Cited by 25Neurological disorders and treatmentsNeurotransmitter Receptor Influence on BehaviorTranscranial Magnetic Stimulation Studies

Deep brain stimulation of the medial forebrain bundle elevates striatal dopamine concentration without affecting spontaneous or reward-induced phasic release

Klanker, Marianne, Feenstra, Matthijs, Willuhn, Ingo, Denys, Damiaan·2017·Neuroscience

Abstract

Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) induces rapid improvement of depressive symptoms in patients suffering from treatment-refractory major depressive disorder (MDD). It has been hypothesized that activation of the dopamine (DA) system contributes to this effect. To investigate whether DBS in the MFB affects DA release in the striatum, we combined DBS with fast-scan cyclic voltammetry (FSCV) in freely moving rats. Animals were implanted with a stimulating electrode at the border of the MFB and the ventral tegmental area, and a FSCV microelectrode in the ventromedial striatum to monitor extracellular DA during the acute onset of DBS and subsequent continued stimulation. DBS onset induced a significant increase in extracellular DA concentration in the ventromedial striatum that was sustained for at least 40s. However, continued DBS did not affect amplitude or frequency of so-called spontaneous phasic DA transients, nor phasic DA release in response to the delivery of unexpected food pellets. These findings suggest that effects of DBS in the MFB are mediated by an acute change in extracellular DA concentration, but more research is needed to further explore the potentially sustained duration of this effect. Together, our results provide both support and refinement of the hypothesis that MFB DBS activates the DA system: DBS induces an increase in overall ambient concentration of DA, but spontaneous or reward-associated more rapid, phasic DA dynamics are not enhanced. This knowledge improves our understanding of how DBS affects brain function and may help improve future therapies for depressive symptoms.

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Crossref · 10.1016/j.neuroscience.2017.09.012

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  • The medial forebrain bundle was selected as a DBS-target for treatment-resistant depression based on its key function within the reward circuit.

    “The medial forebrain bundle (MFB) was selected as a DBS-target for TRD based on its key function within the reward circuit [63,64].”

    From Deep brain stimulation for depression. (2022) · cites this paper as [63]

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Authors
Klanker, M., Feenstra, M., Willuhn, I., & Denys, D.
Affiliations
Netherlands Institute for Neuroscience (NL)
Corresponding author
Klanker, Marianne
Venue
Neuroscience
Publisher
Elsevier BV
Published
2017-11
Volume
364
Pages
82-92
ISSN
0306-4522 (ISSN-L)
OpenAlex
W2755309549
Cited by
25
References
83
Citations by year
2026: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 1
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
deep brain stimulation, medial forebrain bundle, striatal dopamine, extracellular dopamine, phasic dopamine release, ventromedial striatum, ventral tegmental area, major depressive disorder, fast-scan cyclic voltammetry, dopaminergic system
MeSH terms
Animals, Chemistry Techniques, Analytical, Dopamine, Male, Medial Forebrain Bundle, Reward, Rats, Wistar, Ventral Tegmental Area, Deep Brain Stimulation, Rats, Ventral Striatum

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