A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Cardiogenics Consortium, Heinig, Matthias, Petretto, Enrico, Wallace, Chris, Bottolo, Leonardo, Rotival, Maxime, Lu, Han, Li, Yoyo, Sarwar, Rizwan, Langley, Sarah R., Bauerfeind, Anja, Hummel, Oliver, Lee, Young-Ae, Paskas, Svetlana, Rintisch, Carola, Saar, Kathrin, Cooper, Jason, Buchan, Rachel, Gray, Elizabeth E., Cyster, Jason G., Erdmann, Jeanette, Hengstenberg, Christian, Maouche, Seraya, Ouwehand, Willem H., Rice, Catherine M., Samani, Nilesh J., Schunkert, Heribert, Goodall, Alison H., Schulz, Herbert, Roider, Helge G., Vingron, Martin, Blankenberg, Stefan, Münzel, Thomas, Zeller, Tanja, Szymczak, Silke, Ziegler, Andreas, Tiret, Laurence, Smyth, Deborah J., Pravenec, Michal, Aitman, Timothy J., Cambien, Francois, Clayton, David, Todd, John A., Hubner, Norbert, Cook, Stuart A.·2010·Nature
Cited by (277)
Items 201–277 of 277
- Delineating the Hemostaseome as an aid to individualize the analysis of the hereditary basis of thrombotic and bleeding disordersKim Fechtel, Marika L. Osterbur, Hildegard Kehrer‐Sawatzki, Peter D. Stenson, D.N. Cooper · 2011 · Human Genetics
- Unbiased Expression Mapping Identifies a Link between the Complement and Cholinergic Systems in the Rat Central Nervous SystemRickard P. F. Lindblom, Mikael Ström, Matthias Heinig, Faiez Al Nimer, Shahin Aeinehband, Alexander Berg, Cecilia A Dominguez, Swetha Vijayaraghavan, Xing‐Mei Zhang, Karin Harnesk et al. · 2013 · The Journal of Immunology
- Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodellingLaura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon Andrew Johnston, Stephen E. Hamby, Alison H. Goodall, Jessica N.E. Redgrave, Sheila Francis et al. · 2022 · Frontiers in Cardiovascular Medicine
- A Selection Operator for Summary Association Statistics Reveals Allelic Heterogeneity of Complex TraitsNing Zheng, Youngjo Lee, Peter K. Joshi, James F. Wilson, Yudi Pawitan Y, Xia Shen · 2017 · The American Journal of Human Genetics
- Metabolomics Makes a Mark: Early Changes Associated With Autoimmune DiabetesRichard David Leslie, Huriya Beyan · 2011 · Diabetes
- Oxysterols in tumor immune microenvironment (TIME)Yuanxin Liu, Jie Qin, Xiaorui Li, Guangzhen Wu · 2024 · The Journal of Steroid Biochemistry and Molecular Biology
- Deciphering the coordinated roles of the host genome, duodenal mucosal genes, and microbiota in regulating complex traits in chickensFangren Lan, Xiqiong Wang, Qianqian Zhou, Xiaochang Li, Jiaming Jin, Wenxin Zhang, Chaoliang Wen, Guiqin Wu, Guangqi Li, Yiyuan Yan et al. · 2025 · Microbiome
- Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene ExpressionNicolas Greliche, Tanja Zeller, Philipp Sebastian Wild, Maxime Rotival, Arne Schillert, Andreas Ziegler, Panos Deloukas, Jeanette Erdmann, Christian Hengstenberg, Willem Hendrik Ouwehand et al. · 2012 · PLoS ONE
- A Systems-Level Understanding of Cardiovascular Disease through NetworksCharles R. Farber, Larry D. Mesner · 2015 · Elsevier eBooks
- Von Willebrand Factor Gene Variants Associate with Herpes simplex EncephalitisNada Abdelmagid, Biborka Bereczky-Veress, Santosh S. Atanur, Alena Musilová, Václav Zı́dek, Laura M. Saba, Andreas Warnecke, Mohsen Khademi, Marie Studahl, Elisabeth Aurelius et al. · 2016 · PLoS ONE
- Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR modelFrederick R. Roberts, Clinton W. Hupple, Elaine Norowski, Nicole C. Walsh, Natalia Przewozniak, Ken‐Edwin Aryee, Filia M. Van Dessel, Agata Jurczyk, David M. Harlan, Dale L. Greiner et al. · 2017 · PLoS ONE
- Pleiotropy of systemic lupus erythematosus risk alleles and cardiometabolic disorders: A phenome-wide association study and inverse-variance weighted meta-analysisVivian K. Kawai, Mingjian Shi, Ge Liu, QiPing Feng, Wei‐Qi Wei, Cecilia P. Chung, Theresa L. Walunas, ALLAN S. GORDON, James G. Linneman, Scott Joseph Hebbring et al. · 2021 · Lupus
- Salicylate Prevents Virus-Induced Type 1 Diabetes in the BBDR RatChaoxing Yang, Agata Jurczyk, Philip J. diIorio, Elaine Norowski, Michael A. Brehm, Christian W. Grant, Dennis L. Guberski, Dale L. Greiner, Rita Bortell · 2013 · PLoS ONE
- Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cellsXiang Lin, Wei Xia, Wei Ji, Fangfei Xie, Pei He, Xiao-Wei Zhu, Yonghong Zhang, Fei‐Yan Deng, Shu‐Feng Lei · 2017 · Epigenomics
- Expression QTLs Mapping and Analysis: A Bayesian PerspectiveMartha Imprialou, Enrico G. Petretto, Leonardo Bottolo · 2016 · Methods in molecular biology
- Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene ExpressionPamela J. Kaisaki, Georg Otto, Karène Argoud, Stephan C. Collins, Robert H. Wallis, Steven P. Wilder, Anthony C. Y. Yau, Christophe Hue, Sophie Caldérari, Marie‐Thérèse Bihoreau et al. · 2016 · G3 Genes Genomes Genetics
- LncRNA ARGI Contributes to Virus‐Induced Pancreatic β Cell Inflammation Through Transcriptional Activation of IFN‐Stimulated GenesItziar González‐Moro, Koldo García‐Etxebarria, Luis Manuel Mendoza, Nora Fernández‐Jiménez, Jon Mentxaka, Ane Olazagoitia‐Garmendia, María Nicol Arroyo, Toshiaki Sawatani, Cristina Moreno‐Castro, Chiara Vinci et al. · 2023 · Advanced Science
- Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in SingaporeAmelia L.M. Tan, Sarah R. Langley, Chee Fan Tan, Jin Fang Chai, Chin Meng Khoo, Melvin Khee‐Shing Leow, Eric Yin Hao Khoo, Aida Moreno‐Moral, Michal Pravenec, Maxime Rotival et al. · 2018 · The Journal of Clinical Endocrinology & Metabolism
- Dynamic changes in immune gene co-expression networks predict development of type 1 diabetesIngrid Brænne, Suna Önengüt-Gümüşcü, Ruoxi Chen, Ani W Manichaikul, Stephen S. Rich, Wei‐Min Chen, Charles R. Farber, the TEDDY Study Group, Marian Rewers, Aaron Barbour et al. · 2021 · Scientific Reports
- First report on chemometrics-driven multilayered lead prioritization in addressing oxysterol-mediated overexpression of G protein-coupled receptor 183Arnab Bhattacharjee, Supratik Kar, Probir Kumar Ojha · 2024 · Molecular Diversity
- Class A Orphans in GtoPdb v.2023.1S P H Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Khuraijam Dhanachandra Singh, Satoru Eguchi, Anthony J. Harmar, Nicholas D. Holliday et al. · 2023 · IUPHAR/BPS Guide to Pharmacology CITE
- Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traitsMichiel E. Adriaens, Connie R. Bezzina · 2018 · Biophysical Reviews
- Feature screening for multi-response varying coefficient models with ultrahigh dimensional predictorsJun Lü, Lu Lin · 2018 · Computational Statistics & Data Analysis
- Trans -acting genetic variation affects the expression of adjacent genesKrisna Van Dyke, Sheila Lutz, Gemechu Mekonnen, Chad L. Myers, Frank Wolfgang Albert · 2021 · Genetics
- SPIRE, a modular pipeline for eQTL analysis of RNA-Seq data, reveals a regulatory hotspot controlling miRNA expression in C. elegansIvan Kel, Zisong Chang, Nadia Galluccio, Margherita Romeo, Stefano Beretta, Luisa Diomede, Alessandra Mezzelani, Luciano Milanesi, Christoph Dieterich, Ivan Merelli · 2016 · Molecular BioSystems
- The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseasesYing Shao, Yang Mei, Yixin Tan, Ming Yang, Haijing Wu · 2025 · Cell & Bioscience
- Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucoseAnna N. Senko, Rupert W. Overall, Jan Šilhavý, Petr Mlejnek, Hana Malínská, Martina Hüttl, Irena Marková, Klaus Fabel, Lu Lu, Aleš Stuchlı́k et al. · 2022 · PLoS Genetics
- Analyzing Illumina Gene Expression Microarray Data Obtained From Human Whole Blood Cell and Blood Monocyte SamplesAlexander Teumer, Claudia Schurmann, Arne Schillert, Katharina Schramm, Andreas Ziegler, Holger Prokisch · 2015 · Methods in molecular biology
- Type 1 Diabetes Therapy Beyond T Cell Targeting: Monocytes, B Cells, and Innate LymphocytesFlorence Susan Wong, Wen Li · 2012 · The Review of Diabetic Studies
- Cellules grumelées: old terminology revisited. Regarding the cytologic diagnosis of chronic lymphocytic leukemia and well-differentiated lymphocytic lymphoma in pleural effusions.T A Seidel, Archimedes D. Garbes · 1985 · PubMed
- Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1Saloua Jeidane, Marie‐Pier Scott‐Boyer, Nicolas Tremblay, Sophie Cardin, Sylvie Picard, Martin Baril, Daniel Lamarre, Christian F. Deschepper · 2016 · Cell Reports
- The distribution and functional relevance analysis of runs of homozygosity (ROHs) in Chinese Han female populationYihua Lu, Binghua Wang, Wei Xia, Xingbo Mo, Long‐Fei Wu, Xiao-Wei Zhu, Pei He, Fangfei Xie, Xin Lu, Fei‐Yan Deng et al. · 2017 · Molecular Genetics and Genomics
- IRF-7: an Antiviral Factor and BeyondEdvige Perrotti, Giulia Marsili, Marco Sgarbanti, Anna Lisa Remoli, Alessandra Fragale, Chiara Acchioni, Roberto Orsatti, Angela Battistini · 2013 · Future Virology
- Non-Genetic Factors in the Pathogenesis of Type 1 DiabetesSerena Wai-Yan Chiu, Richard David Leslie, Huriya Beyan · 2012 · Springer eBooks
- Rat Genome Mapping and GenomicsClaude Szpirer, Göran Levan · 2012 · Springer eBooks
- Correction: Defining the Transcriptional and Cellular Landscape of Type 1 Diabetes in the NOD MouseJavier A. Carrero, Boris Calderón, Fadi Towfic, Maxim N. Artyomov, Emil R. Unanue · 2014 · PLoS ONE
- Superior neurometabolic protection by 8-hydroxy-dihydromyricetin over dihydromyricetin in diabetic zebrafish: insights from integrated metabolomics and transcriptomicsYong Cheng, Beijun Ang, Dandan Ma, Zhiwei Li, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Jie Chen, Cui Chen, Yun Sheng Yang et al. · 2025 · Food & Function
- CpGmotifs: a tool to discover DNA motifs associated to CpG methylation eventsGiovanni Scala, Antonio Federico, Dario Greco · 2021 · BMC Bioinformatics
- Class A Orphans in GtoPdb v.2021.3S P H Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Khuraijam Dhanachandra Singh, Satoru Eguchi, Anthony J. Harmar, Nicholas D. Holliday et al. · 2021 · IUPHAR/BPS Guide to Pharmacology CITE
- Best Subset Solution Path for Linear Dimension Reduction Models Using Continuous OptimizationBenoît Liquet, Sarat Moka, Samuel Müller · 2024 · Biometrical Journal
- Functional Antagonists of EBI-2Robert Ardecky, Eduard A. Sergienko, Jiwen Zou, Santhi Ganji, Brock T. Brown, Qing Sun, Chen-Ting Ma, Becky L. Hood, Kevin Nguyen, Stefan Vasile et al. · 2015 · Europe PMC (PubMed Central)
- Echovirus Epidemics, Autoimmunity, and Type 1 DiabetesOscar Díaz-Horta, Luís Sarmiento, Andreina Baj, Eduardo Cabrera‐Rode, Antonio Toniolo · 2011 · InTech eBooks
- Biological Data Integration Using Network ModelsGaurav Kumar, Shoba Ranganathan · 2013 · Wiley eBooks
- Exploring the Activation Mechanism of the GPR183 ReceptorLinfeng Hu, Ke An, Yue Zhang, Chen Bai · 2024 · The Journal of Physical Chemistry B
- Speculation on Prevention of Type 1 DiabetesR. Insel · 2013 · Springer eBooks
- Interferon Regulatory Factors and Autoimmune DiseasesShunbin Ning · 2014 · Digital Commons - East Tennessee State University (East Tennessee State University)
- Interaction screening in high-dimensional multi-response regression via projected distance correlationLili Liu, Lu Lin, Lei Liu · 2024 · Communications in Statistics - Simulation and Computation
- A comprehensive bioinformatics method to screen key genes for severe burnQingwen Nong, Shuntang Li, Daen Liu · 2015 · European Journal of Inflammation
- Class A Orphans (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology DatabaseS P H Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Satoru Eguchi, Anthony J. Harmar, Nicholas D. Holliday, Robert T. Jensen et al. · 2019 · IUPHAR/BPS Guide to Pharmacology CITE
- Feature screening for multi-response ultrahigh-dimensional linear models by empirical likelihoodJun Lü, Hu Qinqin, Lu Lin · 2022 · Scientia Sinica Mathematica
- Class A Orphans in GtoPdb v.2022.3S P H Alexander, Jim Battey, Helen E. Benson, Richard V. Benya, Tom I. Bonner, Anthony P. Davenport, Khuraijam Dhanachandra Singh, Satoru Eguchi, Anthony J. Harmar, Nicholas D. Holliday et al. · 2022 · IUPHAR/BPS Guide to Pharmacology CITE
- Studies on causes of multiple sclerosis : From genes to transcriptomeAnu Kemppinen · 2011 · Työväentutkimus Vuosikirja
- Genetic and Immunological Regulation of NeuroinflammationMélanie Thessén Hedreul · 2012 · Figshare
- Early and Late Onset Type 1 Diabetes: One and the Same or Two Distinct Genetic Entities?Laura Espino-Paisán, E. Urcelay, E. G. de la Concha, J. L. Santiago · 2011 · InTech eBooks
- Correction: Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene ExpressionNicolas Greliche, Tanja Zeller, Philipp Sebastian Wild, Maxime Rotival, Arne Schillert, Andreas Ziegler, Tony Attwood, Belz Stephanie, Peter S. Braund, Jessy Brocheton et al. · 2012 · PLoS ONE
- Innate Immune Responses to Viruses Inducing DiabetesKatharina Lind, Malin Flodström Tullberg · 2013 · Springer eBooks
- Rat trans-acting transactions and the genetics of complex traitsFriedrich Cameron Luft · 2010 · Journal of the American Society of Hypertension
- EBI2: the race is onChris Cain · 2011 · Science-Business eXchange
- Cofunctional Subpathways Were Regulated by Transcription Factor with Common Motif, Common Family, or Common TissueFei Su, Desi Shang, Yanjun Xu, Feng Li, Haixiu Yang, Baoquan Liu, Shengyang Su, Lina Chen, Xia Li · 2015 · BioMed Research International
- Identification of novel signaling pathways for cardiomyocyte differentiation and growthJunmei Ye · 2012 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
- Investigating postzygotic de novo mutations and somatic mosaicism in monozygotic twins discordant for complex disordersNirmal Vadgama · 2017 · UCL Discovery (University College London)
- Identification de cibles thérapeutiques et repositionnement de médicaments par analyses de réseaux géniquesAndrée Delahaye‐Duriez, Clémence Réda, Pierre Gressèns · 2019 · médecine/sciences
- Variable Selection and Dimension Reduction for Structured Large DatasetsMatthew W Sutton · 2019 · Queensland University of Technology
- Trans -acting genetic variation affects the expression of adjacent genesKrisna Van Dyke, Gemechu Mekonnen, Chad L. Myers, Frank Wolfgang Albert · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of A systems-level framework for drug discovery identifies Csf1R as an anti-epileptic drug target.Wolfgang Löscher · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Group Combss: Group Selection Via Continuous OptimizationAnant Mathur, Sarat Moka, Benoît Liquet, Zdravko I. Botev · 2024 · Winter Simulation Conference
- Role of gut microbiota, probiotics and prebiotics in diabetesManglam Soni, Kuldip Dwivedi · 2025 · Elsevier eBooks
- Additional file 7 of A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashionFranziska Witte, Jorge Ruiz‐Orera, Mattioli, Camilla Ciolli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke et al. · 2021 · Figshare
- Additional file 1 of A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashionFranziska Witte, Jorge Ruiz‐Orera, Mattioli, Camilla Ciolli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke et al. · 2021 · Figshare
- Additional file 1 of CpGmotifs: a tool to discover DNA motifs associated to CpG methylation eventsGiovanni Scala, Antonio Federico, Greco, Dario · 2021 · Figshare
- Additional file 1 of Identification of biomarkers associated with metabolic cardiovascular disease using mRNA-SNP-miRNA regulatory network analysisFan, Zhiyuan, Peng, Wenjuan, Wang, Zhiwen, Ling Zhang, Liu, Kuo · 2021 · Figshare
- Approches intégrées du génome et du transcriptome dans les maladies complexes humainesMaxime Rotival · 2011 · theses.fr (ABES)
- Species-wide survey of transcript and protein abundance variation in yeastÉlie Teyssonnière · 2023 · theses.fr (ABES)
- Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic TargetXiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen et al. · 2026 · Advanced Science
- Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host‐directed therapyJunfei Wang, Yingnan Zhou, Xunming Ji, Haiping Zhao, Lingjun Zhan · 2026 · Clinical and Translational Medicine
- BindingDB Entry 50020568: Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50044295: Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor.BindingDB · 2015 · UC San Diego