Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex
Open accessAbstract
Different subtypes of GABAergic neurons in sensory cortex exhibit diverse morphology, histochemical markers, and patterns of connectivity. These subtypes likely play distinct roles in cortical function, but their in vivo response properties remain unclear. We used in vivo calcium imaging, combined with immunohistochemical and genetic labels, to record visual responses in excitatory neurons and up to three distinct subtypes of GABAergic neurons (immunoreactive for parvalbumin, somatostatin, or vasoactive intestinal peptide) in layer 2/3 of mouse visual cortex. Excitatory neurons had sharp response selectivity for stimulus orientation and spatial frequency, while all GABAergic subtypes had broader selectivity. Further, bias in the responses of GABAergic neurons toward particular orientations or spatial frequencies tended to reflect net biases of the surrounding neurons. These results suggest that the sensory responses of layer 2/3 GABAergic neurons reflect the pooled activity of the surrounding population--a principle that may generalize across species and sensory modalities.
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Cortical interneurons are generally more broadly tuned than nearby principal cells, but different interneuron types show varying degrees of sensory tuning.
“It appears that for the most part cortical INs are more broadly tuned than nearby PCs, yet different INs show various degrees of sensory tuning.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kerlin et al., 2010
The Results report that GABAergic neurons in mouse visual cortex are generally more broadly tuned than excitatory neurons, and that individual interneurons vary in tuning. However, the Results and Discussion say the studied subtypes were remarkably similar in their sensory tuning, so the source does not support the paraphrase’s implication of substantial differences between interneuron types. (LLM, conf=0.86)
Experimental — accuracy not yet measuredVIP interneurons tend to be more selective for orientation tuning than PV and Sst interneurons.
“VIP INs, for example, tend to be more selective for orientation tuning than PV and Sst INs (Kerlin et al., 2010).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kerlin et al., 2010
The Results section ('GABAergic neurons are broadly tuned for orientation, regardless of subtype') reports no difference in orientation selectivity among PV, SOM (Sst), and VIP neurons on its primary measure. An alternate measure found VIP neurons slightly more selective than PV neurons, but does not establish greater selectivity than SOM neurons (Figure S4B). (LLM, conf=0.88)
Experimental — accuracy not yet measuredVIP neurons show sensory responses.
“It has also been shown that VIP neurons do show sensory responses (Fu et al., 2014; Kerlin et al., 2010; Pi et al., 2013).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kerlin et al., 2010
Experimental — accuracy not yet measuredVIP cells are recruited by afferent sensory signals, even if this does not establish direct thalamic recruitment.
“Although these results do not imply direct thalamic recruitment, it does show that VIP cells are recruited by afferent sensory signals.”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kerlin et al., 2010
Sst and VIP interneurons have also been reported to be less selective to sensory stimulation.
“other IN groups such as Sst and VIP INs have also been reported to be less selective to sensory stimulation (Kerlin et al., 2010).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kerlin et al., 2010
Experimental — accuracy not yet measured
In mouse visual cortex, fast-spiking neurons are more broadly selective for orientation, direction and spatial frequency than pyramidal cells.
“in mouse visual cortex, selectivity to visual stimuli such as orientation, direction, and spatial frequency are broader for FS neurons than for pyramidal cells”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Kerlin et al., 2010
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- Authors
- Kerlin, A. M., Andermann, M. L., Berezovskii, V. K., & Reid, R. C.
- Affiliations
- Harvard University (US)
- Corresponding author
- Reid, R. Clay
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 67
- Issue
- 5
- Pages
- 858-871
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3327881
- OpenAlex
- W2086871516
- Cited by
- 613
- References
- 93
- Citations by year
- 2026: 22 · 2025: 40 · 2024: 39 · 2023: 19 · 2022: 43 · 2021: 34 · 2020: 60 · 2019: 41 · 2018: 36 · 2017: 38 · 2016: 49 · 2015: 40 · 2014: 31 · 2013: 45 · 2012: 33
- FWCI
- 23.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (P30-EY12196, R01EY018742, P30EY012196)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABAergic interneurons, parvalbumin, somatostatin, vasoactive intestinal peptide, mouse visual cortex, layer 2/3, orientation selectivity, spatial frequency selectivity, population coding, response bias, in vivo calcium imaging
- MeSH terms
- Animals, Calcium, Egtazic Acid, Fluorescent Dyes, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Neurons, Orientation, Parvalbumins, Photic Stimulation, Somatostatin, Vasoactive Intestinal Peptide, Visual Cortex, Visual Pathways, Imaging, Three-Dimensional, Green Fluorescent Proteins, Mice
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