The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Open accessAbstract
Major depression is characterized by diverse debilitating symptoms that include hopelessness and anhedonia. Dopamine neurons involved in reward and motivation are among many neural populations that have been hypothesized to be relevant, and certain antidepressant treatments, including medications and brain stimulation therapies, can influence the complex dopamine system. Until now it has not been possible to test this hypothesis directly, even in animal models, as existing therapeutic interventions are unable to specifically target dopamine neurons. Here we investigated directly the causal contributions of defined dopamine neurons to multidimensional depression-like phenotypes induced by chronic mild stress, by integrating behavioural, pharmacological, optogenetic and electrophysiological methods in freely moving rodents. We found that bidirectional control (inhibition or excitation) of specified midbrain dopamine neurons immediately and bidirectionally modulates (induces or relieves) multiple independent depression symptoms caused by chronic stress. By probing the circuit implementation of these effects, we observed that optogenetic recruitment of these dopamine neurons potently alters the neural encoding of depression-related behaviours in the downstream nucleus accumbens of freely moving rodents, suggesting that processes affecting depression symptoms may involve alterations in the neural encoding of action in limbic circuitry.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The nucleus accumbens (NAc) is a critical link in corticomesolimbic reward circuits, integrating information from the prefrontal cortices (PFC), amygdala, and hippocampus to control the release of dopamine from the ventral tegmental area (VTA) back to the telencephalon [19][20][21][22][23].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [20]
In the citing paper
“First, phasic firing changes in VTA DA neurons are inconsistent across stress models (66, 69).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [69]
In the citing paper
“A recent optogenetic study examining dopaminergic ventral tegmental area (VTA) projections into nucleus accumbens found that dopamine receptors are required for the action of these neurons in depression-related escape behavior.23”
From Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions (2021) · cites this paper as [23]
In the citing paper
“chronic mild stressinduced social behavioral deficits are associated with decreased DA release in limbic target regions [150].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [150]
In the citing paper
“Alterations in VTA DA activity will affect activity in multiple downstream targets, including the NAc and mPFC, which appear to be particularly important for mediating social avoidance [149, 150, 156-159].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [150]
In the citing paper
“VTA firing is also reduced in mice exposed to CUS and optogenetic stimulation in this context reverses, instead of promotes, stress-induced behavioral deficits [54].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [54]
In the citing paper
“Selective inhibition of VTA dopamine neurons induces anhedonia and behavioral despair; conversely, phasic activation of VTA dopamine neurons reverses chronic mild/unpredictable stress-induced depression-like phenotypes, a phenomenon dependent on dopamine transmission in the NAc [41].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [41]
In the citing paper
“Selective inhibition of VTA dopamine neurons induces anhedonia and behavioral despair; conversely, phasic activation of VTA dopamine neurons reverses chronic mild/unpredictable stress-induced depression-like phenotypes, a phenomenon dependent on dopamine transmission in the NAc [41].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Depression: a new animal model sensitive to antidepressant treatments
PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307
The mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059
Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 1,000
Fu, R., Zuo, W., Shiwalkar, N., Mei, Q., Fan, Q., Chen, X., Li, J., Bekker, A., & Ye, J.-H. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0378-8 · Cited by 36
The dentate gyrus in depression
Umschweif, G., Greengard, P., & Sagi, Y. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14640 · Cited by 40
Nunes, E. J., Rupprecht, L. E., Foster, D. J., Lindsley, C. W., Conn, P. J., & Addy, N. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108089 · Cited by 36
Döbrössy, M. D., Ramanathan, C., Vajari, D. A., Tong, Y., Schlaepfer, T. E., & Coenen, V. A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14975 · Cited by 37
Depressive Symptoms and Suicidal Thoughts in Restless Legs Syndrome
Chenini, S., Barateau, L., Guiraud, L., Denis, C., Rassu, A. L., Lopez, R., Jaussent, I., & Dauvilliers, Y. A. (2022) · Movement Disorders · doi:10.1002/mds.28903 · Cited by 36
Stress-induced anhedonia correlates with lower hippocampal serotonin transporter protein expression
Tang, M., Lei, J., Sun, X., Liu, G., & Zhao, S. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.042 · Cited by 37
Das, A. K., Bej, S., Pandit, N. R., Banerjee, P., & Biswas, B. (2023) · Journal of Materials Chemistry A · doi:10.1039/d2ta07938k · Cited by 35
Inflammation, Dopaminergic Brain and Bilirubin
Jayanti, S. D., Verde, C. D., Tiribelli, C., & Gazzin, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411478 · Cited by 39
Colonnello, V., Petrocchi, N., Farinelli, M., & Ottaviani, C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160816120209 · Cited by 36
Furuyashiki, T., & Kitaoka, S. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12901 · Cited by 35
Camporeze, B., Manica, B., Bonafé, G. A., Jordão, J., Ferreira, C., Diniz, A. L., Oliveira, C. T. P. D., Roberto, L., Junior, M., Aguiar, P. H. P. D., et al. (2018) · Europe PMC (PubMed Central) · doi:10.13140/rg.2.2.24618.03525 · Cited by 35
Hannah, S., Al-Hatmi, M., Gray, L., & Corrigan, D. K. (2020) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2020.107480 · Cited by 35
Zhang, S., Fu, Y., Sheng, Q., & Zheng, J. (2017) · New Journal of Chemistry · doi:10.1039/c7nj01835e · Cited by 34
McCall, N. M., de Velasco, E. M. F., & Wickman, K. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.3101-18.2019 · Cited by 34
Sex-Specific Effects of Stress on Mood-Related Gene Expression
Barko, K., Paden, W., Cahill, K. M., Seney, M. L., & Logan, R. W. (2019) · Complex Psychiatry · doi:10.1159/000499105 · Cited by 35
Learning to control the brain through adaptive closed-loop patterned stimulation
Tafazoli, S., MacDowell, C. J., Che, Z., Letai, K. C., Steinhardt, C. R., & Buschman, T. J. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abb860 · Cited by 36
Optogenetics, physiology, and emotions
Kravitz, A. V., & Bonci, A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00169 · Cited by 35
Aquili, L., Liu, A. W., Shindou, M., Shindou, T., & Wickens, J. R. (2014) · Learning & Memory · doi:10.1101/lm.034199.113 · Cited by 35
DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity
Shields, B. C., Yan, H., Lim, S. S. X., Burwell, S., Cammarata, C. M., Fleming, E. A., Yousefzadeh, S. A., Goldenshtein, V. Z., Kahuno, E. W., Vagadia, P. P., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02292-9 · Cited by 34
Cathomas, F., Fuertig, R., Sigrist, H., Newman, G. N., Hoop, V., Bizzozzero, M. R., Mueller, A., Luippold, A. H., Ceci, A., Hengerer, B., et al. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.184 · Cited by 33
Li, M., Yang, X., Yang, J., Li, T., Cui, C., Peng, X., Lei, J., Ren, K., Ming, J., Zhang, P., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.06.026 · Cited by 34
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
Zhu, J., Chen, X., Lu, B., Li, X.-Y., Wang, Z., Cao, L., Chen, G., Chen, J.-S., Chen, T., Chen, T.-L., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06665-w · Cited by 35
Yohn, S. E., Harvey, P. D., Brannan, S. K., & Horan, W. P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1421554 · Cited by 36
Zhukovskaya, A., Zimmerman, C. A., Willmore, L., Pan-Vazquez, A., Janarthanan, S. R., Lynch, L. A., Falkner, A. L., & Witten, I. B. (2024) · Neuron · doi:10.1016/j.neuron.2024.09.009 · Cited by 33
Self-citationOptogenetic and chemogenetic insights into the food addiction hypothesis
Krashes, M. J., & Kravitz, A. V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00057 · Cited by 34
Optogenetics: Applications in psychiatric research
Shirai, F., & Hayashi‐Takagi, A. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12516 · Cited by 33
Šabanović, M., Liu, H., Mlambo, V. C., Aqel, H., & Chaudhury, D. (2020) · Brain and Behavior · doi:10.1002/brb3.1896 · Cited by 36
Choi, J. Y., Jang, H. J., Ornelas, S., Fleming, W., Fürth, D., Au, J., Bandi, A., Engel, E. A., & Witten, I. B. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108492 · Cited by 29
Self-citationCao, G., Meng, G., Zhu, L., Zhu, J., Dong, N., Zhou, X., Zhang, S., & Zhang, Y. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00175-z · Cited by 33
Zou, X., & Sun, Y. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.683474 · Cited by 32
The transcription factor BCL11A defines distinct subsets of midbrain dopaminergic neurons
Tolve, M., Ulusoy, A., Patikas, N., Islam, K. U. S., Bodea, G. O., Öztürk, E., Broske, B., Mentani, A., Wagener, A., van Loo, K. M. J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109697 · Cited by 33
Zhu, X., & Grace, A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01820-3 · Cited by 30
Sex Hormones and Brain Dopamine Functions
Sotomayor‐Zárate, R., Cruz, G., Renard, G. M., Espinosa, P., & Ramírez, V. (2015) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524914666141226105137 · Cited by 32
Boxelaere, M. V., Clements, J., Callaerts, P., D’Hooge, R., & Callaerts‐Vegh, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188537 · Cited by 34
Freund, N., Thompson, B. S., Sonntag, K., Meda, S., & Andersen, S. L. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4200-y · Cited by 31
A dual-pathway architecture for stress to disrupt agency and promote habit
Giovanniello, J. R., Paredes, N., Wiener, A., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K., Pimenta, J. S., Vilchez, G. E., et al. (2025) · Nature · doi:10.1038/s41586-024-08580-w · Cited by 30
Self-citationMcFarland, D. C., Shaffer, K. M., BREITBART, W. S., Rosenfeld, B. D., & Miller, A. H. (2018) · Cancer · doi:10.1002/cncr.31859 · Cited by 32
Reiley, H. B., Perez, S. M., Donegan, J. J., & Lodge, D. J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01235-8 · Cited by 32
Wang, H., Cui, W., Chen, W., Liu, F., Dong, Z., Xing, G., Luo, B., Gao, N., Zou, W.-J., Zhao, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01137-7 · Cited by 34
Poggi, G., Albiez, J., & Pryce, C. R. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100451 · Cited by 31
Zhang, B., Guo, F., Ma, Y., Song, Y., Lin, R., Shen, F., Jin, G.-Z., Li, Y., & Liu, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-03680-2 · Cited by 38
Protracted maturation of forebrain afferent connections of the ventral tegmental area in the rat
Yetnikoff, L., Reichard, R. A., Schwartz, Z. M., Parsely, K. P., & Zahm, D. S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23459 · Cited by 30
Bennett, S. N., Chang, A. B., Rogers, F. D., Jones, P., & Peña, C. J. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105472 · Cited by 29
Yu, Q., Hao, S., Wang, H., Song, X., Shen, Q., & Kang, J. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.142117 · Cited by 30
Chohan, M. O., Esses, S., Haft, J., Ahmari, S. E., & Veenstra-VanderWeele, J. M. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05635-4 · Cited by 30
Dopaminergic Modulation of Affective and Social Deficits Induced by Prenatal Glucocorticoid Exposure
Borges, S., Coimbra, B., Soares‐Cunha, C., Pêgo, J. M., Sousa, N., & Rodrigues, A. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.108 · Cited by 31
Zhang, Y., Wang, S., & Hei, M. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111058 · Cited by 36
Matsushita, N., Muroi, Y., Kinoshita, K.-I., & Ishii, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.02.003 · Cited by 29
van Buel, E. M., Sigrist, H., Seifritz, E., Fikse, L., Bosker, F. J., Schoevers, R. A., Klein, H. C., Pryce, C. R., & Eisel, U. L. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184603 · Cited by 36
Hill, D. F., Parent, K. L., Atcherley, C. W., Cowen, S. L., & Heien, M. L. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.11.010 · Cited by 30
Sun, Y., Li, L., Liao, M., Su, M., Wan, C., Zhang, L., & Zhang, H. (2018) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.03.022 · Cited by 30
Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction
Thibeault, K. C., Kutlu, M. G., Sanders, C. M., & Calipari, E. S. (2018) · Brain Research · doi:10.1016/j.brainres.2018.12.024 · Cited by 28
Orrico‐Sánchez, A., Chausset‐Boissarie, L., de Sousa, R. A., Coutens, B., Amin, S. R., Vialou, V., Louis, F., Hessani, A., Dansette, P. M., Zornoza, T., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0548-4 · Cited by 33
Tamura, T., Sugihara, G., Okita, K., Mukai, Y., Matsuda, H., Shiwaku, H., Takagi, S., Daisaki, H., Tateishi, U., & Takahashi, H. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02080-z · Cited by 29
Su, Q., Li, T., Li, T., Zhang, Y., Guo, J., Wang, Z.-J., Wu, M.-N., & Qi, J.-S. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.353479 · Cited by 29
Heteromerization of dopaminergic receptors in the brain: Pharmacological implications
Misganaw, D. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105600 · Cited by 29
Ortiz, V., Campos, R. C., Fofo, H., Fernández, S. P., & Barik, J. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01314-4 · Cited by 30
Yang, S. H., Yang, E., Lee, J., Kim, J. Y., Yoo, H., Park, H. S., Jung, J. T., Lee, D., Chun, S., Jo, Y. S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38180-7 · Cited by 28
Chronic nandrolone administration induces dysfunction of the reward pathway in rats
Zotti, M., Tucci, P., Colaianna, M., Morgese, M. G., Mhillaj, E., Schiavone, S., Scaccianoce, S., Cuomo, V., & Trabace, L. (2013) · Steroids · doi:10.1016/j.steroids.2013.10.005 · Cited by 28
Fu, B., Wen, S., Wang, B., Wang, K., Zhang, J., Weng, X., & Liu, S.-J. (2018) · Journal of Pain Research · doi:10.2147/jpr.s170167 · Cited by 31
Optogenetics in the behaving rat: integration of diverse new technologies in a vital animal model
Zalocusky, K. A., & Deisseroth, K. A. (2013) · Optogenetics · doi:10.2478/optog-2013-0001 · Cited by 29
Self-citationDopaminergic impact of cART and anti-depressants on HIV neuropathogenesis in older adults
Matt, S. M., & Gaskill, P. J. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146398 · Cited by 26
Du, Y.-L., Zhou, S., Ma, C., Chen, H., Du, A., Deng, G., Liu, Y., Tose, A. J., Sun, L., Liu, Y., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.021 · Cited by 27
Shui, B., Lee, J. C., Reining, S., Lee, F. K., & Kotlikoff, M. I. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00428 · Cited by 29
A Transient Dopamine Signal Represents Avoidance Value and Causally Influences the Demand to Avoid
Pultorak, K. J., Schelp, S. A., Isaacs, D. P., Krzystyniak, G., & Oleson, E. B. (2018) · eNeuro · doi:10.1523/eneuro.0058-18.2018 · Cited by 28
Yang, Y., Zhang, K., Zhong, J., Ju, W., Yu, Z., Lei, X., Chen, X., Quan, Y., Xian, J., Chen, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31056-7 · Cited by 26
Gut-brain axis: altered microbiome and depression – review
Mohan, A., Godugu, S., Joshi, S., Shah, K. B., Vanka, S. C., Shakil, H., Dhanush, P., Veliginti, S., Sure, P. S., & Goranti, J. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000000573 · Cited by 28
Mata-Bermúdez, A., Trejo-Chávez, R., Martínez-Vargas, M., Pérez-Arredondo, A., Martínez-Cárdenas, M. D. L. Á., Dı́az-Ruiz, A., Rı́os, C., & Navarro, L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1447688 · Cited by 27
Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity
Eleftheriou, C. G., Cesca, F., Maragliano, L., Benfenati, F., & Maya‐Vetencourt, J. F. (2017) · Journal of Experimental Neuroscience · doi:10.1177/1179069517703354 · Cited by 27
Chakraborty, S., Tripathi, S. J., Srikumar, B. N., Raju, T. R., & Rao, B. S. S. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.01.020 · Cited by 28
Mesocortical BDNF signaling mediates antidepressive-like effects of lithium
Liu, D., Tang, Q., Wang, D., Song, S.-P., Yang, X.-N., Hu, S.-W., Wang, Z.-Y., Xu, Z., Liu, H., Yang, J., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0713-0 · Cited by 27
Zan, G., Wang, Y.-J., Li, X., Fang, J., Yao, S.-Y., Du, J., Wang, Q., Sun, X., Liu, R., Shao, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109913 · Cited by 28
Antidepressant Drugs for Seizures and Epilepsy: Where do we Stand?
Tallarico, M., Pisano, M., Leo, A., Russo, E., Citraro, R., & Sarro, G. D. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220627160048 · Cited by 27
Azogu, I., de la Tremblaye, P. B., Dunbar, M., Lebreton, M., Marec, N. L., & Plamondon, H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.11.015 · Cited by 29
Bruchim-Samuel, M., Lax, E., Gazit, T., Friedman, A., Ahdoot, H. L., Bairachnaya, M., Pinhasov, A., & Yadid, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.016 · Cited by 27
Klanker, M., Feenstra, M., Willuhn, I., & Denys, D. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.09.012 · Cited by 25
Genome-wide linkage on chromosome 10q26 for a dimensional scale of major depression
Knowles, E. E. M., Kent, J. W., McKay, D., Sprooten, E., Mathias, S. R., Curran, J. E., Carless, M. A., Almeida, M., Harald, H. H. G., Dyer, T., et al. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.11.012 · Cited by 25
Postpartum changes in affect-related behavior and VTA dopamine neuron activity in rats
Rincón‐Cortés, M., & Grace, A. A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109768 · Cited by 26
Strauss, M. J., O’Donovan, B., Ma, Y., Xiao, Z., Lin, S., Bardo, M. T., Ortinski, P. I., McLaughlin, J. P., & Zhu, J. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266023 · Cited by 25
Sun, Y., Cao, J., Xu, C., Liu, X., Wang, Z., & Zhao, H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113433 · Cited by 26
Brodnik, Z. D., Xu, W., Batra, A., Lewandowski, S. I., Ruiz, C. M., Mortensen, O. V., Kortagere, S., Mahler, S. V., & España, R. A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0894-20.2020 · Cited by 25
Prettyman, G. E., Kable, J. W., Didier, P. R., Shankar, S., Satterthwaite, T. D., Davatzikos, C. A., Bilker, W. B., Elliott, M. A., Ruparel, K., & Wolf, D. H. (2021) · Schizophrenia · doi:10.1038/s41537-021-00178-9 · Cited by 27
PPARα Signaling: A Candidate Target in Psychiatric Disorder Management
Scheggi, S., Pinna, G., Braccagni, G., Montis, M. G. D., & Gambarana, C. (2022) · Biomolecules · doi:10.3390/biom12050723 · Cited by 25
Li, S., Lo, Y., Tseng, H.-Y., Lin, S.-H., Kuo, C., Chen, T.-C., Chang, C.-W., Liang, Y., Lin, Y.-C., Wang, C.-Y., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100566 · Cited by 29
Optical suppression of drug-evoked phasic dopamine release
McCutcheon, J. E., Cone, J. J., Sinon, C. G., Fortin, S. M., Kantak, P. A., Witten, I. B., Deisseroth, K. A., Stuber, G. D., & Roitman, M. F. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00114 · Cited by 27
Self-citationSikora, M., Tokarski, K., Bobula, B., Zajdel, J., Jastrzębska, K., Cieślak, P. E., Zygmunt, M., Sowa, J., Smutek, M., Kamińska, K., et al. (2016) · eNeuro · doi:10.1523/eneuro.0084-15.2016 · Cited by 27
To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity
Beeler, J. A., & Mourra, D. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00006 · Cited by 28
Alemi, M., Pereira, A. R., Cerqueira-Nunes, M., Monteiro, C., Galhardo, V., & Cardoso-Cruz, H. (2023) · Biomedicines · doi:10.3390/biomedicines11030820 · Cited by 24
Asaoka, N., Nagayasu, K., Nishitani, N., Yamashiro, M., Shirakawa, H., Nakagawa, T., & Kaneko, S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.032 · Cited by 25
Antidepressant-like effect of low dose ketamine and scopolamine co-treatment in mice
Petryshen, T. L., Lewis, M. C., Dennehy, K. A., Garza, J. C., & D, M. F. M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.03.051 · Cited by 25
Bondy, E., Baranger, D. A. A., Balbona, J. V., Sputo, K., Paul, S. E., Oltmanns, T. F., & Bogdan, R. (2021) · Journal of Abnormal Psychology · doi:10.1037/abn0000618 · Cited by 25
Kouhnavardi, S., Ecevitoglu, A., Dragačević, V., Sanna, F., Arias‐Sandoval, E., Kalaba, P., Kirchhofer, M., Lubec, J., Niello, M., Holy, M., et al. (2022) · Biomolecules · doi:10.3390/biom12070881 · Cited by 24
Sex differences in VTA GABA transmission and plasticity during opioid withdrawal
Kalamarides, D. J., Singh, A., Wolfman, S. L., & Dani, J. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-35673-9 · Cited by 24
Nunes, E. J., Bitner, L. E., Hughley, S. M., Small, K. M., Walton, S. N., Rupprecht, L. E., & Addy, N. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.06.028 · Cited by 25
Yang, J., Xiao, Y., Li, L., He, Q., Li, M., & Shu, Y. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00317 · Cited by 29
Influence of aging on the behavioral phenotypes of C57BL/6J mice after social defeat
Oizumi, H., Kuriyama, N., Imamura, S., Tabuchi, M., Omiya, Y., Mizoguchi, K., & Kobayashi, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222076 · Cited by 26
Ren, L. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110910 · Cited by 23
Folate deprivation induced neuroinflammation impairs cognition
Shaikh, A., & Roy, H. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137264 · Cited by 25
Converging circuits between pain and depression: the ventral tegmental area as a therapeutic hub
Flores-García, M., Rizzo, A., Garçon-Poca, M. Z., Fernández‐Dueñas, V., & Bonaventura, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1278023 · Cited by 25
Peris‐Sampedro, F., Reverte, I., Basaure, P., Cabré, M., Domingo, J. L., & Colomina, M. T. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.03.029 · Cited by 23
Metadata
- Authors
- Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., Gunaydin, L. A., Witten, I. B., & Deisseroth, K.
- Affiliations
- Massachusetts Institute of Technology (US)
- Stanford University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Tye, Kay M.
- Deisseroth, Karl
- ORCID
- Venue
- Nature
- Published
- 2012-12-12
- Volume
- 493
- Issue
- 7433
- Pages
- 537-541
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4160519
- OpenAlex
- W2117782909
- Cited by
- 1,073
- References
- 34
- Citations by year
- 2026: 47 · 2025: 79 · 2024: 75 · 2023: 78 · 2022: 87 · 2021: 112 · 2020: 67 · 2019: 98 · 2018: 84 · 2017: 68 · 2016: 72 · 2015: 83 · 2014: 70 · 2013: 50 · 2012: 2
- FWCI
- 27.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- PMC
- Funders
- Howard Hughes Medical Institute
- W. M. Keck Foundation
- McKnight Foundation
- National Alliance for Research on Schizophrenia and Depression
- Defense Advanced Research Projects Agency
- National Institute of Mental Health (F32 MH880102)
- National Institute on Drug Abuse (DP2DA035149)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP2DK102256)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- midbrain dopaminergic neurons, ventral tegmental area, depression, chronic mild stress, social defeat, nucleus accumbens, neural coding, phasic neuronal activity, optogenetic manipulation, stress resilience, anhedonia, depression-like behavior, freely moving rodents
- MeSH terms
- Animals, Depression, Dopamine, Female, Male, Models, Neurological, Nucleus Accumbens, Phenotype, Stress, Psychological, Time Factors, Ventral Tegmental Area, Rats, Long-Evans, Mice, Rats, Dopaminergic Neurons, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
