Roles of Rap1 signaling in tumor cell migration and invasion

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

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Tumor Metastasis: Molecular Insights and Evolving Paradigms

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cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway

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The structural basis of the activation of Ras by Sos

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Rap1 signalling: adhering to new models

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

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Transcriptional Enhancers in Animal Development and Evolution

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Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

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RIAM, an Ena/VASP and Profilin Ligand, Interacts with Rap1-GTP and Mediates Rap1-Induced Adhesion

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RapV12 antagonizes Ras‐dependent activation of ERK1 and ERK2 by LPA and EGF in Rat‐1 fibroblasts.

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Rap1: a key regulator in cell-cell junction formation

Kooistra, M. R. H., Dubé, N., & Bos, J. L. (2006) · Journal of Cell Science · doi:10.1242/jcs.03306 · Cited by 321 · see citing works

Migrastatin analogues target fascin to block tumour metastasis

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Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors

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DOCK4, a GTPase activator, is disrupted during tumorigenesis.

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Membranes as messengers in T cell adhesion signaling

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Extracellular signal‐regulated activation of Rap1 fails to interfere in Ras effector signalling

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Requirement for C3G‐dependent Rap1 activation for cell adhesion and embryogenesis

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Cellular functions of the Rap1 GTP-binding protein: a pattern emerges

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The role of Rap1 in integrin-mediated cell adhesion

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A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion

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Targeting tumor cell motility as a strategy against invasion and metastasis

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Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking

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Specificity in Ras and Rap Signaling

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The E6 Oncoproteins of High-Risk Papillomaviruses Bind to a Novel Putative GAP Protein, E6TP1, and Target It for Degradation

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Rap1 GTPase: Functions, Regulation, and Malignancy

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Junctional Adhesion Molecule A Interacts with Afadin and PDZ-GEF2 to Activate Rap1A, Regulate β1 Integrin Levels, and Enhance Cell Migration

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E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function

Balzac, F., Avolio, M., Degani, S., Kaverina, I., Torti, M., Silengo, L., Small, J. V., & Retta, S. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.02584 · Cited by 173 · see citing works

Regulation of E-cadherin Endocytosis by Nectin through Afadin, Rap1, and p120ctn

Hoshino, T., Sakisaka, T., Baba, T., Yamada, T., Kimura, T., & Takai, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414447200 · Cited by 171 · see citing works

Regulating Rap small G-proteins in time and space

Gloerich, M., & Bos, J. L. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.07.001 · Cited by 163 · see citing works

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase

Grewal, S., Horgan, A., York, R. D., Withers, G. S., Banker, G. A., & Stork, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3722 · Cited by 162 · see citing works

Cell–cell junction formation: The role of Rap1 and Rap1 guanine nucleotide exchange factors

Pannekoek, W., Kooistra, M. R. H., Zwartkruis, F. J. T., & Bos, J. L. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.12.010 · Cited by 156 · see citing works

Activation of Rap1 Promotes Prostate Cancer Metastasis

Bailey, C. L., Kelly, P., & Casey, P. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4269 · Cited by 152 · see citing works

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting

Butler, G. S., & Overall, C. M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2945 · Cited by 144 · see citing works

Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29

Post, A. M., Pannekoek, W., Ross, S. H., Verlaan-Klink, I., Brouwer, P. M., & Bos, J. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306595110 · Cited by 140 · see citing works

Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase

McSherry, E. A., Brennan, K., Hudson, L., Hill, A. D. K., & Hopkins, A. M. (2011) · Breast Cancer Research · doi:10.1186/bcr2853 · Cited by 131 · see citing works

The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization

Gérard, A., Mertens, A. E. E., van der Kammen, R. A., & Collard, J. G. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608161 · Cited by 130 · see citing works

Ras-Associated Protein-1 Regulates Extracellular Signal-Regulated Kinase Activation and Migration in Melanoma Cells: Two Processes Important to Melanoma Tumorigenesis and Metastasis

Gao, L., Feng, Y., Bowers, R., Becker‐Hapak, M., Gardner, J., Linette, G. P., Zhao, H., & Cornelius, L. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0254 · Cited by 108 · see citing works

Direct Spatial Control of Epac1 by Cyclic AMP

Ponsioen, B., Gloerich, M., Ritsma, L., Rehmann, H., Bos, J. L., & Jalink, K. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01630-08 · Cited by 99 · see citing works

AF-6 Controls Integrin-mediated Cell Adhesion by Regulating Rap1 Activation through the Specific Recruitment of Rap1GTP and SPA-1

Su, L., Hattori, M., Moriyama, M., Murata, N., Harazaki, M., Kaibuchi, K., & Minato, N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211888200 · Cited by 97 · see citing works

Downregulation of Rap1GAP through Epigenetic Silencing and Loss of Heterozygosity Promotes Invasion and Progression of Thyroid Tumors

Zuo, H., Gandhi, M., Edreira, M. M., Hochbaum, D. R., Nimgaonkar, V. L., Zhang, P., DiPaola, J. E., Evdokimova, V. N., Altschuler, D. L., & Nikiforov, Y. E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2812 · Cited by 96 · see citing works

Down-regulation of Rap1GAP via Promoter Hypermethylation Promotes Melanoma Cell Proliferation, Survival, and Migration

Zheng, H., Gao, L., Feng, Y., Yuan, L., Zhao, H., & Cornelius, L. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2399 · Cited by 94 · see citing works

Activation of Rac1 by Paxillin-Crk-DOCK180 Signaling Complex Is Antagonized by Rap1 in Migrating NBT-II Cells

Vallés, A. M., Beuvin, M., & Boyer, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405144200 · Cited by 93 · see citing works

Identification of a Putative Tumor Suppressor Gene Rap1GAP in Pancreatic Cancer

Zhang, L., Li, C., Mahmood, R. Z., van Golen, K., Greenson, J., Li, G., D’Silva, N. J., Li, X., Burant, C., Logsdon, C. D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3025 · Cited by 93 · see citing works

Functional Interaction between Gαz and Rap1GAP Suggests a Novel Form of Cellular Cross-talk

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Rap1: A turnabout for the crosstalk between cadherins and integrins

Retta, S. F., Balzac, F., & Avolio, M. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.09.007 · Cited by 88 · see citing works

An Adenosine-Mediated Signaling Pathway Suppresses Prenylation of the GTPase Rap1B and Promotes Cell Scattering

Ntantie, E., Gonyo, P., Lorimer, E., Hauser, A. D., Schuld, N. J., McAllister, D. M., Kalyanaraman, B., Dwinell, M. B., Auchampach, J. A., & Williams, C. L. (2013) · Science Signaling · doi:10.1126/scisignal.2003374 · Cited by 87 · see citing works

Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form

Mitra, R. S., Zhang, Z., Henson, B. S., Kurnit, D. M., Carey, T. E., & D’Silva, N. J. (2003) · Oncogene · doi:10.1038/sj.onc.1206534 · Cited by 76 · see citing works

MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis

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Rap1GAP Promotes Invasion via Induction of Matrix Metalloproteinase 9 Secretion, Which Is Associated with Poor Survival in Low N-Stage Squamous Cell Carcinoma

Mitra, R. S., Goto, M., Lee, J. J., Maldonado, D., Taylor, J. M. G., Pan, Q., Carey, T. E., Bradford, C. R., Prince, M. E., Cordell, K. G., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2755 · Cited by 73 · see citing works

EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation

Huang, M., Anand, S., Murphy, E. A., Desgrosellier, J. S., Stupack, D. G., Shattil, S. J., Schlaepfer, D. D., & Cheresh, D. A. (2011) · Oncogene · doi:10.1038/onc.2011.450 · Cited by 67 · see citing works

The C3G/Rap1 pathway promotes secretion of MMP-2 and MMP-9 and is involved in serous ovarian cancer metastasis

Che, Y., Luo, S., Li, G., Cheng, M., Gao, Y., Li, X., Dai, J.-M., He, H., Wang, J., Peng, H., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.01.019 · Cited by 67 · see citing works

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

Mathieu, V., Pirker, C., Schmidt, W. M., Spiegl‐Kreinecker, S., Lötsch, D., Heffeter, P., Hegedűs, B., Grusch, M., Robert Kiss, A., & Berger, W. (2012) · Oncotarget · doi:10.18632/oncotarget.473 · Cited by 63 · see citing works

β-Arrestin2 Regulates Lysophosphatidic Acid-Induced Human Breast Tumor Cell Migration and Invasion via Rap1 and IQGAP1

Alemayehu, M., Dragan, M., Pape, C., Siddiqui, I. F. S., Sacks, D. B., Guglielmo, G. M. D., Babwah, A. V., & Bhattacharya, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056174 · Cited by 62 · see citing works

Rap1 Stabilizes β-Catenin and Enhances β-Catenin–Dependent Transcription and Invasion in Squamous Cell Carcinoma of the Head and Neck

Goto, M., Mitra, R. S., Liu, M., Lee, J. J., Henson, B. S., Carey, T. E., Bradford, C. R., Prince, M. E., Wang, C.-Y., Fearon, E. R., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1122 · Cited by 59 · see citing works

Prostaglandin E2 Regulates Renal Cell Carcinoma Invasion through the EP4 Receptor-Rap GTPase Signal Transduction Pathway

Wu, J., Zhang, Y., Frilot, N., Kim, J. I., Kim, W.-J., & Daaka, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187344 · Cited by 58 · see citing works

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration

Takahashi, M., Dillon, T. J., Liu, C., Kariya, Y., Wang, Z., & Stork, P. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.466904 · Cited by 56 · see citing works

cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics

Lyle, K. S., Raaijmakers, J. H., Bruinsma, W., Bos, J. L., & de Rooij, J. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.01.018 · Cited by 56 · see citing works

Activation of the Rap GTPases in B Lymphocytes Modulates B Cell Antigen Receptor-induced Activation of Akt but Has No Effect on MAPK Activation

Christian, S. L., Lee, R. L., McLeod, S. J., Burgess, A. E., Li, A. H. Y., Dang-Lawson, M., Lin, K. B. L., & Gold, M. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303180200 · Cited by 53 · see citing works

Downregulation of Rap1GAP Contributes to Ras Transformation

Tsygankova, O. M., Prendergast, G. V., Puttaswamy, K., Wang, Y., Feldman, M. D., Wang, H., Brose, M. S., & Meinkoth, J. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00155-07 · Cited by 50 · see citing works

Sequential activation of Rap1 and Rac1 small G proteins by PDGF locally at leading edges of NIH3T3 cells

Takahashi, M., Rikitake, Y., Nagamatsu, Y., Hara, T., Ikeda, W., Hirata, K., & Takai, Y. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01187.x · Cited by 50 · see citing works

Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells

Zhang, Y., Gong, Y., Hu, D., Zhu, P., Wang, N., Zhang, Q., Wang, M., Aldeewan, A. B., Xia, H., Qu, X., et al. (2014) · Oncogene · doi:10.1038/onc.2014.36 · Cited by 46 · see citing works

Rap1GAP regulates renal cell carcinoma invasion

Kim, W.-J., Gersey, Z. C., & Daaka, Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.022 · Cited by 45 · see citing works

Rap1-GTP-interacting Adaptor Molecule (RIAM) Protein Controls Invasion and Growth of Melanoma Cells

Hernández-Varas, P., Coló, G. P., Bartolomé, R. A., Paterson, A., Medraño-Fernández, I., Arellano‐Sánchez, N., Cabañas, C., Sánchez‐Mateos, P., Lafuente, E. M., Boussiotis, V. A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.189811 · Cited by 42 · see citing works

SPA‐1 controls the invasion and metastasis of human prostate cancer

Shimizu, Y., Hamazaki, Y., Hattori, M., Doi, K., Terada, N., Kobayashi, T., Toda, Y., Yamasaki, T., Inoue, T., Kajita, Y., et al. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01876.x · Cited by 37 · see citing works

Control of Epithelial Cell Migration and Invasion by the IKKβ- and CK1α-Mediated Degradation of RAPGEF2

Magliozzi, R., Low, T. Y., Weijts, B. G. M. W., Cheng, T., Spanjaard, E., Mohammed, S., van Veen, A., Ovaa, H., de Rooij, J., Zwartkruis, F. J. T., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.10.023 · Cited by 37 · see citing works

Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells

Ho, S., Lau, K., Mok, S. C., & Syed, V. (2003) · Oncogene · doi:10.1038/sj.onc.1206437 · Cited by 34 · see citing works

Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid—induced Migration by Isoproterenol in Glioma Cells

Malchinkhuu, E., Sato, K., Maehama, T., Ishiuchi, S., Yoshimoto, Y., Mogi, C., Kimura, T., Kurose, H., Tomura, H., & Okajima, F. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-08-0692 · Cited by 33 · see citing works

Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b

Infante, E., Heasman, S. J., & Ridley, A. J. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0810441 · Cited by 31 · see citing works

The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas

Lin, K. B. L., Tan, P., Freeman, S. A., Lam, M., McNagny, K. M., & Gold, M. R. (2009) · Oncogene · doi:10.1038/onc.2009.345 · Cited by 30 · see citing works

Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP)

Tsygankova, O. M., Wang, H., & Meinkoth, J. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464594 · Cited by 30 · see citing works

Expression of signal-induced proliferation-associated gene 1 (SIPA1), a RapGTPase-activating protein, is increased in colorectal cancer and has diverse effects on functions of colorectal cancer cells.

Ji, K., Ye, L., Toms, A.-M., Hargest, R., Martin, T. A., Ruge, F., Ji, J., & Jiang, W. G. (2012) · PubMed · Cited by 26 · see citing works

Rap1GAP alters leukemia cell differentiation, apoptosis and invasion in vitro

Qiu, T., Qi, X., Cen, J., & Chen, Z. (2012) · Oncology Reports · doi:10.3892/or.2012.1825 · Cited by 24 · see citing works

Radil controls neutrophil adhesion and motility through β2-integrin activation

Liu, L., Aerbajinai, W., Ahmed, S. M., Rodgers, G. P., Angers, S., & Parent, C. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-05-0408 · Cited by 22 · see citing works

RAP1GAP inhibits cytoskeletal remodeling and motility in thyroid cancer cells

Dong, X., Tang, W., Stopenski, S. J., Brose, M. S., Korch, C. T., & Meinkoth, J. L. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0086 · Cited by 19 · see citing works

Critical role for DOK1 in PDGF-BB stimulated glioma cell invasion via p130Cas and Rap1 signalling

Barrett, A. N., Evans, I. M., Frolov, A., Britton, G., Pellet‐Many, C., Yamaji, M., Mehta, V., Bandophadyay, R., Li, N., Brandner, S., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.135988 · Cited by 17 · see citing works

Rap1GAP impairs cell-matrix adhesion in the absence of effects on cell-cell adhesion

Vuchak, L. A., Tsygankova, O. M., & Meinkoth, J. L. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.4.17041 · Cited by 15 · see citing works

The small GTPase Rap1 promotes cell movement rather than stabilizes adhesion in epithelial cells responding to insulin-like growth factor I

Guvakova, M. A., Lee, W., Furstenau, D. K., Prabakaran, I., Li, D. C., Hung, R. K., & Kushnir, N. (2014) · Biochemical Journal · doi:10.1042/bj20131638 · Cited by 13 · see citing works

pathfindR: An R Package for Comprehensive Identification of Enriched Pathways in Omics Data Through Active Subnetworks

Ülgen, E., Özışık, O., & Sezerman, O. U. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00858 · Cited by 456 · see citing works

Potential Effects of MSC-Derived Exosomes in Neuroplasticity in Alzheimer’s Disease

Reza-Zaldívar, E. E., Hernández-Sapiéns, M. A., Minjarez, B. D., Gutiérrez-Mercado, Y. K., Márquez-Aguirre, A. L., & Canales-Aguirre, A. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00317 · Cited by 168 · see citing works

Progress on Ras/MAPK Signaling Research and Targeting in Blood and Solid Cancers

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Evaluation of Diagnostic Potential of Epigenetically Deregulated MiRNAs in Epithelial Ovarian Cancer

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Self‐Assembled DNA Nanocages Promote Cell Migration and Differentiation of Human Umbilical Vein Endothelial Cells**

Rajwar, A., Vaswani, P., Singh, R. S., & Bhatia, D. D. (2023) · ChemBioChem · doi:10.1002/cbic.202200634 · Cited by 15 · see citing works

Low GPR81 in ER+ breast cancer cells drives tamoxifen resistance through inducing PPARα-mediated fatty acid oxidation

Yu, J., Du, Y., Liu, C., Xie, Y., Yuan, M., Shan, M., Li, N., Liu, C., Wang, Y., & Qin, J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122763 · Cited by 15 · see citing works

Genome-wide methylation analysis identifies novel prognostic methylation markers in colon adenocarcinoma

Xue, W., Wu, X., Wang, F., Han, P., & Cui, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.043 · Cited by 15 · see citing works

Identification of Key Genes and Prognostic Analysis between Chromophobe Renal Cell Carcinoma and Renal Oncocytoma by Bioinformatic Analysis

Wu, H., Fan, L., Liu, H., Guan, B., Hu, B., Liu, F., Hocher, B., & Yin, L. (2020) · BioMed Research International · doi:10.1155/2020/4030915 · Cited by 14 · see citing works

CD34+ HSPCs-derived exosomes contain dynamic cargo and promote their migration through functional binding with the homing receptor E-selectin

Isaioglou, I., Aldehaiman, M. M., Li, Y., Lahcen, A. A., Rauf, S., Al-Amoodi, A. S., Habiba, U., Alghamdi, A., Nozue, S., Habuchi, S., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1149912 · Cited by 13 · see citing works

Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes

Andreu, Z., Hidalgo, M. R., Masiá, E., Romera-Giner, S., Malmierca-Merlo, P., López‐Guerrero, J. A., Garcia‐García, F., & Vicent, M. J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05403-z · Cited by 13 · see citing works

An N-glycoproteomic site-mapping analysis reveals glycoprotein alterations in esophageal squamous cell carcinoma

Gao, Y., Shen, L., Dong, T., Yang, X. L., Cui, H., Guo, Y., Ma, Y., Kong, P., Cheng, X., Zhang, L., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03489-2 · Cited by 13 · see citing works

A protein microarray‐based serum proteomic investigation reveals distinct autoantibody signature in colorectal cancer

Barpanda, A., Tuckley, C., Ray, A., Banerjee, A., Duttagupta, S. P., Kantharia, C. V., & Srivastava, S. (2022) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202200062 · Cited by 13 · see citing works

Uncovering missed indels by leveraging unmapped reads

Hasan, M. S., Wu, X., & Zhang, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-47405-z · Cited by 13 · see citing works

Systematic understanding of anti-tumor mechanisms of Tamarixetin through network and experimental analyses

Shaji, S. K., Drishya, G., Sunilkumar, D., Suravajhala, P., Kumar, G. B., & Nair, B. G. (2022) · Scientific Reports · doi:10.1038/s41598-022-07087-6 · Cited by 12 · see citing works

Centrosome amplification promotes cell invasion via cell–cell contact disruption and Rap-1 activation

Prakash, A., Paunikar, S., Webber, M., McDermott, E. A., Vellanki, S. H., Thompson, K., Dockery, P., Jahns, H., Brown, J. A. L., Hopkins, A. M., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.261150 · Cited by 12 · see citing works

Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period

Wang, Y., Wang, J., Li, Q., Xuan, R., Guo, Y., He, P., & Chao, T. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01318-8 · Cited by 13 · see citing works

Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models

Shorning, B. Y., Trent, N., Griffiths, D. F. R., Worzfeld, T., Offermanns, S., Smalley, M. J., & Williamson, M. P. (2023) · Cancer Research Communications · doi:10.1158/2767-9764.crc-22-0480 · Cited by 12 · see citing works

Identification of potential key genes in esophageal adenocarcinoma using bioinformatics

Dong, Z., Wang, J., Zhang, H., Zhan, T., Chen, Y., & Xu, S. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7973 · Cited by 12 · see citing works

Loss of TTC17 promotes breast cancer metastasis through RAP1/CDC42 signaling and sensitizes it to rapamycin and paclitaxel

Zhang, J., Guo, F., Li, C., Wang, Y., Wang, J., Sun, F., Zhou, Y., Ma, F., Zhang, B., & Qian, H. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01004-8 · Cited by 11 · see citing works

Pravastatin‐induced changes in expression of long non‐coding and coding RNAs in endothelial cells

Singh, S., Nguyen, H. C., Ehsan, M., Michels, D., Singh, P., Qadura, M., & Singh, K. K. (2020) · Physiological Reports · doi:10.14814/phy2.14661 · Cited by 10 · see citing works

Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data

Kutlay, A., & Son, Y. A. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.637355 · Cited by 11 · see citing works

Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis

Morovat, P., Morovat, S., Ashrafi, A. M., & Teimourian, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-08867-w · Cited by 11 · see citing works

Driver gene detection through Bayesian network integration of mutation and expression profiles

Chen, Z., Lü, Y., Cao, B., Zhang, W., Edwards, A., & Zhang, K. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac203 · Cited by 11 · see citing works

The Roles of Rap1 in Cancer Metastasis and Pancreatic Islet Beta Cell Function

Bailey, C. L. (2009) · DukeSpace (Duke University) · Cited by 6 · see citing works

Rac1: A Regulator of Cell Migration and a Potential Target for Cancer Therapy

Ma, N., Xu, E., Luo, Q., & Song, G. (2023) · Molecules · doi:10.3390/molecules28072976 · Cited by 87 · see citing works

Rap1 promotes Prostate Cancer metastasis

Bailey, C. L., & Casey, P. J. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.1029.7

Tumor Cell Migration and Invasion Are Enhanced by Depletion of Rap1 GTPase-activating Protein (Rap1GAP)

Tsygankova, O. M., Wang, H., & Meinkoth, J. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464594 · Cited by 30 · see citing works

Reduced Rap1 Signaling Is Associated with Prostate Cancer Progression, Migration, Invasion, and Metastasis

Henderson, V., Osunkoya, A. O., Zhou, W., Williams, D. J., Anderson, N., Kitayama, H., CSETE, M. E., & Moreno, C. S. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.438.2