The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Open accessAbstract
Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae), Caenorhabditis elegans and Drosophila melanogaster. Studies of the effects of genes on ageing are vulnerable to confounding effects of genetic background. Here we re-examined the reported effects of sirtuin overexpression on ageing and found that standardization of genetic background and the use of appropriate controls abolished the apparent effects in both C. elegans and Drosophila. In C. elegans, outcrossing of a line with high-level sir-2.1 overexpression abrogated the longevity increase, but did not abrogate sir-2.1 overexpression. Instead, longevity co-segregated with a second-site mutation affecting sensory neurons. Outcrossing of a line with low-copy-number sir-2.1 overexpression also abrogated longevity. A Drosophila strain with ubiquitous overexpression of dSir2 using the UAS-GAL4 system was long-lived relative to wild-type controls, as previously reported, but was not long-lived relative to the appropriate transgenic controls, and nor was a new line with stronger overexpression of dSir2. These findings underscore the importance of controlling for genetic background and for the mutagenic effects of transgene insertions in studies of genetic effects on lifespan. The life-extending effect of dietary restriction on ageing in Drosophila has also been reported to be dSir2 dependent. We found that dietary restriction increased fly lifespan independently of dSir2. Our findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“These findings have recently been called into question, however, with the report that the lifespan extension originally observed in the worm and fly studies was mostly due to confounding genetic background differences and not to the overexpression of sir-2.1 or dSir2, respectively (Burnett et al., 2011).”
From The Hallmarks of Aging (2013) · cites this paper as Burnett et al., 2011
In the citing paper
“recent reports fail to show robust effects of SIRT on lifespan in these same model systems (56).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,161
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,510
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,618
The Nematode Caenorhabditis elegans
Wood, W. B. (1988) · Cold Spring Harbor Laboratory eBooks · Cited by 2,820
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Self-citationMammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 625
Cheng, D., Zhao, L., Xu, Y., Ou, R., Li, G., Yang, H., & Li, W. (2015) · Tumor Biology · doi:10.1007/s13277-015-3429-8 · Cited by 17
Changes in human sirtuin 6 gene promoter methylation during aging
Sahin, K., Yılmaz, S., & Gözükırmızı, N. (2014) · Biomedical Reports · doi:10.3892/br.2014.266 · Cited by 16
Stenvinkel, P., Kooman, J. P., & Shiels, P. G. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000234 · Cited by 16
Dubayee, M. A., Alshahrani, A. S., Almalki, M. H., Hakami, A., Homoud, B., Alzneidi, N., Aldhalaan, J., Aljbli, G., Nasr, A., Farahat, A. I., et al. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107758 · Cited by 15
Guo, X., & Garcia, L. R. (2014) · eLife · doi:10.7554/elife.01730 · Cited by 18
Representation of probabilistic scientific knowledge
Soldatova, L., Rzhetsky, A., Grave, K. D., & King, R. D. (2013) · Journal of Biomedical Semantics · doi:10.1186/2041-1480-4-s1-s7 · Cited by 15
Salam, S. A., Mostafa, F., Alnamshan, M. M., Elshewemi, S. S., & Sorour, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112149 · Cited by 15
PCH-2 regulates Caenorhabditis elegans lifespan
Qian, H., Xu, X. Z. S., & Niklason, L. E. (2015) · Aging · doi:10.18632/aging.100713 · Cited by 15
Leow, S.-S., LUU, A., Shrestha, S., Hayes, K. C., & Sambanthamurthi, R. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.03.013 · Cited by 15
Wen, D., Zheng, L., Li, J., Cheng, D., Liu, Y., Lǚ, K., & Hou, W.-Q. (2019) · Biology Open · doi:10.1242/bio.044719 · Cited by 15
Beghelli, D., Zallocco, L., Barbalace, M. C., Paglia, S., Strocchi, S., Cirilli, I., Marzano, V., Putignani, L., Lupidi, G., Hrelia, S., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1744408 · Cited by 15
Caron, M. J., Gely, L., Garvis, S., Adrait, A., Couté, Y., Palladino, F., & Fabrizio, P. (2021) · Life Science Alliance · doi:10.26508/lsa.202101140 · Cited by 15
The Contentious History of Sirtuin Debates
Naiman, S., & Cohen, H. Y. (2012) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10093 · Cited by 15
Does transcription-associated DNA damage limit lifespan?
Callegari, A. J. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.03.001 · Cited by 15
Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells
Liu, Y., Yao, Z., Zhang, L., Zhu, H., Deng, W., & Qin, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.034 · Cited by 15
Pharmaceutical Intervention of Aging
Qian, M., & Liu, B. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1117-8_15 · Cited by 17
Chromatin: the old and young of it
Emerson, F. J., & Lee, S. S. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1270285 · Cited by 15
Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome
Zhou, X., Sen, I., Lin, X.-X., & Riedel, C. G. (2018) · Current Genomics · doi:10.2174/1389202919666180503125850 · Cited by 15
Driscoll, M., Sedore, C. A., Onken, B., Coleman-Hulbert, A. L., Johnson, E., Phillips, P. C., & Lithgow, G. J. (2025) · GeroScience · doi:10.1007/s11357-025-01627-4 · Cited by 13
The Use of Calorie Restriction Mimetics to Study Aging
Kitada, M., & Koya, D. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-556-9_8 · Cited by 14
Sirtuins and ageing—new findings
Guarente, L. (2013) · EMBO Reports · doi:10.1038/embor.2013.121 · Cited by 13
Jasper, H. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1369 · Cited by 13
Resveratrol and SIRT1 Activators for the Treatment of Aging and Age-Related Diseases
Stacchiotti, A., Favero, G., & Rezzani, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.78977 · Cited by 16
Ucar, D., & Benayoun, B. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00001-2 · Cited by 14
Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging
Solovev, I. A., Shaposhnikov, M. V., Kudryavtseva, A. V., & Moskalev, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00014-0 · Cited by 13
Mołoń, M., & Żebrowski, J. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox031 · Cited by 13
Will the real aging Sirtuin please stand up?
Liao, C., & Kennedy, B. K. (2012) · Cell Research · doi:10.1038/cr.2012.62 · Cited by 13
Epigenetic mechanisms in Alzheimer's disease
Balázs, R. (2014) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s37341 · Cited by 15
Sinclair, D. A., & Verdin, E. M. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.12.004 · Cited by 12
Sirtuins, Tissue Maintenance, and Tumorigenesis
Mohrin, M., & Chen, D. (2013) · Genes & Cancer · doi:10.1177/1947601912474930 · Cited by 11
Candidate Genes That Affect Aging Through Protein Homeostasis
Argon, Y., & Gidalevitz, T. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_2 · Cited by 13
Potential role of sirtuins in livestock production
Ghinis-Hozumi, Y., Antaramián, A., Villarroya, F., Piña, E., & Mora, O. (2012) · animal · doi:10.1017/s1751731112001115 · Cited by 12
Talbert, M. E., Barnett, B., Hoff, R., Amella, M., Kuczynski, K., Lavington, E., Koury, S. A., Brud, E., & Eanes, W. F. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1646 · Cited by 12
Curjuric, I., Imboden, M., Bridevaux, P., Gerbase, M. W., Haun, M., Keidel, D., Kumar, A., Pons, M., Rochat, T., Schikowski, T., et al. (2016) · AGE · doi:10.1007/s11357-016-9917-y · Cited by 13
Histone Modification Changes During Aging
Cao, X., & Dang, W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-811060-7.00015-2 · Cited by 15
CCAR‐1 is a negative regulator of the heat‐shock response in Caenorhabditis elegans
Brunquell, J., Raynes, R., Bowers, P., Morris, S., Snyder, A. N., Lugano, D. I., Deonarine, A., & Westerheide, S. D. (2018) · Aging Cell · doi:10.1111/acel.12813 · Cited by 11
Viswanathan, M., & Tissenbaum, H. A. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-637-5_3 · Cited by 11
Sirtuins, Healthspan, and Longevity in Mammals
Giblin, W., & Lombard, D. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00003-4 · Cited by 12
Rejuvenation of Adult Stem Cells: Is Age-Associated Dysfunction Epigenetic?
Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1424 · Cited by 12
Parmentier, F., Lejeune, F., & Néri, C. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00022 · Cited by 12
Sirtuins and Neurodegeneration
Dönmez, G. (2017) · Journal of Neurology and Neuromedicine · doi:10.29245/2572.942x/2017/1.1168 · Cited by 11
Li, J., Li, X., Sun, W. S., Zhang, J., Yan, Q., Wu, J., Jin, J., Lu, R., & Miao, D. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.63876 · Cited by 11
Trade-Offs Between Anti-Aging Dietary Supplementation and Exercise
Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1484 · Cited by 11
Role of sirtuins in epigenetic regulation and aging control
Samoilova, E. M., Romanov, S. E., Chudakova, D. A., & Laktionov, P. P. (2024) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-24-26 · Cited by 10
Herbal Supplement Extends Life Span Under Some Environmental Conditions and Boosts Stress Resistance
Villeponteau, B., Matsagas, K. C., Nobles, A. C., Rizza, C. L., Horwitz, M., Benford, G., & Mockett, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119068 · Cited by 10
The effects of Rpd3 on fly metabolism, health, and longevity
Woods, J. K., & Rogina, B. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.015 · Cited by 10
Nutritional Control of Chronological Aging and Heterochromatin inSaccharomyces cerevisiae
McCleary, D. F., & Rine, J. (2017) · Genetics · doi:10.1534/genetics.116.196485 · Cited by 11
A conserved mechanism of sirtuin signalling through steroid hormone receptors
Bayele, H. K. (2019) · Bioscience Reports · doi:10.1042/bsr20193535 · Cited by 10
Tadesse, S. E., & Mekonnen, T. C. (2020) · Nutrition and Dietary Supplements · doi:10.2147/nds.s237407 · Cited by 10
A budding yeast's perspective on aging: The shape I'm in
Smith, J. T., Wright, J., & Schneider, B. L. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215577584 · Cited by 10
Dietary Restriction Increases Protein Acetylation in the Livers of Aged Rats
Nakamura, A., Kawakami, K., Kametani, F., & Goto, S. (2013) · Gerontology · doi:10.1159/000354087 · Cited by 9
Grapevine Stilbenoids: Bioavailability and Neuroprotection
Waffo‐Téguo, P., Krisa, S., Pawlus, A. D., Richard, T., Monti, J., & Mérillon, J. (2013) · Springer eBooks · doi:10.1007/978-3-642-22144-6_74 · Cited by 11
Sirtuins as regulators of mammalian aging
Naiman, S., Kanfi, Y., & Cohen, H. Y. (2012) · Aging · doi:10.18632/aging.100478 · Cited by 9
An unSIRTain role in longevity
Accili, D., de Cabo, R., & Sinclair, D. A. (2011) · Nature Medicine · doi:10.1038/nm1111-1350 · Cited by 9
Longevity Regulation by Insulin/IGF-1 Signalling
An, S. W. A., Artan, M., Park, S., Altıntaş, Ö., & Lee, S. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_4 · Cited by 9
What do we mean by “aging”? Questions and perspectives revealed by studies in Drosophila
Wodrich, A. P. K., Scott, A. W., & Giniger, E. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111839 · Cited by 10
The Evolutionary Portrait of Metazoan NAD Salvage
Carneiro, J., Duarte-Pereira, S., Azevedo, L., Castro, L. F. C., Aguiar, P., Moreira, I. S., Amorim, A., & Silva, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064674 · Cited by 9
Dihydrocapsiate improved age-associated impairments in mice by increasing energy expenditure
Ohyama, K., & Suzuki, K. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00132.2017 · Cited by 9
Ngubo, M., Reid, J. L., & Patterton, H. G. (2022) · PLoS ONE · doi:10.1371/journal.pone.0268760 · Cited by 7
Resveratrol: Die Geschichte geht weiter
Quideau, S., Deffieux, D., & Pouységu, L. (2012) · Angewandte Chemie · doi:10.1002/ange.201203059 · Cited by 8
C. eleganssirtuin SIR-2.4 and its mammalian homolog SIRT6 in stress response
Jedrusik, M. A. (2014) · Worm · doi:10.4161/worm.29102 · Cited by 7
The dangers lurking in the genetic background
Burgess, D. J. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3089 · Cited by 8
Aging and the Biological Clock
Judge, M. T., Griffith, J. W., & Arnold, J. (2017) · Healthy ageing and longevity · doi:10.1007/978-3-319-64543-8_10 · Cited by 8
Hansen, M. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_15 · Cited by 7
Walters, H., & Cox, L. S. (2019) · Biogerontology · doi:10.1007/s10522-018-09792-0 · Cited by 7
Sims, C. A., Labiner, H. E., Shah, S. S., & Baur, J. A. (2021) · GeroScience · doi:10.1007/s11357-020-00311-z · Cited by 7
Zabihihesari, A., Parand, S., Coulthard, A. B., Molnar, A., Hilliker, A. J., & Rezai, P. (2022) · 3 Biotech · doi:10.1007/s13205-022-03336-7 · Cited by 7
Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder
Zelena, D. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3345-3_10 · Cited by 7
Higuchi‐Sanabria, R., Vevea, J., Charalel, J. K., Sapar, M. L., & Pon, L. A. (2016) · Microbial Cell · doi:10.15698/mic2016.02.478 · Cited by 8
Electroporation of Small Interfering RNAs into Tibialis Anterior Muscles of Mice
Stephan, A., Graça, F. A., Hunt, L. C., & Demontis, F. (2022) · BIO-PROTOCOL · doi:10.21769/bioprotoc.4428 · Cited by 6
Short lifespan is one’s fate, long lifespan is one’s achievement: lessons from Daphnia
Beam, T. C., Bright, M. P., Pearson, A. C., Dua, I., Smith, M. L., Dutta, A. K., Bhadra, S. C., Salman, S., Strickler, C. N., Anderson, C. E., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01244-7 · Cited by 6
Pukhalskaia, A. E., Diatlova, A., Linkova, N. S., & Kvetnoy, I. M. (2022) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-022-01217-3 · Cited by 6
Implications of altered sirtuins in metabolic regulation and oral cancer
Xu, Q., Xin, Y., Wang, H., Sun, Y., Chen, C., & Zhang, J. (2023) · PeerJ · doi:10.7717/peerj.14752 · Cited by 6
Lysine modifications and autophagy
Norris, K. L., & Yao, T. (2012) · Essays in Biochemistry · doi:10.1042/bse0520065 · Cited by 6
Mockett, R. J., & Nobles, A. C. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt031 · Cited by 7
The Enzymatic Activities of Sirtuins
Lin, H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00004-6 · Cited by 6
Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress
Yasukawa, T., Nakahara, Y., Hirai, J., & Inoue, Y. H. (2015) · Genes & Genetic Systems · doi:10.1266/ggs.90.11 · Cited by 6
Sir2 plays a key role in cell fate determination upon SAPK activation
Vendrell, A., & Posas, F. (2011) · Aging · doi:10.18632/aging.100419 · Cited by 8
Lemus, A. J. J., Tewelde, E., Bhala, R., Guan, A., Xu, A., & Benayoun, B. A. (2026) · Open Biology · doi:10.1098/rsob.250093 · Cited by 7
Prospects of Pharmacological Interventions to Organismal Aging
Hillson, O., Gonzalez, S., & Rallis, C. (2018) · BioMolecular Concepts · doi:10.1515/bmc-2018-0018 · Cited by 5
A science-based review of the world's best-selling book on aging
Brenner, C. (2022) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2022.104825 · Cited by 7
Extended lifespan in female Drosophila melanogaster through late-life calorie restriction
Li, M., Macro, J., Huggins, B., Meadows, K., Mishra, D., Martin, D., Kannan, K., & Rogina, B. (2024) · GeroScience · doi:10.1007/s11357-024-01233-w · Cited by 5
Rare Sugars D-Psicose and D-Allose as Calorie Restriction Mimetic
Shintani, T., Ohkuma, K., Sakoguchi, H., & Sato, M. (2013) · JOURNAL OF THE BREWING SOCIETY OF JAPAN · doi:10.6013/jbrewsocjapan.108.565 · Cited by 5
The Phenotypic Effects of Royal Jelly on Wild-Type D. melanogaster Are Strain-Specific
Morgan, S. L., Seggio, J. A., Nascimento, N. F., Huh, D. D., Hicks, J. A., Sharp, K. A., Axelrod, J. D., & Wang, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159456 · Cited by 5
Sirtuin Modulation as Novel Neuroprotective Strategy for Alzheimer’s Disease
Polito, L., Biella, G., & Albani, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00008-9 · Cited by 5
Biology is the root of variability: cautionary tales in Caenorhabditis elegans biology
Pho, K. B., & MacNeil, L. T. (2019) · Biochemical Society Transactions · doi:10.1042/bst20190001 · Cited by 5
Multidisciplinary Approach to Aging
Takahashi, R., & Odera, K. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00193-1 · Cited by 5
SIRT2, une déacétylase aux multiples talents
Sayd, S., Junier, M., & Chneiweiss, H. (2014) · médecine/sciences · doi:10.1051/medsci/20143005016 · Cited by 5
Contemporary insights into neuroimmune interactions across development and aging
Yeo, X. Y., Choi, Y., Hong, Y., Kwon, H. N., & Jung, S. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1611124 · Cited by 5
New genetic and epigenetic approaches in gerontology
Баранов, В. С., Glotov, O. S., & Baranova, E. V. (2014) · Advances in Gerontology · doi:10.1134/s2079057014040055 · Cited by 4
Chromatin and epigenetics in aging biology
Greer, E. L., Lee, S. S., & Prahlad, V. (2025) · Genetics · doi:10.1093/genetics/iyaf055 · Cited by 5
Yeast as a model organism for aging research
Kriško, A., & Kennedy, B. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00008-1 · Cited by 5
Mitochondrial sirtuins sir - 2.2 and sir - 2.3 regulate lifespan in C. elegansPreprint
Chang, S. M., McReynolds, M. R., & Hanna‐Rose, W. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/181727 · Cited by 4
Regulatory Roles for SIRT1 in Aging and Immunosenescence
Brissett-Lasalle, D., Syed, Z., Yarubandi, Y., Leips, J., & Green, E. M. (2025) · Results and problems in cell differentiation · doi:10.1007/978-3-031-91459-1_10 · Cited by 4
Hormetic Stress Responses in Aging: From Molecular Mechanisms to Clinical Translation
Ferreira, J. M. A., & Тукаєв, С. (2026) · Stresses · doi:10.3390/stresses6030055 · Cited by 4
Dietary Restriction in C. elegans
Zhang, Y., & Mair, W. B. (2016) · Healthy ageing and longevity · doi:10.1007/978-3-319-44703-2_16 · Cited by 4
Klinaki, E., & Ogrodnik, M. B. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111929 · Cited by 3
Epigenetic Responses to Diet in Aging
Ford, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00016-9 · Cited by 3
SIRT1 activators as novel therapy for cancer
Joudah, M. S., Al-Sudani, B. T., & Arif, I. S. (2019) · Al Mustansiriyah Journal of Pharmaceutical Sciences · doi:10.32947/ajps.19.03.0410 · Cited by 3
Pukhalskaia, A. E., Kvetnoy, I. M., Linkova, N. S., Diatlova, A., Gutop, E. O., Kozlov, K. L., & Paltsev, M. A. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01379-8 · Cited by 3
Metadata
- Authors
- Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A.-M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M., Sőti, C., Partridge, L., & Gems, D.
- Affiliations
- University College London (GB)
- Semmelweis University (HU)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Inserm (FR)
- MRC Laboratory for Molecular Cell Biology (GB)
- Max Planck Institute for Biology of Ageing (DE)
- Corresponding author
- Gems, David
- ORCID
- Venue
- Nature
- Published
- 2011-09
- Volume
- 477
- Issue
- 7365
- Pages
- 482-485
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3188402
- OpenAlex
- W2074974899
- Cited by
- 624
- References
- 36
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 23 · 2020: 18 · 2019: 33 · 2018: 26 · 2017: 43 · 2016: 54 · 2015: 71 · 2014: 60 · 2013: 98 · 2012: 100
- FWCI
- 32.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Wellcome Trust (081394)
- European Commission
- National Institutes of Health
- National Institute on Aging (R01AG031108, T32AG000057)
- National Cancer Institute (CA129132, R01CA129132)
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Sir2, sirtuins, lifespan extension, aging, dietary restriction, Caenorhabditis elegans, Drosophila melanogaster, outcrossing, sensory neurons, NAD+-dependent deacetylase
- MeSH terms
- Aging, Animals, Crosses, Genetic, Drosophila melanogaster, Female, Histone Deacetylases, Longevity, Male, RNA, Messenger, Gene Expression, Caenorhabditis elegans, Drosophila Proteins, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Caloric Restriction, Sirtuins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
