Cited by 625Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in MedicineNeurobiology and Insect Physiology Research

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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Burnett, Camilla, Valentini, Sara, Cabreiro, Filipe, Goss, Martin, Somogyvári, Milán, Piper, Matthew D., Hoddinott, Matthew, Sutphin, George L., Leko, Vid, McElwee, Joshua J., Vazquez-Manrique, Rafael P., Orfila, Anne-Marie, Ackerman, Daniel, Au, Catherine, Vinti, Giovanna, Riesen, Michèle, Howard, Ken, Neri, Christian, Bedalov, Antonio, Kaeberlein, Matt, Sőti, Csaba, Partridge, Linda, Gems, David·2011·Nature

DOI 10.1038/nature10296PMC PMC3188402

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Abstract

Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae), Caenorhabditis elegans and Drosophila melanogaster. Studies of the effects of genes on ageing are vulnerable to confounding effects of genetic background. Here we re-examined the reported effects of sirtuin overexpression on ageing and found that standardization of genetic background and the use of appropriate controls abolished the apparent effects in both C. elegans and Drosophila. In C. elegans, outcrossing of a line with high-level sir-2.1 overexpression abrogated the longevity increase, but did not abrogate sir-2.1 overexpression. Instead, longevity co-segregated with a second-site mutation affecting sensory neurons. Outcrossing of a line with low-copy-number sir-2.1 overexpression also abrogated longevity. A Drosophila strain with ubiquitous overexpression of dSir2 using the UAS-GAL4 system was long-lived relative to wild-type controls, as previously reported, but was not long-lived relative to the appropriate transgenic controls, and nor was a new line with stronger overexpression of dSir2. These findings underscore the importance of controlling for genetic background and for the mutagenic effects of transgene insertions in studies of genetic effects on lifespan. The life-extending effect of dietary restriction on ageing in Drosophila has also been reported to be dSir2 dependent. We found that dietary restriction increased fly lifespan independently of dSir2. Our findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila.

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THE GENETICS OF CAENORHABDITIS ELEGANS
Brenner, S. (1974) · Genetics · doi:10.1093/genetics/77.1.71 · Cited by 15,161
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
Brand, A. H., & Perrimon, N. (1993) · Development · doi:10.1242/dev.118.2.401 · Cited by 9,510
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Kamath, R. S., Fraser, A. G., Yan, D., Poulin, G. B., Durbin, R. M., Gotta, M., Kanapin, A. A., Bot, N. L., Moreno, S., Sohrmann, M., et al. (2003) · Nature · doi:10.1038/nature01278 · Cited by 3,618
The Nematode Caenorhabditis elegans
Wood, W. B. (1988) · Cold Spring Harbor Laboratory eBooks · Cited by 2,820
The genetics of ageing
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Self-citation
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775

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Self-citation

Authors: Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A.-M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M., Sőti, C., Partridge, L., & Gems, D.
Affiliations: University College London (GB)
Semmelweis University (HU)
University of Washington (US)
Fred Hutch Cancer Center (US)
Inserm (FR)
MRC Laboratory for Molecular Cell Biology (GB)
Max Planck Institute for Biology of Ageing (DE)
Corresponding author: Gems, David
ORCID: Cabreiro, Filipe
Somogyvári, Milán
Piper, Matthew D.
Sutphin, George L.
Leko, Vid
McElwee, Joshua J.
Ackerman, Daniel
Au, Catherine
Bedalov, Antonio
Kaeberlein, Matt
Sőti, Csaba
Partridge, Linda
Gems, David
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-09
Volume: 477
Issue: 7365
Pages: 482-485
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10296
PMC: PMC3188402
OpenAlex: W2074974899
Cited by: 624
References: 36
Citations by year: 2026: 10 · 2025: 15 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 23 · 2020: 18 · 2019: 33 · 2018: 26 · 2017: 43 · 2016: 54 · 2015: 71 · 2014: 60 · 2013: 98 · 2012: 100
FWCI: 32.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Spiral (Imperial College London) (submittedVersion)
Funders: Wellcome Trust (081394)
European Commission
National Institutes of Health
National Institute on Aging (R01AG031108, T32AG000057)
National Cancer Institute (CA129132, R01CA129132)
National Center for Research Resources
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: Sir2, sirtuins, lifespan extension, aging, dietary restriction, Caenorhabditis elegans, Drosophila melanogaster, outcrossing, sensory neurons, NAD+-dependent deacetylase
MeSH terms: Aging, Animals, Crosses, Genetic, Drosophila melanogaster, Female, Histone Deacetylases, Longevity, Male, RNA, Messenger, Gene Expression, Caenorhabditis elegans, Drosophila Proteins, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Caloric Restriction, Sirtuins

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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