Kaeberlein, Matt

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature

Genomics and Chromatin DynamicsSirtuins and Resveratrol in Medicine

Cited by 3,510

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 2,253

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,676

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 1,293

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

Lin, S.-J., Kaeberlein, M., Andalis, A. A., Sturtz, L. A., Defossez, P.-A., Culotta, V. C., Fink, G. R., & Guarente, L. (2002) · Nature

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 1,057

Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 982

Substrate-specific activation of sirtuins by resveratrol

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 745

Histone H4 lysine 16 acetylation regulates cellular lifespan

Dang, W., Steffen, K. K., Perry, R., Dorsey, J. A., Johnson, F. B., Shilatifard, A., Kaeberlein, M., Kennedy, B. K., & Berger, S. L. (2009) · Nature

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 667

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., et al. (2011) · Nature

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 624

Replicative and chronological aging in Saccharomyces cerevisiae

Longo, V. D., Shadel, G. S., Kaeberlein, M., & Kennedy, B. (2012) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 595

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

Bitto, A., Ito, T. K., Pineda, V. V., LeTexier, N. J., Huang, H. Z., Sutlief, E., Tung, H., Vizzini, N., Chen, B., Smith, K., et al. (2016) · eLife

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 474

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., et al. (2008) · Cell

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 465

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 441

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

Ramos, F. J., Chen, S. C., Garelick, M. G., Dai, D.-F., Liao, C.-Y., Schreiber, K. H., MacKay, V. L., An, E. H., Strong, R., Ladiges, W. C., et al. (2012) · Science Translational Medicine

Nuclear Structure and FunctionMuscle Physiology and Disorders

Cited by 349

Healthy aging: The ultimate preventative medicine

Kaeberlein, M., Rabinovitch, P. S., & Martin, G. M. (2015) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 341

Dietary restriction and lifespan: lessons from invertebrate models

Kapahi, P., Kaeberlein, M., & Hansen, M. (2017) · Ageing Research Reviews

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 340

Recent developments in yeast aging

Kaeberlein, M., Burtner, C. R., & Kennedy, B. K. (2007) · PLoS Genetics

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 239

H3K36 methylation promotes longevity by enhancing transcriptional fidelity

Sen, P., Dang, W., Donahue, G., Dai, J., Dorsey, J., Cao, X., Liu, W., Cao, K., Perry, R., Lee, J. Y., et al. (2015) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

Cited by 233

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

Leiser, S. F., Miller, H., Rossner, R., Fletcher, M., Leonard, A., Primitivo, M., Rintala, N., Ramos, F. J., Miller, D. L., & Kaeberlein, M. (2015) · Science

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 159

Molecular mechanisms underlying genotype‐dependent responses to dietary restriction

Schleit, J., Johnson, S. C., Bennett, C. F., Simko, M., Trongtham, N., Castanza, A., Hsieh, E. J., Moller, R. M., Wasko, B. M., Delaney, J. R., et al. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 159

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

Dang, W., Sutphin, G. L., Dorsey, J. A., Otte, G. L., Cao, K., Perry, R. M., Wanat, J. J., Saviolaki, D., Murakami, C. J., Tsuchiyama, S., et al. (2014) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsGenomics and Chromatin Dynamics

Cited by 83

Hot topics in aging research: protein translation and TOR signaling, 2010

Kaeberlein, M., & Kennedy, B. K. (2011) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 66

Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

Mehta, R., Chandler-Brown, D., Ramos, F. J., Shamieh, L. S., & Kaeberlein, M. (2010) · Advances in Experimental Medicine and Biology

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 44

Systems biology approach to late‐onset Alzheimer's disease genome‐wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments

Mukherjee, S., Russell, J. C., Carr, D. T., Burgess, J. D., Allen, M., Serie, D. J., Boehme, K. L., Kauwe, J. S. K., Naj, A. C., Fardo, D. W., et al. (2017) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 39