The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
Open accessAbstract
Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae), Caenorhabditis elegans and Drosophila melanogaster. Studies of the effects of genes on ageing are vulnerable to confounding effects of genetic background. Here we re-examined the reported effects of sirtuin overexpression on ageing and found that standardization of genetic background and the use of appropriate controls abolished the apparent effects in both C. elegans and Drosophila. In C. elegans, outcrossing of a line with high-level sir-2.1 overexpression abrogated the longevity increase, but did not abrogate sir-2.1 overexpression. Instead, longevity co-segregated with a second-site mutation affecting sensory neurons. Outcrossing of a line with low-copy-number sir-2.1 overexpression also abrogated longevity. A Drosophila strain with ubiquitous overexpression of dSir2 using the UAS-GAL4 system was long-lived relative to wild-type controls, as previously reported, but was not long-lived relative to the appropriate transgenic controls, and nor was a new line with stronger overexpression of dSir2. These findings underscore the importance of controlling for genetic background and for the mutagenic effects of transgene insertions in studies of genetic effects on lifespan. The life-extending effect of dietary restriction on ageing in Drosophila has also been reported to be dSir2 dependent. We found that dietary restriction increased fly lifespan independently of dSir2. Our findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“These findings have recently been called into question, however, with the report that the lifespan extension originally observed in the worm and fly studies was mostly due to confounding genetic background differences and not to the overexpression of sir-2.1 or dSir2, respectively (Burnett et al., 2011).”
From The Hallmarks of Aging (2013) · cites this paper as Burnett et al., 2011
In the citing paper
“recent reports fail to show robust effects of SIRT on lifespan in these same model systems (56).”
From Redox regulation of mitochondrial function (2012) · cites this paper as [56]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,161
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,510
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,618
The Nematode Caenorhabditis elegans
Wood, W. B. (1988) · Cold Spring Harbor Laboratory eBooks · Cited by 2,820
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Self-citationMammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 625
Dictyostelium discoideum: A Model System to Study Autophagy Mediated Life Extension
Jain, P., Sharma, P., Shrivastava, A., & Saran, S. (2016) · Springer eBooks · doi:10.1007/978-981-10-2155-8_2 · Cited by 3
SIRT1 in Metabolic Health and Disease
Boutant, M., & Cantó, C. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_4 · Cited by 3
Benetti, F., Dias, T. A., Costa, J. A. V., & Bertolin, T. E. (2020) · Research Society and Development · doi:10.33448/rsd-v9i8.6210 · Cited by 3
Food for Thought: Linking Caloric Intake to Behavior via Sirtuin Activity
Drew, L., & Hen, R. (2011) · Cell · doi:10.1016/j.cell.2011.11.052 · Cited by 4
Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences
Cantó, C. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115003225 · Cited by 3
Exploring the Sirtuin Functionality in Ageing Through Human Protein Interaction Networks
Nahálková, J. (2020) · SN Computer Science · doi:10.1007/s42979-020-00192-1 · Cited by 3
Aging in the Nematode Caenorhabditis elegans
Daskalaki, I., Markaki, M., & Tavernarakis, N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11376-5 · Cited by 4
Sirtuins, healthspan, and longevity in mammals
Kumar, S., Giblin, W., & Lombard, D. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00005-6 · Cited by 2
Wang, D.-T., Wu, M., Li, S., Gao, Q., & Zeng, Q.-P. (2014) · doi:10.7287/peerj.preprints.565v1 · Cited by 3
Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans
Chang, S. M., Franklin, L. P., Sattar, S., Moro, C. A., DeGennaro, M. V., LaGanke, N. G., & Hanna‐Rose, W. (2025) · Genetics · doi:10.1093/genetics/iyaf185 · Cited by 2
Convergent evolution of H4K16ac-mediated dosage compensation in the ZW species Artemia franciscana
Zimmer, F., Fox, A. M., Pan, Q., Rühle, F., Andersen, P. R., Huylmans, A. K., Schwander, T., Basilicata, M. F., & Valsecchi, C. I. K. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011895 · Cited by 5
Aging: Reading, Reasoning, and Resolving Using Drosophila as a Model System
Nisha, N., Raj, K., Pragati, Tandon, S., Chanu, S. I., & Sarkar, S. (2020) · Springer eBooks · doi:10.1007/978-981-32-9005-1_14 · Cited by 3
Kanno, K., Kayashima, Y., TAMURA, K., Miyara, T., Baba, K., Koganei, M., Natsume, M., & Imai, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-16471-1 · Cited by 2
Sirtuins and metabolic regulation: food and supplementation
Santos, S. H. S., Guimarães, V. H. D., Oliveira, J. R., & de Rezende, L. F. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822467-0.00003-6 · Cited by 3
[Molecular gerontology: towards healthy aging].
Castillo-Quan, J. I., & Kinghorn, K. J. (2013) · PubMed · Cited by 2
Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process
Calvo, S. S.-C., Navas, P., & López‐Lluch, G. (2012) · InTech eBooks · doi:10.5772/35702 · Cited by 2
The Dynamics of Histone Modifications During Aging
Bainor, A. J., & David, G. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800140-0.00007-8 · Cited by 2
Sirtuins: A Future Perspective
Kennedy, B. K. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_13 · Cited by 2
Cantó, C., & Houtkooper, R. H. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_10 · Cited by 2
Cellular lifespan and senescence: a complex balance between multiple cellular pathways
Dolivo, D., Hernandez, S. J., & Dominko, T. (2015) · Inside the Cell · doi:10.1002/icl3.1036 · Cited by 3
The Controversy Around Sirtuins and Their Functions in Aging
Sun, Y., & Dang, W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00017-0 · Cited by 2
Regulation of Sirtuins by Systemic NAD + Biosynthesis
Yoshida, M., & Imai, S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813499-3.00002-2 · Cited by 3
Sirtuins in the biology of aging
Wątroba, M., & Szukiewicz, D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00002-1 · Cited by 3
The Aging Epigenome and The Rejuvenation Strategies
Meiliana, A., Dewi, N. M., & Wijaya, A. (2022) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v14i1.1777 · Cited by 1
Novel targets for pharmacological intervention in age-related diseases
Polak‐Jonkisz, D., Rehan, L., Laszki‐Szcząchor, K., & Sobieszczańska, M. I. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.10.008 · Cited by 2
Shulgau, Z., Palamarchuk, I. V., Dezhko, E., Sergazy, S. D., Urazbayeva, A., Safarova, Y., Gulyayev, A., Gatilov, Y. V., & Kulakov, I. V. (2025) · Molecules · doi:10.3390/molecules30163331 · Cited by 1
Research progress on sirtuin family genes in colorectal cancer
Liu, T., Wu, T., Luo, L., Li, W., & Zhang, M. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1570030 · Cited by 2
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Misawa, T., Amruta, A., Hickson, L. J., & Wolfram, J. (2026) · Advanced Science · doi:10.1002/advs.202519392 · Cited by 1
Vázquez‐Manrique, R. P., Tourette, C., & Néri, C. (2012) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-27928-7_9 · Cited by 1
Baumann, K. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3218 · Cited by 1
Hartse, K. M. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2089-1_62 · Cited by 1
Cellular and Molecular Mechanisms of Resveratrol and Its Derivatives
Stuart, J. A., & Robb, E. L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6968-1_3 · Cited by 1
Chromatin Signaling in Aging and Cellular Senescence
Couteau, F., & Mallette, F. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802389-1.00016-2 · Cited by 1
Vaiserman, A. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12295-4 · Cited by 1
Ma, Q., Chen, S., Ma, Z., Li, D.-F., Dang, X., Xu, J.-S., & Zhou, Z. (2024) · Discover Life · doi:10.1007/s11084-024-09660-7 · Cited by 2
Alternsumkehr und Lebensspannenverlängerung
Bollheimer, L. C., Volkert, D., Bertsch, T., Sieber, C. C., & Büttner, R. (2012) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-012-0415-2 · Cited by 1
Longevity Pathways in Mammalian Stem Cells
Brunet, A., Mahmoudi, S., Mancini, E., Rafalski, V. A., & Webb, A. E. (2014) · Annual Review of Gerontology and Geriatrics · doi:10.1891/0198-8794.34.1 · Cited by 1
Aging in the Single-Celled Eukaryote, S. cerevisiae
He, C. Z., & Kennedy, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_2 · Cited by 1
Biochemistry and Enzymology of Sirtuins
Yang, Y. J., & Sauve, A. A. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_1 · Cited by 1
de Paiva, Y. R. Y., & Baptista, G. M. D. M. (2018) · Revista Brasileira de Cartografia · doi:10.14393/rbcv69n7-43998 · Cited by 1
The Institutional Pressure to Become a Professor-Entrepreneur
Franzen, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-68063-3_5 · Cited by 1
Robb, E. L. (2013) · Brock University Digital Repository (Brock University) · Cited by 1
Ledford, H. K. (2011) · Nature · doi:10.1038/news.2011.549 · Cited by 1
Harrington, M. (2011) · Lab Animal · doi:10.1038/laban1111-330b · Cited by 1
Ayyub, C., & Kolthur‐Seetharam, U. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/631176 · Cited by 1
Examining The Predictability of Genetic Background Effects in The Drosophila Wing
Daley, C. (2019) · MacSphere (McMaster University) · doi:10.71548/10990 · Cited by 1
An evolutionarily conserved metallophosphodiesterase is a determinant of lifespan in DrosophilaPreprint
Gupta, K., Janardan, V., Banerjee, S., Chakrabarti, S., Srinivas, S., Mahishi, D., Raghu, P., & Visweswariah, S. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.08.084137 · Cited by 1
Zimmer, F., Fox, A. M., Pan, Q., Rühle, F., Andersen, P. R., Huylmans, A. K., Schwander, T., Basilicata, M. F., & Valsecchi, C. I. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.10.648168 · Cited by 1
Modulating Sirtuin Activity - Design, Synthesis and Evaluation of Sirtuin 2 Inhibitors
Seifert, T. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)
The catalytic activity of sirtuins in physiology and disease from the epigenetic point of view
Albani, D., & Forloni, G. (2014) · Epigenetics of Degenerative Diseases · doi:10.2478/end-2014-0001
Khojah, S. M. (2015) · Enlighten: Theses (The University of Glasgow)
Haq, I. U. (2014) · Digital Commons - East Tennessee State University (East Tennessee State University)
Quantitative Genetic Mapping of Life History Traits in Drosophila melanogaster
McNeil, C. L. (2012) · KU ScholarWorks (University of Kansas)
Cantle, J. P., Lu, X., Gu, X., & Yang, X. W. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1246-7
Red Wine Polyphenols and Vascular Function
Botden, I. P. G. (2012) · RePub (Erasmus University Rotterdam)
An integrative approach to understanding effects of valproate in C. elegans
Munasinghe, D. H. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)
Stratmann, H. G. (2015) · Science and fiction · doi:10.1007/978-3-319-16015-3_9
SIRT2: in the crossroad of aging, neurodegeneration and autophagy
Martinho, R. (2013) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Transcriptional Mediators of Growth and Survival in Response to Nutritional Cues in Drosophila
Killip, L. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28503
Kirkland, J. L., & Tchkonia, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_19
Zeng, Q.-P. (2015) · Springer briefs in molecular science · doi:10.1007/978-3-662-47688-8_6
The Role of Neurosensory Systems in the Modulation of Aging
Waterson, M. J., & Pletcher, S. D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00005-8
Ligand Binding and Catalysis in Selected Sirtuin Isozymes
Yu, J. (2016) · NDSU Repository (North Dakota State University)
NAD+ as a Pharmacological Tool to Boost Sirtuin Activity
Houtkooper, R. H. (2016) · Springer eBooks · doi:10.1007/978-94-024-0962-8_2
Maulucci, G., & Pani, G. (2012)
Spatio-Temporal Control of Cellular and Organismal Physiology by Sirtuins
Deota, S., Shukla, N., & Kolthur‐Seetharam, U. (2017) · Journal of the Indian Institute of Science · doi:10.1007/s41745-016-0018-9
King, C. (2017) · UWA Profiles and Research Repository (University of Western Australia)
HDACi-induced DNA damage: identifying potential endpoints for safety assessment
Wang, W. (2016) · ORCA Online Research @Cardiff (Cardiff University)
A Role for Sirtuins in Maintaining Mammalian Lifespan and Healthspan
Giblin, W. (2017) · Deep Blue (University of Michigan)
Amaral, S., Amaral, A., & Ramalho‐Santos, J. (2013)
Energy Metabolism and Epigenetics
Bultman, S. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_87-1 · Cited by 1
Biologische Grundlagen des Alterns und dessen Relevanz für die Lebensqualität
Schosserer, M., & Grillari, J. (2017) · Springer eBooks · doi:10.1007/978-3-662-53101-3_1
Gao, C. (2015) · Louisiana State University · doi:10.31390/gradschool_dissertations.2424
Vitamin B3 salvage and NAD\(^+\) metabolism in skeletal muscle
Fletcher, R. S. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)
Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity
Delaney, C. E. (2017) · Deep Blue (University of Michigan)
Natural Genetic Variation Underlying UVR Sensitivity in Drosophila melanogaster
Chana, K. (2015) · Leicester Research Archive (University of Leicester)
RNAi: applications and possibilities in next generation ageing research.
Saha, M. K. (2012)
Ngubo, M., Reid, J., & Patterton, H. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.16.878983
Maiväli, Ü. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418689-7.00003-x
Genetic and Molecular Aspects of the Aging Auditory System
Someya, S., & Kim, M. (2020) · Springer handbook of auditory research · doi:10.1007/978-3-030-49367-7_2
Sirtuins and life span extension
Lee, S., & Min, K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-814118-2.00006-9
Diet’s impact dictated by synonymous mitochondrial SNP interacting with nucleotypePreprint
Dobson, A. J., Voigt, S., Kumpitsch, L., Langer, L., Voigt, E., Ibrahim, R., Dowling, D. K., & Reinhardt, K. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.07.434274
Bollheimer, L. C., Volkert, D., Bertsch, T., Sieber, C. C., & Büttner, R. (2013) · Zeitschrift für Gerontologie und Geriatrie
Hinterding, H. M., & Deelen, J. (2021) · Springer eBooks · doi:10.1007/978-3-030-22009-9_727
Faculty Opinions recommendation of The role of sirtuins in antioxidant and redox signaling.
Ji, L. L. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731078139.793582081
Energy Metabolism and Epigenetics
Bultman, S. J. (2019) · Springer eBooks · doi:10.1007/978-3-319-55530-0_87
Ghosh, S. (2019) · Springer theses · doi:10.1007/978-981-32-9267-3_1
Faculty Opinions recommendation of The hallmarks of aging.
Hickson, I. D., & Mankouri, H. W. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718061760.793481794
Hinterding, H. M., & Deelen, J. (2019) · Springer eBooks · doi:10.1007/978-3-319-69892-2_727-1
Restriction of caloric intake is a key to prevention of vascular ageing
Orlova, Y. A. (2015) · Systemic Hypertension · doi:10.26442/2075-082x_12.2.89-95
Soda, K. (2014) · NIPPON SHOKUHIN KOGYO GAKKAISHI · doi:10.3136/nskkk.61.607
The Hypoxic Response and Aging
Leiser, S. F., Miller, H. A., & Kaeberlein, M. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-411596-5.00004-6
Self-citation(2011) · Nature · doi:10.1038/480468a
Metadata
- Authors
- Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A.-M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M., Sőti, C., Partridge, L., & Gems, D.
- Affiliations
- University College London (GB)
- Semmelweis University (HU)
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- Inserm (FR)
- MRC Laboratory for Molecular Cell Biology (GB)
- Max Planck Institute for Biology of Ageing (DE)
- Corresponding author
- Gems, David
- ORCID
- Venue
- Nature
- Published
- 2011-09
- Volume
- 477
- Issue
- 7365
- Pages
- 482-485
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3188402
- OpenAlex
- W2074974899
- Cited by
- 624
- References
- 36
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 23 · 2020: 18 · 2019: 33 · 2018: 26 · 2017: 43 · 2016: 54 · 2015: 71 · 2014: 60 · 2013: 98 · 2012: 100
- FWCI
- 32.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- Wellcome Trust (081394)
- European Commission
- National Institutes of Health
- National Institute on Aging (R01AG031108, T32AG000057)
- National Cancer Institute (CA129132, R01CA129132)
- National Center for Research Resources
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Sir2, sirtuins, lifespan extension, aging, dietary restriction, Caenorhabditis elegans, Drosophila melanogaster, outcrossing, sensory neurons, NAD+-dependent deacetylase
- MeSH terms
- Aging, Animals, Crosses, Genetic, Drosophila melanogaster, Female, Histone Deacetylases, Longevity, Male, RNA, Messenger, Gene Expression, Caenorhabditis elegans, Drosophila Proteins, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Caloric Restriction, Sirtuins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
