Deep brain stimulation of the medial forebrain bundle elevates striatal dopamine concentration without affecting spontaneous or reward-induced phasic release
Abstract
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) induces rapid improvement of depressive symptoms in patients suffering from treatment-refractory major depressive disorder (MDD). It has been hypothesized that activation of the dopamine (DA) system contributes to this effect. To investigate whether DBS in the MFB affects DA release in the striatum, we combined DBS with fast-scan cyclic voltammetry (FSCV) in freely moving rats. Animals were implanted with a stimulating electrode at the border of the MFB and the ventral tegmental area, and a FSCV microelectrode in the ventromedial striatum to monitor extracellular DA during the acute onset of DBS and subsequent continued stimulation. DBS onset induced a significant increase in extracellular DA concentration in the ventromedial striatum that was sustained for at least 40s. However, continued DBS did not affect amplitude or frequency of so-called spontaneous phasic DA transients, nor phasic DA release in response to the delivery of unexpected food pellets. These findings suggest that effects of DBS in the MFB are mediated by an acute change in extracellular DA concentration, but more research is needed to further explore the potentially sustained duration of this effect. Together, our results provide both support and refinement of the hypothesis that MFB DBS activates the DA system: DBS induces an increase in overall ambient concentration of DA, but spontaneous or reward-associated more rapid, phasic DA dynamics are not enhanced. This knowledge improves our understanding of how DBS affects brain function and may help improve future therapies for depressive symptoms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The medial forebrain bundle was selected as a DBS-target for treatment-resistant depression based on its key function within the reward circuit.
“The medial forebrain bundle (MFB) was selected as a DBS-target for TRD based on its key function within the reward circuit [63,64].”
From Deep brain stimulation for depression. (2022) · cites this paper as [63]
Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 2× · see citing works
“…of dopaminergic pathways is thought to contribute to anhedonia and motivational dysfunction in depressive patients (Dunlop and Nemeroff, 2007; Drevets et al., 2008; Russo and Nestler, 2013) and has been linked to depression-like behavior in rodent models (Friedman et al., 2012; Chaudhury et…”
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244 · see citing works
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
Tye, K. M., Mirzabekov, J. J., Warden, M. R., Ferenczi, E. A., Tsai, H.-C., Finkelstein, J., Kim, S.-Y., Adhikari, A., Thompson, K. R., Andalman, A. S., et al. (2013) · Nature · doi:10.1038/nature11740 · Cited by 1,073 · see citing works
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027 · see citing works
Garonzik, I., Weiss, N., Samdani, A., & Lenz, F. (2008) · Springer Berlin Heidelberg · doi:10.1007/978-3-642-30991-5 · Cited by 975 · see citing works
Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression
Malone, D. A., Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Friehs, G. M., Eskandar, E. N., Rauch, S. L., Rasmussen, S. A., Machado, A. G., Kubu, C. S., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.029 · Cited by 897 · see citing works
Greenberg, B. D., Gabriels, L. A., Malone, D. A., Rezai, A. R., Friehs, G. M., Okun, M. S., Shapira, N. A., Foote, K. D., Cosyns, P. R., Kubu, C. S., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.55 · Cited by 867 · see citing works
Denys, D., Mantione, M., Figee, M., van den Munckhof, P., Koerselman, F., Westenberg, H., Bosch, A., & Schuurman, R. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.122 · Cited by 763 · see citing works
Self-citationDetecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo
Robinson, D. L., Venton, B. J., Heien, M. L., & Wightman, R. M. (2003) · Clinical Chemistry · doi:10.1373/49.10.1763 · Cited by 602 · see citing works
Prolonged dopamine signalling in striatum signals proximity and value of distant rewards
Howe, M. W., Tierney, P. L., Sandberg, S. G., Phillips, P. E. M., & Graybiel, A. M. (2013) · Nature · doi:10.1038/nature12475 · Cited by 565 · see citing works
Rapid effects of deep brain stimulation for treatment-resistant major depression
Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Mädler, B., & Coenen, V. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.034 · Cited by 563 · see citing works
Expected value and prediction error abnormalities in depression and schizophrenia
Gradin, V. B., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., & Steele, J. D. (2011) · Brain · doi:10.1093/brain/awr059 · Cited by 485 · see citing works
Reduced Reward Learning Predicts Outcome in Major Depressive Disorder
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P. A., de Boer, P., Schmidt, M. E., & Claes, S. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.014 · Cited by 443 · see citing works
Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals
Clark, J. J., Sandberg, S. G., Wanat, M. J., Gan, J. O., Horne, E. A., Hart, A. S., Akers, C. A., Parker, J. G., Willuhn, I., Martinez, V., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1412 · Cited by 378 · see citing works
Self-citationAbnormal temporal difference reward-learning signals in major depression
Kumar, P., Waiter, G., Ahearn, T., Milders, M., Reid, I., & Steele, J. D. (2008) · Brain · doi:10.1093/brain/awn136 · Cited by 374 · see citing works
Bewernick, B. H., Kayser, S., Sturm, V., & Schlaepfer, T. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.44 · Cited by 371 · see citing works
The medial forebrain bundle of the rat. I. General introduction
Nieuwenhuys, R., Geeraedts, L. M. G., & Veening, J. G. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902060106 · Cited by 354 · see citing works
Resolving Neurotransmitters Detected by Fast-Scan Cyclic Voltammetry
Heien, M. L., Johnson, M. A., & Wightman, R. M. (2004) · Analytical Chemistry · doi:10.1021/ac0491509 · Cited by 353 · see citing works
Role of the dopaminergic system in depression
Kapur, S., & Mann, J. J. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90137-o · Cited by 350 · see citing works
Cannabinoids Enhance Subsecond Dopamine Release in the Nucleus Accumbens of Awake Rats
Cheer, J. F., Wassum, K. M., Heien, M. L. A. V., Phillips, P. E. M., & Wightman, R. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0529-04.2004 · Cited by 343 · see citing works
Bergfeld, I. O., Mantione, M., Hoogendoorn, M. L. C., Ruhé, H. G., Notten, P., van Laarhoven, J., Visser, I., Figee, M., de Kwaasteniet, B. P., Horst, F., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0152 · Cited by 336 · see citing works
Self-citationDissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327 · see citing works
Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats
Hamani, C., Diwan, M., Macedo, C. E., Brandão, M. L., Shumake, J., Gonzalez-Lima, F., Raymond, R., Lozano, A. M., Fletcher, P. J., & Nobrega, J. N. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.025 · Cited by 324 · see citing works
Dysfunctional reward circuitry in obsessive-compulsive disorder
Figee, M., Vink, M., de Geus, F., Vulink, N., Veltman, D. J., Westenberg, H., & Denys, D. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.003 · Cited by 315 · see citing works
Self-citationRobinson, D. L., Heien, M. L. A. V., & Wightman, R. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10477.2002 · Cited by 290 · see citing works
(2004) · PubMed · Cited by 279 · see citing works
Self-citationCoenen, V. A., Schlaepfer, T. E., Maedler, B., & Panksepp, J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.009 · Cited by 246 · see citing works
Willuhn, I., Burgeno, L. M., Everitt, B. J., & Phillips, P. E. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213460109 · Cited by 241 · see citing works
Self-citationPuigdemont, D., Pérez‐Egea, R., Portella, M. J., Molet, J., de Diego-Adeliño, J., Gironell, A., Raduà, J., Gómez‐Ansón, B., Rodríguez, R. R., Serra-Blasco, M., et al. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001088 · Cited by 235 · see citing works
Perani, D., Garibotto, V., Gorini, A., Moresco, R. M., Henin, M., Panzacchi, A., Matarrese, M., Carpinelli, A., Bellodi, L., & Fazio, F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.233 · Cited by 219 · see citing works
Veening, J. G., Swanson, L. W., Cowan, W. M., Nieuwenhuys, R., & Geeraedts, L. M. G. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902060107 · Cited by 212 · see citing works
Multivariate concentration determination using principal component regression with residual analysis
Keithley, R. B., Wightman, R. M., & Heien, M. L. (2009) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2009.07.002 · Cited by 205 · see citing works
Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder
Denys, D., van der Wee, N., Janssen, J., De Geus, F., & Westenberg, H. G. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.023 · Cited by 195 · see citing works
Self-citationGarris, P. A., Christensen, J. R. C., Rebec, G. V., & Wightman, R. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010152.x · Cited by 192 · see citing works
Dopamine release is heterogeneous within microenvironments of the rat nucleus accumbens
Wightman, R. M., Heien, M. L., Wassum, K. M., Sombers, L. A., Aragona, B. J., Khan, A. S., Ariansen, J. L., Cheer, J. F., Phillips, P. E. M., & Carelli, R. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05772.x · Cited by 179 · see citing works
Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder
Denys, D. A. J. P., de Vries, F., Cath, D. C., Figee, M., Vulink, N. C. C., Veltman, D. J., van der Doef, T. F., Boellaard, R., Westenberg, H. G. M., van Balkom, A. J. L. M., et al. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.05.012 · Cited by 167 · see citing works
Self-citationSchlaepfer, T. E., Bewernick, B. H., Kayser, S., Hurlemann, R., & Coenen, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.28 · Cited by 160 · see citing works
Bruet, N., Windels, F., Bertrand, A., Feuerstein, C., Poupard, A., & Savasta, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.1.15 · Cited by 147 · see citing works
Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action
Anderson, R. J., Frye, M. A., Abulseoud, O. A., Lee, K. H., McGillivray, J., Berk, M., & Tye, S. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.001 · Cited by 137 · see citing works
The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder
Coenen, V. A., Schlaepfer, T. E., Goll, P., Reinacher, P. C., Voderholzer, U., Tebartz van Elst, L., Urbach, H., & Freyer, T. (2017) · CNS Spectrums · doi:10.1017/s1092852916000286 · Cited by 128 · see citing works
Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine
Kim, I. H., Rossi, M. A., Aryal, D. K., Racz, B., Kim, N., Uezu, A., Wang, F., Wetsel, W. C., Weinberg, R. J., Yin, H., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4015 · Cited by 127 · see citing works
Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation
Collins, A. L., Greenfield, V. Y., Bye, J. K., Linker, K. E., Wang, A. S., & Wassum, K. M. (2016) · Scientific Reports · doi:10.1038/srep20231 · Cited by 116 · see citing works
Deep Brain Stimulation for Intractable Psychiatric Disorders
Goodman, W. K., & Alterman, R. L. (2010) · Annual Review of Medicine · doi:10.1146/annurev-med-052209-100401 · Cited by 115 · see citing works
Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder
Figee, M., de Koning, P., Klaassen, S., Vulink, N., Mantione, M., van den Munckhof, P., Schuurman, R., van Wingen, G., van Amelsvoort, T., Booij, J., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.021 · Cited by 112 · see citing works
Self-citationYou, Z. ‐., Chen, Y., & Wise, R. A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00379-7 · Cited by 112 · see citing works
Phillips, P. E. M., Robinson, D. L., Stuber, G. D., Carelli, R. M., & Wightman, R. M. (2003) · Humana Press eBooks · doi:10.1385/1-59259-358-5:443 · Cited by 112 · see citing works
Weele, C. M. V., Porter‐Stransky, K. A., Mabrouk, O. S., Lovic, V., Singer, B. F., Kennedy, R. T., & Aragona, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12709 · Cited by 109 · see citing works
Hernández, G., Hamdani, S., Rajabi, H., Conover, K. L., Stewart, J., Arvanitogiannis, A., & Shizgal, P. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.4.888 · Cited by 105 · see citing works
Schneier, F. R., Martínez, D., Abi‐Dargham, A., Zea‐Ponce, Y., Simpson, H. B., Liebowitz, M. R., & Laruelle, M. A. (2007) · Depression and Anxiety · doi:10.1002/da.20268 · Cited by 100 · see citing works
The coaction of tonic and phasic dopamine dynamics
Atcherley, C. W., Wood, K. M., Parent, K. L., Hashemi, P., & Heien, M. L. (2014) · Chemical Communications · doi:10.1039/c4cc06165a · Cited by 89 · see citing works
Jiménez-Sánchez, L., Castañé, A., Pérez-Caballero, L., Grifoll, M., López-Gil, X., Campa, L., Galofré, M., Berrocoso, E., & Adell, A. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv133 · Cited by 83 · see citing works
Gratton, A. P., Hoffer, B. J., & Gerhardt, G. A. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90247-x · Cited by 82 · see citing works
Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells
Yeomans, J. S., Maidment, N. T., & Bunney, B. S. (1988) · Brain Research · doi:10.1016/0006-8993(88)91547-8 · Cited by 81 · see citing works
van Dijk, A., Klompmakers, A. A., Feenstra, M. G. P., & Denys, D. A. J. P. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12054 · Cited by 80 · see citing works
Self-citationKilpatrick, M., Rooney, M. B., MICHAEL, D., & Wightman, R. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00578-3 · Cited by 80 · see citing works
Tracking the mechanisms of deep brain stimulation for neuropsychiatric disorders
Luján, J. L. (2008) · Frontiers in bioscience · doi:10.2741/3124 · Cited by 69 · see citing works
Jung, W. H., Kang, D.-H., Han, J. Y., Jang, J. H., Gu, B.-M., Choi, J.-S., Jung, M. H., Choi, C.-H., & Kwon, J. S. (2011) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01659.x · Cited by 68 · see citing works
Two substrates for medial forebrain bundle self-stimulation: Myelinated axons and dopamine axons
Yeomans, J. S. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80016-8 · Cited by 67 · see citing works
Shon, Y., Chang, S.-Y., Tye, S. J., Kimble, C. J., Bennet, K. E., Blaha, C. D., & Lee, K. H. (2009) · Journal of neurosurgery · doi:10.3171/2009.7.jns09787 · Cited by 61 · see citing works
St�hle, L., Collin, A.-K., & Ungerstedt, U. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00166955 · Cited by 57 · see citing works
Isoflurane anesthesia induces biphasic effect on dopamine release in the rat striatum
Adachi, Y., Yamada, S., Satomoto, M., Higuchi, H., Watanabe, K., & Kazama, T. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.06.020 · Cited by 55 · see citing works
Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder
Marsh, R., Tau, G. Z., Wang, Z., Huo, Y., Liu, G., Hao, X., Packard, M. G., Peterson, B. S., & Simpson, H. B. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121700 · Cited by 53 · see citing works
Re-evaluation of the role of dopamine in intracranial self-stimulation using in vivo microdialysis
Miliaressis, E., Émond, C., & Merali, Z. (1991) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80095-6 · Cited by 52 · see citing works
Döbrössy, M. D., Furlanetti, L. L., & Coenen, V. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.018 · Cited by 47 · see citing works
Edemann-Callesen, H., Voget, M., Empl, L., Vogel, M., Wieske, F., Rummel, J., Heinz, A., Mathé, A. A., Hadar, R., & Winter, C. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.02.009 · Cited by 40 · see citing works
Bregman, T., Reznikov, R., Diwan, M., Raymond, R., Butson, C. R., Nóbrega, J. N., & Hamani, C. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.02.007 · Cited by 37 · see citing works
Furlanetti, L. L., Coenen, V. A., & Döbrössy, M. D. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.036 · Cited by 37 · see citing works
Furlanetti, L. L., Coenen, V. A., Aranda, I. A. A., & Döbrössy, M. D. (2015) · Experimental Brain Research · doi:10.1007/s00221-015-4375-9 · Cited by 36 · see citing works
Adachi, Y., Yamada, S., Satomoto, M., Higuchi, H., Watanabe, K., Kazama, T., Mimuro, S., & Sato, S. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.07.012 · Cited by 31 · see citing works
Friedman, A., Lax, E., Abraham, L., Tischler, H., & Yadid, G. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.04.005 · Cited by 28 · see citing works
Rodeberg, N. T., Johnson, J. A., Bucher, E. S., & Wightman, R. M. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00142 · Cited by 28 · see citing works
Stamford, J. A., Kruk, Z. L., & Millar, J. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90124-8 · Cited by 24 · see citing works
Furlanetti, L. L., Döbrössy, M. D., Aranda, I. A. A., & Coenen, V. A. (2015) · Behavioural Neurology · doi:10.1155/2015/256196 · Cited by 23 · see citing works
Cossette, M.-P., Conover, K. L., & Shizgal, P. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.029 · Cited by 17 · see citing works
Deep Brain Stimulation in Psychiatric Disorders
Mallet, L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-045396-5.00249-9 · Cited by 15 · see citing works
Paek, S. B., Knight, E. J., Chang, S.-Y., Luján, J. L., Jang, D. P., Bennet, K. E., & Lee, K. H. (2013) · Biomedical Engineering Letters · doi:10.1007/s13534-013-0086-y · Cited by 15 · see citing works
Rat hypothalamic arcuate neuron response in electroacupuncture-induced analgesia
Hamba, M., & Toda, K. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90116-5 · Cited by 14 · see citing works
Animal Studies in Deep Brain Stimulation Research
Feenstra, M., & Denys, D. (2012) · Springer eBooks · doi:10.1007/978-3-642-30991-5_20 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis
Cho, H., Kim, S., Sim, J., Yang, S., An, H., Nam, M., Jang, D. P., & Lee, C. J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00646-3 · Cited by 142 · see citing works
Fenoy, A. J., Quevedo, J., & Soares, J. C. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01100-6 · Cited by 57 · see citing works
Döbrössy, M. D., Ramanathan, C., Vajari, D. A., Tong, Y., Schlaepfer, T. E., & Coenen, V. A. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14975 · Cited by 36 · see citing works
Thiele, S., Furlanetti, L. L., Pfeiffer, L.-M., Coenen, V. A., & Döbrössy, M. D. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.02.002 · Cited by 35 · see citing works
Vajari, D. A., Ramanathan, C., Tong, Y., Stieglitz, T., Coenen, V. A., & Döbrössy, M. D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113224 · Cited by 29 · see citing works
Zhang, K. K., Matin, R., Gorodetsky, C., Ibrahim, G. M., & Gouveia, F. V. (2024) · Translational Psychiatry · doi:10.1038/s41398-023-02727-5 · Cited by 28 · see citing works
Kumari, L. S., & Kouzani, A. Z. (2022) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2022.3141369 · Cited by 26 · see citing works
Thiele, S., Sörensen, A., Weis, J., Braun, F., Meyer, P. T., Coenen, V. A., & Döbrössy, M. D. (2020) · Stereotactic and Functional Neurosurgery · doi:10.1159/000504860 · Cited by 23 · see citing works
Biomarkers for Deep Brain Stimulation in Animal Models of Depression
Yuen, J., Rusheen, A. E., Price, J. B., Barath, A. S., Shin, H., Kouzani, A. Z., Berk, M., Blaha, C. D., Lee, K. H., & Oh, Y. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13483 · Cited by 16 · see citing works
Neurochemical mechanisms of deep brain stimulation for depression in animal models
Campos, A. C. P., Pople, C. B., Silk, E., Surendrakumar, S., Rabelo, T. K., Meng, Y., Gouveia, F. V., Lipsman, N., Giacobbe, P., & Hamani, C. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.12.003 · Cited by 16 · see citing works
Tong, Y., Pfeiffer, L., Serchov, T., Coenen, V. A., & Döbrössy, M. D. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25014 · Cited by 14 · see citing works
Telega, L. M., Vajari, D. A., Stieglitz, T., Coenen, V. A., & Döbrössy, M. D. (2022) · Brain Sciences · doi:10.3390/brainsci12081105 · Cited by 13 · see citing works
Cui, D., Mesaros, A., Burdeos, G. C., Voigt, I., Giavalisco, P., Hinze, Y., Purrio, M., Neumaier, B., Drzezga, A. E., Obata, Y., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176297 · Cited by 7 · see citing works
Telega, L. M., Vajari, D. A., Ramanathan, C., Coenen, V. A., & Döbrössy, M. D. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16223 · Cited by 6 · see citing works
Gardner, W., Fuchs, F., Durieux, L., Bourgin, P., Coenen, V. A., Döbrössy, M. D., & Lecourtier, L. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.06.023 · Cited by 4 · see citing works
Miniature FSCV Devices: A Review
Corva, D. M., Adams, S. D., Bennet, K. E., Berk, M., & Kouzani, A. Z. (2021) · IEEE Sensors Journal · doi:10.1109/jsen.2021.3069950 · Cited by 3 · see citing works
Putative novel neuromodulatory treatments for affective disorders – What might emerge?
Kilian, H. M., Meyer, D. M., & Schlaepfer, T. E. (2019) · Personalized Medicine in Psychiatry · doi:10.1016/j.pmip.2019.07.002 · Cited by 2 · see citing works
Electrochemical detection of serotonin release in rodents
Robke, R., Parthasarathy, A., Willuhn, I., & Hashemi, P. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00008-6 · Cited by 2 · see citing works
Self-citationDerksen, M., Zuidinga, B., van der Veer, M., Rhemrev, V., Jolink, L., Reneman, L., Nederveen, A. J., Forstmann, B. U., Feenstra, M. G. P., Willuhn, I., et al. (2023) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2023.111611 · Cited by 1 · see citing works
Self-citationStereotaxic Surgery in Rodents for Stimulation of the Brain Reward System
Geiger, B. M., Irene, M., & Pothos, E. N. (2020) · Neuromethods · doi:10.1007/978-1-0716-1146-3_2
Ghoreishian, F., & Pooyan, M. (2021) · International Journal of Engineering · doi:10.5829/ije.2021.34.05b.20
Mechanisms of deep brain stimulation for psychiatric disorders
Brusco, C., Feigen, C. M., & Eskandar, E. N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00017-3
Shevlin, B. R. K., Fu, Q. X., Batten, S. R., Kopell, B. H., Davis, A. N., Heflin, M., Heisig, S., Rozell, C. J., Kato, A., Kulkarni, K. R., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.03.353
- Authors
- Klanker, M., Feenstra, M., Willuhn, I., & Denys, D.
- Affiliations
- Netherlands Institute for Neuroscience (NL)
- Corresponding author
- Klanker, Marianne
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 364
- Pages
- 82-92
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2755309549
- Cited by
- 25
- References
- 83
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, medial forebrain bundle, striatal dopamine, extracellular dopamine, phasic dopamine release, ventromedial striatum, ventral tegmental area, major depressive disorder, fast-scan cyclic voltammetry, dopaminergic system
- MeSH terms
- Animals, Chemistry Techniques, Analytical, Dopamine, Male, Medial Forebrain Bundle, Reward, Rats, Wistar, Ventral Tegmental Area, Deep Brain Stimulation, Rats, Ventral Striatum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review