Cited by 518Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

Choosing between glycolysis and oxidative phosphorylation: a tumor’s dilemma?

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Jose, Caroline, Bellance, Nadège, Rossignol, Rodrigue·2011·Biochimica et Biophysica Acta (BBA) - Bioenergetics

Abstract

A considerable amount of knowledge has been produced during the last five years on the bioenergetics of cancer cells, leading to a better understanding of the regulation of energy metabolism during oncogenesis, or in adverse conditions of energy substrate intermittent deprivation. The general enhancement of the glycolytic machinery in various cancer cell lines is well described and recent analyses give a better view of the changes in mitochondrial oxidative phosphorylation during oncogenesis. While some studies demonstrate a reduction of oxidative phosphorylation (OXPHOS) capacity in different types of cancer cells, other investigations revealed contradictory modifications with the upregulation of OXPHOS components and a larger dependency of cancer cells on oxidative energy substrates for anabolism and energy production. This apparent conflictual picture is explained by differences in tumor size, hypoxia, and the sequence of oncogenes activated. The role of p53, C-MYC, Oct and RAS on the control of mitochondrial respiration and glutamine utilization has been explained recently on artificial models of tumorigenesis. Likewise, the generation of induced pluripotent stem cells from oncogene activation also showed the role of C-MYC and Oct in the regulation of mitochondrial biogenesis and ROS generation. In this review article we put emphasis on the description of various bioenergetic types of tumors, from exclusively glycolytic to mainly OXPHOS, and the modulation of both the metabolic apparatus and the modalities of energy substrate utilization according to tumor stage, serial oncogene activation and associated or not fluctuating microenvironmental substrate conditions. We conclude on the importance of a dynamic view of tumor bioenergetics.

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Crossref · 10.1016/j.bbabio.2010.10.012

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Authors
Jose, C., Bellance, N., & Rossignol, R.
Affiliations
Maladies Rares: Génétique et Métabolisme (FR)
Corresponding author
Rossignol, Rodrigue
Venue
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Publisher
Elsevier BV
Published
2011-06
Volume
1807
Issue
6
Pages
552-561
ISSN
0005-2728 (ISSN-L)
OpenAlex
W2029436635
Cited by
518
References
117
Citations by year
2026: 16 · 2025: 23 · 2024: 34 · 2023: 31 · 2022: 48 · 2021: 45 · 2020: 52 · 2019: 45 · 2018: 39 · 2017: 25 · 2016: 36 · 2015: 33 · 2014: 28 · 2013: 20 · 2012: 37
FWCI
1.65
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Bioenergetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fonds Québécois de la Recherche sur la Nature et les Technologies
  • Institut National de la Santé et de la Recherche Médicale
  • Cancéropôle Grand Ouest
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
tumor bioenergetics, aerobic glycolysis, oxidative phosphorylation, mitochondrial respiration, cancer cell energy metabolism, oncogene activation, hypoxia, p53, c-Myc, Oct4, Ras, glutamine utilization, mitochondrial biogenesis, reactive oxygen species, induced pluripotent stem cells, Warburg effect, metabolic therapy, tumor microenvironment
MeSH terms
Animals, Energy Metabolism, Glycolysis, Humans, Mitochondria, Models, Biological, Neoplasms, Oxidative Phosphorylation, Cell Respiration, Metabolic Networks and Pathways

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