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A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
Open accessAbstract
Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epstein-Barr virus induced gene 2 (Ebi2, also known as Gpr183), which lies at this locus and controls B lymphocyte migration, is expressed in macrophages and regulates the IDIN. The human orthologous locus on chromosome 13q32 controlled the human equivalent of the IDIN, which was conserved in monocytes. IDIN genes were more likely to associate with susceptibility to type 1 diabetes (T1D)-a macrophage-associated autoimmune disease-than randomly selected immune response genes (P = 8.85 × 10(-6)). The human locus controlling the IDIN was associated with the risk of T1D at single nucleotide polymorphism rs9585056 (P = 7.0 × 10(-10); odds ratio, 1.15), which was one of five single nucleotide polymorphisms in this region associated with EBI2 (GPR183) expression. These data implicate IRF7 network genes and their regulatory locus in the pathogenesis of T1D.
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“Such integration of genetic information with network modeling has been used to highlight pathways that contribute to disease and to identify “key drivers” in biologic processes [72–74, 78].”
From Multi-omics approaches to disease (2017) · cites this paper as [78]
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
Self-citationIRF-7 is the master regulator of type-I interferon-dependent immune responses
Honda, K., Yanai, H., Negishi, H., Asagiri, M., Sato, M., Mizutani, T., Shimada, N., Ohba, Y., Takaoka, A., Yoshida, N., et al. (2005) · Nature · doi:10.1038/nature03464 · Cited by 2,229
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
The Type 1 Diabetes Genetics Consortium, Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.381 · Cited by 1,746
Self-citationGenetic Mapping in Human Disease
Altshuler, D., Daly, M. J., & Lander, E. S. (2008) · Science · doi:10.1126/science.1156409 · Cited by 1,452
Genetic Dissection of Transcriptional Regulation in Budding Yeast
Brem, R. B., Yvert, G., Clinton, R., & Kruglyak, L. (2002) · Science · doi:10.1126/science.1069516 · Cited by 1,392
Kawai, T., Sato, S., Ishii, K. J., Coban, C., Hemmi, H., Yamamoto, M., Terai, K., Matsuda, M., Inoue, J., Uematsu, S., et al. (2004) · Nature Immunology · doi:10.1038/ni1118 · Cited by 1,058
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
Eizirik, D. L., Colli, M. L., & Ortis, F. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.21 · Cited by 1,011
Rare Variants of IFIH1 , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes
Nejentsev, S., Walker, N., Riches, D., Egholm, M., & Todd, J. A. (2009) · Science · doi:10.1126/science.1167728 · Cited by 958
Self-citationVariations in DNA elucidate molecular networks that cause disease
Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., et al. (2008) · Nature · doi:10.1038/nature06757 · Cited by 887
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Johnson, M. R., & Shorvon, S. D. (2011) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2011.07.031 · Cited by 48
EBI2 regulates CXCL13‐mediated responses by heterodimerization with CXCR5
Barroso, R., Martínez‐Muñoz, L., Barrondo, S., Vega, B., Holgado, B., Lucas, P., Baı́llo, A., Sallés, J., Rodrı́guez-Frade, J. M., & Mellado, M. (2012) · The FASEB Journal · doi:10.1096/fj.12-208876 · Cited by 45
7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases
Sun, S., & Liu, C. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00060 · Cited by 52
Rocañín-Arjó, A., Cohen, W., Carcaillon‐Bentata, L., Frère, C., Saut, N., Letenneur, L., Alhenc‐Gelas, M., Dupuy, A., Bertrand, M., Alessi, M., et al. (2013) · Blood · doi:10.1182/blood-2013-10-529628 · Cited by 44
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Liquet, B., Mengersen, K. L., Pettitt, A. N., & Sutton, M. (2017) · Bayesian Analysis · doi:10.1214/17-ba1081 · Cited by 44
Christofidou, P., Nelson, C. P., Nikpay, M., Qu, L., Li, M., Loley, C., Dębiec, R., Braund, P. S., Denniff, M. J., Charchar, F. J., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.06.001 · Cited by 45
Self-citationGO-Module: functional synthesis and improved interpretation of Gene Ontology patterns
Yang, X. H., Li, J., Lee, Y., & Lussier, Y. A. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr142 · Cited by 43
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Salem, H. H., Trojanowski, B. M., Fiedler, K., Maier, H. J., Schirmbeck, R., Wagner, M., Boehm, B. O., Wirth, T., & Baumann, B. (2013) · Diabetes · doi:10.2337/db13-1037 · Cited by 42
Lutz, S., Brion, C., Kliebhan, M., & Albert, F. W. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008375 · Cited by 46
Lind, K., Hühn, M. H., & Flodström‐Tullberg, M. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04557.x · Cited by 41
Rotival, M., & Petretto, E. G. (2013) · Briefings in Functional Genomics · doi:10.1093/bfgp/elt030 · Cited by 41
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Stefan–Lifshitz, M., Karaköse, E., Cui, L., Ettela, A., Yi, Z., Zhang, W., & Tomer, Y. (2019) · JCI Insight · doi:10.1172/jci.insight.126663 · Cited by 40
Gat‐Viks, I., Chevrier, N., Wilentzik, R., Eisenhaure, T., Raychowdhury, R., Steuerman, Y., Shalek, A. K., Hacohen, N., Amit, I., & Regev, A. (2013) · Nature Biotechnology · doi:10.1038/nbt.2519 · Cited by 41
Standard of hygiene and immune adaptation in newborn infants
Kallionpää, H., Laajala, E., Öling, V., Härkönen, T., Tillmann, V., Доршакова, Н. В., Ilonen, J., Lähdesmäki, H. J., Knip, M., Lahesmaa, R., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.09.009 · Cited by 40
Type I Diabetes Mellitus: Genetic Factors and Presumptive Enteroviral Etiology or Protection
Precechtelova, J., Borsanyiova, M., Šarmírová, S., & Bopegamage, S. (2014) · Journal of Pathogens · doi:10.1155/2014/738512 · Cited by 39
Chung, S. A., ., G. X., Roshandel, D., Sherva, R., Edberg, J. C., Kravitz, M., Dellaripa, P. F., Hoffman, G. S., Mahr, A., Seo, P., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34496 · Cited by 38
The BB Rat as a Model of Human Type 1 Diabetes
Bortell, R., & Yang, C. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-068-7_3 · Cited by 38
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Marroquí, L., Perez-Serna, A. A., Babiloni-Chust, I., & dos Santos, R. S. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.02.011 · Cited by 37
Simonis, M., Atanur, S. S., Linsen, S. E. V., Guryev, V., Ruzius, F.-P., Gamé, L., Lansu, N. R., de Bruijn, E., van Heesch, S., Jones, S. J. M., et al. (2012) · Genome biology · doi:10.1186/gb-2012-13-4-r31 · Cited by 37
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Hutchinson, A., Watson, H., & Wallace, C. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007829 · Cited by 36
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Shao, F., Zheng, P., Yu, D., Zhou, Z., & Jia, L. (2019) · The FASEB Journal · doi:10.1096/fj.201901637r · Cited by 36
Genome-wide association studies and systems biology: together at last
Ala‐Korpela, M., Kangas, A. J., & Inouye, M. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.09.002 · Cited by 33
ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration
Bottolo, L., Chadeau‐Hyam, M., Hastie, D. I., Langley, S. R., Petretto, E. G., Tiret, L., Trégouët, D., & Richardson, S. T. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btq684 · Cited by 33
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Self-citationDou, Y., Yim, H. C. H., Kirkwood, C. D., Williams, B. R. G., & Sadler, A. J. (2017) · The EMBO Journal · doi:10.15252/embj.201696273 · Cited by 33
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Yang, J. H. M., Downes, K., Howson, J. M. M., Nutland, S. L., Stevens, H. E., Walker, N. M., & Todd, J. A. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-59 · Cited by 34
Self-citationHasin-Brumshtein, Y., Khan, A. H., Hormozdiari, F., Pan, C., Parks, B. W., Petyuk, V., Piehowski, P., Brümmer, A., Pellegrini, M. A., Xiao, X. G., et al. (2016) · eLife · doi:10.7554/elife.15614 · Cited by 34
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Nagaraj, S. H., Gowda, H., Reverter, A., Colgrave, M. L., Sharma, R., Andronicos, N. M., Hunt, P. W., Menzies, M., Lees, M. S., Sekhar, N. R., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.01.016 · Cited by 32
Wu, J., Kakoola, D. N., Lenchik, N. I., Desiderio, D. M., Marshall, D. R., & Gerling, I. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046941 · Cited by 31
Lewin, A., Saadi, H., Peters, J. E., Moreno‐Moral, A., Lee, J. C., Smith, K. G. C., Petretto, E. G., Bottolo, L., & Richardson, S. T. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv568 · Cited by 31
Self-citationMiao, F., Chen, Z., Zhang, L., Wang, J., Gao, H., Wu, X., & Natarajan, R. D. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00001.2013 · Cited by 32
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de Jong, T. V., Pan, Y., Rastas, P. M. A., Munro, D. B., Tutaj, M., Akil, H., Benner, C. W., Chen, D., Chitre, A. S., Chow, W., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100527 · Cited by 31
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Wu, C., & Pan, W. (2018) · Genetic Epidemiology · doi:10.1002/gepi.22110 · Cited by 28
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The emerging role for rat models in gene discovery
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Morrissey, C., Grieve, I. C., Heinig, M., Atanur, S. S., Petretto, E. G., Pravenec, M., Hübner, N., & Aitman, T. J. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00210.2010 · Cited by 25
Self-citationZhang, F., Zhang, B., Ding, H., Li, X., Wang, X., Zhang, X., Liu, Q., Feng, Q., Han, M., Chen, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202207108 · Cited by 24
Rakitsch, B., & Stegle, O. (2016) · Genome biology · doi:10.1186/s13059-016-0895-2 · Cited by 25
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Morse, Z. J., & Horwitz, M. S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00249 · Cited by 24
Génin, P., Lin, R., Hiscott, J. B., & Civas, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038336 · Cited by 23
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Adriaens, M. E., Lodder, E. M., Moreno‐Moral, A., Šilhavý, J., Heinig, M., Glinge, C., Belterman, C. N. W., Wolswinkel, R., Petretto, E. G., Pravenec, M., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009243 · Cited by 21
Self-citationJohnson, M. D., Mueller, M., Adamowicz‐Brice, M., Collins, M. J., Gellert, P., Maratou, K., Srivastava, P. K., Rotival, M., Butt, S., Gamé, L., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004813 · Cited by 20
Self-citationSantín, I., dos Santos, R. S., & Eizirik, D. L. (2015) · Methods in molecular biology · doi:10.1007/7651_2015_291 · Cited by 20
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Cao, W. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000212 · Cited by 18
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Qin, H., Niu, T., & Zhao, J. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00110 · Cited by 19
Kim, T. W., Johnston, J. M., Castillo‐Lluva, S., Cimas, F. J., Hamby, S. E., González‐Moreno, S., Villarejo‐Campos, P., Goodall, A. H., Velasco, G., Ocaña, A., et al. (2022) · Theranostics · doi:10.7150/thno.72192 · Cited by 18
Self-citationZhao, Y., Sheng, Z., & Huang, J. (2011) · Molecular BioSystems · doi:10.1039/c1mb05415e · Cited by 18
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Hermann, R., & Ilonen, J. (2013) · Springer eBooks · doi:10.1007/978-1-4614-4051-2_3
Bagnati, M., Moreno‐Moral, A., Ko, J., Nicod, J., Harmston, N., Imprialou, M., Gamé, L., Gil, J., Petretto, E. G., & Behmoaras, J. V. (2019) · JCI Insight · doi:10.1172/jci.insight.125736 · Cited by 18
Self-citationLu, Y., Wang, B., Jiang, F., Mo, X., Wu, L., He, P., Lu, X., Deng, F., & Lei, S. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14315 · Cited by 17
Witte, F., Ruiz‐Orera, J., Mattioli, C. C., Blachut, S., Adami, E., Schulz, J. F., Schneider-Lunitz, V., Hummel, O., Patone, G., Mücke, M. B., et al. (2021) · Genome biology · doi:10.1186/s13059-021-02397-w · Cited by 16
Self-citationJu, J. H., Shenoy, S. A., Crystal, R. G., & Mezey, J. G. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005537 · Cited by 17
Velasco‐Estevez, M., Koch, N., Klejbor, I., Laurent, S., Dev, K. K., Szutowicz, A., Sailer, A. W., & Rutkowska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094342 · Cited by 15
Hedreul, M. T., Möller, S., Stridh, P., Gupta, Y., Gillett, A., Beyeen, A. D., Öckinger, J., Flytzani, S., Diez, M., Olsson, T. P., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt343 · Cited by 15
Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
Erdely, A., Antonini, J. M., Salmen‐Muniz, R., Liston, A., Hulderman, T., Simeonova, P. P., Kashon, M. L., Li, S., Gu, J. K., Stone, S., et al. (2012) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-9-25 · Cited by 15
Braden, K., Campolo, M., Li, Y., Chen, Z., Doyle, T. M., Giancotti, L. A., Esposito, E., Zhang, J., Cuzzocrea, S., Arnatt, C. K., et al. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001283 · Cited by 14
Self-citationThe Past, Present, and Future of Genetic Associations in Type 1 Diabetes
Baker, P. R., & Steck, A. K. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0212-0 · Cited by 16
IRF7 suppresses hematopoietic regeneration under stress via CXCR4
Chen, Y., Liu, Y., Liu, Y., Deng, X., & Zhou, J. (2020) · Stem Cells · doi:10.1002/stem.3308 · Cited by 14
Network science for the identification of novel therapeutic targets in epilepsy
Scott, R. C. (2016) · F1000Research · doi:10.12688/f1000research.8214.1 · Cited by 14
Pöllänen, P. M., Lempainen, J., Laine, A., Toppari, J., Veijola, R., Ilonen, J., Siljander, H., & Knip, M. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01069 · Cited by 14
Burren, O. S., Guo, H., & Wallace, C. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu571 · Cited by 15
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Self-citationDu, Y., Thompson, E. G., Müller, J., Valvo, J., Braun, J., Shankar, S., van den Berg, R. A., Jongert, E., Dover, D., SADOFF, J. C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00669 · Cited by 13
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Fan, Z., Peng, W., Wang, Z., Zhang, L., & Liu, K. (2021) · BMC Cardiovascular Disorders · doi:10.1186/s12872-021-02166-4 · Cited by 12
Metadata
- Authors
- Cardiogenics Consortium, Heinig, M., Petretto, E., Wallace, C., Bottolo, L., Rotival, M., Lu, H., Li, Y., Sarwar, R., Langley, S. R., Bauerfeind, A., Hummel, O., Lee, Y.-A., Paskas, S., Rintisch, C., Saar, K., Cooper, J., Buchan, R., Gray, E. E., Cyster, J. G., Erdmann, J., Hengstenberg, C., Maouche, S., Ouwehand, W. H., Rice, C. M., Samani, N. J., Schunkert, H., Goodall, A. H., Schulz, H., Roider, H. G., Vingron, M., Blankenberg, S., Münzel, T., Zeller, T., Szymczak, S., Ziegler, A., Tiret, L., Smyth, D. J., Pravenec, M., Aitman, T. J., Cambien, F., Clayton, D., Todd, J. A., Hubner, N., & Cook, S. A.
- Affiliations
- Max Delbrück Center (DE)
- Hammersmith Hospital (GB)
- University of Cambridge (GB)
- Inserm (FR)
- Howard Hughes Medical Institute (US)
- University of Lübeck (DE)
- University of Regensburg (DE)
- National Health Service (GB)
- Wellcome Sanger Institute (GB)
- University of Leicester (GB)
- Max Planck Institute for Molecular Genetics (DE)
- Johannes Gutenberg University Mainz (DE)
- University Hospital Schleswig-Holstein (DE)
- Czech Academy of Sciences (CZ)
- Corresponding author
- Cook, Stuart A.
- ORCID
- Heinig, Matthias
- Petretto, Enrico
- Wallace, Chris
- Bottolo, Leonardo
- Rotival, Maxime
- Sarwar, Rizwan
- Langley, Sarah R.
- Hummel, Oliver
- Lee, Young-Ae
- Saar, Kathrin
- Cooper, Jason
- Buchan, Rachel
- Gray, Elizabeth E.
- Cyster, Jason G.
- Erdmann, Jeanette
- Maouche, Seraya
- Ouwehand, Willem H.
- Samani, Nilesh J.
- Schunkert, Heribert
- Goodall, Alison H.
- Schulz, Herbert
- Roider, Helge G.
- Vingron, Martin
- Blankenberg, Stefan
- Münzel, Thomas
- Zeller, Tanja
- Szymczak, Silke
- Ziegler, Andreas
- Smyth, Deborah J.
- Pravenec, Michal
- Aitman, Timothy J.
- Clayton, David
- Todd, John A.
- Cook, Stuart A.
- Venue
- Nature
- Published
- 2010-09
- Volume
- 467
- Issue
- 7314
- Pages
- 460-464
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3657719
- OpenAlex
- W2166903146
- Cited by
- 283
- References
- 30
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 23 · 2020: 8 · 2019: 16 · 2018: 13 · 2017: 20 · 2016: 20 · 2015: 22 · 2014: 27 · 2013: 26 · 2012: 38
- FWCI
- 18.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- National University of Singapore (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- ASEP (submittedVersion, public-domain)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Site cant be reached (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Juvenile Diabetes Research Foundation International
- Wellcome Trust (FP7/2007–2013, 061858, 089989, 076113)
- University Hospitals of Leicester NHS Trust
- National Institute for Health and Care Research (FP7/2007–2013, NF-SI-0508-10275)
- British Heart Foundation (P301/10/0290)
- Research Councils UK
- Imperial College London
- European Commission (2007–2013, LSHG-CT-2005-019015, FP7 2007-2013, LSHM-CT 2006–037593, FP7/2007, 241504)
- Fondation Leducq
- Grantová Agentura České Republiky (1M6837805002)
- Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- type 1 diabetes, IRF7, EBI2, GPR183, macrophages, Epstein-Barr virus, monocytes, gene co-expression network, autoimmune disease susceptibility, systems genetics
- MeSH terms
- Animals, Base Sequence, Chromosomes, Human, Pair 13, Diabetes Mellitus, Type 1, Humans, Immunity, Innate, Inflammation, Macrophages, Organ Specificity, Viruses, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Chromosomes, Mammalian, Quantitative Trait Loci, Receptors, G-Protein-Coupled, Interferon Regulatory Factor-7, Rats, Gene Regulatory Networks, Genome-Wide Association Study, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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