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Multiscale Simulations of Biological Membranes: The Challenge To Understand Biological Phenomena in a Living Substance

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Studies on the mechanism of general anesthesia

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Effects of protein crowding on membrane systems

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Anaesthetics stop diverse plant organ movements, affect endocytic vesicle recycling and ROS homeostasis, and block action potentials in Venus flytraps

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Understanding of anesthesia – Why consciousness is essential for life and not based on genes

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Quantum effects in the brain: A review

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Electron spin changes during general anesthesia in <i>Drosophila</i>

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Xenon and Other Volatile Anesthetics Change Domain Structure in Model Lipid Raft Membranes

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The Sentient Cell

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · doi:10.1093/oso/9780198873211.001.0001 · Cited by 64 · see citing works

From membrane excitability to metazoan psychology

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Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties

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Live cell imaging of signaling and metabolic activities

Depaoli, M. R., Bischof, H., Eroğlu, E., Burgstaller, S., Ramadani‐Muja, J., Rauter, T., Schinagl, M., Waldeck‐Weiermair, M., Hay, J., Graier, W. F., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.06.003 · Cited by 52 · see citing works

Mechanosensory Transduction: Focus on Ion Channels ☆

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Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function

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The actions of volatile anesthetics: a new perspective

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α-Arrestins and Their Functions: From Yeast to Human Health

Zbieralski, K., & Wawrzycka, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094988 · Cited by 44 · see citing works

Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties

Herold, K. F., Sanford, R. L., Lee, W., Schultz, M. F., Ingólfsson, H. I., Andersen, O. S., & Hemmings, H. C. (2014) · The Journal of General Physiology · doi:10.1085/jgp.201411172 · Cited by 32 · see citing works

Divergent effects of anesthetics on lipid bilayer properties and sodium channel function

Herold, K. F., Andersen, O. S., & Hemmings, H. C. (2017) · European Biophysics Journal · doi:10.1007/s00249-017-1239-1 · Cited by 32 · see citing works

Interaction of neurotransmitters with a phospholipid bilayer: A molecular dynamics study

Peters, G. H. J., Werge, M. P., Elf-Lind, M. N., Madsen, J. J., Velardez, G. F., & Westh, P. (2014) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2014.08.003 · Cited by 28 · see citing works

Mechanistic insights into volatile anesthetic modulation of K2P channels

Wague, A., Joseph, T. T., Woll, K. A., Bu, W., Vaidya, K. A., Bhanu, N. V., Garcia, B. A., Nimigean, C. M., Eckenhoff, R. G., & Riegelhaupt, P. M. (2020) · eLife · doi:10.7554/elife.59839 · Cited by 25 · see citing works

Association of Model Neurotransmitters with Lipid Bilayer Membranes

Josey, B. P., Heinrich, F., Silin, V. I., & Lösche, M. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.01.016 · Cited by 26 · see citing works

Calcium and protons affect the interaction of neurotransmitters and anesthetics with anionic lipid membranes

Pérez-Isidoro, R., & Ruiz‐Suárez, J. C. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.06.017 · Cited by 19 · see citing works

Exploiting large-scale drug-protein interaction information for computational drug repurposing

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Membrane effects of dihydropyrimidine analogues with larvicidal activity

Sánchez-Borzone, M. E., Mariani, M. E., Miguel, V., Gleiser, R. M., Odhav, B., Venugopala, K. N., & Garcı́a, D. A. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.11.028 · Cited by 18 · see citing works

Exploring the Mechanism of General Anesthesia: Kinetic Analysis of GABAA Receptor Electrophysiology

Lee, D. K., Albershardt, D. J., & Cantor, R. S. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2014.12.052 · Cited by 15 · see citing works

Thermodynamics of Amide + Amine Mixtures. 1. Volumetric, Speed of Sound, and Refractive Index Data for N,N-Dimethylformamide + N-Propylpropan-1-amine, + N-Butylbutan-1-amine, + Butan-1-amine, or + Hexan-1-amine Systems at Several Temperatures

Hevia, F., Cobos, A., González, J. A., de la Fuenté, I. G., & Sanz, L. F. (2016) · Journal of Chemical & Engineering Data · doi:10.1021/acs.jced.5b00802 · Cited by 14 · see citing works

Pharmacology of Inhaled Anesthetics

Hudson, A. E., Herold, K. F., & Hemmings, H. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-48110-6.00011-9 · Cited by 14 · see citing works

Studies on the mechanism of membrane mediated general anesthesiaPreprint

Pavel, M. A., Petersen, E. N., Wang, H., Lerner, R. A., & Hansen, S. B. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/313973 · Cited by 14 · see citing works

Advanced Praise for The Sentient Cell: The Cellular Foundations of Consciousness

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.002.0008 · Cited by 15 · see citing works

Anionic Phospholipids Bind to and Modulate the Activity of Human TRESK Background K+ Channel

Giblin, J. P., Etayo, I., Castellanos, A., Andrés‐Bilbé, A., & Gasull, X. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1244-0 · Cited by 12 · see citing works

Thermodynamics of Amide + Amine Mixtures. 2. Volumetric, Speed of Sound and Refractive Index Data for N,N-Dimethylacetamide + N-Propylpropan-1-Amine, + N-Butylbutan-1-Amine, + Butan-1-Amine, or + Hexan-1-Amine Systems at Several Temperatures

Hevia, F., Cobos, A., González, J. A., de la Fuenté, I. G., & Alonso‐Gómez, V. (2016) · Journal of Solution Chemistry · doi:10.1007/s10953-016-0560-0 · Cited by 12 · see citing works

Mechanisms of Drug Action

Paul, A. (2019) · Introduction to Basics of Pharmacology and Toxicology · doi:10.1007/978-981-32-9779-1_9 · Cited by 11 · see citing works

Effect of neurosteroids on a model lipid bilayer including cholesterol: An Atomic Force Microscopy study

Sacchi, M., Balleza, D., Vena, G., Puia, G., Facci, P., & Alessandrini, A. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.01.002 · Cited by 10 · see citing works

Temperature Dependent Solvation and Partitioning of Coumarin 152 in Phospholipid Membranes

Gobrogge, C. A., Kong, V. A., & Walker, R. A. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b09505 · Cited by 9 · see citing works

Thermodynamics of amide + amine mixtures. 4. Relative permittivities of N,N-dimethylacetamide + N-propylpropan-1-amine, + N-butylbutan-1-amine, + butan-1-amine, or + hexan-1-amine systems and of N,N-dimethylformamide + aniline mixture at several temperatures. Characterization of amine + amide systems using ERAS

Hevia, F., González, J. A., Cobos, A., de la Fuenté, I. G., & Sanz, L. F. (2017) · The Journal of Chemical Thermodynamics · doi:10.1016/j.jct.2017.11.011 · Cited by 8 · see citing works

The evolutionary origin of the need to sleep: an inevitable consequence of synaptic neurotransmission?

Cantor, R. S. (2015) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2015.00015 · Cited by 8 · see citing works

Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats.

Yuan, C., Zhang, Y., Zhang, Y., Cao, S., Wang, Y., Fu, B., & Yu, T. (2016) · PubMed Central · Cited by 8 · see citing works

Thermodynamics of amide + amine mixtures. 3. Relative permittivities of N , N -dimethylformamide + N -propylpropan-1-amine, + N -butylbutan-1-amine, + butan-1-amine, or + hexan-1-amine systems at several temperatures

Hevia, F., González, J. A., de la Fuenté, I. G., Sanz, L. F., & Cobos, J. C. (2017) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2017.05.025 · Cited by 7 · see citing works

Solving the crisis in psychopharmacological research: Cellular-membrane(s) pharmacology to the rescue?

Drukarch, B., Jacobs, G. E., & Wilhelmus, M. M. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110545 · Cited by 7 · see citing works

Pharmacology of Inhaled Anesthetics

Hudson, A. E., Herold, K. F., & Hemmings, H. C. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1679-5.00010-7 · Cited by 7 · see citing works

Toxic and signaling effects of the anaesthetic lidocaine on rice cultured cells

Sylvain-Bonfanti, L., Arbelet-Bonnin, D., Filaine, F., Lalanne, C., Renault, A., Meimoun, P., Laurenti, P., Grésillon, É., & Bouteau, F. (2024) · Plant Signaling & Behavior · doi:10.1080/15592324.2024.2388443 · Cited by 6 · see citing works

Open‐channel blocking action of volatile anaesthetics desflurane and sevoflurane on human voltage‐gated K v 1.5 channel

Fukushima, Y., Kojima, A., Mi, X., Ding, W., Kitagawa, H., & Matsuura, H. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15105 · Cited by 6 · see citing works

Allosteric Modulation of Membrane Proteins by Small Low-Affinity Ligands

Treptow, W. L. (2023) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.2c01542 · Cited by 6 · see citing works

Effects of neurosteroids on a model membrane including cholesterol: A micropipette aspiration study

Balleza, D., Sacchi, M., Vena, G., Galloni, D., Puia, G., Facci, P., & Alessandrini, A. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.01.017 · Cited by 6 · see citing works

The Biological Information Cycle

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0007 · Cited by 5 · see citing works

Inhaled Anesthetics: Beyond the Operating Room

Darwish, D., Kumar, P., Urs, K., & Dave, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13247513 · Cited by 5 · see citing works

Beta-Site Amyloid Precursor Protein-Cleaving Enzyme Inhibition Partly Restores Sevoflurane-Induced Deficits on Synaptic Plasticity and Spine Loss

Wang, X., Shi, Q., Pradhan, A. K., Ziegon, L., Schlegel, M., & Rammes, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126637 · Cited by 4 · see citing works

Exploring the Modulation of Hypoxia-Inducible Factor (HIF)-1α by Volatile Anesthetics as a Possible Mechanism Underlying Volatile Anesthetic-Induced CNS Injury

Giles, E. K., Lawrence, A. J., & Duncan, J. R. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1379-y · Cited by 4 · see citing works

The Un(f)told Story of General Anesthesia

Zsila, F. (2018) · ChemBioChem · doi:10.1002/cbic.201700691 · Cited by 4 · see citing works

Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast

Kozu, F., Shirahama‐Noda, K., Araki, Y., Kira, S., Niwa, H., & Noda, T. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13302 · Cited by 3 · see citing works

Thermodynamics of amide + amine mixtures. 5. Excess molar enthalpies of N,N-dimethylformamide or N,N-dimethylacetamide + N-propylpropan-1-amine, + N-butylbutan-1-amine, + butan-1-amine, or + hexan-1-amine systems at 298.15 K. Application of the ERAS model

Hevia, F., Ballerat‐Busserolles, K., Coulier, Y., Coxam, J. Y., González, J. A., de la Fuenté, I. G., & Cobos, J. C. (2019) · Fluid Phase Equilibria · doi:10.1016/j.fluid.2019.112283 · Cited by 3 · see citing works

Plant Sentience

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0011 · Cited by 2 · see citing works

What Is Life? The Vitalism–Mechanism Debate and the Origins of Life

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0003 · Cited by 2 · see citing works

Probing interactions of neurotransmitters with twin tailed anionic surfactant: A detailed physicochemical study

Kaur, R., Sanan, R., & Mahajan, R. K. (2016) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2016.02.006 · Cited by 2 · see citing works

Alcohols Inhibit Glucose Transporters Noncompetitively at a Constant Membrane Concentration According to Lipid Theory

Uesono, Y. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03540 · Cited by 1 · see citing works

General Anesthetics in Cancer Surgery: Can Anesthesiologists Help the Patient with More than a Safe Sleep

Bonvini, J. M. (2022) · Medicina · doi:10.3390/medicina58091156 · Cited by 1 · see citing works

It’s Cells All the Way Down

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0002 · Cited by 1 · see citing works

Mechanisms of Action of Inhaled Volatile General Anesthetics: Unconsciousness at the Molecular Level

Baldassarre, D., Scarpati, G., & Piazza, O. (2019) · Neuromethods · doi:10.1007/978-1-4939-9891-3_6 · Cited by 1 · see citing works

Association of Model Neurotransmitters with Lipid Bilayer MembranesPreprint

Josey, B. P., Heinrich, F., Silin, V. I., & Lösche, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/822189

Thermodynamics of amine mixtures. Systems formed by alkyl-amine and ether, or N,N-dialkylamide, or ethanenitrile

González, J. A., Hevia, F., de la Fuenté, I. G., Cobos, J. C., Ballerat‐Busserolles, K., Coulier, Y., & Coxam, J. Y. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.112907

Hydroxide ions amplified by water entanglement underly the mechanism of general anesthesiaPreprint

Qian, H., Li, N., Yang, L., Xu, Y., Chen, R., Lu, D., Zhao, R.-H., Liu, H., Cui, N., Zhou, Q., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.28.428716

Atividade analgésica em camundongos Swiss submetidos a diferentes doses de cloreto de magnésio (MgCl2) associado ou não a paracetamol e clonazepam

Treto, R. R. R., da Cunha, R. M., & Pinto, W. D. J. (2021) · Revista de Medicina da UFC · doi:10.20513/2447-6595.2021v61n1e40986p1-7

Faculty Opinions recommendation of Studies on the mechanism of general anesthesia.

Parton, R. G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738042219.793575489

Faculty Opinions recommendation of Studies on the mechanism of general anesthesia.

Roth, M. G. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738042219.793575173

Genes Are Tools of Intelligent Cells

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0008

The Biophysical Basis of Cellular Sentience

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0006

Copyright Page

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.002.0003

The N-Space Episenome

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0009

The Cellular Basis of Consciousness (CBC)

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0001

The Structural and Bioelectrical Basis of Cells

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0005

Anaesthetics and Their Cellular Targets

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0010

Prologue: Setting the Stage

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.002.0005

Emergence and Evolution of Cells

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0004

Issues of Ethics and Morality

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.003.0012

Abbreviations

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.002.0007

Glossary of Technical Terms in the Biological Sciences

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.005.0002

Preface

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.002.0004

An Exercise in Lexicography: Defining(?) Consciousness

Reber, A. S., Baluška, F., & Miller, W. B. (2023) · Oxford University Press eBooks · doi:10.1093/oso/9780198873211.005.0001

Unmasking Conformationally Adaptable Lipids as Drug Receptors

Regen, S. L. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c01035

Molecular mechanisms of general anesthetic action

Healy, T. E. J., & Knight, P. (2003) · CRC Press eBooks · doi:10.1201/b13549-22

Theoretical model of anesthetic action upon ion channels mediated by lipid membrane

Suezaki, Y., Petrov, A. G., & Ueda, I. (2005) · International Congress Series · doi:10.1016/j.ics.2005.06.087 · Cited by 1 · see citing works

Divergent effects of anesthetics on lipid bilayer properties and sodium channel function

Herold, K. F., Andersen, O. S., & Hemmings, H. C. (2017) · European Biophysics Journal · doi:10.1007/s00249-017-1239-1 · Cited by 32 · see citing works

Channel Site Effects of Volatile Anesthetics on Molecular Network Levels in the Central Neuron

Tseng, C.-S., Luk, H., Kang, H.-M., Shen, W., Cheng, F., Lee, T.-C., Lai, H., Wang, J.-P., & Chen, G. (2005) · 疼痛醫學雜誌 · doi:10.29792/ttjp.200503.0006

Chapter 10 Lipid Membrane and Ligand-Gated Ion Channels in General Anesthetic Action

Sandberg, W. S., Dubois, B. W., & Miller, K. W. (1999) · Current topics in membranes · doi:10.1016/s0070-2161(08)61048-5 · Cited by 4 · see citing works