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Cited by 870

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Network anatomy and in vivo physiology of visual cortical neurons

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Bock, Davi D., Lee, Wei-Chung Allen, Kerlin, Aaron M., Andermann, Mark L., Hood, Greg, Wetzel, Arthur W., Yurgenson, Sergey, Soucy, Edward R., Kim, Hyon Suk, Reid, R. Clay·2011·Nature
DOI 10.1038/nature09802
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Abstract

In the cerebral cortex, local circuits consist of tens of thousands of neurons, each of which makes thousands of synaptic connections. Perhaps the biggest impediment to understanding these networks is that we have no wiring diagrams of their interconnections. Even if we had a partial or complete wiring diagram, however, understanding the network would also require information about each neuron's function. Here we show that the relationship between structure and function can be studied in the cortex with a combination of in vivo physiology and network anatomy. We used two-photon calcium imaging to characterize a functional property—the preferred stimulus orientation—of a group of neurons in the mouse primary visual cortex. Large-scale electron microscopy of serial thin sections was then used to trace a portion of these neurons’ local network. Consistent with a prediction from recent physiological experiments, inhibitory interneurons received convergent anatomical input from nearby excitatory neurons with a broad range of preferred orientations, although weak biases could not be rejected.

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Metadata

Authors
Bock, D. D., Lee, W.-C. A., Kerlin, A. M., Andermann, M. L., Hood, G., Wetzel, A. W., Yurgenson, S., Soucy, E. R., Kim, H. S., & Reid, R. C.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2011-03
Volume
471
Issue
7337
Pages
177-182
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/nature09802
OpenAlex
W2022235653
Cited by
870
References
12
FWCI
43.26
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

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CoChat. (2026). Citation check: Network anatomy and in vivo physiology of visual cortical neurons. https://app.cochat.ai/papers/10.1038/nature09802
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Bock, D. D., Lee, W.-C. A., Kerlin, A. M., Andermann, M. L., Hood, G., Wetzel, A. W., Yurgenson, S., Soucy, E. R., Kim, H. S., & Reid, R. C. (2011). Network anatomy and in vivo physiology of visual cortical neurons. Nature. https://doi.org/10.1038/nature09802

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