The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists
Open accessAbstract
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-ERB-β have an integral role in regulating the expression of core clock proteins driving rhythms in activity and metabolism. Here we describe the identification of potent synthetic REV-ERB agonists with in vivo activity. Administration of synthetic REV-ERB ligands alters circadian behaviour and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.
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Self-citationMolecular components of the mammalian circadian clock
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Self-citationSuprachiasmatic Nucleus: Cell Autonomy and Network Properties
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Self-citationCircadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1
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Self-citationRev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways
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Cited by
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Self-citationMolecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
Metadata
- Authors
- Solt, L. A., Wang, Y., Banerjee, S., Hughes, T., Kojetin, D. J., Lundasen, T., Shin, Y., Liu, J., Cameron, M. D., Noel, R., Yoo, S.-H., Takahashi, J. S., Butler, A. A., Kamenecka, T. M., & Burris, T. P.
- Venue
- Nature
- Published
- 2012-03-29
- Volume
- 485
- Issue
- 7396
- Pages
- 62-68
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1990356462
- Cited by
- 831
- References
- 28
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Solt, L. A., Wang, Y., Banerjee, S., Hughes, T., Kojetin, D. J., Lundasen, T., Shin, Y., Liu, J., Cameron, M. D., Noel, R., Yoo, S.-H., Takahashi, J. S., Butler, A. A., Kamenecka, T. M., & Burris, T. P. (2012). Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. https://doi.org/10.1038/nature11030
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