nature. https://doi.org/10.1038/nature08978
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
